Influence of DEHP on thyroid, sex steroid-related genes and gonadal differentiation in Rana chensinensis tadpoles.

Abstract:

:In the present study, responses of the Chinese brown frog (Rana chensinensis) to exposure to di-2-ethylhexyl phthalate (DEHP), a common plasticizer, during the larval period were characterized. The effects of DEHP on metamorphosis rate, thyroid hormone, thyroid histology and the expression of genes involved in the steroid hormone synthesis in gonad were investigated. Metamorphosis rate and 50 percent of the tadpoles to reach Gosner stage 42 (T0.5 ) were significantly slower in all DEHP groups. The thyroid glands of the tadpoles exposed to DEHP clearly exhibited colloid depletion. In addition, decreased concentrations of T4 and T3 were observed in the tadpoles exposed to DEHP. Moreover, the highest DEHP exposure (10 µmol/L DEHP) showed increased ratio of females significantly. Also, up-regulation significantly of transcripts of cytochrome P450 aromatase (CYP19) gene was detected in male tadpoles exposed to DEHP. The present results indicate that this increase in estrogens could lead to female-biased sex ratio in DEHP exposure group. Taken together, the present study indicates that DEHP disrupt thyroid hormone and sex steroid signaling in R. chensinensis tadpoles. Our present observations support evidence of a crosstalk between TH and sex steroids in gonad differentiation.

journal_name

Environ Toxicol

journal_title

Environmental toxicology

authors

Zhang Y,Li X,Gao J,Wang H

doi

10.1002/tox.22504

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

112-121

issue

1

eissn

1520-4081

issn

1522-7278

journal_volume

33

pub_type

杂志文章
  • Protection of Nrf2 against arsenite-induced oxidative damage is regulated by the cyclic guanosine monophosphate-protein kinase G signaling pathway.

    abstract::Arsenite has been shown to induce a variety of oxidative damage in mammalian cells. However, the mechanisms underlying cellular responses to its adverse effects remain unknown. We previously showed that the level of Nrf2, a nuclear transcription factor significantly increased in arsenite-treated human bronchial epithe...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.22374

    authors: Chen C,Jiang X,Gu S,Lai Y,Liu Y,Zhang Z

    更新日期:2017-08-01 00:00:00

  • Elemental sulfur: toxicity in vivo and in vitro to bacterial luciferase, in vitro yeast alcohol dehydrogenase, and bovine liver catalase.

    abstract::The aim of this research was to analyze the effects and the modes of action of elemental sulfur (S(0)) in bioluminescence and respiration of Vibrio fischeri cells and the enzymes crude luciferase, pure catalase, and alcohol dehydrogenase (ADH). Metallic copper removed sulfur and reduced the toxicity of acetone extract...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.20025

    authors: Cetkauskaite A,Pessala P,Södergren A

    更新日期:2004-08-01 00:00:00

  • Differential effects between one week and four weeks exposure to same mass of SO2 on synaptic plasticity in rat hippocampus.

    abstract::Sulfur dioxide (SO2 ) is a ubiquitous air pollutant. The previous studies have documented the adverse effects of SO2 on nervous system health, suggesting that acutely SO2 inhalation at high concentration may be associated with neurotoxicity and increase risk of hospitalization and mortality of many brain disorders. Ho...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.22093

    authors: Yao G,Yun Y,Sang N

    更新日期:2016-07-01 00:00:00

  • Lupeol alters ER stress-signaling pathway by downregulating ABCG2 expression to induce Oxaliplatin-resistant LoVo colorectal cancer cell apoptosis.

    abstract::Colorectal cancer (CRC) is one of the most common cancers and causes of cancer-related death. There are several first-line chemotherapeutic drugs used to treat CRC. Oxaliplatin (OXA) is an alkylating cytotoxic agent that is usually combined with other chemotherapeutic drugs to treat stage II and stage III CRC. However...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.22544

    authors: Chen MC,Hsu HH,Chu YY,Cheng SF,Shen CY,Lin YJ,Chen RJ,Viswanadha VP,Lin YM,Huang CY

