Abstract:
:A high throughput culture methodology of unicellular eukaryote Tetrahymena pyriformis, strain GL were used for the determination of catecholamines toxicity and their metabolism. Catecholamines exhibited acute toxicity to Tetrahymena cells where dopamine and L-DOPA showed higher toxic potential of EC(10) (0.39 and 0.63 mg/L, respectively) and EC(20) (1.1 and 1.0 mg/L, respectively). All the testing catecholamines were highly degradable in the PPY-medium due to the oxidizing environment during incubation. They were also naturally synthesized and released by Tetrahymena cells into the culture medium and increasingly accumulated with time where as noradrenalin demonstrated significant results. Cells were exposed with physiological concentration (0.12 mg/L) and one higher concentration (8.0 mg/L) of catecholamines, resulting noradrenalin depletion and in vivo generation of a metabolite in response to dopamine with higher concentration treatment. This dopamine metabolite was relatively nonpolar compared with the catecholamines and was eluted later from the reverse phase C-18 column.
journal_name
Environ Toxicoljournal_title
Environmental toxicologyauthors
Ud-Daula A,Pfister G,Schramm KWdoi
10.1002/tox.20457subject
Has Abstractpub_date
2009-12-01 00:00:00pages
549-54issue
6eissn
1520-4081issn
1522-7278journal_volume
24pub_type
杂志文章abstract::Trichloroethylene (TCE) is ubiquitous in our living environment, and prenatal exposure to TCE is reported to cause congenital heart disease in humans. Although multiple studies have been performed using animal models, they have limited value in predicting effects on humans due to the unknown species-specific toxicolog...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22142
更新日期:2016-11-01 00:00:00
abstract::Oral cancer is one of the cancer-related diseases in human populations and its incidence rates are rising worldwide. Fisetin, a flavonoid from natural products, has been shown to exhibit anticancer activities in many human cancer cell lines but the molecular mechanism of fisetin-induced apoptosis in human oral cancer ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22396
更新日期:2017-06-01 00:00:00
abstract::Glyphosate is the active ingredient of several herbicide formulations. Different reports suggest that glyphosate-based herbicides (GBHs) may act as endocrine disruptors. We evaluated the potential estrogenic effects of a GBH formulation using the uterotrophic assay. Adult ovariectomized rats were sc injected for 3 con...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22316
更新日期:2017-04-01 00:00:00
abstract::Wood dusts, as a group, are categorized as known human carcinogens, but the risks of exposure to specific types of wood dusts and the carcinogenic chemicals they contain are not well studied. Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that is linked to the carcinogenic action of specifi...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22007
更新日期:2015-12-01 00:00:00
abstract::Bisphenol AF (BPAF) has been shown to inhibit testicular steroidogenesis in male rats. However, the precise mechanisms related to the toxic effects of BPAF on reproduction remain poorly understood. In the present study, a mouse Leydig tumor cell line (mLTC-1) was used as a model to investigate the mechanism of steroid...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22554
更新日期:2018-06-01 00:00:00
abstract::We hypothesized that chronic exposure to arsenic would deplete the reduced glutathione (GSH) and methionine in vivo, thereby impair the methylation capacity of inorganic arsenic (iAs) ingested. Our experiment was designed to explore the effects of exogenous GSH and methionine on arsenic methylation in mice exposed to ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20509
更新日期:2010-08-01 00:00:00
abstract::A recent study has shown that nonanoic acid (NA) is one of the strongest allelochemicals to a cyanobacterium Microcystis aeruginosa, but the physiological responses of M. aeruginosa to NA stress remain unknown. In this study, physiological characters such as the growth rate, photosynthetic processes, phosphorus and ni...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20462
更新日期:2009-12-01 00:00:00
abstract::Renal cell carcinoma (RCC) is the most common type of kidney cancer in adults and the major cause of mortality in urological cancer. Most patients with RCC are asymptomatic until the disease is advanced and unresectable. In this situation, systemic therapy with immunotherapy or molecularly targeted therapy agents play...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22411
