Butein induces cellular senescence through reactive oxygen species-mediated p53 activation in osteosarcoma U-2 OS cells.

abstract：:The 8-hydroxy-2'-deoxyguanosine (8-OHdG), an oxidized nucleoside of DNA, not only is a widely used biomarker for the measurement of endogenous oxidative DNA damage, but might also be a risk factor for many diseases including cancer. Elevated level of urinary 8-OHdG has been detected in patients with various malignanci...

journal_title：Environmental toxicology

authors： Yang Y,Tian Y,Yan C,Jin X,Tang J,Shen X

更新日期：2009-10-01 00:00:00

abstract：:This study assessed the potential hepatoprotective effect of telmisartan (TLM), a selective angiotensin II type 1 (AT1 ) receptor blocker, on carbon tetrachloride (CCl4 )-induced acute hepatotoxity in rats. Intraperitoneal injection of male Wistar rats with CCl4 1 mL kg-1 , 1:1 mixture with corn oil for 3 days increas...

journal_title：Environmental toxicology

authors： Atawia RT,Esmat A,Elsherbiny DA,El-Demerdash E

更新日期：2017-02-01 00:00:00

abstract：:Titanium dioxide nanoparticles (TiO2 NPs) have been used in environmental management, food, medicine, and industry. But TiO2 NPs have been demonstrated to cross the blood-brain barrier and store up in the brain organization, leading to glutamate-mediated neurotoxicity. However, the neurotoxicity in the brain is not we...

journal_title：Environmental toxicology

authors： Ze X,Su M,Zhao X,Jiang H,Hong J,Yu X,Liu D,Xu B,Sheng L,Zhou Q,Zhou J,Cui J,Li K,Wang L,Ze Y,Hong F

更新日期：2016-06-01 00:00:00

abstract：:Fluorescent pseudomonads were a major component [log (10) 4.2-6.1 colony-forming units mL-1] of the culturable heterotrophic gram-negative bacterioplankton observed in three Mississippi Delta oxbow lakes in this study. Pure cultures of fluorescent pseudomonads were isolated from three Mississippi Delta oxbow lakes (18...

journal_title：Environmental toxicology

authors： Zablotowicz RM,Locke MA,Hoagland RE,Knight SS,Cash B

更新日期：2001-01-01 00:00:00

abstract：:Linear alkylbenzene sulfonate (LAS) is an anionic surfactant commonly used in cleaning agents such as laundry detergents. Trace amounts of LAS are released into environmental waters after processing in wastewater treatment plants after the use of this chemical. Acute toxicity of LAS has been well-studied using various...

journal_title：Environmental toxicology

authors： Tasaki J,Nakayama K,Shimizu I,Yamada H,Suzuki T,Nishiyama N,Yamane M

更新日期：2017-01-01 00:00:00

abstract：:The cytotoxic and genotoxic effects induced by alachlor and dichlorvos, two pesticides broadly used, were studied on RTG-2 fish cell line. As measure of cytotoxicity, neutral red assay was used to determine the cellular viability. Toxicity ranking based on IC(50) values found that alachlor was more cytotoxic than dich...

journal_title：Environmental toxicology

authors： Parra JM,Sánchez-Fortún S,Castaño A

更新日期：2012-03-01 00:00:00

abstract：:Malathion is one of the most commonly used insecticides. Recent findings have demonstrated that it induces oxidative stress in somatic cells, but there are not enough studies that have demonstrated this effect in germ cells. Malathion impairs porcine oocyte viability and maturation, but studies have not shown how oxid...

journal_title：Environmental toxicology

authors： Flores D,Souza V,Betancourt M,Teteltitla M,González-Márquez H,Casas E,Bonilla E,Ramírez-Noguera P,Gutiérrez-Ruíz MC,Ducolomb Y

更新日期：2017-06-01 00:00:00

abstract：:Exposure to sublethal hexavalent chromium (as 2 and 4 mg L⁻¹ potassium dichromate for 1 and 2 months) during late preparatory to mid prespawning phase of annual reproductive cycle severely affected the pituitary-ovarian axis of a teleost Channa punctatus. Gonadosomatic index (GSI), ovarian histopathology, immunocytoch...

journal_title：Environmental toxicology

authors： Mishra AK,Mohanty B

更新日期：2012-07-01 00:00:00

abstract：:Culture-independent methods employed in fungal genetic studies using in vitro amplification (PCR) and analysis of specific genes or gene fragments have proved to be useful for detection, identification, and molecular taxonomy of various plant pathogens including Fusarium spp. This approach may be faster than culture-d...

journal_title：Environmental toxicology

authors： Bezuidenhout CC,Prinsloo M,Van der Walt AM

更新日期：2006-08-01 00:00:00

abstract：:Ionic liquids (ILs) are widely used as reaction media in various commercial applications. Many reports have indicated that most ILs are poorly decomposed by microorganisms and are toxic to aquatic organisms. In this study, differential gene expression profiling was conducted using a suppression subtraction hybridizati...