    更新日期:2018-05-01 00:00:00

  • Mechanisms of copper toxicity in Saccharomyces cerevisiae determined by microarray analysis.

    abstract::The effect of the heavy metal copper on the expression of a wide spectrum of genes was analyzed by using a DNA microarray. The gene expression profile of baker's yeast Saccharomyces cerevisiae grown in a medium containing a sublethal concentration of cupric sulfate was compared with that of yeast grown in a normal med...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.20406

    authors: Yasokawa D,Murata S,Kitagawa E,Iwahashi Y,Nakagawa R,Hashido T,Iwahashi H

    更新日期:2008-10-01 00:00:00

  • Differential susceptibility of brain regions to tributyltin chloride toxicity.

    abstract::Tributyltin (TBT), a well-known endocrine disruptor, is an omnipresent environmental pollutant and is explicitly used in many industrial applications. Previously we have shown its neurotoxic potential on cerebral cortex of male Wistar rats. As the effect of TBT on other brain regions is not known, we planned this stud...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.22009

    authors: Mitra S,Siddiqui WA,Khandelwal S

    更新日期:2015-12-01 00:00:00

  • Formation of MTBE-DNA adducts in mice measured with accelerator mass spectrometry.

    abstract::Methyl tert-butyl ether (MTBE) is a gasoline oxygenate and antiknock additive substituting for lead alkyls currently in use worldwide. Previous studies have shown that MTBE at very high doses induces tumors in rodents. The aim of the present study was to examine directly the binding ability of MTBE onto DNA, demonstra...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.20124

    authors: Du HF,Xu LH,Wang HF,Liu YF,Tang XY,Liu KX,Peng SX

    更新日期:2005-08-01 00:00:00

  • Chronic lead exposure enhances the sympathoexcitatory response associated with P2X4 receptor in rat stellate ganglia.

    abstract::Chronic lead exposure causes peripheral sympathetic nerve stimulation, including increased blood pressure and heart rate. Purinergic receptors are involved in the sympathoexcitatory response induced by myocardial ischemia injury. However, whether P2X4 receptor participates in sympathoexcitatory response induced by chr...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.22547

    authors: Zhu G,Chen Z,Dai B,Zheng C,Jiang H,Xu Y,Sheng X,Guo J,Dan Y,Liang S,Li G

    更新日期:2018-06-01 00:00:00

  • Biological effects of new-generation dialkyl phosphinate flame retardants and their hydrolysates in BALB/C mice.

    abstract::Aluminum methylcyclohexylphosphinate (AMHP), calcium methylcyclohexylphosphinate (CMHP), aluminum diethylphosphinate (ADEP), and aluminum methylethylphosphinate (AMEP) are organic dialkyl phosphinates (DPs) and emerging phosphorus-based flame retardants. The broad-spectrum DPs flame retardants occupy high-end industri...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.22383

    authors: Bao J,Liu Y,Li L,Chen M,Liu J,Niu Y,Liu J,Liang Y

    更新日期:2017-05-01 00:00:00

  • ISTA13-catecholamine toxicity and metabolism in the ciliated protozoan, Tetrahymena pyriformis.

    abstract::A high throughput culture methodology of unicellular eukaryote Tetrahymena pyriformis, strain GL were used for the determination of catecholamines toxicity and their metabolism. Catecholamines exhibited acute toxicity to Tetrahymena cells where dopamine and L-DOPA showed higher toxic potential of EC(10) (0.39 and 0.63...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.20457

    authors: Ud-Daula A,Pfister G,Schramm KW

    更新日期:2009-12-01 00:00:00

  • Cellular and molecular hypoxic response in common carp (Cyprinus carpio) exposed to linear alkylbenzene sulfonate at sublethal concentrations.

