Abstract：
:Intake of arsenic (As) via drinking water has been a serious threat to global public health. Though there are numerous reports of As neurotoxicity, its pathogenesis mechanisms remain vague especially its chronic effects on metabolic network. Hippocampus is a renowned area in relation to learning and memory, whilst recently, cerebellum is argued to be involved with process of cognition. Therefore, the study aimed to explore metabolomics alternations in these two areas after chronic As exposure, with the purpose of further illustrating details of As neurotoxicity. Twelve 3-week-old male C57BL/6J mice were divided into two groups, receiving deionized drinking water (control group) or 50 mg/L of sodium arsenite (via drinking water) for 24 weeks. Learning and memory abilities were tested by Morris water maze (MWM) test. Pathological and morphological changes of hippocampus and cerebellum were captured via transmission electron microscopy (TEM). Metabolic alterations were analyzed by gas chromatography-mass spectrometry (GC-MS). MWM test confirmed impairments of learning and memory abilities of mice after chronic As exposure. Metabolomics identifications indicated that tyrosine increased and aspartic acid (Asp) decreased simultaneously in both hippocampus and cerebellum. Intermediates (succinic acid) and indirect involved components of tricarboxylic acid cycle (proline, cysteine, and alanine) were found declined in cerebellum, indicating disordered energy metabolism. Our findings suggest that these metabolite alterations are related to As-induced disorders of amino acids and energy metabolism, which might therefore, play an important part in mechanisms of As neurotoxicity.
journal_name
Environ Toxicoljournal_title
Environmental toxicologyauthors
Mo TT,Dai H,Du H,Zhang RY,Chai KP,An Y,Chen JJ,Wang JK,Chen ZJ,Chen CZ,Jiang XJ,Tang R,Wang LP,Tan Q,Tang P,Miao XY,Meng P,Zhang LB,Cheng SQ,Peng B,Tu BJ,Han TL,Xia YY,Baker PNdoi
10.1002/tox.22662subject
Has Abstractpub_date
2019-02-01 00:00:00pages
103-111issue
2eissn
1520-4081issn
1522-7278journal_volume
34pub_type
杂志文章abstract：:Seasonal changes in developmental stages, condition factor (CF), gonadosomatic index, and plasma vitellogenin (Vtg) concentrations in male and female hornyhead turbot were examined at the wastewater outfall (T1) of the Orange County Sanitation District, and two farfield sites T11 (7.7 km northwest of the outfall) and ...
journal_title：Environmental toxicology
pub_type： 杂志文章
doi：10.1002/tox.20287
更新日期：2007-10-01 00:00:00
abstract：:The acute toxicity of the insecticide fenitrothion was measured using four freshwater algae (Chlorella saccharophila, Chlorella vulgaris, Scenedesmus acutus, and Scenedesmus subspicatus) and one cyanobacteria (Pseudanabaena galeata). Insecticide concentrations eliciting 50% growth reduction over 96 hr (EC50) ranged fr...
journal_title：Environmental toxicology
pub_type： 杂志文章
doi：10.1002/tox.1038
更新日期：2001-01-01 00:00:00
abstract：:Andrographolide, the main bioactive component of the medicinal plant Andrographis paniculata, has been shown to possess potent anti-inflammatory activity. Endothelin 1 (ET-1), a potent vasoconstrictor peptide produced by vascular endothelial cells, displays proinflammatory property. Hypoxia-inducible factor 1α (HIF-1α...
journal_title：Environmental toxicology
pub_type： 杂志文章
doi：10.1002/tox.22293
更新日期：2017-03-01 00:00:00
abstract：:There is increasing worldwide interest in developing of markers for tumor diagnosis and identification of individuals who are at high cancer risk. Cancer, like other diseases accompanied by metabolic disorders, causes characteristic effects on cell turnover rate, activity of modifying enzymes, and RNA/DNA modification...