更新日期:2017-07-01 00:00:00
abstract::Hydroponics studies were conducted to investigate the antioxidant adaptations, ascorbate and glutathione metabolism in hyperaccumulating ecotype of Sedum alfredii (HE) exposed to high Cd environment, when compared with its nonhyperaccumulating ecotype (NHE). Exposure to Cd induced a burst of oxidative stress in both e...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20362
更新日期:2008-08-01 00:00:00
abstract::We performed an interspecies comparison for the human hepatoma cell line HepG2 and the eukaryotic single cell organism Tetrahymena pyriformis (T. pyriformis) for 17 xenobiotics with diverse structures and four metals. The cytotoxicity was assessed by four different cell viability assays (3-[4,5-dimethylthiazol-2-yl]-2...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20541
更新日期:2011-04-01 00:00:00
abstract::Global use of azole fungicides is expected to increase over the next several years. Triticonazole is a triazole fungicide that is used for turf protection, residential, and other commercial applications. As such, it can enter local rural and urban water systems via run-off and rain events. Early life stages of aquatic...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22862
更新日期:2020-02-01 00:00:00
abstract::Acetaminophen (APAP) is one of the few recommended analgesic and antipyretic drugs in some critical cases such as viral disease COVID-19. However, the unrestricted use of APAP develops liver disorders. Hepatotoxicity and liver injury can also be induced by ionizing radiation (IR) during radiotherapy. The data of the c...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.23077
更新日期:2020-12-17 00:00:00
abstract::Manganese (Mn) plays a critical role in individual growth and development, yet excessive exposure can result in neurotoxicity, especially cognitive impairment. Neuronal apoptosis is considered as one of the mechanisms of Mn-induced neurotoxicity. Recent evidence suggests that cAMP-PKA-CREB signaling regulates apoptosi...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22776
更新日期:2019-09-01 00:00:00
abstract::Although marine and coastal environments which are contaminated with xenobiotic organic compounds often become hypoxic during the summer, the interactive effects of hypoxia and xenobiotic exposure on marine species such as teleost fishes remain poorly understood. The expression and activity of monooxygenase enzyme cyt...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22527
更新日期:2018-04-01 00:00:00
abstract::Cantharidin is one of the major compounds from mylabris and it has cytotoxic effects in many different types of human cancer cells. Previously, we found that cantharidin induced cell death through cell cycle arrest and apoptosis induction in human lung cancer NCI-H460 cells. However, cantharidin-affected DNA damage, r...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21986
更新日期:2015-09-01 00:00:00
abstract::Modulation of microcystin production has been extensively studied in both batch and continuous cultures. Positive correlations with medium nitrogen, medium phosphorous, light intensity, inorganic carbon availability, and growth rate have been reported. Negative correlations have been reported between microcystin conte...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20106
更新日期:2005-06-01 00:00:00
abstract::So far, little is known on the distribution of hepatotoxic microcystin (MC) in various organs of bivalves, and there is no study on MC accumulation in bivalves from Chinese waters. Distribution pattern and seasonal dynamics of MC-LR, -YR and -RR in various organs (hepatopancreas, intestine, visceral mass, gill, foot, ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20146
更新日期:2005-12-01 00:00:00
abstract::Lead is a major heavy-metal contaminant in the environment that has various anthropogenic and natural sources. To study the phytotoxic effects of Pb on the popular vegetable Chinese cabbage (Brassica pekinensis Rupr.) via depression of nitrogen assimilation, pot culture experiments with three concentrations of treatme...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20167
更新日期:2006-04-01 00:00:00
abstract::Polybrominated diphenyl ethers (PBDEs) are ubiquitous and prolific contaminant in both the abiotic and biotic environment because of the wide industrial applications of these chemicals. In the present study, the effects of 2,2',4,4'-tetrabrominateddiphenyl ether (BDE-47) and 2,2',4,4',5,5'-hexabromodiphenyl ether (BDE...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22985
