Abstract:
:Numerous studies have shown that rutin has anticancer effects. We have previously reported that rutin induced cell cycle arrest and apoptosis in murine leukemia WEHI-3 cells in vitro and in vivo. However, there are no data showing that rutin inhibits human leukemia HL-60 cells in vivo in a murine xenograft animal model. Human leukemia HL-60 cells were implanted into mice and treated with vehicle (1% DMSO), rutin (120 mg/kg of body weight) or vinblastine (120 μg/kg of body weight). Compounds and agents were injected once every four days intraperitoneally (i.p.) for 36 days. Treatment with 120 mg/kg of rutin or with 120 μg/kg of vinblastine resulted in a reduction of tumor weight and volume when compared with the control groups. Tumor size in xenograft mice treated with 120 mg/kg of rutin was significantly smaller than that in the untreated-control group. These novel findings indicate that rutin inhibits tumor growth in a xenograft animal model. Rutin may be useful in treating leukemia but certainly much more research is needed. © 2011 Wiley Periodicals, Inc. Environ Toxicol, 2012.
journal_name
Environ Toxicoljournal_title
Environmental toxicologyauthors
Lin JP,Yang JS,Lin JJ,Lai KC,Lu HF,Ma CY,Sai-Chuen Wu R,Wu KC,Chueh FS,Gibson Wood W,Chung JGdoi
10.1002/tox.20662subject
Has Abstractpub_date
2012-08-01 00:00:00pages
480-4issue
8eissn
1520-4081issn
1522-7278journal_volume
27pub_type
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