Abstract:
:Multi-walled carbon nanotubes (MWCNTs) have many applications in industry and used as additives in polymers, catalysts, anodes in lithium-battery and drug delivery. There is little information about MWCNTs' (210 nm) genotoxic potential on juvenile freshwater fish Channa punctatus. Therefore, in this study, we have determined the toxic effects of MWCNTs on freshwater fish C. punctatus by assessing toxicological endpoints such as oxidative stress, mutagenicity, and genotoxicity after acute MWCNTs exposure for 5 days. MWCNTs LC50 -96 hours value for C. punctatus was 21.8 mg/L and on this basis three different MWCNTs concentrations were selected, that is, sub-lethal I, II, and III, for 5-days exposure trials with C. punctatus. The level of lipid peroxidation increased in the gills and kidney of exposed fish at sub-lethal concentrations II and III. Contrastingly, glutathione decreased more in the gills than in the kidney. The activity of catalase enzymes decreased more in the gills than in the kidney at sublethal concentrations I and II. Glutathione S-transferase decreased in gill tissue but increased in kidney tissue following sub-lethal III exposure. Moreover, the level of glutathione reductase decreased in both tissues. In addition, MWCNTs genotoxicity was confirmed by DNA damage in lymphocytes, gills, kidney cells, and production of micronuclei (MNi) in red blood cells of freshwater fish following sub-lethal I, II, and III exposures. In conclusion, this study revealed that application of micronucleus and comet assays for in vivo laboratory studies using freshwater fish for screening the genotoxic potential of MWCNTs.
journal_name
Environ Toxicoljournal_title
Environmental toxicologyauthors
Ali D,Falodah FA,Almutairi B,Alkahtani S,Alarifi Sdoi
10.1002/tox.22871subject
Has Abstractpub_date
2020-03-01 00:00:00pages
359-367issue
3eissn
1520-4081issn
1522-7278journal_volume
35pub_type
杂志文章abstract::We hypothesized that chronic exposure to arsenic would deplete the reduced glutathione (GSH) and methionine in vivo, thereby impair the methylation capacity of inorganic arsenic (iAs) ingested. Our experiment was designed to explore the effects of exogenous GSH and methionine on arsenic methylation in mice exposed to ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20509
更新日期:2010-08-01 00:00:00
abstract::Aspartame is one of the most common consumed artificial sweeteners utilized in many food products and beverages. It has been indicated that long-term consumption of aspartame leads to reproductive toxicity but its mechanism is not well-clear. In this study we investigated mechanism of aspartame-induced reproductive to...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.23028
更新日期:2021-02-01 00:00:00
abstract::Micronucleus induction by the diarrhetic shellfish toxin okadaic acid (OA) was investigated in two intestinal models, cultured human Caco-2 cells and colon epithelial cells of mice treated in vivo. Exposure to OA for 4 and 24 h induced dose-responsive increases in the frequency of micronucleated Caco-2 cells; the mini...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20154
更新日期:2006-02-01 00:00:00
abstract::Recent interest in adverse effects of infrasound on organisms arises from health concerns. We assessed the association between infrasound exposure of 5 Hz at 130 dB and changes of cardiac ultrastructure and function in rats. Thirty-two Sprague-Dawley rats were randomized into control, 1, 7, and 14 days groups for 2 h ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20244
更新日期:2007-04-01 00:00:00
abstract::In the current study, the toxicological mechanisms of microcystin-LR and its disadvantageous effects on Daphnia magna were examined. Survival rate, number of newborn, activity of several important enzymes [glutathione S-transferase (GST), lactate dehydrogenase (LDH), phosphatases, and glutathione], accumulated microcy...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20108
更新日期:2005-06-01 00:00:00
abstract::An enormous quantity of pharmacologically active principles are currently being introduced into the environment, with consequent escalation of environmental problems, but only a small number of studies are focusing on an assessment of their genotoxic effects. The aim of this article is to assess the genotoxic effects ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20685
