Subchronic effects of perfluorooctanesulfonate exposure on inflammation in adult male C57BL/6 mice.

abstract：:Tris (1,3-dichloro-2-propyl) phosphate (TDCIPP) is one of the widely used organophosphorus flame retardants (OPFRs), which are regarded as suitable substitutes for brominated flame retardants (BFRs). Previously, we have validated the toxicity of TDCIPP in PC12 cells owing to the induced alterations in GAP43, NF-H, CaM...

journal_title：Environmental toxicology

authors： Li C,Li L,Lin B,Fang Y,Yang H,Liu H,Xi Z

更新日期：2017-06-01 00:00:00

abstract：:Several estuaries along the Pacific Ocean coast of North America were identified recently as having elevated 4-nonylphenol (4-NP) in sediments and biota, raising concerns about reproductive impacts for wildlife given 4-NP's established estrogenic activity as an endocrine-disrupting compound. Here we characterize 4-NP ...

journal_title：Environmental toxicology

authors： Johnson KM,Lema SC

更新日期：2017-05-01 00:00:00

abstract：:Oral cancer is one of the cancer-related diseases in human populations and its incidence rates are rising worldwide. Fisetin, a flavonoid from natural products, has been shown to exhibit anticancer activities in many human cancer cell lines but the molecular mechanism of fisetin-induced apoptosis in human oral cancer ...

journal_title：Environmental toxicology

authors： Su CH,Kuo CL,Lu KW,Yu FS,Ma YS,Yang JL,Chu YL,Chueh FS,Liu KC,Chung JG

更新日期：2017-06-01 00:00:00

abstract：:Chronic lead exposure causes peripheral sympathetic nerve stimulation, including increased blood pressure and heart rate. Purinergic receptors are involved in the sympathoexcitatory response induced by myocardial ischemia injury. However, whether P2X4 receptor participates in sympathoexcitatory response induced by chr...

journal_title：Environmental toxicology

authors： Zhu G,Chen Z,Dai B,Zheng C,Jiang H,Xu Y,Sheng X,Guo J,Dan Y,Liang S,Li G

更新日期：2018-06-01 00:00:00

abstract：:Sulfur dioxide (SO2 ) is a ubiquitous air pollutant. The previous studies have documented the adverse effects of SO2 on nervous system health, suggesting that acutely SO2 inhalation at high concentration may be associated with neurotoxicity and increase risk of hospitalization and mortality of many brain disorders. Ho...

journal_title：Environmental toxicology

authors： Yao G,Yun Y,Sang N

更新日期：2016-07-01 00:00:00

abstract：:Modulation of microcystin production has been extensively studied in both batch and continuous cultures. Positive correlations with medium nitrogen, medium phosphorous, light intensity, inorganic carbon availability, and growth rate have been reported. Negative correlations have been reported between microcystin conte...

journal_title：Environmental toxicology

authors： Downing TG,Meyer C,Gehringer MM,van de Venter M

更新日期：2005-06-01 00:00:00

abstract：:Ecological risk assessments are, in part, based on results of toxicity tests conducted under standard exposure conditions. Global climate change will have a wide range of effects on estuarine habitats, including potentially increasing water temperature and salinity, which may alter the risk assessment of estuarine pol...

journal_title：Environmental toxicology

authors： DeLorenzo ME,Danese LE,Baird TD

更新日期：2013-07-01 00:00:00

abstract：:The 8-hydroxy-2'-deoxyguanosine (8-OHdG), an oxidized nucleoside of DNA, not only is a widely used biomarker for the measurement of endogenous oxidative DNA damage, but might also be a risk factor for many diseases including cancer. Elevated level of urinary 8-OHdG has been detected in patients with various malignanci...

journal_title：Environmental toxicology

authors： Yang Y,Tian Y,Yan C,Jin X,Tang J,Shen X

更新日期：2009-10-01 00:00:00

abstract：:So far, little is known on the distribution of hepatotoxic microcystin (MC) in various organs of bivalves, and there is no study on MC accumulation in bivalves from Chinese waters. Distribution pattern and seasonal dynamics of MC-LR, -YR and -RR in various organs (hepatopancreas, intestine, visceral mass, gill, foot, ...

journal_title：Environmental toxicology

authors： Chen J,Xie P

更新日期：2005-12-01 00:00:00

abstract：:Thallium (Tl) is a highly toxic heavy metal though up to now its mechanisms are poorly understood. In this study, we comparatively investigated the cytotoxic mechanisms of Tl(I) and Tl(III) in isolated rat hepatocytes. Both Tl(I) and Tl(III) cytotoxicities were associated with reactive oxygen species (ROS) formation, ...

journal_title：Environmental toxicology

authors： Pourahmad J,Eskandari MR,Daraei B

更新日期：2010-10-01 00:00:00

abstract：:Alpha-cypermethrin (α-CYP) is one of the most widely used insecticides. It may become an air pollutant and adversely affect the health. The present study was designed to determine whether treatment with N-acetyl cysteine (NAC), a well-known antioxidant, can be useful for the management of the deleterious effects of α-...

