Human albumin augmented airway inflammation induced by PM2.5 in NC/Nga mice.

Abstract:

:The synergic allergic inflammatory effects of particulate matter (PM) 2.5 and human albumin were investigated in NC/Nga mice, which are hypersensitive to mite allergens. PM2.5 or PM2.5 plus human albumin with aluminum oxide was injected twice intraperitoneally for sensitization. After 7 days, PM2.5 or PM2.5 plus human albumin was administered five times intranasally to mice for further sensitization. Subsequently, PM2.5 was administered as a challenge on the 11th day. On the 12th day, mice were examined for airway hyperresponsiveness (AHR), bronchoalveolar lavage fluid (BALF) cell count, mRNA expression of Th1 , Th2 cytokines, chemokines, and mucus proteins (MUC5AC and MUC5B) in the lung tissue and histopathology. Although PM2.5 or human albumin alone did not induce allergic airway inflammation, simultaneous inoculation of PM2.5 and human albumin-induced airway inflammation showing increase in AHR, total BALF cell numbers, mRNA levels of IL-13, eotaxin 1, eotaxin 2, and MUC5AC, and anti-IG against human serum albumin. Inflammation was observed around the bronchus in PM2.5 plus human albumin-induced lungs. These results demonstrate that PM2.5 can induce allergic airway inflammation through the synergistic action with human albumin in NC/Nga mice.

journal_name

Environ Toxicol

journal_title

Environmental toxicology

authors

Nagaoka K,Ogino K,Ogino N,Ito T,Takemoto K,Ogino S,Seki Y,Hamada H,Fujikura Y

doi

10.1002/tox.22751

subject

Has Abstract

pub_date

2019-07-01 00:00:00

pages

836-843

issue

7

eissn

1520-4081

issn

1522-7278

journal_volume

34

pub_type

杂志文章
  • In vivo effects of fenthion on oxidative processes by the modulation of glutathione metabolism in the brain of Oreochromis niloticus.

    abstract::The present study was designed to understand the oxidative stress potential of fenthion, an organophosphate (OP) pesticide and its involvement in glutathione metabolism modulated buthionine sulfoximine (BSO, 50 mg/kg) and N-acetylcysteine (NAC, 100 mg/kg) in the brain of fish, Oreochromis niloticus. A sublethal fenthi...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.20286

    authors: Piner P,Sevgiler Y,Uner N

    更新日期:2007-12-01 00:00:00

  • Chronic lead exposure enhances the sympathoexcitatory response associated with P2X4 receptor in rat stellate ganglia.

    abstract::Chronic lead exposure causes peripheral sympathetic nerve stimulation, including increased blood pressure and heart rate. Purinergic receptors are involved in the sympathoexcitatory response induced by myocardial ischemia injury. However, whether P2X4 receptor participates in sympathoexcitatory response induced by chr...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.22547

    authors: Zhu G,Chen Z,Dai B,Zheng C,Jiang H,Xu Y,Sheng X,Guo J,Dan Y,Liang S,Li G

    更新日期:2018-06-01 00:00:00

  • Microcystin content of Microcystis aeruginosa is modulated by nitrogen uptake rate relative to specific growth rate or carbon fixation rate.

    abstract::Modulation of microcystin production has been extensively studied in both batch and continuous cultures. Positive correlations with medium nitrogen, medium phosphorous, light intensity, inorganic carbon availability, and growth rate have been reported. Negative correlations have been reported between microcystin conte...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.20106

    authors: Downing TG,Meyer C,Gehringer MM,van de Venter M

    更新日期:2005-06-01 00:00:00

  • Diallyl trisulfide inhibits cell migration and invasion of human melanoma a375 cells via inhibiting integrin/facal adhesion kinase pathway.

    abstract::Melanoma is the leading cause of death from skin disease due to its propensity for metastasis. Studies have shown that integrin-mediated focal adhesion kinase (FAK) signal pathway is implicated in cell proliferation, survival and metastasis of tumor cells. Our previous results indicated that diallyl trisulfide (DATS) ...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.22445

    authors: Wang HC,Chu YL,Hsieh SC,Sheen LY

    更新日期:2017-11-01 00:00:00

  • Low-dose in utero exposure to finasteride promotes developmental changes in both male and female gerbil prostates.

    abstract::The prostate is an accessory reproductive gland that is sensitive to the action of exogenous compounds known as endocrine disrupters that alter normal hormonal function. Finasteride is a widely used chemical that acts to inhibit the conversion of testosterone in its most active form, dihydrotestosterone. It is known t...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.22838

    authors: Maldarine JS,Sanches BDA,Santos VA,Amaro GM,Calmon MF,Rahal P,Góes RM,Vilamaior PSL,Taboga SR