更新日期:2012-10-01 00:00:00
abstract::Methyl tert-butyl ether (MTBE) is a gasoline oxygenate and antiknock additive substituting for lead alkyls currently in use worldwide. Previous studies have shown that MTBE at very high doses induces tumors in rodents. The aim of the present study was to examine directly the binding ability of MTBE onto DNA, demonstra...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20124
更新日期:2005-08-01 00:00:00
abstract::Arsenite has been shown to induce a variety of oxidative damage in mammalian cells. However, the mechanisms underlying cellular responses to its adverse effects remain unknown. We previously showed that the level of Nrf2, a nuclear transcription factor significantly increased in arsenite-treated human bronchial epithe...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22374
更新日期:2017-08-01 00:00:00
abstract::Sick building syndrome (SBS) is a set of several clinically recognizable symptoms reported by occupants of a building without a clear cause. Neuropathy target esterase (NTE) is a membrane bound serine esterase and its reaction with organophosphates (OPs) can lead to OP-induced delayed neuropathy (OPIDN) and nerve axon...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21839
更新日期:2014-10-01 00:00:00
abstract::The bioaccumulation of the triazine herbicides terbutryn and terbuthylazine in rainbow trout was investigated at water temperatures of 4 degrees C, 10 degrees C, and 17 degrees C. The synergetic effect of water temperature and herbicide on fish liver detoxification metabolism was also studied by measuring liver ethoxy...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.10118
更新日期:2003-08-01 00:00:00
abstract::The effect of heavy metals and organic compounds on the activity of the enzyme beta-galactosidase in a standardized bioassay has been evaluated, considering future applications in environmental monitoring. The tests were done using a commercial extract of a hydrolase from the eukaryote yeast Kluyveromyces lactis and o...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.1014
更新日期:2001-01-01 00:00:00
abstract::PM10 was collected in a Milan urban site, representative of the city air quality, during winter and summer 2006. Mean daily PM10 concentration was 48 μg m(-3) during summer and 148 μg m(-3) during winter. Particles collected on Teflon filters were chemically characterized and the endotoxin content determined by the ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20611
更新日期:2012-02-01 00:00:00
abstract::Polybrominated diphenyl ethers (PBDEs) are ubiquitous and prolific contaminant in both the abiotic and biotic environment because of the wide industrial applications of these chemicals. In the present study, the effects of 2,2',4,4'-tetrabrominateddiphenyl ether (BDE-47) and 2,2',4,4',5,5'-hexabromodiphenyl ether (BDE...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22985
更新日期:2020-11-01 00:00:00
abstract::Perfluorooctane sulfonate (PFOS) is an animal carcinogen. However, the underlying mechanism in cancer initiation is still largely unknown. Recently identified microRNAs (miRNAs) may play an important role in toxicant exposure and in the process of toxicant-induced tumorigenesis. We used PFOS to investigate PFOS-induce...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21949
更新日期:2015-05-01 00:00:00
abstract::Tris (1,3-dichloro-2-propyl) phosphate (TDCIPP) is one of the widely used organophosphorus flame retardants (OPFRs), which are regarded as suitable substitutes for brominated flame retardants (BFRs). Previously, we have validated the toxicity of TDCIPP in PC12 cells owing to the induced alterations in GAP43, NF-H, CaM...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22401
更新日期:2017-06-01 00:00:00
abstract::Doxorubicin (DOX)-induced cardiomyopathy is a lethal disease. DOX-induced cardiotoxic effects are attributed towards increased redox status and apoptotic signaling. In this study, we show that genistein offers protection against DOX-induced cardio toxicity in the mice model. DOX-mediated increase in serum cardiac trop...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22730
更新日期:2019-05-01 00:00:00