    abstract::Linear alkylbenzene sulfonate (LAS) is an anionic surfactant commonly used in cleaning agents such as laundry detergents. Trace amounts of LAS are released into environmental waters after processing in wastewater treatment plants after the use of this chemical. Acute toxicity of LAS has been well-studied using various...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.22217

    authors: Tasaki J,Nakayama K,Shimizu I,Yamada H,Suzuki T,Nishiyama N,Yamane M

    更新日期:2017-01-01 00:00:00

  • Casticin impairs cell migration and invasion of mouse melanoma B16F10 cells via PI3K/AKT and NF-κB signaling pathways.

    abstract::Casticin, a polymethoxyflavone, is one of the major active components obtained from Fructus viticis, which have been shown to have anticancer activities including induce cell apoptosis in human cancer cells. The aim of this study was to investigate the molecular mechanisms by which casticin inhibits cell migration and...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.22417

    authors: Shih YL,Chou HM,Chou HC,Lu HF,Chu YL,Shang HS,Chung JG

    更新日期:2017-09-01 00:00:00

  • Human albumin augmented airway inflammation induced by PM2.5 in NC/Nga mice.

    abstract::The synergic allergic inflammatory effects of particulate matter (PM) 2.5 and human albumin were investigated in NC/Nga mice, which are hypersensitive to mite allergens. PM2.5 or PM2.5 plus human albumin with aluminum oxide was injected twice intraperitoneally for sensitization. After 7 days, PM2.5 or PM2.5 plus human...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.22751

    authors: Nagaoka K,Ogino K,Ogino N,Ito T,Takemoto K,Ogino S,Seki Y,Hamada H,Fujikura Y

    更新日期:2019-07-01 00:00:00

  • Persistent hexavalent chromium exposure impaired the pubertal development and ovarian histoarchitecture in wistar rat offspring.

    abstract::Hexavalent chromium (CrVI) is a highly toxic metal and a major environmental pollutant. Several studies indicate that CrVI exposure adversely affects reproductive function. We reported that maternal Cr exposure resulted in Cr accumulation in the reproductive organs of female offsprings. CrVI can cross the placental ba...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.21810

    authors: Samuel JB,Stanley JA,Sekar P,Princess RA,Sebastian MS,Aruldhas MM

    更新日期:2014-05-01 00:00:00

  • Safrole induces cell death in human tongue squamous cancer SCC-4 cells through mitochondria-dependent caspase activation cascade apoptotic signaling pathways.

    abstract::Safrole is one of important food-borne phytotoxin that exhibits in many natural products such as oil of sassafras and spices such as anise, basil, nutmeg, and pepper. This study was performed to elucidate safrole-induced apoptosis in human tongue squamous carcinoma SCC-4 cells. The effect of safrole on apoptosis was m...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.20658

    authors: Yu FS,Huang AC,Yang JS,Yu CS,Lu CC,Chiang JH,Chiu CF,Chung JG

    更新日期:2012-07-01 00:00:00

  • Association of sick building syndrome with neuropathy target esterase (NTE) activity in Japanese.

    abstract::Sick building syndrome (SBS) is a set of several clinically recognizable symptoms reported by occupants of a building without a clear cause. Neuropathy target esterase (NTE) is a membrane bound serine esterase and its reaction with organophosphates (OPs) can lead to OP-induced delayed neuropathy (OPIDN) and nerve axon...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.21839

    authors: Matsuzaka Y,Ohkubo T,Kikuti YY,Mizutani A,Tsuda M,Aoyama Y,Kakuta K,Oka A,Inoko H,Sakabe K,Ishikawa S,Kulski JK,Kimura M

    更新日期:2014-10-01 00:00:00

  • Hematotoxic and hepatotoxic effects of dichlorvos at sublethal dosages in rats.