    更新日期:2020-01-01 00:00:00

  • TiO2 nanoparticle-induced neurotoxicity may be involved in dysfunction of glutamate metabolism and its receptor expression in mice.

    abstract::Titanium dioxide nanoparticles (TiO2 NPs) have been used in environmental management, food, medicine, and industry. But TiO2 NPs have been demonstrated to cross the blood-brain barrier and store up in the brain organization, leading to glutamate-mediated neurotoxicity. However, the neurotoxicity in the brain is not we...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.22077

    authors: Ze X,Su M,Zhao X,Jiang H,Hong J,Yu X,Liu D,Xu B,Sheng L,Zhou Q,Zhou J,Cui J,Li K,Wang L,Ze Y,Hong F

    更新日期:2016-06-01 00:00:00

  • Pesticide induced alterations in marrow physiology and depletion of stem and stromal progenitor population: an experimental model to study the toxic effects of pesticide.

    abstract::Long-term exposure of agriculturally used organochloride and organophosphate pesticides have been shown to cause long-lasting hematotoxicity and increased incidence of aplastic anemia in humans. The mechanisms involved in pesticide induced hematotoxicity and the features of toxicity that may play a major role in bone ...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.20775

    authors: Chatterjee S,Basak P,Chaklader M,Das P,Pereira JA,Chaudhuri S,Law S

    更新日期:2014-01-01 00:00:00

  • Chronic effects of p-nonylphenol on survival and reproduction of Daphnia galeata: multigenerational life table experiment.

    abstract::The chronic effect of p-nonylphenol on survival and reproduction for two generations of the freshwater cladoceran Daphnia galeata was examined by life table experiments. The effects on survival and reproduction were used as the intrinsic rate of natural increase, r, with the Euler-Lotka equation and were analyzed with...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.10083

    authors: Tanaka Y,Nakanishi J

    更新日期:2002-10-01 00:00:00

  • Effect of particulate matter 2.5 on gene expression profile and cell signaling in JEG-3 human placenta cells.

    abstract::Particulate matter the environmental toxicant, with a diameter less than or equal to 2.5 μm (PM2.5 ) is a common cause of several respiratory diseases. In recent years, several studies have suggested that PM2.5 can influence diverse diseases, such as respiratory diseases, cardiovascular diseases, metabolic diseases, d...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.22591

    authors: Kim W,Cho Y,Song MK,Lim JH,Kim JY,Gye MC,Ryu JC

    更新日期:2018-11-01 00:00:00

  • Cyanobacterium producing cylindrospermopsin cause histopathological changes at environmentally relevant concentrations in subchronically exposed tilapia (Oreochromis niloticus).

    abstract::The acute toxicity of cylindrospermopsin (CYN) has been established in rodents, based on diverse intraperitoneal an oral exposure studies and more recently in fish. But no data have been reported in fish after subchronic exposure to cyanobacterial cells containing this cyanotoxin, so far. In this work, tilapia (Oreoch...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.21904

    authors: Guzmán-Guillén R,Prieto AI,Moreno I,Vasconcelos VM,Moyano R,Blanco A,Cameán Fernandez AM

    更新日期:2015-03-01 00:00:00

  • Casticin impairs cell migration and invasion of mouse melanoma B16F10 cells via PI3K/AKT and NF-κB signaling pathways.

    abstract::Casticin, a polymethoxyflavone, is one of the major active components obtained from Fructus viticis, which have been shown to have anticancer activities including induce cell apoptosis in human cancer cells. The aim of this study was to investigate the molecular mechanisms by which casticin inhibits cell migration and...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.22417

    authors: Shih YL,Chou HM,Chou HC,Lu HF,Chu YL,Shang HS,Chung JG

    更新日期:2017-09-01 00:00:00

  • Disruption of cardiogenesis in human embryonic stem cells exposed to trichloroethylene.

    abstract::Trichloroethylene (TCE) is ubiquitous in our living environment, and prenatal exposure to TCE is reported to cause congenital heart disease in humans. Although multiple studies have been performed using animal models, they have limited value in predicting effects on humans due to the unknown species-specific toxicolog...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.22142

    authors: Jiang Y,Wang D,Zhang G,Wang G,Tong J,Chen T

    更新日期:2016-11-01 00:00:00

  • PM10-biogenic fraction drives the seasonal variation of proinflammatory response in A549 cells.

    abstract::PM10 was collected in a Milan urban site, representative of the city air quality, during winter and summer 2006. Mean daily PM10 concentration was 48 μg m(-3) during summer and 148 μg m(-3) during winter. Particles collected on Teflon filters were chemically characterized and the endotoxin content determined by the ...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.20611

    authors: Camatini M,Corvaja V,Pezzolato E,Mantecca P,Gualtieri M

    更新日期:2012-02-01 00:00:00

  • ISTA13-catecholamine toxicity and metabolism in the ciliated protozoan, Tetrahymena pyriformis.