journal_title：Environmental toxicology

authors： Arafa MH,Mohamed DA,Atteia HH

更新日期：2015-01-01 00:00:00

abstract：:There is emerging evidence suggesting that oxidative stress and DNA methylation can alter miRNA expression. However, little is known on the mechanism of miR-17-5p expression changes in paraquat (PQ)-induced nerve cell damage. In the present study, neuro-2a cells were pretreated with antioxidant N-acetylcysteine (NAC) ...

journal_title：Environmental toxicology

authors： Zhan Y,Guo Z,Zheng F,Zhang Z,Li K,Wang Q,Wang L,Cai Z,Chen N,Wu S,Li H

更新日期：2020-12-01 00:00:00

abstract：:Effects of perchlorate on sodium-iodide symporter (NIS) and pendrin gene expression in deer mice kidney and stomach were investigated. This was accomplished by isolating a partial cDNA sequence of deer mice NIS gene of 425 bps, and quantitatively analyzing NIS mRNA expression in various deer mouse tissues. The highest...

journal_title：Environmental toxicology

authors： Cheng Q,Smith EE,Liu F,Gentle A,Hooper MJ,Anderson TA

更新日期：2007-08-01 00:00:00

abstract：:The use of malachite green (MG) in fish farming is prohibited in China due to its potentially toxicological and carcinogenic nature, but it is still illegally used in some places. The aim of this study was to investigate the time and concentration-dependent responses of xenobiotic metabolizing and detoxification-relat...

journal_title：Environmental toxicology

authors： Li G,Shen D,Liang XF,He Y,He S

更新日期：2013-03-01 00:00:00

abstract：:Cardiomyocyte apoptosis is the major risk factor for the development of heart failure (HF). The purpose of this study was to evaluate the effects of Gamma-aminobutyric acid (GABA) tea on hypertension-induced cardiac apoptotic pathways in spontaneously hypertensive rats (SHR). In order to reveal the mechanisms, 36 male...

journal_title：Environmental toxicology

authors： Chen BC,Hung MY,Wang HF,Yeh LJ,Pandey S,Chen RJ,Chang RL,Viswanadha VP,Lin KH,Huang CY

更新日期：2018-07-01 00:00:00

abstract：:This work investigated the effects of mercury chloride (HgCl2 ) acute exposure on virgin, pregnant and lactating rats by determination of renal and hepatic morphological and ultrastructural parameters and the expression of oxidative stress and stress tolerance markers, due to kidney and liver are the organs that more ...

journal_title：Environmental toxicology

authors： Oliveira VA,Favero G,Stacchiotti A,Giugno L,Buffoli B,de Oliveira CS,Lavazza A,Albanese M,Rodella LF,Pereira ME,Rezzani R

更新日期：2017-05-01 00:00:00

abstract：:Intake of arsenic (As) via drinking water has been a serious threat to global public health. Though there are numerous reports of As neurotoxicity, its pathogenesis mechanisms remain vague especially its chronic effects on metabolic network. Hippocampus is a renowned area in relation to learning and memory, whilst rec...

journal_title：Environmental toxicology

authors： Mo TT,Dai H,Du H,Zhang RY,Chai KP,An Y,Chen JJ,Wang JK,Chen ZJ,Chen CZ,Jiang XJ,Tang R,Wang LP,Tan Q,Tang P,Miao XY,Meng P,Zhang LB,Cheng SQ,Peng B,Tu BJ,Han TL,Xia YY,Baker PN

更新日期：2019-02-01 00:00:00

abstract：:8-Hydroxy-2'-deoxyguanosine (8-OHdG) is the most common biomarker of oxidative DNA damage, it is formed by chemical carcinogens and can be measured in any species. Perfluorooctanoic acid (PFOA) and perfluorononanoic acid (PFNA) are suspected genotoxic carcinogens through induction of reactive oxygen species that are r...

journal_title：Environmental toxicology

authors： Yahia D,Haruka I,Kagashi Y,Tsuda S

更新日期：2016-02-01 00:00:00

abstract：:Liver is one of the major target organs of arsenic toxicity and carcinogenesis. Nuclear factor (erythroid-2 related) factor 2 (Nrf2) is a redox-sensitive transcription factor, regulating critically cellular defense responses against the toxic metallic arsenic in many cell types and tissues. This study was conducted to...

journal_title：Environmental toxicology

authors： Li B,Li X,Zhu B,Zhang X,Wang Y,Xu Y,Wang H,Hou Y,Zheng Q,Sun G

更新日期：2013-07-01 00:00:00

abstract：:Recent interest in adverse effects of infrasound on organisms arises from health concerns. We assessed the association between infrasound exposure of 5 Hz at 130 dB and changes of cardiac ultrastructure and function in rats. Thirty-two Sprague-Dawley rats were randomized into control, 1, 7, and 14 days groups for 2 h ...