    abstract::The present study was designed to understand the effects of sublethal concentrations of dichlorvos (DIC) on hematological constituent [red blood corpuscles, white blood corpuscles (WBC), mean cell volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, platelet counts, hemoglobin and hematocrit...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.20390

    authors: Celik I,Yilmaz Z,Turkoglu V

    更新日期:2009-04-01 00:00:00

  • Differentiation between microcystin contaminated and uncontaminated fish by determination of unconjugated MCs using an ELISA anti-Adda test based on receiver-operating characteristic curves threshold values: application to Tinca tinca from natural ponds.

    abstract::The aim of this study was to evaluate whether the enzyme-linked immunosorbent assay (ELISA) anti-Adda technique could be used to monitor free microcystins (MCs) in biological samples from fish naturally exposed to toxic cyanobacteria by using receiver operating characteristic (ROC) curve software to establish an optim...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.20528

    authors: Moreno IM,Herrador MÁ,Atencio L,Puerto M,González AG,Cameán AM

    更新日期:2011-02-01 00:00:00

  • Depletion of Kupffer cells modulates ethanol-induced hepatocyte DNA synthesis in C57Bl/6 mice.

    abstract::Kupffer cells (KCs) are important in hepatic homeostasis and responses to xenobiotics. KCs are activated on interaction with endotoxin, releasing cytokines, and reactive oxygen species normally associated with increased gene expression, cellular growth, or hepatic injury. Ethanol-induced endotoxemia is one means of KC...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.21814

    authors: Owumi SE,Corthals SM,Uwaifo AO,Kamendulis LM,Klaunig JE

    更新日期:2014-08-01 00:00:00

  • Early exposure of 17α-ethynylestradiol and diethylstilbestrol induces morphological changes and alters ovarian steroidogenic pathway enzyme gene expression in catfish, Clarias gariepinus.

    abstract::Environmental estrogens are major cause of endocrine disruption in vertebrates, including aquatic organisms. Teleosts are valuable and popular models for studying the effects of endocrine disrupting chemicals (EDCs) in the environment. In the present study, we investigated the changes caused by exposure to the synthet...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.21920

    authors: Sridevi P,Chaitanya RK,Prathibha Y,Balakrishna SL,Dutta-Gupta A,Senthilkumaran B

    更新日期:2015-04-01 00:00:00

  • Assessment of reproductive biomarkers in three-spined stickleback (Gasterosteus aculeatus) from sewage effluent recipients.

    abstract::The aim of this study was to examine the occurrence of endocrine disruption close to sewage treatment plant effluent discharges along the Finnish Baltic Sea coast using a set of reproductive biomarkers present in adult three-spined stickleback (Gasterosteus aculeatus). Possible variation and sensitivity of the biomark...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.20715

    authors: Björkblom C,Mustamäki N,Olsson PE,Katsiadaki I,Wiklund T

    更新日期:2013-04-01 00:00:00

  • cDNA cloning and expression of a xenobiotic metabolizing cytochrome P4501A (CYP1A) from the yellow catfish, Pelteobagrus fulvidraco (Siluriformes).

    abstract::We cloned the full-length cDNA sequence of xenobiotic metabolizing cytochrome P4501A (CYP1A) gene from the yellow catfish (Pelteobagrus fulvidraco, Siluriformes, Bagridae). P. fulvidraco is a commercially important fish generally distributed in Southeast Asian countries and Korea. This is the first report of any xenob...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.20333

    authors: Kim JH,Hwang DS,Son KH,Raisuddin S,Ki JS,Lee JS,Han KN

    更新日期:2008-06-01 00:00:00

  • Toxicity of perfluorooctane sulfonate and perfluorooctanoic acid to plants and aquatic invertebrates.

    abstract::Acute toxicities of perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) were tested on four freshwater species and three plant species. PFOS was more toxic than PFOA for all species tested in this study. Similar time-response patterns of PFOS and PFOA toxicity were observed for each tested species. Valu...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.20396

    authors: Li MH

    更新日期:2009-02-01 00:00:00

  • Genotoxic, cytotoxic, and apoptotic effects of Hypogymnia physodes (L.) Nyl. on breast cancer cells.

