Abstract:
:The prostate is an accessory reproductive gland that is sensitive to the action of exogenous compounds known as endocrine disrupters that alter normal hormonal function. Finasteride is a widely used chemical that acts to inhibit the conversion of testosterone in its most active form, dihydrotestosterone. It is known that intrauterine exposure to finasteride causes changes in the male prostate even at low dosages; however, it is not known whether these dosages are capable of causing changes in the female prostate, which is present in a large number of mammalian species, including humans. In the present study, histochemistry, immunohistochemistry, immunofluorescence, serological dosages, and three-dimensional reconstruction techniques were employed to evaluate the effects of intrauterine exposure to a low dose of finasteride (100 μg.BW/d) on postnatal prostate development in male and female Mongolian gerbils. The results indicate that the gerbil female prostate also undergoes alterations following intrauterine exposure to finasteride, exhibiting a thickening of periductal smooth muscle and increased stromal proliferation. There are also intersex differences in the impact of exposure on the expression of the androgen receptor, which was increased in males, and of the estrogen-α receptor, which was decreased in the male prostate but unchanged in females. Altogether, this study indicates there are sex differences in the effects of finasteride exposure even at low dosages.
journal_name
Environ Toxicoljournal_title
Environmental toxicologyauthors
Maldarine JS,Sanches BDA,Santos VA,Amaro GM,Calmon MF,Rahal P,Góes RM,Vilamaior PSL,Taboga SRdoi
10.1002/tox.22838subject
Has Abstractpub_date
2020-01-01 00:00:00pages
15-26issue
1eissn
1520-4081issn
1522-7278journal_volume
35pub_type
杂志文章abstract::The freshwater crabs Sinopotamon henanense were exposed to different concentrations of waterborne cadmium (Cd). The relationship between tissue-specific Cd accumulation and metallothionein (MT) induction was investigated using the Cd saturation assay and atomic absorption spectrophotometry method. The results showed t...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20339
更新日期:2008-06-01 00:00:00
abstract::Chlorpyrifos (CPF) is one of the most widely used organophosphorus, which has spurred renewed interest. This study was conducted to investigate the protective effect of ziziphora tenuior extract against CPF-induced liver and lung toxicity. This study conducted 8-week rat sub-chronic toxicity study and then the effect ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22432
更新日期:2017-09-01 00:00:00
abstract::Microcystin-LR (MC-LR) is the most commonly encountered of the toxic cyclic peptide hepatotoxins occurring in China. It is a model compound for toxicological studies. In this study, the toxicity of MC-LR (50 and 500 micrograms/L) on isolated carp hepatocytes was determined and the ultrastructural alterations of cells ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.10012
更新日期:2001-01-01 00:00:00
abstract::Microcystin-LR (MC-LR) is a potent inhibitor of protein phosphatases 1 and 2A, and has potent hepatotoxicity and tumor promotion activity. Numerous studies on MC-LR toxicity have been conducted in rat hepatocytes, but few studies of the effects of microcystins on human hepatocytes have been done. In this study, HL7702...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21854
更新日期:2014-11-01 00:00:00
abstract::Avian vacuolar myelinopathy (AVM) is a neurological disease affecting bald eagles (Haliaeetus leucocephalus), American coots (Fulica americana), waterfowl, and other birds in the southeastern United States. The cause of the disease is unknown, but is thought to be a naturally produced toxin. AVM is associated with aqu...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20424
更新日期:2009-08-01 00:00:00
abstract::Andrographolide, the main bioactive component of the medicinal plant Andrographis paniculata, has been shown to possess potent anti-inflammatory activity. Endothelin 1 (ET-1), a potent vasoconstrictor peptide produced by vascular endothelial cells, displays proinflammatory property. Hypoxia-inducible factor 1α (HIF-1α...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22293
更新日期:2017-03-01 00:00:00
abstract::Metabolic products are often more toxic than their pharmacological parent compounds. Therefore, the acute and chronic effects of the main metabolites--salicylic acid (SAL), gentisic acid (GEN), and o-hydroxyhippuric acid (HDP)--of acetylsalicylic acid (ASA), the active ingredient in Aspirin and many other pharmaceutic...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20060
更新日期:2004-10-01 00:00:00
