Abstract:
:Quinolines are aromatic nitrogen compounds with wide therapeutic potential to treat parasitic and microbial diseases. In this study, the genotoxicity of quinoline, 4-methylquinoline, 4-nitroquinoline-1-oxide (4-NQO), and diversely functionalized quinoline derivatives and the influence of the substituents (functional groups and/or atoms) on their genotoxicity were tested using the SOS chromotest. Quinoline derivatives that induce genotoxicity by the formation of an enamine epoxide structure did not induce the SOS response in Escherichia coli PQ37 cells, with the exception of 4-methylquinoline that was weakly genotoxic. The chemical nature of the substitution (C-5 to C-8: hydroxyl, nitro, methyl, isopropyl, chlorine, fluorine, and iodine atoms; C-2: phenyl and 3,4-methylenedioxyphenyl rings) of quinoline skeleton did not significantly modify compound genotoxicities; however, C-2 substitution with α-, β-, or γ-pyridinyl groups removed 4-methylquinoline genotoxicity. On the other hand, 4-NQO derivatives whose genotoxic mechanism involves reduction of the C-4 nitro group were strong inducers of the SOS response. Methyl and nitrophenyl substituents at C-2 of 4-NQO core affected the genotoxic potency of this molecule. The relevance of these results is discussed in relation to the potential use of the substituted quinolines. The work showed the sensitivity of SOS chromotest for studying structure-genotoxicity relationships and bioassay-guided quinoline synthesis.
journal_name
Environ Toxicoljournal_title
Environmental toxicologyauthors
Duran LT,Rincón NO,Galvis CE,Kouznetsov VV,Lorenzo JLdoi
10.1002/tox.21905subject
Has Abstractpub_date
2015-03-01 00:00:00pages
278-92issue
3eissn
1520-4081issn
1522-7278journal_volume
30pub_type
杂志文章abstract::Interspecies differences in the accumulation of dietary tributyltin (TBT) between sea perch, Lateolabrax japonicus, and red sea bream, Pagrus major, were studied. Although TBTs in both species reached steady-state condition in low-concentration group (L-group, 200 ng/g nominal concentration) by 1 week, it increased up...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20526
更新日期:2011-02-01 00:00:00
abstract::Global use of azole fungicides is expected to increase over the next several years. Triticonazole is a triazole fungicide that is used for turf protection, residential, and other commercial applications. As such, it can enter local rural and urban water systems via run-off and rain events. Early life stages of aquatic...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22862
更新日期:2020-02-01 00:00:00
abstract::The microbial assay for risk assessment (MARA) is an innovative system based on an array of 11 different microbial species freeze-dried in a 96-well micro-titer plate. Developed for testing the toxicity of chemicals, mixtures, and environmental samples, the assay employs species of a taxonomically diverse range. In ad...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20419
更新日期:2008-10-01 00:00:00
abstract::In May of 2006 we suddenly began to observe neural tube defects (NTDs) in embryos of untreated control mice. We hypothesized the mice were being exposed unknowingly to a teratogenic agent and investigated the cause. Our results suggested that NTDs were not resulting from bedding material, feed, strain, or source of th...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20600
更新日期:2011-11-01 00:00:00
abstract::This work investigated the effects of mercury chloride (HgCl2 ) acute exposure on virgin, pregnant and lactating rats by determination of renal and hepatic morphological and ultrastructural parameters and the expression of oxidative stress and stress tolerance markers, due to kidney and liver are the organs that more ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22370
更新日期:2017-05-01 00:00:00
abstract::Tributyltin (TBT), a proven endocrine-disrupting chemical, is well known to induce imposex in female gastropods. Herein we demonstrate the effects of low doses of tributyltin chloride (TBTCl) on the female offspring of KM mice. Pregnant mice were administered by gavage with 0, 1, 10, or 100 μg TBTCl/kg body weight/day...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21756
更新日期:2012-11-01 00:00:00
abstract::We cloned the full-length cDNA sequence of xenobiotic metabolizing cytochrome P4501A (CYP1A) gene from the yellow catfish (Pelteobagrus fulvidraco, Siluriformes, Bagridae). P. fulvidraco is a commercially important fish generally distributed in Southeast Asian countries and Korea. This is the first report of any xenob...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20333
更新日期:2008-06-01 00:00:00