    abstract::The aim of this study is to determine the chemical composition, and evaluate the genotoxic, and anti-growth potency of the methanol extracts of lichen species Hypogymnia physodes (L.) Nyl. (HPE). Anti-growth effect was tested in two different human breast cancer cell lines (MCF-7 and MDA-MB-231) by the MTT and ATP via...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.21809

    authors: Ari F,Celikler S,Oran S,Balikci N,Ozturk S,Ozel MZ,Ozyurt D,Ulukaya E

    更新日期:2014-05-01 00:00:00

  • Toxicity of the antimicrobial compound triclosan and formation of the metabolite methyl-triclosan in estuarine systems.

    abstract::Triclosan, a commonly used antimicrobial compound, has been measured in aquatic systems worldwide. This study exposed marine species to triclosan to examine effects primarily on survival and to investigate the formation of the degradation product, methyl-triclosan, in the estuarine environment. Acute toxicity was asse...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.20327

    authors: Delorenzo ME,Keller JM,Arthur CD,Finnegan MC,Harper HE,Winder VL,Zdankiewicz DL

    更新日期:2008-04-01 00:00:00

  • Evaluation of renal markers of T1D in Sprague-Dawley exposed to 2-aminoanthracene.

    abstract::The incidence of type 1 diabetes (T1D) and its associated risks of chronic kidney disease or end-stage renal disease development are on the rise. T1D is an autoimmune disease in which insulin-producing beta cells are destroyed. Increased incidence of T1D has been suggested to be a result of environmental factors such ...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.22857

    authors: Pierre TH,Reynolds AS,Seise I,Pilz Z,McHale BJ,Gato WE

    更新日期:2020-02-01 00:00:00

  • Carboxy terminus of HSP70-interacting protein (CHIP) attenuates the stemness of thyroid cancer cells through decreasing OCT4 protein stability.

    abstract::Cancer cell stemness results in the occurrence and progression of tumors and Oct4 (octamer-binding transcription factor) has been confirmed to be a critical contributor and marker of cancer cell stemness. Here, we aimed to explore the underlying mechanisms contributing to Oct4 protein stability, which is necessary for...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.23072

    authors: Xu Y,Xu G,Dang H,Qu W,Chang D,He X,Li M,Wang Q

    更新日期:2020-12-03 00:00:00

  • Effects of a pre-incubation period on the photoinduced toxicity of polycyclic aromatic hydrocarbons to the luminescent bacterium Vibrio fischeri.

    abstract::Irradiation of polycyclic aromatic hydrocarbons (PAHs) in aqueous solution with simulated solar radiation (SSR; a light source with a visible light: UV-A:UV-B ratio similar to that of sunlight) can greatly enhance their toxicity. Two microbial toxicity tests with Vibrio fischeri were used to investigate the effect of ...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.1034

    authors: el-Alawi YS,Dixon DG,Greenberg BM

    更新日期:2001-06-01 00:00:00

  • Perinatal exposure to low doses of tributyltin chloride advances puberty and affects patterns of estrous cyclicity in female mice.

    abstract::Tributyltin (TBT), a proven endocrine-disrupting chemical, is well known to induce imposex in female gastropods. Herein we demonstrate the effects of low doses of tributyltin chloride (TBTCl) on the female offspring of KM mice. Pregnant mice were administered by gavage with 0, 1, 10, or 100 μg TBTCl/kg body weight/day...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.21756

    authors: Si J,Han X,Zhang F,Xin Q,An L,Li G,Li C

    更新日期:2012-11-01 00:00:00

  • Inflammatory activity in river-water samples.

    abstract::Contamination of the urban aquatic environment with chemical and biological substances could have a long-term impact on human health because these substances threaten the integrity of the urban ecosystem and the availability of high-quality water for recreation and consumption. In light of this, the aim of the present...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.20067

    authors: Wichmann G,Daegelmann C,Herbarth O,Strauch G,Schirmer K,Wöstemeyer J,Lehmann I

    更新日期:2004-12-01 00:00:00