journal_title：Environmental toxicology

authors： Nan P,Yan S,Wang Y,Du Q,Chang Z

更新日期：2017-02-01 00:00:00

abstract：:Acute toxicities of perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) were tested on four freshwater species and three plant species. PFOS was more toxic than PFOA for all species tested in this study. Similar time-response patterns of PFOS and PFOA toxicity were observed for each tested species. Valu...

journal_title：Environmental toxicology

authors： Li MH

更新日期：2009-02-01 00:00:00

abstract：:Trichloroethylene (TCE) is ubiquitous in our living environment, and prenatal exposure to TCE is reported to cause congenital heart disease in humans. Although multiple studies have been performed using animal models, they have limited value in predicting effects on humans due to the unknown species-specific toxicolog...

journal_title：Environmental toxicology

authors： Jiang Y,Wang D,Zhang G,Wang G,Tong J,Chen T

更新日期：2016-11-01 00:00:00

abstract：:There is emerging evidence suggesting that oxidative stress and DNA methylation can alter miRNA expression. However, little is known on the mechanism of miR-17-5p expression changes in paraquat (PQ)-induced nerve cell damage. In the present study, neuro-2a cells were pretreated with antioxidant N-acetylcysteine (NAC) ...

journal_title：Environmental toxicology

authors： Zhan Y,Guo Z,Zheng F,Zhang Z,Li K,Wang Q,Wang L,Cai Z,Chen N,Wu S,Li H

更新日期：2020-12-01 00:00:00

abstract：:Endotoxins exist anywhere including in water pools, dust, humidifier systems, and machining fluids. The major causal factor is endotoxins in many serious diseases, such as fever, sepsis, multi-organ failure, meningococcemia, and severe morbidities like neurologic disability, or hearing loss. Endotoxins are also called...

journal_title：Environmental toxicology

authors： Huang YC,Horng CT,Chen ST,Lee SS,Yang ML,Lee CY,Kuo WH,Yeh CH,Kuan YH

更新日期：2016-02-01 00:00:00

abstract：:Human exposure to bisphenol A (BPA) could favor obesity and related metabolic disorders such as hepatic steatosis. Investigations in rodents have shown that these deleterious effects are observed not only when BPA is administered during the adult life but also with different protocols of perinatal exposure. Whether pe...

journal_title：Environmental toxicology

authors： Bucher S,Jalili P,Le Guillou D,Begriche K,Rondel K,Martinais S,Zalko D,Corlu A,Robin MA,Fromenty B

更新日期：2017-03-01 00:00:00

abstract：:Environmental stress factors may be responsible for biological changes in living species that are able to overcome deleterious effects depending on their detoxifying capacities. Defense systems present in every living species are involved in elimination of reactive chemical species of endogenous or exogenous origin, n...

journal_title：Environmental toxicology

authors： Vasseur P,Leguille C

更新日期：2004-08-01 00:00:00

abstract：:Chronic lead exposure causes peripheral sympathetic nerve stimulation, including increased blood pressure and heart rate. Purinergic receptors are involved in the sympathoexcitatory response induced by myocardial ischemia injury. However, whether P2X4 receptor participates in sympathoexcitatory response induced by chr...

journal_title：Environmental toxicology

authors： Zhu G,Chen Z,Dai B,Zheng C,Jiang H,Xu Y,Sheng X,Guo J,Dan Y,Liang S,Li G

更新日期：2018-06-01 00:00:00

abstract：:The environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is known to affect bone metabolism. We evaluated the protective effects of the triterpene glycoside actein from the herb black cohosh against TCDD-induced toxicity in MC3T3-E1 osteoblastic cells. We found that TCDD significantly reduced cell viabil...

journal_title：Environmental toxicology

authors： Choi EM,Suh KS,Jung WW,Park SY,Chin SO,Rhee SY,Pak YK,Chon S

更新日期：2017-12-01 00:00:00

abstract：:Multi-walled carbon nanotubes (MWCNTs) have many applications in industry and used as additives in polymers, catalysts, anodes in lithium-battery and drug delivery. There is little information about MWCNTs' (210 nm) genotoxic potential on juvenile freshwater fish Channa punctatus. Therefore, in this study, we have det...

journal_title：Environmental toxicology

authors： Ali D,Falodah FA,Almutairi B,Alkahtani S,Alarifi S

更新日期：2020-03-01 00:00:00

abstract：:Melamine is a heterocyclic, aromatic amine and nitrogen-enriched environmental toxicant, found in not only adulterated foodstuffs but also industrial household tableware and paints. Previous studies demonstrated adverse effects of high-dose melamine on human infants and pregnant animals, but effects of low-dose melami...

