Protective effects of Ziziphora tenuior extract against chlorpyrifos induced liver and lung toxicity in rat: Mechanistic approaches in subchronic study.

abstract：:Acute severe carbon monoxide (CO) poisoning induces hypoxia that leads to cardiovascular and nervous systems disturbances. Different complex mechanisms lead to CO neurotoxicity including lipid peroxidation, inflammatory and immune-mediated reactions, myelin degeneration and finally neuronal apoptosis and necrosis. Gra...

journal_title：Environmental toxicology

authors： Ghorbani M,Mohammadpour AH,Abnous K,Movassaghi AR,Sarshoori JR,Shahsavand S,Hashemzaei M,Moallem SA

更新日期：2017-01-01 00:00:00

abstract：:Microcystins (MCs), as the most dominant bloom-forming strains in eutrophic surface water, can induce hepatotoxicity by oxidative stress. Alpha-lipoic acid (α-LA) is a super antioxidant that can induce the synthesis of antioxidants, such as glutathione (GSH), by nuclear factor erythroid 2-related factor 2 (Nrf2). Howe...

journal_title：Environmental toxicology

authors： Gu L,Li S,Bai J,Zhang Q,Han Z

更新日期：2020-07-01 00:00:00

abstract：:Sulfur dioxide (SO2 ) is a ubiquitous air pollutant. The previous studies have documented the adverse effects of SO2 on nervous system health, suggesting that acutely SO2 inhalation at high concentration may be associated with neurotoxicity and increase risk of hospitalization and mortality of many brain disorders. Ho...

journal_title：Environmental toxicology

authors： Yao G,Yun Y,Sang N

更新日期：2016-07-01 00:00:00

abstract：:Crude extract of Rheum palmatum L (CERP) has been used to treat different diseases in the Chinese population for decades. In this study, we investigated the effects of CERP on LS1034 human colorectal cancer cells in vitro and also examined possible mechanisms of cell death. Flow cytometric assays were used to measure ...

journal_title：Environmental toxicology

authors： Ma YS,Hsu SC,Weng SW,Yu CC,Yang JS,Lai KC,Lin JP,Lin JG,Chung JG

更新日期：2014-09-01 00:00:00

abstract：:Three methods of algal assays--the standard assay, microassay, and the proposed fluorescence assay--are compared from the point of view of reliability of EC50 detection, the minimum required time for the detection, sensitivity of individual measurement, i.e. at which cell density the particular assay can be used for E...

journal_title：Environmental toxicology

authors： Kvíderová J

更新日期：2010-12-01 00:00:00

abstract：:Aluminum methylcyclohexylphosphinate (AMHP), calcium methylcyclohexylphosphinate (CMHP), aluminum diethylphosphinate (ADEP), and aluminum methylethylphosphinate (AMEP) are organic dialkyl phosphinates (DPs) and emerging phosphorus-based flame retardants. The broad-spectrum DPs flame retardants occupy high-end industri...

journal_title：Environmental toxicology

authors： Bao J,Liu Y,Li L,Chen M,Liu J,Niu Y,Liu J,Liang Y

更新日期：2017-05-01 00:00:00

abstract：:New reports indicate that the toxic alkaloid cylindrospermopsin occurs in cyanobacteria in Israel, Florida, South America, and Australia in drinking water sources. This toxin is now recognised as a potential threat to human health. Furthermore, we have recently demonstrated the mutagenicity of cylindrospermopsin in vi...

journal_title：Environmental toxicology

authors： Falconer IR,Humpage AR

更新日期：2001-01-01 00:00:00

abstract：:Several estuaries along the Pacific Ocean coast of North America were identified recently as having elevated 4-nonylphenol (4-NP) in sediments and biota, raising concerns about reproductive impacts for wildlife given 4-NP's established estrogenic activity as an endocrine-disrupting compound. Here we characterize 4-NP ...

journal_title：Environmental toxicology

authors： Johnson KM,Lema SC

更新日期：2017-05-01 00:00:00

abstract：:Widespread occupational and environmental exposure to benzene is unavoidable and poses a public health threat. Studies of potential interventions to prevent or relieve benzene toxicity are, thus, essential. Research has shown l-carnitine (LC) has beneficial effects against various pathological processes and diseases. ...

journal_title：Environmental toxicology

authors： Sun R,Man Z,Ji J,Ji S,Xu K,Pu Y,Yu L,Zhang J,Yin L,Pu Y

更新日期：2020-10-01 00:00:00

abstract：:Tributyltin (TBT), a well-known endocrine disruptor, is an omnipresent environmental pollutant and is explicitly used in many industrial applications. Previously we have shown its neurotoxic potential on cerebral cortex of male Wistar rats. As the effect of TBT on other brain regions is not known, we planned this stud...