abstract::The chronic effect of p-nonylphenol on survival and reproduction for two generations of the freshwater cladoceran Daphnia galeata was examined by life table experiments. The effects on survival and reproduction were used as the intrinsic rate of natural increase, r, with the Euler-Lotka equation and were analyzed with...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.10083
更新日期:2002-10-01 00:00:00
abstract::An important disturbance of anthropogenic origin frequently occurring in freshwater ecosystems is a rise in the concentration of heavy metals in solution, among which copper stands out due to its known toxicity. However, the study of the chemical behavior of copper in solution is highly dependent on pH. In this study,...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.10001
更新日期:2001-10-01 00:00:00
abstract::The synergic allergic inflammatory effects of particulate matter (PM) 2.5 and human albumin were investigated in NC/Nga mice, which are hypersensitive to mite allergens. PM2.5 or PM2.5 plus human albumin with aluminum oxide was injected twice intraperitoneally for sensitization. After 7 days, PM2.5 or PM2.5 plus human...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22751
更新日期:2019-07-01 00:00:00
abstract::Oral cancer is one of the cancer-related diseases in human populations and its incidence rates are rising worldwide. Fisetin, a flavonoid from natural products, has been shown to exhibit anticancer activities in many human cancer cell lines but the molecular mechanism of fisetin-induced apoptosis in human oral cancer ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22396
更新日期:2017-06-01 00:00:00
abstract::Microcystins are a family of potent hepatotoxins produced by freshwater cyanobacteria and can cause animal intoxications and human diseases. In this study, the effect of microcystin-LR (MC-LR) on the tissues of freshwater pearl mussel (Hyriopsis cumingii) was evaluated and differentially expressed genes in the hepatop...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20652
更新日期:2012-07-01 00:00:00
abstract::Renal cell carcinoma (RCC) is the most common type of kidney cancer in adults and the major cause of mortality in urological cancer. Most patients with RCC are asymptomatic until the disease is advanced and unresectable. In this situation, systemic therapy with immunotherapy or molecularly targeted therapy agents play...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22411
更新日期:2017-07-01 00:00:00
abstract::Biotransformation enzymatic activities, such as the cytochrome P450 one, have been used as biomarkers for pollution assessment for a long time. Nevertheless, such biochemical tools are destructive processes, because they are performed on fish liver or total larvae homogenates. Moreover, the adaptation of this bioassay...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20184
更新日期:2006-08-01 00:00:00
abstract::In the present study, the modulatory effect of phytol against benzo(a)pyrene [B(a)P] induced lung carcinogenesis was investigated in Swiss albino mice. During the experimental period, phytol treatment showed no adverse toxic effect and mortality to the experimental animals. Lung tumor was observed in B(a)P treated gro...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22690
更新日期:2019-04-01 00:00:00
abstract::T-2 toxin is the most toxic among mycotoxins and poses a potential health hazard for both humans and animals. At high doses, T-2 toxin can cause shock-like syndrome that can result in death. We evaluated the effect of time course and route of exposure on hepatic oxidative damage in mice and it is only such study so fa...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21895
更新日期:2015-01-01 00:00:00
abstract::Di(2-ethylhexyl) phthalate, which is a ubiquitous environmental contaminant because of its extensive use as a plasticizer, is a potential nongenotoxic carcinogen. To assess the effects of DEHP exposure on the cytoskeleton of Chironomus, we characterized full-length cDNA sequences of the calponin gene from Chironomus r...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20463
更新日期:2009-12-01 00:00:00
abstract::Cyanotoxins are a group of compounds produced by cyanobacteria that can have severe physiological effects on other organisms, including humans. The potential allelopathic effects of Microcystis aeruginosa, a toxic cyanobacterium, on the duckweed plant, Lemna gibba L., were examined using three experimental methods: (1...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20079
更新日期:2005-02-01 00:00:00
abstract::The cytotoxic and genotoxic effects induced by alachlor and dichlorvos, two pesticides broadly used, were studied on RTG-2 fish cell line. As measure of cytotoxicity, neutral red assay was used to determine the cellular viability. Toxicity ranking based on IC(50) values found that alachlor was more cytotoxic than dich...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20637