journal_title：Environmental toxicology
pub_type： 杂志文章
doi：10.1002/tox.21970
更新日期：2015-07-08 00:00:00
abstract：:Dibutyltin (DBT) is the degradation products of TBT, which is generally considered higher toxicity than TBT in the immune system. In order to learn more about the mechanisms of immune-toxic of DBT, we exposed zebrafish (Danio rerio) to 0, 1, 10 and 100 ng/L DBT for 8 weeks. At the end of the experiment, we determined ...
journal_title：Environmental toxicology
pub_type： 杂志文章
doi：10.1002/tox.22502
更新日期：2018-01-01 00:00:00
abstract：:Petroleum products-petrol, kerosene, and diesel-composed of volatile organic constituents contribute to air pollution. Exposure of gas station attendants (GSAs) to petroleum products fumes (PPFs) may account for occupation-related predisposition to respiratory toxicity and disease pathogenesis. We simulated GSA exposu...
journal_title：Environmental toxicology
pub_type： 杂志文章
doi：10.1002/tox.23019
更新日期：2020-09-07 00:00:00
abstract：:The present study was designed to understand the effects of sublethal concentrations of dichlorvos (DIC) on hematological constituent [red blood corpuscles, white blood corpuscles (WBC), mean cell volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, platelet counts, hemoglobin and hematocrit...
journal_title：Environmental toxicology
pub_type： 杂志文章
doi：10.1002/tox.20390
更新日期：2009-04-01 00:00:00
abstract：:The aim of this study is to determine the chemical composition, and evaluate the genotoxic, and anti-growth potency of the methanol extracts of lichen species Hypogymnia physodes (L.) Nyl. (HPE). Anti-growth effect was tested in two different human breast cancer cell lines (MCF-7 and MDA-MB-231) by the MTT and ATP via...
journal_title：Environmental toxicology
pub_type： 杂志文章
doi：10.1002/tox.21809
更新日期：2014-05-01 00:00:00
abstract：:Widespread occupational and environmental exposure to benzene is unavoidable and poses a public health threat. Studies of potential interventions to prevent or relieve benzene toxicity are, thus, essential. Research has shown l-carnitine (LC) has beneficial effects against various pathological processes and diseases. ...
journal_title：Environmental toxicology
pub_type： 杂志文章
doi：10.1002/tox.22939
更新日期：2020-10-01 00:00:00
abstract：:Toxicants can perturb cellular homeostasis by modifying phosphorylation-based signaling. In the present study, we examined the effects of cerulein, an inducer of acute pancreatitis, on keratin 8 (K8) phosphorylation. We found that cerulein dose-dependently induced K8 phosphorylation and perinuclear reorganization in P...
journal_title：Environmental toxicology
pub_type： 杂志文章
doi：10.1002/tox.22186
更新日期：2016-12-01 00:00:00
abstract：:Biotransformation enzymatic activities, such as the cytochrome P450 one, have been used as biomarkers for pollution assessment for a long time. Nevertheless, such biochemical tools are destructive processes, because they are performed on fish liver or total larvae homogenates. Moreover, the adaptation of this bioassay...
journal_title：Environmental toxicology
pub_type： 杂志文章
doi：10.1002/tox.20184
更新日期：2006-08-01 00:00:00
abstract：:Casticin, a polymethoxyflavone, is one of the major active components obtained from Fructus viticis, which have been shown to have anticancer activities including induce cell apoptosis in human cancer cells. The aim of this study was to investigate the molecular mechanisms by which casticin inhibits cell migration and...
journal_title：Environmental toxicology
pub_type： 杂志文章
doi：10.1002/tox.22417
更新日期：2017-09-01 00:00:00
abstract：:Butein is a flavonoid isolated from various medicinal plants. It is known to have different biological activities including anti-inflammation, anti-adipogenesis, and anti-angiogenesis. In the study, we demonstrated the anti-proliferative effect of butein in human osteosarcoma U-2 OS cells. Our data showed that butein ...
