Antitumor effects of deguelin on H460 human lung cancer cells in vitro and in vivo: Roles of apoptotic cell death and H460 tumor xenografts model.

abstract：:The phthalate plasticizer, di(2-ethyl-hexyl) phthalate (DEHP), and its derived metabolites are common anthropogenic environmental toxins, which are known to act as endocrine disruptors. Numerous studies have associated DEHP with disruption of sex hormones, abnormal development of reproductive organs, allergies, and in...

journal_title：Environmental toxicology

authors： Wong JH,Wang YS,Nam S,Ho KH,Chang CM,Chen KC,Chen YF,Chang WC

更新日期：2019-11-01 00:00:00

abstract：:Four-week-old mice, weighing about 25-35 g were divided into five groups (8 mice in each group): vehicle control, low- (0.5 g/kg), middle- (1 g/kg), high- (3 g/kg), and exceptionally high-dose (5 g/kg). After first and second weeks of intraperitoneal exposure to AgNPs, biochemical, histopathological, and electron micr...

journal_title：Environmental toxicology

authors： Ansari MA,Khan HM,Khan AA,Alzohairy MA,Waseem M,Ahmad MK,Mahdi AA

更新日期：2016-08-01 00:00:00

abstract：:A 7 day in situ assay to assess sediment toxicity was carried out per replicate in two sites from Guadalete Estuary (Guad1 and Guad2) (South-West, Spain) using the polychaete Arenicola marina (n = 20) in benthic cages. After the exposure period, a battery of biomarkers were determined to asses the sediment toxicity. F...

journal_title：Environmental toxicology

authors： Ramos-Gómez J,Martín-Díaz ML,Rodríguez A,Riba I,DelValls TA

更新日期：2008-10-01 00:00:00

abstract：:The prostate is an accessory reproductive gland that is sensitive to the action of exogenous compounds known as endocrine disrupters that alter normal hormonal function. Finasteride is a widely used chemical that acts to inhibit the conversion of testosterone in its most active form, dihydrotestosterone. It is known t...

journal_title：Environmental toxicology

authors： Maldarine JS,Sanches BDA,Santos VA,Amaro GM,Calmon MF,Rahal P,Góes RM,Vilamaior PSL,Taboga SR

更新日期：2020-01-01 00:00:00

abstract：:We hypothesized that chronic exposure to arsenic would deplete the reduced glutathione (GSH) and methionine in vivo, thereby impair the methylation capacity of inorganic arsenic (iAs) ingested. Our experiment was designed to explore the effects of exogenous GSH and methionine on arsenic methylation in mice exposed to ...

journal_title：Environmental toxicology

authors： Jin Y,Zhao F,Zhong Y,Yu X,Sun D,Liao Y,Lv X,Li G,Sun G

更新日期：2010-08-01 00:00:00

abstract：:Colorectal cancer (CC) is an important human malignancy with high cancer related death worldwide. The chemotherapy using doxorubicin hydrochloride is one of the most common cancer therapeutic methods. However, drug resistance lowers the treatment efficacy in CC patients. The combination therapies seem to be more promi...

journal_title：Environmental toxicology

authors： Jadid MFS,Aghaei E,Taheri E,Seyyedsani N,Chavoshi R,Abbasi S,Khorrami A,Goleij P,Hajazimian S,Taefehshokr S,Isazadeh A,Shanehbandi D

更新日期：2021-01-28 00:00:00

abstract：:The toxicity and chemical quality of surface water and sediment in the River Traun in Austria were studied because of recurrent fish mortality in some alpine rivers over the last few years. The analyses were carried out on samples collected during winter and summer upstream and downstream of two municipal wastewater t...

journal_title：Environmental toxicology

authors： Latif M,Licek E

更新日期：2004-08-01 00:00:00

abstract：:In May of 2006 we suddenly began to observe neural tube defects (NTDs) in embryos of untreated control mice. We hypothesized the mice were being exposed unknowingly to a teratogenic agent and investigated the cause. Our results suggested that NTDs were not resulting from bedding material, feed, strain, or source of th...

journal_title：Environmental toxicology

authors： Mallela MK,Werre SR,Hrubec TC

更新日期：2011-11-01 00:00:00

abstract：:In recent years, the protective effect of hydrogensulfide donor sodium hydrosulfide(NaHS) on multiple organs has been widely reported. The study aimed to explorethe effect of commonly used concentration of NaHS on theliver and its potential damage mechanism. Rats divided into 4 groups: control, NaHS I (1 mg/kg), II (3...

journal_title：Environmental toxicology

authors： Feng X,Zhang H,Shi M,Chen Y,Yang T,Fan H

更新日期：2020-03-01 00:00:00

abstract：:The acute toxicity of the insecticide fenitrothion was measured using four freshwater algae (Chlorella saccharophila, Chlorella vulgaris, Scenedesmus acutus, and Scenedesmus subspicatus) and one cyanobacteria (Pseudanabaena galeata). Insecticide concentrations eliciting 50% growth reduction over 96 hr (EC50) ranged fr...