更新日期:2012-03-01 00:00:00
abstract::Tributyltin (TBT), a proven endocrine-disrupting chemical, is well known to induce imposex in female gastropods. Herein we demonstrate the effects of low doses of tributyltin chloride (TBTCl) on the female offspring of KM mice. Pregnant mice were administered by gavage with 0, 1, 10, or 100 μg TBTCl/kg body weight/day...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21756
更新日期:2012-11-01 00:00:00
abstract::Rheumatoid arthritis (RA) is the most common type of chronic inflammatory disease which is triggered by dysfunction in the immune system which in turn affects synovial joints. Current treatment of RA with NSAIDs and DMRDs is limited by their side effect. As a result, the interest in alternative, well tolerated anti-in...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22264
更新日期:2017-02-01 00:00:00
abstract::The toxicity and chemical quality of surface water and sediment in the River Traun in Austria were studied because of recurrent fish mortality in some alpine rivers over the last few years. The analyses were carried out on samples collected during winter and summer upstream and downstream of two municipal wastewater t...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20027
更新日期:2004-08-01 00:00:00
abstract::Four-week-old mice, weighing about 25-35 g were divided into five groups (8 mice in each group): vehicle control, low- (0.5 g/kg), middle- (1 g/kg), high- (3 g/kg), and exceptionally high-dose (5 g/kg). After first and second weeks of intraperitoneal exposure to AgNPs, biochemical, histopathological, and electron micr...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22104
更新日期:2016-08-01 00:00:00
abstract::Aspartame is one of the most common consumed artificial sweeteners utilized in many food products and beverages. It has been indicated that long-term consumption of aspartame leads to reproductive toxicity but its mechanism is not well-clear. In this study we investigated mechanism of aspartame-induced reproductive to...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.23028
更新日期:2021-02-01 00:00:00
abstract::The environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is known to affect bone metabolism. We evaluated the protective effects of the triterpene glycoside actein from the herb black cohosh against TCDD-induced toxicity in MC3T3-E1 osteoblastic cells. We found that TCDD significantly reduced cell viabil...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22459
更新日期:2017-12-01 00:00:00
abstract::Methoxychlor (MXC), an organochloride insecticide, is a potent toxicant-targeting female reproductive system and known to cause follicular atresia by inducing apoptosis within granulosa cells. Oxidative stress plays a pivotal role in apoptosis; thus, this study focuses on the ameliorative action of N-acetyl cysteine (...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22221
更新日期:2017-01-01 00:00:00
abstract::Lake Elphinstone is a tropical inland water body in the far north of the Fitzroy Catchment in Central Queensland, Australia, and has experienced recurrent toxic cyanoprokaryote blooms since 1997. This article reports on an examination of the environmental conditions of the lake and the concurrent cyanoprokaryote speci...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.10142
更新日期:2003-12-01 00:00:00
abstract::Exposure to sublethal hexavalent chromium (as 2 and 4 mg L⁻¹ potassium dichromate for 1 and 2 months) during late preparatory to mid prespawning phase of annual reproductive cycle severely affected the pituitary-ovarian axis of a teleost Channa punctatus. Gonadosomatic index (GSI), ovarian histopathology, immunocytoch...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20654
更新日期:2012-07-01 00:00:00
abstract::This study investigated lethal effects (i.e., survival) and sublethal effects (glutathione, GSH; lipid peroxidation, LPx; cholesterol, CHL; and acetylcholinesterase, AChE) of the antihyperlipidemic drug simvastatin on larval and adult grass shrimp (Palaemonetes pugio). The 96-h LC50 test for larvae resulted in an esti...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20318
更新日期:2008-04-01 00:00:00
abstract::The frequent occurrences of the toxic cyanobacterial (specifically Microcystis aeruginosa) bloom are becoming a global environmental issue. Lots of researches have been focused on the pure cyanobacterial toxins, but little on the natural cyanobacterial bloom. This study was undertaken to investigate the effect of the ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20374
更新日期:2008-12-01 00:00:00