abstract::This study investigated lethal effects (i.e., survival) and sublethal effects (glutathione, GSH; lipid peroxidation, LPx; cholesterol, CHL; and acetylcholinesterase, AChE) of the antihyperlipidemic drug simvastatin on larval and adult grass shrimp (Palaemonetes pugio). The 96-h LC50 test for larvae resulted in an esti...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20318
更新日期:2008-04-01 00:00:00
abstract::Exposure to sublethal hexavalent chromium (as 2 and 4 mg L⁻¹ potassium dichromate for 1 and 2 months) during late preparatory to mid prespawning phase of annual reproductive cycle severely affected the pituitary-ovarian axis of a teleost Channa punctatus. Gonadosomatic index (GSI), ovarian histopathology, immunocytoch...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20654
更新日期:2012-07-01 00:00:00
abstract::Throughout life, the human eye is continuously exposed to sunlight and artificial lighting. Ambient light exposure can lead to visual impairment and transient or permanent blindness. To mimic benign light stress conditions, Mus musculus eyes were exposed to low-energy UVB radiation, ensuring no severe morphological ch...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22494
更新日期:2018-01-01 00:00:00
abstract::Nonsmall cell lung cancer (NSCLC) is the most common type of lung cancer with a high mortality rate and still remains a therapeutic challenge. A strategy for targeting NSCLC is to identify agents that are effective against NSCLC cells while sparing normal cells. Dihydromyricetin (DHM) is the major flavonoid component ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22336
更新日期:2017-04-01 00:00:00
abstract::Smoking increases the risk of cardiovascular disorders and leads to damage caused by inflammation and oxidative stress. The actin cytoskeleton is a key player in the response to inflammatory stimuli and is an early target of cellular oxidative stress. The purpose of this study was to investigate the changes in actin c...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22133
更新日期:2016-11-01 00:00:00
abstract::Microcystin-LR (MC-LR) is a potent inhibitor of protein phosphatases 1 and 2A, and has potent hepatotoxicity and tumor promotion activity. Numerous studies on MC-LR toxicity have been conducted in rat hepatocytes, but few studies of the effects of microcystins on human hepatocytes have been done. In this study, HL7702...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21854
更新日期:2014-11-01 00:00:00
abstract::Long-term exposure of agriculturally used organochloride and organophosphate pesticides have been shown to cause long-lasting hematotoxicity and increased incidence of aplastic anemia in humans. The mechanisms involved in pesticide induced hematotoxicity and the features of toxicity that may play a major role in bone ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20775
更新日期:2014-01-01 00:00:00
abstract::Within the last decade, numerous epidemiological studies have demonstrated that endocrine disruptors are a possible cause for a decline in semen quality. Cypermethrin is a widely used pyrethroid insecticide, but little is known about its potentially adverse effects on male reproduction. In the present study, we invest...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20566
更新日期:2011-08-01 00:00:00
abstract::Two phylogenetically distant types of test-systems-root tip meristems of barley (Hordeum vulgare) and human lymphocytes in vitro were used to detect genotoxicity and cytotoxicity induced by the herbicide paraquat (PQ) in the concentration range (10(-6) to 5 x 10(-4) mol/l). As an endpoint for cytotoxicity the mitotic ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20503
更新日期:2010-06-01 00:00:00
abstract::Dibutyltin (DBT) is the degradation products of TBT, which is generally considered higher toxicity than TBT in the immune system. In order to learn more about the mechanisms of immune-toxic of DBT, we exposed zebrafish (Danio rerio) to 0, 1, 10 and 100 ng/L DBT for 8 weeks. At the end of the experiment, we determined ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22502
更新日期:2018-01-01 00:00:00
abstract::Seasonal changes in developmental stages, condition factor (CF), gonadosomatic index, and plasma vitellogenin (Vtg) concentrations in male and female hornyhead turbot were examined at the wastewater outfall (T1) of the Orange County Sanitation District, and two farfield sites T11 (7.7 km northwest of the outfall) and ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20287
更新日期:2007-10-01 00:00:00
abstract::Long non-coding RNA (lncRNA) plays a critical role in male germline development. Atrazine (AZ) as an environmental endocrine disrupting chemical (EDCs) can induce male reproductive toxicity in amphibians. Our previous studies demonstrated that AZ can alter gene and circular RNA (circRNA) expression of damaged testes i...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22704
