Mechanisms involved in reproductive toxicity caused by nickel nanoparticle in female rats.

abstract：:Microcystin-LR (MC-LR) is the most commonly encountered of the toxic cyclic peptide hepatotoxins occurring in China. It is a model compound for toxicological studies. In this study, the toxicity of MC-LR (50 and 500 micrograms/L) on isolated carp hepatocytes was determined and the ultrastructural alterations of cells ...

journal_title：Environmental toxicology

authors： Li X,Liu Y,Song L

更新日期：2001-01-01 00:00:00

abstract：:Metabolic products are often more toxic than their pharmacological parent compounds. Therefore, the acute and chronic effects of the main metabolites--salicylic acid (SAL), gentisic acid (GEN), and o-hydroxyhippuric acid (HDP)--of acetylsalicylic acid (ASA), the active ingredient in Aspirin and many other pharmaceutic...

journal_title：Environmental toxicology

authors： Marques CR,Abrantes N,Gonçalves F

更新日期：2004-10-01 00:00:00

abstract：:There is emerging evidence suggesting that oxidative stress and DNA methylation can alter miRNA expression. However, little is known on the mechanism of miR-17-5p expression changes in paraquat (PQ)-induced nerve cell damage. In the present study, neuro-2a cells were pretreated with antioxidant N-acetylcysteine (NAC) ...

journal_title：Environmental toxicology

authors： Zhan Y,Guo Z,Zheng F,Zhang Z,Li K,Wang Q,Wang L,Cai Z,Chen N,Wu S,Li H

更新日期：2020-12-01 00:00:00

abstract：:We measured the concentrations of monoamines in the brain of Japanese medaka, Oryzias latipes, exposed to tributyltin (TBT). Fish were exposed to 0, 1, 5, 25, or 125 microg g(-1) of TBT via the diet for 21 days. After the administration period, six males and six females in each treatment group were dissected and their...

journal_title：Environmental toxicology

authors： Nakayama K,Oshima Y,Tachibana T,Furuse M,Honjo T

更新日期：2007-02-01 00:00:00

abstract：:Sick building syndrome (SBS) is a set of several clinically recognizable symptoms reported by occupants of a building without a clear cause. Neuropathy target esterase (NTE) is a membrane bound serine esterase and its reaction with organophosphates (OPs) can lead to OP-induced delayed neuropathy (OPIDN) and nerve axon...

journal_title：Environmental toxicology

authors： Matsuzaka Y,Ohkubo T,Kikuti YY,Mizutani A,Tsuda M,Aoyama Y,Kakuta K,Oka A,Inoko H,Sakabe K,Ishikawa S,Kulski JK,Kimura M

更新日期：2014-10-01 00:00:00

abstract：:Within the last decade, numerous epidemiological studies have demonstrated that endocrine disruptors are a possible cause for a decline in semen quality. Cypermethrin is a widely used pyrethroid insecticide, but little is known about its potentially adverse effects on male reproduction. In the present study, we invest...

journal_title：Environmental toxicology

authors： Wang H,Wang SF,Ning H,Ji YL,Zhang C,Zhang Y,Yu T,Ma XH,Zhao XF,Wang Q,Liu P,Meng XH,Xu DX

更新日期：2011-08-01 00:00:00

abstract：:Ouabain, a cardiotonic steroid, was used for the treatment of heart failure and atrial fibrillation and induces cancer cell apoptosis in many human cancer cells including human leukemia cells. However, there are no reports to show the effects on immune responses in a leukemia mouse model. In this study, WEHI-3 cell ge...

journal_title：Environmental toxicology

authors： Shih YL,Shang HS,Chen YL,Hsueh SC,Chou HM,Lu HF,Lee MZ,Hou HT,Chuang YY,Lee MH,Chen KW,Chung JG

更新日期：2019-05-01 00:00:00

abstract：:Casticin, a polymethoxyflavone, is one of the major active components obtained from Fructus viticis, which have been shown to have anticancer activities including induce cell apoptosis in human cancer cells. The aim of this study was to investigate the molecular mechanisms by which casticin inhibits cell migration and...

journal_title：Environmental toxicology

authors： Shih YL,Chou HM,Chou HC,Lu HF,Chu YL,Shang HS,Chung JG

更新日期：2017-09-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is the most common type of chronic inflammatory disease which is triggered by dysfunction in the immune system which in turn affects synovial joints. Current treatment of RA with NSAIDs and DMRDs is limited by their side effect. As a result, the interest in alternative, well tolerated anti-in...

journal_title：Environmental toxicology

authors： Neha,Ansari MM,Khan HA

更新日期：2017-02-01 00:00:00

abstract：:Colorectal cancer (CRC) is one of the most common cancers and causes of cancer-related death. There are several first-line chemotherapeutic drugs used to treat CRC. Oxaliplatin (OXA) is an alkylating cytotoxic agent that is usually combined with other chemotherapeutic drugs to treat stage II and stage III CRC. However...