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVES:We evaluated the role of oxidative stress in Sudan IV-induced DNA damage, using human liver-derived HepG2 cells. METHODS:The DNA damaging effects of Sudan IV in HepG2 cells were evaluated by alkaline single cell gel electrophoresis assay and micronucleus test (MNT). To clarify the underlying mechanisms, we ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20558
更新日期:2011-06-01 00:00:00
abstract::Sick building syndrome (SBS) is a set of several clinically recognizable symptoms reported by occupants of a building without a clear cause. Neuropathy target esterase (NTE) is a membrane bound serine esterase and its reaction with organophosphates (OPs) can lead to OP-induced delayed neuropathy (OPIDN) and nerve axon...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21839
更新日期:2014-10-01 00:00:00
abstract::Chlorpyrifos (CPF) is one of the most widely used organophosphorus, which has spurred renewed interest. This study was conducted to investigate the protective effect of ziziphora tenuior extract against CPF-induced liver and lung toxicity. This study conducted 8-week rat sub-chronic toxicity study and then the effect ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22432
更新日期:2017-09-01 00:00:00
abstract::Di(2-ethylhexyl) phthalate, which is a ubiquitous environmental contaminant because of its extensive use as a plasticizer, is a potential nongenotoxic carcinogen. To assess the effects of DEHP exposure on the cytoskeleton of Chironomus, we characterized full-length cDNA sequences of the calponin gene from Chironomus r...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20463
更新日期:2009-12-01 00:00:00
abstract::Nickel oxide nanoparticles (nano NiO) could induce hepatocyte apoptosis, while its potential mechanisms are unclear. This study aimed to explore the role of endoplasmic reticulum (ER) stress pathways in hepatocyte apoptosis induced by nano NiO. Male Wistar rats were administrated with nano NiO (0.015, 0.06, and 0.24 m...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22492
更新日期:2017-12-01 00:00:00
abstract::Phenols are environmentally important compounds that are widely used in agriculture and industry. Thus, phenols are of interest to environmental toxicologists, which has led to the development of several quantitative structure-activity relationship (QSAR) models. The most successful QSARs have been established for com...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.10040
更新日期:2002-01-01 00:00:00
abstract::The environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is known to affect bone metabolism. We evaluated the protective effects of the triterpene glycoside actein from the herb black cohosh against TCDD-induced toxicity in MC3T3-E1 osteoblastic cells. We found that TCDD significantly reduced cell viabil...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22459
更新日期:2017-12-01 00:00:00
abstract::New reports indicate that the toxic alkaloid cylindrospermopsin occurs in cyanobacteria in Israel, Florida, South America, and Australia in drinking water sources. This toxin is now recognised as a potential threat to human health. Furthermore, we have recently demonstrated the mutagenicity of cylindrospermopsin in vi...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.1024
更新日期:2001-01-01 00:00:00
abstract::Aluminum methylcyclohexylphosphinate (AMHP), calcium methylcyclohexylphosphinate (CMHP), aluminum diethylphosphinate (ADEP), and aluminum methylethylphosphinate (AMEP) are organic dialkyl phosphinates (DPs) and emerging phosphorus-based flame retardants. The broad-spectrum DPs flame retardants occupy high-end industri...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22383
更新日期:2017-05-01 00:00:00
abstract::Acute severe carbon monoxide (CO) poisoning induces hypoxia that leads to cardiovascular and nervous systems disturbances. Different complex mechanisms lead to CO neurotoxicity including lipid peroxidation, inflammatory and immune-mediated reactions, myelin degeneration and finally neuronal apoptosis and necrosis. Gra...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22210
更新日期:2017-01-01 00:00:00
abstract::The cytotoxic and genotoxic effects induced by alachlor and dichlorvos, two pesticides broadly used, were studied on RTG-2 fish cell line. As measure of cytotoxicity, neutral red assay was used to determine the cellular viability. Toxicity ranking based on IC(50) values found that alachlor was more cytotoxic than dich...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20637
更新日期:2012-03-01 00:00:00