journal_title：Environmental toxicology

authors： Sabater C,Carrasco JM

更新日期：2001-01-01 00:00:00

abstract：:The present study was designed to understand the oxidative stress potential of fenthion, an organophosphate (OP) pesticide and its involvement in glutathione metabolism modulated buthionine sulfoximine (BSO, 50 mg/kg) and N-acetylcysteine (NAC, 100 mg/kg) in the brain of fish, Oreochromis niloticus. A sublethal fenthi...

journal_title：Environmental toxicology

authors： Piner P,Sevgiler Y,Uner N

更新日期：2007-12-01 00:00:00

abstract：:There is emerging evidence suggesting that oxidative stress and DNA methylation can alter miRNA expression. However, little is known on the mechanism of miR-17-5p expression changes in paraquat (PQ)-induced nerve cell damage. In the present study, neuro-2a cells were pretreated with antioxidant N-acetylcysteine (NAC) ...

journal_title：Environmental toxicology

authors： Zhan Y,Guo Z,Zheng F,Zhang Z,Li K,Wang Q,Wang L,Cai Z,Chen N,Wu S,Li H

更新日期：2020-12-01 00:00:00

abstract：:Acetaminophen (APAP) is one of the few recommended analgesic and antipyretic drugs in some critical cases such as viral disease COVID-19. However, the unrestricted use of APAP develops liver disorders. Hepatotoxicity and liver injury can also be induced by ionizing radiation (IR) during radiotherapy. The data of the c...

journal_title：Environmental toxicology

authors： Eassawy MMT,Salem AA,Ismail AFM

更新日期：2020-12-17 00:00:00

abstract：:Methoxychlor (MXC), an organochloride insecticide, is a potent toxicant-targeting female reproductive system and known to cause follicular atresia by inducing apoptosis within granulosa cells. Oxidative stress plays a pivotal role in apoptosis; thus, this study focuses on the ameliorative action of N-acetyl cysteine (...

journal_title：Environmental toxicology

authors： Bhardwaj JK,Saraf P

更新日期：2017-01-01 00:00:00

abstract：:The environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is known to affect bone metabolism. We evaluated the protective effects of the triterpene glycoside actein from the herb black cohosh against TCDD-induced toxicity in MC3T3-E1 osteoblastic cells. We found that TCDD significantly reduced cell viabil...

journal_title：Environmental toxicology

authors： Choi EM,Suh KS,Jung WW,Park SY,Chin SO,Rhee SY,Pak YK,Chon S

更新日期：2017-12-01 00:00:00

abstract：:Females are born with a finite number of oocyte-containing follicles and ovary damage results in reduced fertility. Cadmium accumulates in the reproductive system, damaging it, and the cigarette smoke is a potential exposure route. Natural therapies are relevant to health benefits and disease prevention. This study ve...

journal_title：Environmental toxicology

authors： Izaguirry AP,Soares MB,Vargas LM,Spiazzi CC,Dos Santos Brum D,Noremberg S,Mendez AS,Santos FW

更新日期：2017-01-01 00:00:00

abstract：:Di (2-ethylhexyl) phthalate (DEHP) is a plasticizer that gives flexibility to various polyvinyl chloride products. It is a pollutant easily released into the environment and can cause many adverse effects to living organisms including hepatotoxicity. The thioredoxin system is a determining factor in the redox balance ...

journal_title：Environmental toxicology

authors： Amara I,Timoumi R,Annabi E,Di Rosa G,Scuto M,Najjar MF,Calabrese V,Abid-Essefi S

更新日期：2020-01-01 00:00:00

abstract：:Several estuaries along the Pacific Ocean coast of North America were identified recently as having elevated 4-nonylphenol (4-NP) in sediments and biota, raising concerns about reproductive impacts for wildlife given 4-NP's established estrogenic activity as an endocrine-disrupting compound. Here we characterize 4-NP ...

journal_title：Environmental toxicology

authors： Johnson KM,Lema SC

更新日期：2017-05-01 00:00:00

abstract：:Increasing use of pesticides all over the world makes it necessary to reveal the toxic risk in populations of nontargeted organisms. Bendiocarb is one of the 12 insecticides recommended by the World Health Organization for use in malaria control in Africa, and is used against a variety of insects. The liver has an imp...

journal_title：Environmental toxicology

authors： Petrovova E,Purzyc H,Mazensky D,Luptakova L,Torma N,Sopoliga I,Sedmera D

更新日期：2015-02-01 00:00:00

abstract：:Aspartame is one of the most common consumed artificial sweeteners utilized in many food products and beverages. It has been indicated that long-term consumption of aspartame leads to reproductive toxicity but its mechanism is not well-clear. In this study we investigated mechanism of aspartame-induced reproductive to...