journal_title：Environmental toxicology

authors： Chu CY,Tang LY,Li L,Shum AS,Fung KP,Wang CC

更新日期：2017-01-01 00:00:00

abstract：:Metals such as lead (Pb), magnesium (Mg), and iron (Fe) are ubiquitous in the environment as a result of natural occurrence and anthropogenic activities. Although Mg, Fe, and others are considered essential elements, high level of exposure has been associated with severe adverse health effects including cardiovascular...

journal_title：Environmental toxicology

authors： Sanders T,Liu YM,Tchounwou PB

更新日期：2015-12-01 00:00:00

abstract：:Cardiomyocyte apoptosis is the major risk factor for the development of heart failure (HF). The purpose of this study was to evaluate the effects of Gamma-aminobutyric acid (GABA) tea on hypertension-induced cardiac apoptotic pathways in spontaneously hypertensive rats (SHR). In order to reveal the mechanisms, 36 male...

journal_title：Environmental toxicology

authors： Chen BC,Hung MY,Wang HF,Yeh LJ,Pandey S,Chen RJ,Chang RL,Viswanadha VP,Lin KH,Huang CY

更新日期：2018-07-01 00:00:00

abstract：:Tributyltin (TBT) and dibutyltin (DBT) are widespread environmental contaminants found in food, beverages, and human blood samples. Both of these butyltins (BTs) interfere with the ability of human natural killer (NK) cells to lyse target cells and alter secretion of the pro-inflammatory cytokine tumor necrosis factor...

journal_title：Environmental toxicology

authors： Lawrence S,Reid J,Whalen M

更新日期：2015-05-01 00:00:00

abstract：:A 7 day in situ assay to assess sediment toxicity was carried out per replicate in two sites from Guadalete Estuary (Guad1 and Guad2) (South-West, Spain) using the polychaete Arenicola marina (n = 20) in benthic cages. After the exposure period, a battery of biomarkers were determined to asses the sediment toxicity. F...

journal_title：Environmental toxicology

authors： Ramos-Gómez J,Martín-Díaz ML,Rodríguez A,Riba I,DelValls TA

更新日期：2008-10-01 00:00:00

abstract：:Cyanotoxins are a group of compounds produced by cyanobacteria that can have severe physiological effects on other organisms, including humans. The potential allelopathic effects of Microcystis aeruginosa, a toxic cyanobacterium, on the duckweed plant, Lemna gibba L., were examined using three experimental methods: (1...

journal_title：Environmental toxicology

authors： LeBlanc S,Pick FR,Aranda-Rodriguez R

更新日期：2005-02-01 00:00:00

abstract：:Biotransformation enzymatic activities, such as the cytochrome P450 one, have been used as biomarkers for pollution assessment for a long time. Nevertheless, such biochemical tools are destructive processes, because they are performed on fish liver or total larvae homogenates. Moreover, the adaptation of this bioassay...

journal_title：Environmental toxicology

authors： Noury P,Geffard O,Tutundjian R,Garric J

更新日期：2006-08-01 00:00:00

abstract：:Crude extract of Rheum palmatum L (CERP) has been used to treat different diseases in the Chinese population for decades. In this study, we investigated the effects of CERP on LS1034 human colorectal cancer cells in vitro and also examined possible mechanisms of cell death. Flow cytometric assays were used to measure ...

journal_title：Environmental toxicology

authors： Ma YS,Hsu SC,Weng SW,Yu CC,Yang JS,Lai KC,Lin JP,Lin JG,Chung JG

更新日期：2014-09-01 00:00:00

abstract：:The phthalate plasticizer, di(2-ethyl-hexyl) phthalate (DEHP), and its derived metabolites are common anthropogenic environmental toxins, which are known to act as endocrine disruptors. Numerous studies have associated DEHP with disruption of sex hormones, abnormal development of reproductive organs, allergies, and in...

journal_title：Environmental toxicology

authors： Wong JH,Wang YS,Nam S,Ho KH,Chang CM,Chen KC,Chen YF,Chang WC

更新日期：2019-11-01 00:00:00

abstract：:The chronic effect of p-nonylphenol on survival and reproduction for two generations of the freshwater cladoceran Daphnia galeata was examined by life table experiments. The effects on survival and reproduction were used as the intrinsic rate of natural increase, r, with the Euler-Lotka equation and were analyzed with...

journal_title：Environmental toxicology

authors： Tanaka Y,Nakanishi J

更新日期：2002-10-01 00:00:00

abstract：:Organic wastewater contaminants (OWCs) have recently been documented in several aquatic ecosystems. We examined the effects of three OWCs (caffeine, acetaminophen, and triclosan) on the activity level, startle response, survivorship, and growth of northern leopard frog (Rana pipiens) tadpoles. We conducted two experim...

journal_title：Environmental toxicology

authors： Fraker SL,Smith GR

更新日期：2004-06-01 00:00:00