journal_title：Environmental toxicology

authors： Chen MC,Hsu HH,Chu YY,Cheng SF,Shen CY,Lin YJ,Chen RJ,Viswanadha VP,Lin YM,Huang CY

更新日期：2018-05-01 00:00:00

abstract：:Nonsmall cell lung cancer (NSCLC) is the most common type of lung cancer with a high mortality rate and still remains a therapeutic challenge. A strategy for targeting NSCLC is to identify agents that are effective against NSCLC cells while sparing normal cells. Dihydromyricetin (DHM) is the major flavonoid component ...

journal_title：Environmental toxicology

authors： Kao SJ,Lee WJ,Chang JH,Chow JM,Chung CL,Hung WY,Chien MH

更新日期：2017-04-01 00:00:00

abstract：:Trichloroethylene (TCE) is ubiquitous in our living environment, and prenatal exposure to TCE is reported to cause congenital heart disease in humans. Although multiple studies have been performed using animal models, they have limited value in predicting effects on humans due to the unknown species-specific toxicolog...

journal_title：Environmental toxicology

authors： Jiang Y,Wang D,Zhang G,Wang G,Tong J,Chen T

更新日期：2016-11-01 00:00:00

abstract：:Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used therapeutic agents; however, their pharmacological actions raise concerns about potential risks to the reproductive health of aquatic vertebrates. In the present study, a medaka ovulation assay was applied as an in vitro model to evaluate NSAID-induced anti...

journal_title：Environmental toxicology

authors： Yokota H,Eguchi S,Hasegawa S,Okada K,Yamamoto F,Sunagawa A,Tanaka M,Yamamoto R,Nakano E

更新日期：2016-12-01 00:00:00

abstract：:Irradiation of polycyclic aromatic hydrocarbons (PAHs) in aqueous solution with simulated solar radiation (SSR; a light source with a visible light: UV-A:UV-B ratio similar to that of sunlight) can greatly enhance their toxicity. Two microbial toxicity tests with Vibrio fischeri were used to investigate the effect of ...

journal_title：Environmental toxicology

authors： el-Alawi YS,Dixon DG,Greenberg BM

更新日期：2001-06-01 00:00:00

abstract：:Tributyltin (TBT) and dibutyltin (DBT) are widespread environmental contaminants found in food, beverages, and human blood samples. Both of these butyltins (BTs) interfere with the ability of human natural killer (NK) cells to lyse target cells and alter secretion of the pro-inflammatory cytokine tumor necrosis factor...

journal_title：Environmental toxicology

authors： Lawrence S,Reid J,Whalen M

更新日期：2015-05-01 00:00:00

abstract：:An unexpectedly high frequency of skeletal deformations in brown trout has previously been observed in the brook Vallkärrabäcken in southern Sweden. Environmental pollutants from storm water and leachate from an old landfill have been suggested as responsible for the observed deformations. Biomarkers in farmed rainbow...

journal_title：Environmental toxicology

authors： Hanson N,Larsson Å

更新日期：2011-06-01 00:00:00

abstract：:This study investigated lethal effects (i.e., survival) and sublethal effects (glutathione, GSH; lipid peroxidation, LPx; cholesterol, CHL; and acetylcholinesterase, AChE) of the antihyperlipidemic drug simvastatin on larval and adult grass shrimp (Palaemonetes pugio). The 96-h LC50 test for larvae resulted in an esti...

journal_title：Environmental toxicology

authors： Key PB,Hoguet J,Reed LA,Chung KW,Fulton MH

更新日期：2008-04-01 00:00:00

abstract：:Global use of azole fungicides is expected to increase over the next several years. Triticonazole is a triazole fungicide that is used for turf protection, residential, and other commercial applications. As such, it can enter local rural and urban water systems via run-off and rain events. Early life stages of aquatic...

journal_title：Environmental toxicology

authors： Souders CL 2nd,Perez-Rodriguez V,El Ahmadie N,Zhang X,Tischuk C,Martyniuk CJ

更新日期：2020-02-01 00:00:00

abstract：:An enormous quantity of pharmacologically active principles are currently being introduced into the environment, with consequent escalation of environmental problems, but only a small number of studies are focusing on an assessment of their genotoxic effects. The aim of this article is to assess the genotoxic effects ...

journal_title：Environmental toxicology

authors： Rocco L,Peluso C,Stingo V

更新日期：2012-10-01 00:00:00

abstract：:The aim of this study was to investigate the signaling pathways involved in the cyclooxygenase (COX)-2 regulation induced by nonylphenol (NP) in mouse testis Sertoli TM4 cells. Our results showed that treatment of TM4 cells with NP increased COX-2 protein expression and interleukin-6 (IL)-6 and prostaglandin E2 (PGE2)...