journal_title：Environmental toxicology
pub_type： 杂志文章
doi：10.1002/tox.23079
更新日期：2020-12-16 00:00:00
abstract：:Lake Elphinstone is a tropical inland water body in the far north of the Fitzroy Catchment in Central Queensland, Australia, and has experienced recurrent toxic cyanoprokaryote blooms since 1997. This article reports on an examination of the environmental conditions of the lake and the concurrent cyanoprokaryote speci...
journal_title：Environmental toxicology
pub_type： 杂志文章
doi：10.1002/tox.10142
更新日期：2003-12-01 00:00:00
abstract：:Ionic liquids (ILs) are widely used as reaction media in various commercial applications. Many reports have indicated that most ILs are poorly decomposed by microorganisms and are toxic to aquatic organisms. In this study, differential gene expression profiling was conducted using a suppression subtraction hybridizati...
journal_title：Environmental toxicology
pub_type： 杂志文章
doi：10.1002/tox.22244
更新日期：2017-02-01 00:00:00
abstract：OBJECTIVES:We evaluated the role of oxidative stress in Sudan IV-induced DNA damage, using human liver-derived HepG2 cells. METHODS:The DNA damaging effects of Sudan IV in HepG2 cells were evaluated by alkaline single cell gel electrophoresis assay and micronucleus test (MNT). To clarify the underlying mechanisms, we ...
journal_title：Environmental toxicology
pub_type： 杂志文章
doi：10.1002/tox.20558
更新日期：2011-06-01 00:00:00
abstract：:The aim of this study was to examine the occurrence of endocrine disruption close to sewage treatment plant effluent discharges along the Finnish Baltic Sea coast using a set of reproductive biomarkers present in adult three-spined stickleback (Gasterosteus aculeatus). Possible variation and sensitivity of the biomark...
journal_title：Environmental toxicology
pub_type： 杂志文章
doi：10.1002/tox.20715
更新日期：2013-04-01 00:00:00
abstract：:Liver is one of the major target organs of arsenic toxicity and carcinogenesis. Nuclear factor (erythroid-2 related) factor 2 (Nrf2) is a redox-sensitive transcription factor, regulating critically cellular defense responses against the toxic metallic arsenic in many cell types and tissues. This study was conducted to...
journal_title：Environmental toxicology
pub_type： 杂志文章
doi：10.1002/tox.20731
更新日期：2013-07-01 00:00:00
abstract：:There is emerging evidence suggesting that oxidative stress and DNA methylation can alter miRNA expression. However, little is known on the mechanism of miR-17-5p expression changes in paraquat (PQ)-induced nerve cell damage. In the present study, neuro-2a cells were pretreated with antioxidant N-acetylcysteine (NAC) ...
journal_title：Environmental toxicology
pub_type： 杂志文章
doi：10.1002/tox.23001
更新日期：2020-12-01 00:00:00
abstract：:The chronic effect of p-nonylphenol on survival and reproduction for two generations of the freshwater cladoceran Daphnia galeata was examined by life table experiments. The effects on survival and reproduction were used as the intrinsic rate of natural increase, r, with the Euler-Lotka equation and were analyzed with...
journal_title：Environmental toxicology
pub_type： 杂志文章
doi：10.1002/tox.10083
更新日期：2002-10-01 00:00:00
abstract：:Doxorubicin (DOX)-induced cardiomyopathy is a lethal disease. DOX-induced cardiotoxic effects are attributed towards increased redox status and apoptotic signaling. In this study, we show that genistein offers protection against DOX-induced cardio toxicity in the mice model. DOX-mediated increase in serum cardiac trop...
journal_title：Environmental toxicology
pub_type： 杂志文章
doi：10.1002/tox.22730
更新日期：2019-05-01 00:00:00
abstract：:Triclosan, a commonly used antimicrobial compound, has been measured in aquatic systems worldwide. This study exposed marine species to triclosan to examine effects primarily on survival and to investigate the formation of the degradation product, methyl-triclosan, in the estuarine environment. Acute toxicity was asse...