journal_title：Environmental toxicology

authors： Pei Z,Sang H,Li R,Xiao P,He J,Zhuang Z,Zhu M,Chen J,Ma H

更新日期：2007-04-01 00:00:00

abstract：:Four-week-old mice, weighing about 25-35 g were divided into five groups (8 mice in each group): vehicle control, low- (0.5 g/kg), middle- (1 g/kg), high- (3 g/kg), and exceptionally high-dose (5 g/kg). After first and second weeks of intraperitoneal exposure to AgNPs, biochemical, histopathological, and electron micr...

journal_title：Environmental toxicology

authors： Ansari MA,Khan HM,Khan AA,Alzohairy MA,Waseem M,Ahmad MK,Mahdi AA

更新日期：2016-08-01 00:00:00

abstract：:Tributyltin (TBT), a well-known endocrine disruptor, is an omnipresent environmental pollutant and is explicitly used in many industrial applications. Previously we have shown its neurotoxic potential on cerebral cortex of male Wistar rats. As the effect of TBT on other brain regions is not known, we planned this stud...

journal_title：Environmental toxicology

authors： Mitra S,Siddiqui WA,Khandelwal S

更新日期：2015-12-01 00:00:00

abstract：:Deguelin, a naturally occurring rotenoid of the flavonoid family, is known to be an Akt inhibitor, to have chemopreventive activities and anti-tumor effect on several cancers. In this study, investigation to elucidate the effect of deguelin on apoptotic pathways in human lung cancer cells and on the anti-tumor effect ...

journal_title：Environmental toxicology

authors： Hsu YC,Chiang JH,Yu CS,Hsia TC,Wu RS,Lien JC,Lai KC,Yu FS,Chung JG

更新日期：2017-01-01 00:00:00

abstract：:A 7 day in situ assay to assess sediment toxicity was carried out per replicate in two sites from Guadalete Estuary (Guad1 and Guad2) (South-West, Spain) using the polychaete Arenicola marina (n = 20) in benthic cages. After the exposure period, a battery of biomarkers were determined to asses the sediment toxicity. F...

journal_title：Environmental toxicology

authors： Ramos-Gómez J,Martín-Díaz ML,Rodríguez A,Riba I,DelValls TA

更新日期：2008-10-01 00:00:00

abstract：:Toxicants can perturb cellular homeostasis by modifying phosphorylation-based signaling. In the present study, we examined the effects of cerulein, an inducer of acute pancreatitis, on keratin 8 (K8) phosphorylation. We found that cerulein dose-dependently induced K8 phosphorylation and perinuclear reorganization in P...

journal_title：Environmental toxicology

authors： Park MK,Lee CH

更新日期：2016-12-01 00:00:00

abstract：:Three methods of algal assays--the standard assay, microassay, and the proposed fluorescence assay--are compared from the point of view of reliability of EC50 detection, the minimum required time for the detection, sensitivity of individual measurement, i.e. at which cell density the particular assay can be used for E...

journal_title：Environmental toxicology

authors： Kvíderová J

更新日期：2010-12-01 00:00:00

abstract：:Organic wastewater contaminants (OWCs) have recently been documented in several aquatic ecosystems. We examined the effects of three OWCs (caffeine, acetaminophen, and triclosan) on the activity level, startle response, survivorship, and growth of northern leopard frog (Rana pipiens) tadpoles. We conducted two experim...

journal_title：Environmental toxicology

authors： Fraker SL,Smith GR

更新日期：2004-06-01 00:00:00

abstract：:PM10 was collected in a Milan urban site, representative of the city air quality, during winter and summer 2006. Mean daily PM10 concentration was 48 μg m(-3) during summer and 148 μg m(-3) during winter. Particles collected on Teflon filters were chemically characterized and the endotoxin content determined by the ...

journal_title：Environmental toxicology

authors： Camatini M,Corvaja V,Pezzolato E,Mantecca P,Gualtieri M

更新日期：2012-02-01 00:00:00

abstract：:The acute toxicity of cylindrospermopsin (CYN) has been established in rodents, based on diverse intraperitoneal an oral exposure studies and more recently in fish. But no data have been reported in fish after subchronic exposure to cyanobacterial cells containing this cyanotoxin, so far. In this work, tilapia (Oreoch...

journal_title：Environmental toxicology

authors： Guzmán-Guillén R,Prieto AI,Moreno I,Vasconcelos VM,Moyano R,Blanco A,Cameán Fernandez AM

更新日期：2015-03-01 00:00:00

abstract：:Hypothyroxinemia induced by maternal mild iodine deficiency causes neurological deficits and impairments of brain function in offspring. Hypothyroxinemia is prevalent in developing and developed countries alike. However, the mechanism underlying these deficits remains less well known. Given that the myelin plays an im...

journal_title：Environmental toxicology

authors： Wei W,Wang Y,Dong J,Wang Y,Min H,Song B,Shan Z,Teng W,Xi Q,Chen J

更新日期：2015-11-01 00:00:00