journal_title：Environmental toxicology

authors： Liu X,Nie S,Huang D,Xie M

更新日期：2015-09-01 00:00:00

abstract：:Metal oxide nanoparticles and carbon nanoparticles, as common nanoparticles (NPs), can cause autophagy in certain cells, which will lead to biohealth risk issues. This study determined the difference in autophagy induced by zinc oxide nanoparticles (ZnO NPs) and single-walled carbon nanotubes (SWCNTs) in respiratory e...

journal_title：Environmental toxicology

authors： Zhang H,Chen F,Li Y,Shan X,Yin L,Hao X,Zhong Y

更新日期：2021-02-01 00:00:00

abstract：:Toxicants can perturb cellular homeostasis by modifying phosphorylation-based signaling. In the present study, we examined the effects of cerulein, an inducer of acute pancreatitis, on keratin 8 (K8) phosphorylation. We found that cerulein dose-dependently induced K8 phosphorylation and perinuclear reorganization in P...

journal_title：Environmental toxicology

authors： Park MK,Lee CH

更新日期：2016-12-01 00:00:00

abstract：:Arsenite has been shown to induce a variety of oxidative damage in mammalian cells. However, the mechanisms underlying cellular responses to its adverse effects remain unknown. We previously showed that the level of Nrf2, a nuclear transcription factor significantly increased in arsenite-treated human bronchial epithe...

journal_title：Environmental toxicology

authors： Chen C,Jiang X,Gu S,Lai Y,Liu Y,Zhang Z

更新日期：2017-08-01 00:00:00

abstract：:Water bodies are routinely monitored for the presence of potentially toxic cyanobacteria; however, the methodology for confirming toxicity is currently complex and expensive. Here we describe the application of gene-based technology to rapidly identify cylindrospermopsin-producing cyanobacteria, specifically, Cylindro...

journal_title：Environmental toxicology

authors： Fergusson KM,Saint CP

更新日期：2003-04-01 00:00:00

abstract：:Modulation of microcystin production has been extensively studied in both batch and continuous cultures. Positive correlations with medium nitrogen, medium phosphorous, light intensity, inorganic carbon availability, and growth rate have been reported. Negative correlations have been reported between microcystin conte...

journal_title：Environmental toxicology

authors： Downing TG,Meyer C,Gehringer MM,van de Venter M

更新日期：2005-06-01 00:00:00

abstract：OBJECTIVES:We evaluated the role of oxidative stress in Sudan IV-induced DNA damage, using human liver-derived HepG2 cells. METHODS:The DNA damaging effects of Sudan IV in HepG2 cells were evaluated by alkaline single cell gel electrophoresis assay and micronucleus test (MNT). To clarify the underlying mechanisms, we ...

journal_title：Environmental toxicology

authors： Zhang Y,An Y,Jiang L,Geng C,Cao J,Jiang L,Zhong L

更新日期：2011-06-01 00:00:00

abstract：:Contamination of the urban aquatic environment with chemical and biological substances could have a long-term impact on human health because these substances threaten the integrity of the urban ecosystem and the availability of high-quality water for recreation and consumption. In light of this, the aim of the present...

journal_title：Environmental toxicology

authors： Wichmann G,Daegelmann C,Herbarth O,Strauch G,Schirmer K,Wöstemeyer J,Lehmann I

更新日期：2004-12-01 00:00:00

abstract：:Although triphenyltin (TPT) compounds are ubiquitous pollutants in urbanised coastal environments in Asian regions, their toxicities to marine organisms are still poorly known. This study was designed to investigate the toxicity of triphenyltin chloride (TPTCl) on the rotifer Brachionus koreanus across different level...

journal_title：Environmental toxicology

authors： Yi AX,Han J,Lee JS,Leung KM

更新日期：2016-01-01 00:00:00

abstract：:Hypothyroxinemia induced by maternal mild iodine deficiency causes neurological deficits and impairments of brain function in offspring. Hypothyroxinemia is prevalent in developing and developed countries alike. However, the mechanism underlying these deficits remains less well known. Given that the myelin plays an im...

journal_title：Environmental toxicology

authors： Wei W,Wang Y,Dong J,Wang Y,Min H,Song B,Shan Z,Teng W,Xi Q,Chen J

更新日期：2015-11-01 00:00:00

abstract：:The aim of this research was to analyze the effects and the modes of action of elemental sulfur (S(0)) in bioluminescence and respiration of Vibrio fischeri cells and the enzymes crude luciferase, pure catalase, and alcohol dehydrogenase (ADH). Metallic copper removed sulfur and reduced the toxicity of acetone extract...

journal_title：Environmental toxicology

authors： Cetkauskaite A,Pessala P,Södergren A

更新日期：2004-08-01 00:00:00