journal_title：Environmental toxicology
pub_type： 杂志文章
doi：10.1002/tox.20327
更新日期：2008-04-01 00:00:00
abstract：:The genotoxic effects of a particular mixture of acetamiprid (Acm, neonicotinoid insecticide) and alpha-cypermethrin (alpha-cyp, pyrethroid insecticide) on human peripheral lymphocytes were examined in vitro by chromosomal aberrations (CAs), sister chromatid exchange (SCE), and micronucleus (MN) tests. The human perip...
journal_title：Environmental toxicology
pub_type： 杂志文章
doi：10.1002/tox.20485
更新日期：2010-04-01 00:00:00
abstract：:Ecological risk assessments are, in part, based on results of toxicity tests conducted under standard exposure conditions. Global climate change will have a wide range of effects on estuarine habitats, including potentially increasing water temperature and salinity, which may alter the risk assessment of estuarine pol...
journal_title：Environmental toxicology
pub_type： 杂志文章
doi：10.1002/tox.20726
更新日期：2013-07-01 00:00:00
abstract：:Four-week-old mice, weighing about 25-35 g were divided into five groups (8 mice in each group): vehicle control, low- (0.5 g/kg), middle- (1 g/kg), high- (3 g/kg), and exceptionally high-dose (5 g/kg). After first and second weeks of intraperitoneal exposure to AgNPs, biochemical, histopathological, and electron micr...
journal_title：Environmental toxicology
pub_type： 杂志文章
doi：10.1002/tox.22104
更新日期：2016-08-01 00:00:00
abstract：:Multi-walled carbon nanotubes (MWCNTs) have many applications in industry and used as additives in polymers, catalysts, anodes in lithium-battery and drug delivery. There is little information about MWCNTs' (210 nm) genotoxic potential on juvenile freshwater fish Channa punctatus. Therefore, in this study, we have det...
journal_title：Environmental toxicology
pub_type： 杂志文章
doi：10.1002/tox.22871
更新日期：2020-03-01 00:00:00
abstract：:Structure-activity relationships for oestrogenicity were developed based on 120 aromatic chemicals evaluated in the Saccharomyces cerevisiae-based Lac-Z reporter assay. Relative gene activation was compared to 17 beta-estradiol and varied over eight orders of magnitude. Analysis of the data compared to 17 beta-estradi...
journal_title：Environmental toxicology
pub_type： 杂志文章
doi：10.1002/tox.10027
更新日期：2002-02-01 00:00:00
abstract：:Being one of the notorious weed P. hysterophorus has invaded almost every part India and is the lead cause of skin allergies and severe dermatitis among farmers and rural population. It is an invasive obnoxious weed capable of surviving extreme environmental conditions and various parts of this plant are reported to c...
journal_title：Environmental toxicology
pub_type： 杂志文章
doi：10.1002/tox.22989
更新日期：2020-11-01 00:00:00
abstract：:So far, little is known on the distribution of hepatotoxic microcystin (MC) in various organs of bivalves, and there is no study on MC accumulation in bivalves from Chinese waters. Distribution pattern and seasonal dynamics of MC-LR, -YR and -RR in various organs (hepatopancreas, intestine, visceral mass, gill, foot, ...
journal_title：Environmental toxicology
pub_type： 杂志文章
doi：10.1002/tox.20146
更新日期：2005-12-01 00:00:00
abstract：:Microcystin-LR (MC-LR) is the most commonly encountered of the toxic cyclic peptide hepatotoxins occurring in China. It is a model compound for toxicological studies. In this study, the toxicity of MC-LR (50 and 500 micrograms/L) on isolated carp hepatocytes was determined and the ultrastructural alterations of cells ...
journal_title：Environmental toxicology
pub_type： 杂志文章
doi：10.1002/tox.10012
更新日期：2001-01-01 00:00:00