journal_title：Environmental toxicology

authors： Anbara H,Sheibani MT,Razi M,Kian M

更新日期：2021-02-01 00:00:00

abstract：:Numerous studies have shown that rutin has anticancer effects. We have previously reported that rutin induced cell cycle arrest and apoptosis in murine leukemia WEHI-3 cells in vitro and in vivo. However, there are no data showing that rutin inhibits human leukemia HL-60 cells in vivo in a murine xenograft animal mode...

journal_title：Environmental toxicology

authors： Lin JP,Yang JS,Lin JJ,Lai KC,Lu HF,Ma CY,Sai-Chuen Wu R,Wu KC,Chueh FS,Gibson Wood W,Chung JG

更新日期：2012-08-01 00:00:00

abstract：:The aim of this study was to determine whether repeated exposure to iron oxide nanoparticles (Fe2 O3 -NPs) could be toxic to mice testis. Fe2 O3 -NPs (25 and 50 mg/kg) were intraperitoneally administered into mice once a week for 4 weeks. Our study showed that Fe2 O3 -NPs have the ability to cross the blood-testis bar...

journal_title：Environmental toxicology

authors： Sundarraj K,Manickam V,Raghunath A,Periyasamy M,Viswanathan MP,Perumal E

更新日期：2017-02-01 00:00:00

abstract：:Previous studies indicate that exposure to perfluorooctanesulfonate (PFOS), a ubiquitous and highly persistent environmental contaminant, induces immunotoxicity in mice. However, few studies have specifically assessed the effects of PFOS on inflammation. This study utilized a standard 60-day oral exposure period to as...

journal_title：Environmental toxicology

authors： Dong GH,Zhang YH,Zheng L,Liang ZF,Jin YH,He QC

更新日期：2012-05-01 00:00:00

abstract：:Widespread occupational and environmental exposure to benzene is unavoidable and poses a public health threat. Studies of potential interventions to prevent or relieve benzene toxicity are, thus, essential. Research has shown l-carnitine (LC) has beneficial effects against various pathological processes and diseases. ...

journal_title：Environmental toxicology

authors： Sun R,Man Z,Ji J,Ji S,Xu K,Pu Y,Yu L,Zhang J,Yin L,Pu Y

更新日期：2020-10-01 00:00:00

abstract：:The effect of the heavy metal copper on the expression of a wide spectrum of genes was analyzed by using a DNA microarray. The gene expression profile of baker's yeast Saccharomyces cerevisiae grown in a medium containing a sublethal concentration of cupric sulfate was compared with that of yeast grown in a normal med...

journal_title：Environmental toxicology

authors： Yasokawa D,Murata S,Kitagawa E,Iwahashi Y,Nakagawa R,Hashido T,Iwahashi H

更新日期：2008-10-01 00:00:00

abstract：:Toxicity of lead on male reproductive functions has raised wide public concern as environmental lead contamination remains common worldwide. Conflicting and controversial data are available regarding effects of lead on male fertility. More importantly, our knowledge on effects of lead on sperm DNA integrity is signifi...

journal_title：Environmental toxicology

authors： Li C,Zhao K,Zhang H,Liu L,Xiong F,Wang K,Chen B

更新日期：2018-05-01 00:00:00

abstract：:Three methods of algal assays--the standard assay, microassay, and the proposed fluorescence assay--are compared from the point of view of reliability of EC50 detection, the minimum required time for the detection, sensitivity of individual measurement, i.e. at which cell density the particular assay can be used for E...

journal_title：Environmental toxicology

authors： Kvíderová J

更新日期：2010-12-01 00:00:00

abstract：:Acute severe carbon monoxide (CO) poisoning induces hypoxia that leads to cardiovascular and nervous systems disturbances. Different complex mechanisms lead to CO neurotoxicity including lipid peroxidation, inflammatory and immune-mediated reactions, myelin degeneration and finally neuronal apoptosis and necrosis. Gra...

journal_title：Environmental toxicology

authors： Ghorbani M,Mohammadpour AH,Abnous K,Movassaghi AR,Sarshoori JR,Shahsavand S,Hashemzaei M,Moallem SA

更新日期：2017-01-01 00:00:00

abstract：:Acetaminophen (AP) is a widely used, cheap, and over-the-counter nonsteroidal anti-inflammatory drug. Its toxicity depends on the cytochrome P-450 (CYP)-mediated oxidation to the toxic metabolite N-acetyl-p-benzoquinoneimine. On the other hand, arsenic, a global groundwater and environmental contaminant of major publi...

journal_title：Environmental toxicology

authors： Manimaran A,Sarkar SN,Sankar P

更新日期：2011-06-01 00:00:00

abstract：:This study investigated lethal effects (i.e., survival) and sublethal effects (glutathione, GSH; lipid peroxidation, LPx; cholesterol, CHL; and acetylcholinesterase, AChE) of the antihyperlipidemic drug simvastatin on larval and adult grass shrimp (Palaemonetes pugio). The 96-h LC50 test for larvae resulted in an esti...

journal_title：Environmental toxicology

authors： Key PB,Hoguet J,Reed LA,Chung KW,Fulton MH

更新日期：2008-04-01 00:00:00