更新日期:2019-04-01 00:00:00
abstract::Bergapten is a natural compound and has potent anticancer activities. In this study, we explored the cytotoxicity of bergapten on colorectal cancer (CRC) cell DLD-1 and LoVo and its underlying mechanisms. We observed that bergapten (30 and 50 μM) decreased the viability of the CRC cells and induced the G0/G1 and sub-G...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22685
更新日期:2019-03-01 00:00:00
abstract::Melamine is a heterocyclic, aromatic amine and nitrogen-enriched environmental toxicant, found in not only adulterated foodstuffs but also industrial household tableware and paints. Previous studies demonstrated adverse effects of high-dose melamine on human infants and pregnant animals, but effects of low-dose melami...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22218
更新日期:2017-01-01 00:00:00
abstract::A recent study has shown that nonanoic acid (NA) is one of the strongest allelochemicals to a cyanobacterium Microcystis aeruginosa, but the physiological responses of M. aeruginosa to NA stress remain unknown. In this study, physiological characters such as the growth rate, photosynthetic processes, phosphorus and ni...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20462
更新日期:2009-12-01 00:00:00
abstract::Human exposure to bisphenol A (BPA) could favor obesity and related metabolic disorders such as hepatic steatosis. Investigations in rodents have shown that these deleterious effects are observed not only when BPA is administered during the adult life but also with different protocols of perinatal exposure. Whether pe...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22301
更新日期:2017-03-01 00:00:00
abstract::Tributyltin (TBT) and dibutyltin (DBT) are widespread environmental contaminants found in food, beverages, and human blood samples. Both of these butyltins (BTs) interfere with the ability of human natural killer (NK) cells to lyse target cells and alter secretion of the pro-inflammatory cytokine tumor necrosis factor...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21932
更新日期:2015-05-01 00:00:00
abstract::The phthalate plasticizer, di(2-ethyl-hexyl) phthalate (DEHP), and its derived metabolites are common anthropogenic environmental toxins, which are known to act as endocrine disruptors. Numerous studies have associated DEHP with disruption of sex hormones, abnormal development of reproductive organs, allergies, and in...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22820
更新日期:2019-11-01 00:00:00
abstract::The health of a large rural population in the southern Pampa (Argentina) is at risk owing to newly detected areas where As-groundwater exceeds 0.01 mg/L standard (WHO (1995) Guidelines for drinking water quality, 2nd edition. pp 43-45). Currently, devitrification of volcanic glass is invoked to interpret the origin of...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20219
更新日期:2006-12-01 00:00:00
abstract::Ecological risk assessments are, in part, based on results of toxicity tests conducted under standard exposure conditions. Global climate change will have a wide range of effects on estuarine habitats, including potentially increasing water temperature and salinity, which may alter the risk assessment of estuarine pol...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20726
更新日期:2013-07-01 00:00:00
abstract::8-Hydroxy-2'-deoxyguanosine (8-OHdG) is the most common biomarker of oxidative DNA damage, it is formed by chemical carcinogens and can be measured in any species. Perfluorooctanoic acid (PFOA) and perfluorononanoic acid (PFNA) are suspected genotoxic carcinogens through induction of reactive oxygen species that are r...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22034
更新日期:2016-02-01 00:00:00
abstract::Effect-directed analysis (EDA) has been reported to be a powerful tool for the identification of the responsible toxicants in contaminated, hazardous environmental samples. The aim of this study was to investigate whether it also is possible to use currently available EDA methodology to identify potentially relevant t...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20135
更新日期:2005-10-01 00:00:00
abstract::Structure-activity relationships for oestrogenicity were developed based on 120 aromatic chemicals evaluated in the Saccharomyces cerevisiae-based Lac-Z reporter assay. Relative gene activation was compared to 17 beta-estradiol and varied over eight orders of magnitude. Analysis of the data compared to 17 beta-estradi...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.10027
更新日期:2002-02-01 00:00:00