    abstract::A high throughput culture methodology of unicellular eukaryote Tetrahymena pyriformis, strain GL were used for the determination of catecholamines toxicity and their metabolism. Catecholamines exhibited acute toxicity to Tetrahymena cells where dopamine and L-DOPA showed higher toxic potential of EC(10) (0.39 and 0.63...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.20457

    authors: Ud-Daula A,Pfister G,Schramm KW

    更新日期:2009-12-01 00:00:00

  • Oral administration of cyanobacterial bloom extract induced the altered expression of the PP2A, Bax, and Bcl-2 in mice.

    abstract::The frequent occurrences of the toxic cyanobacterial (specifically Microcystis aeruginosa) bloom are becoming a global environmental issue. Lots of researches have been focused on the pure cyanobacterial toxins, but little on the natural cyanobacterial bloom. This study was undertaken to investigate the effect of the ...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.20374

    authors: Huang P,Zheng YF,Xu LH

    更新日期:2008-12-01 00:00:00

  • Neural tube defects in mice exposed to tap water.

    abstract::In May of 2006 we suddenly began to observe neural tube defects (NTDs) in embryos of untreated control mice. We hypothesized the mice were being exposed unknowingly to a teratogenic agent and investigated the cause. Our results suggested that NTDs were not resulting from bedding material, feed, strain, or source of th...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.20600

    authors: Mallela MK,Werre SR,Hrubec TC

    更新日期:2011-11-01 00:00:00

  • Assessment of genotoxic effects induced by selected pesticides on RTG-2 fish cells by means of a modified fast micromethod assay.

    abstract::The cytotoxic and genotoxic effects induced by alachlor and dichlorvos, two pesticides broadly used, were studied on RTG-2 fish cell line. As measure of cytotoxicity, neutral red assay was used to determine the cellular viability. Toxicity ranking based on IC(50) values found that alachlor was more cytotoxic than dich...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.20637

    authors: Parra JM,Sánchez-Fortún S,Castaño A

    更新日期:2012-03-01 00:00:00

  • More serious autophagy can be induced by ZnO nanoparticles than single-walled carbon nanotubes in rat tracheal epithelial cells.

    abstract::Metal oxide nanoparticles and carbon nanoparticles, as common nanoparticles (NPs), can cause autophagy in certain cells, which will lead to biohealth risk issues. This study determined the difference in autophagy induced by zinc oxide nanoparticles (ZnO NPs) and single-walled carbon nanotubes (SWCNTs) in respiratory e...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.23029

    authors: Zhang H,Chen F,Li Y,Shan X,Yin L,Hao X,Zhong Y

    更新日期:2021-02-01 00:00:00

  • Hematotoxic and hepatotoxic effects of dichlorvos at sublethal dosages in rats.

    abstract::The present study was designed to understand the effects of sublethal concentrations of dichlorvos (DIC) on hematological constituent [red blood corpuscles, white blood corpuscles (WBC), mean cell volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, platelet counts, hemoglobin and hematocrit...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.20390

    authors: Celik I,Yilmaz Z,Turkoglu V

    更新日期:2009-04-01 00:00:00

  • Dibutyltin depressed immune functions via NF-κB, and JAK/STAT signaling pathways in zebrafish (Danio rerio).

    abstract::Dibutyltin (DBT) is the degradation products of TBT, which is generally considered higher toxicity than TBT in the immune system. In order to learn more about the mechanisms of immune-toxic of DBT, we exposed zebrafish (Danio rerio) to 0, 1, 10 and 100 ng/L DBT for 8 weeks. At the end of the experiment, we determined ...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.22502

    authors: Zhang CN,Zhang JL,Huang Y,Ren HT,Guan SH,Zeng QH

    更新日期:2018-01-01 00:00:00

  • Differential susceptibility of brain regions to tributyltin chloride toxicity.

    abstract::Tributyltin (TBT), a well-known endocrine disruptor, is an omnipresent environmental pollutant and is explicitly used in many industrial applications. Previously we have shown its neurotoxic potential on cerebral cortex of male Wistar rats. As the effect of TBT on other brain regions is not known, we planned this stud...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.22009

    authors: Mitra S,Siddiqui WA,Khandelwal S

    更新日期:2015-12-01 00:00:00

  • Effect of sublethal hexavalent chromium exposure on the pituitary-ovarian axis of a teleost, Channa punctatus (Bloch).