journal_title：Environmental toxicology

authors： Mitra S,Siddiqui WA,Khandelwal S

更新日期：2015-12-01 00:00:00

abstract：:Microcystin-LR (MC-LR) is a potent inhibitor of protein phosphatases 1 and 2A, and has potent hepatotoxicity and tumor promotion activity. Numerous studies on MC-LR toxicity have been conducted in rat hepatocytes, but few studies of the effects of microcystins on human hepatocytes have been done. In this study, HL7702...

journal_title：Environmental toxicology

authors： Sun Y,Zheng Q,Sun YT,Huang P,Guo ZL,Xu LH

更新日期：2014-11-01 00:00:00

abstract：:Some species of the genera Anabaena can produce various kinds of cyanotoxins, which may pose risks to environment and human health. Anabaena has frequently been observed in eutrophic freshwater of China in recent years, but its toxicity has been reported only in a few studies. In the present study, the toxicity of an ...

journal_title：Environmental toxicology

authors： Pan X,Chang F,Liu Y,Li D,Xu A,Shen Y,Huang Z

更新日期：2009-02-01 00:00:00

abstract：:We performed an interspecies comparison for the human hepatoma cell line HepG2 and the eukaryotic single cell organism Tetrahymena pyriformis (T. pyriformis) for 17 xenobiotics with diverse structures and four metals. The cytotoxicity was assessed by four different cell viability assays (3-[4,5-dimethylthiazol-2-yl]-2...

journal_title：Environmental toxicology

authors： Rudzok S,Krejči S,Graebsch C,Herbarth O,Mueller A,Bauer M

更新日期：2011-04-01 00:00:00

abstract：:Metabolic products are often more toxic than their pharmacological parent compounds. Therefore, the acute and chronic effects of the main metabolites--salicylic acid (SAL), gentisic acid (GEN), and o-hydroxyhippuric acid (HDP)--of acetylsalicylic acid (ASA), the active ingredient in Aspirin and many other pharmaceutic...

journal_title：Environmental toxicology

authors： Marques CR,Abrantes N,Gonçalves F

更新日期：2004-10-01 00:00:00

abstract：:In this study, toxic effects of the cypermethrin in Allium cepa L. cells were investigated. For this aim, we investigated the changes in pigment contents, antioxidant enzymes, mitotic index and chromosomal abnormalities as indicators of toxicity. The seeds were treated with different doses (1.5, 3.0, 6.0 ppm) of cyper...

journal_title：Environmental toxicology

authors： Çavuşoğlu K,Kaya A,Yilmaz F,Yalçin E

更新日期：2012-10-01 00:00:00

abstract：:Renal cell carcinoma (RCC) is the most common type of kidney cancer in adults and the major cause of mortality in urological cancer. Most patients with RCC are asymptomatic until the disease is advanced and unresectable. In this situation, systemic therapy with immunotherapy or molecularly targeted therapy agents play...

journal_title：Environmental toxicology

authors： Wu SW,Chen PN,Lin CY,Hsieh YS,Chang HR

更新日期：2017-07-01 00:00:00

abstract：:Organic wastewater contaminants (OWCs) have recently been documented in several aquatic ecosystems. We examined the effects of three OWCs (caffeine, acetaminophen, and triclosan) on the activity level, startle response, survivorship, and growth of northern leopard frog (Rana pipiens) tadpoles. We conducted two experim...

journal_title：Environmental toxicology

authors： Fraker SL,Smith GR

更新日期：2004-06-01 00:00:00

abstract：:The toxicity of petroleum hydrocarbons to marine aquatic organisms has been widely investigated; however, the effects on freshwater environments have largely been ignored. Selected biomarkers were measured in a freshwater species, the crimson-spotted rainbowfish (Melanotaenia fluviatilis). Fish were exposed to either ...

journal_title：Environmental toxicology

authors： Pollino CA,Holdway DA

更新日期：2003-02-01 00:00:00

abstract：:Bergapten is a natural compound and has potent anticancer activities. In this study, we explored the cytotoxicity of bergapten on colorectal cancer (CRC) cell DLD-1 and LoVo and its underlying mechanisms. We observed that bergapten (30 and 50 μM) decreased the viability of the CRC cells and induced the G0/G1 and sub-G...

journal_title：Environmental toxicology

authors： Lin CP,Lin CS,Lin HH,Li KT,Kao SH,Tsao SM

更新日期：2019-03-01 00:00:00

abstract：:Micronucleus induction by the diarrhetic shellfish toxin okadaic acid (OA) was investigated in two intestinal models, cultured human Caco-2 cells and colon epithelial cells of mice treated in vivo. Exposure to OA for 4 and 24 h induced dose-responsive increases in the frequency of micronucleated Caco-2 cells; the mini...

journal_title：Environmental toxicology

authors： Le Hégarat L,Jacquin AG,Bazin E,Fessard V

更新日期：2006-02-01 00:00:00

abstract：:In recent years, the protective effect of hydrogensulfide donor sodium hydrosulfide(NaHS) on multiple organs has been widely reported. The study aimed to explorethe effect of commonly used concentration of NaHS on theliver and its potential damage mechanism. Rats divided into 4 groups: control, NaHS I (1 mg/kg), II (3...

journal_title：Environmental toxicology

authors： Feng X,Zhang H,Shi M,Chen Y,Yang T,Fan H

更新日期：2020-03-01 00:00:00

abstract：:Exposure to sublethal hexavalent chromium (as 2 and 4 mg L⁻¹ potassium dichromate for 1 and 2 months) during late preparatory to mid prespawning phase of annual reproductive cycle severely affected the pituitary-ovarian axis of a teleost Channa punctatus. Gonadosomatic index (GSI), ovarian histopathology, immunocytoch...

journal_title：Environmental toxicology

authors： Mishra AK,Mohanty B

更新日期：2012-07-01 00:00:00

abstract：:The acute toxicity of the insecticide fenitrothion was measured using four freshwater algae (Chlorella saccharophila, Chlorella vulgaris, Scenedesmus acutus, and Scenedesmus subspicatus) and one cyanobacteria (Pseudanabaena galeata). Insecticide concentrations eliciting 50% growth reduction over 96 hr (EC50) ranged fr...

journal_title：Environmental toxicology

authors： Sabater C,Carrasco JM

更新日期：2001-01-01 00:00:00

abstract：:This work investigated the effects of mercury chloride (HgCl2 ) acute exposure on virgin, pregnant and lactating rats by determination of renal and hepatic morphological and ultrastructural parameters and the expression of oxidative stress and stress tolerance markers, due to kidney and liver are the organs that more ...

journal_title：Environmental toxicology

authors： Oliveira VA,Favero G,Stacchiotti A,Giugno L,Buffoli B,de Oliveira CS,Lavazza A,Albanese M,Rodella LF,Pereira ME,Rezzani R

更新日期：2017-05-01 00:00:00

abstract：:Particulate matter the environmental toxicant, with a diameter less than or equal to 2.5 μm (PM2.5 ) is a common cause of several respiratory diseases. In recent years, several studies have suggested that PM2.5 can influence diverse diseases, such as respiratory diseases, cardiovascular diseases, metabolic diseases, d...

journal_title：Environmental toxicology

authors： Kim W,Cho Y,Song MK,Lim JH,Kim JY,Gye MC,Ryu JC

更新日期：2018-11-01 00:00:00

abstract：:Tributyltin (TBT) and dibutyltin (DBT) are widespread environmental contaminants found in food, beverages, and human blood samples. Both of these butyltins (BTs) interfere with the ability of human natural killer (NK) cells to lyse target cells and alter secretion of the pro-inflammatory cytokine tumor necrosis factor...

journal_title：Environmental toxicology

authors： Lawrence S,Reid J,Whalen M

更新日期：2015-05-01 00:00:00

abstract：:The genotoxic effects of a particular mixture of acetamiprid (Acm, neonicotinoid insecticide) and alpha-cypermethrin (alpha-cyp, pyrethroid insecticide) on human peripheral lymphocytes were examined in vitro by chromosomal aberrations (CAs), sister chromatid exchange (SCE), and micronucleus (MN) tests. The human perip...

journal_title：Environmental toxicology

authors： Kocaman AY,Topaktaş M

更新日期：2010-04-01 00:00:00

abstract：:Endotoxins exist anywhere including in water pools, dust, humidifier systems, and machining fluids. The major causal factor is endotoxins in many serious diseases, such as fever, sepsis, multi-organ failure, meningococcemia, and severe morbidities like neurologic disability, or hearing loss. Endotoxins are also called...

journal_title：Environmental toxicology

authors： Huang YC,Horng CT,Chen ST,Lee SS,Yang ML,Lee CY,Kuo WH,Yeh CH,Kuan YH

更新日期：2016-02-01 00:00:00

abstract：:Interspecies differences in the accumulation of dietary tributyltin (TBT) between sea perch, Lateolabrax japonicus, and red sea bream, Pagrus major, were studied. Although TBTs in both species reached steady-state condition in low-concentration group (L-group, 200 ng/g nominal concentration) by 1 week, it increased up...

journal_title：Environmental toxicology

authors： Uno S,Murakami M,Kokushi E,Koyama J

更新日期：2011-02-01 00:00:00

abstract：:Culture-independent methods employed in fungal genetic studies using in vitro amplification (PCR) and analysis of specific genes or gene fragments have proved to be useful for detection, identification, and molecular taxonomy of various plant pathogens including Fusarium spp. This approach may be faster than culture-d...

journal_title：Environmental toxicology

authors： Bezuidenhout CC,Prinsloo M,Van der Walt AM

更新日期：2006-08-01 00:00:00