    abstract::Exposure to sublethal hexavalent chromium (as 2 and 4 mg L⁻¹ potassium dichromate for 1 and 2 months) during late preparatory to mid prespawning phase of annual reproductive cycle severely affected the pituitary-ovarian axis of a teleost Channa punctatus. Gonadosomatic index (GSI), ovarian histopathology, immunocytoch...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.20654

    authors: Mishra AK,Mohanty B

    更新日期:2012-07-01 00:00:00

  • Response of antioxidant enzymes, ascorbate and glutathione metabolism towards cadmium in hyperaccumulator and nonhyperaccumulator ecotypes of Sedum alfredii H.

    abstract::Hydroponics studies were conducted to investigate the antioxidant adaptations, ascorbate and glutathione metabolism in hyperaccumulating ecotype of Sedum alfredii (HE) exposed to high Cd environment, when compared with its nonhyperaccumulating ecotype (NHE). Exposure to Cd induced a burst of oxidative stress in both e...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.20362

    authors: Jin X,Yang X,Mahmood Q,Islam E,Liu D,Li H

    更新日期:2008-08-01 00:00:00

  • Identification of toxicants from marine sediment using effect-directed analysis.

    abstract::Effect-directed analysis (EDA) has been reported to be a powerful tool for the identification of the responsible toxicants in contaminated, hazardous environmental samples. The aim of this study was to investigate whether it also is possible to use currently available EDA methodology to identify potentially relevant t...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.20135

    authors: Grote M,Brack W,Altenburger R

    更新日期:2005-10-01 00:00:00

  • Alterations in cellular lipid metabolism produce neutral lipid accumulation following exposure to the organochlorine compound trans-nonachlor in rat primary hepatocytes.

    abstract::Recent epidemiological studies have revealed significant positive associations between exposure to organochlorine (OC) pesticides and occurrence of the metabolic syndrome and there are a growing number of animal-based studies to support causality. However, the cellular mechanisms linking OC compound exposure and metab...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.22583

    authors: Howell GE 3rd,McDevitt E,Henein L,Mulligan C,Young D

    更新日期:2018-09-01 00:00:00

  • Safrole induces cell death in human tongue squamous cancer SCC-4 cells through mitochondria-dependent caspase activation cascade apoptotic signaling pathways.

    abstract::Safrole is one of important food-borne phytotoxin that exhibits in many natural products such as oil of sassafras and spices such as anise, basil, nutmeg, and pepper. This study was performed to elucidate safrole-induced apoptosis in human tongue squamous carcinoma SCC-4 cells. The effect of safrole on apoptosis was m...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.20658

    authors: Yu FS,Huang AC,Yang JS,Yu CS,Lu CC,Chiang JH,Chiu CF,Chung JG

    更新日期:2012-07-01 00:00:00

  • Interactive effects of hypoxia and PCB co-exposure on expression of CYP1A and its potential regulators in Atlantic croaker liver.

    abstract::Although marine and coastal environments which are contaminated with xenobiotic organic compounds often become hypoxic during the summer, the interactive effects of hypoxia and xenobiotic exposure on marine species such as teleost fishes remain poorly understood. The expression and activity of monooxygenase enzyme cyt...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.22527

    authors: Rahman MS,Thomas P

    更新日期:2018-04-01 00:00:00

  • Gene expression profile changes induced by acute toxicity of [C16 mim]Cl in loach (Paramisgurnus dabryanus).

    abstract::Ionic liquids (ILs) are widely used as reaction media in various commercial applications. Many reports have indicated that most ILs are poorly decomposed by microorganisms and are toxic to aquatic organisms. In this study, differential gene expression profiling was conducted using a suppression subtraction hybridizati...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.22244

    authors: Nan P,Yan S,Wang Y,Du Q,Chang Z

    更新日期:2017-02-01 00:00:00

  • Depletion of Kupffer cells modulates ethanol-induced hepatocyte DNA synthesis in C57Bl/6 mice.

    abstract::Kupffer cells (KCs) are important in hepatic homeostasis and responses to xenobiotics. KCs are activated on interaction with endotoxin, releasing cytokines, and reactive oxygen species normally associated with increased gene expression, cellular growth, or hepatic injury. Ethanol-induced endotoxemia is one means of KC...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.21814

    authors: Owumi SE,Corthals SM,Uwaifo AO,Kamendulis LM,Klaunig JE

    更新日期:2014-08-01 00:00:00

  • Tris (1,3-dichloro-2-propyl) phosphate induces toxicity by stimulating CaMK2 in PC12 cells.

    abstract::Tris (1,3-dichloro-2-propyl) phosphate (TDCIPP) is one of the widely used organophosphorus flame retardants (OPFRs), which are regarded as suitable substitutes for brominated flame retardants (BFRs). Previously, we have validated the toxicity of TDCIPP in PC12 cells owing to the induced alterations in GAP43, NF-H, CaM...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.22401

    authors: Li C,Li L,Lin B,Fang Y,Yang H,Liu H,Xi Z

    更新日期:2017-06-01 00:00:00