abstract::The roles of long noncoding RNA (lncRNA) MACC1-AS1 have been revealed in various tumors. This work aims to explore the roles of lncRNA MACC1-AS1 in the stemness of nonsmall cell lung cancer (NSCLC) cells and the underlying mechanism. We showed that overexpression of MACC1-AS1 enhanced the stemness of NSCLC cells, whic...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22936
更新日期:2020-09-01 00:00:00
abstract::Microcystins are a family of potent hepatotoxins produced by freshwater cyanobacteria and can cause animal intoxications and human diseases. In this study, the effect of microcystin-LR (MC-LR) on the tissues of freshwater pearl mussel (Hyriopsis cumingii) was evaluated and differentially expressed genes in the hepatop...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20652
更新日期:2012-07-01 00:00:00
abstract::Fascinating super paramagnetic uniqueness of iron oxide particles at nano-scale level make them extremely useful in the state of the art therapies, equipments, and techniques. Cobalt ferrite (CoFe2 O4 ) magnetic nanoparticles (MNPs) are extensively used in nano-based medicine and electronics, results in extensive disc...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22206
更新日期:2016-12-01 00:00:00
abstract::We cloned the full-length cDNA sequence of xenobiotic metabolizing cytochrome P4501A (CYP1A) gene from the yellow catfish (Pelteobagrus fulvidraco, Siluriformes, Bagridae). P. fulvidraco is a commercially important fish generally distributed in Southeast Asian countries and Korea. This is the first report of any xenob...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20333
更新日期:2008-06-01 00:00:00
abstract::Although marine and coastal environments which are contaminated with xenobiotic organic compounds often become hypoxic during the summer, the interactive effects of hypoxia and xenobiotic exposure on marine species such as teleost fishes remain poorly understood. The expression and activity of monooxygenase enzyme cyt...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22527
更新日期:2018-04-01 00:00:00
abstract::Global use of azole fungicides is expected to increase over the next several years. Triticonazole is a triazole fungicide that is used for turf protection, residential, and other commercial applications. As such, it can enter local rural and urban water systems via run-off and rain events. Early life stages of aquatic...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22862
更新日期:2020-02-01 00:00:00
abstract::Dibutyltin (DBT) is the degradation products of TBT, which is generally considered higher toxicity than TBT in the immune system. In order to learn more about the mechanisms of immune-toxic of DBT, we exposed zebrafish (Danio rerio) to 0, 1, 10 and 100 ng/L DBT for 8 weeks. At the end of the experiment, we determined ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22502
更新日期:2018-01-01 00:00:00
abstract::Irradiation of polycyclic aromatic hydrocarbons (PAHs) in aqueous solution with simulated solar radiation (SSR; a light source with a visible light: UV-A:UV-B ratio similar to that of sunlight) can greatly enhance their toxicity. Two microbial toxicity tests with Vibrio fischeri were used to investigate the effect of ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.1034
更新日期:2001-06-01 00:00:00
abstract::Hypothyroxinemia induced by maternal mild iodine deficiency causes neurological deficits and impairments of brain function in offspring. Hypothyroxinemia is prevalent in developing and developed countries alike. However, the mechanism underlying these deficits remains less well known. Given that the myelin plays an im...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21997
更新日期:2015-11-01 00:00:00
abstract::Lead ions (Pb(2+) ) are toxic industrial pollutants associated with chronic inflammatory diseases in humans and animals. Previously, we found that Pb(2+) ions induce COX-2 gene expression via the EGF receptor/nuclear factor-κB signal transduction pathway in epidermoid carcinoma cell line A431. In this study, to see wh...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21976
更新日期:2015-09-01 00:00:00
abstract::The risk presented by β-blockers on aquatic organisms remains uncertain, particularly given the enantiospecific differences in toxicity of chiral β-blockers. In this study, the toxicity of two β-blockers, propranolol and metoprolol, was determined. The 96-h LC50 of propranolol in the zebrafish larvae was 2.48 mg/L, wh...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21867
更新日期:2014-12-01 00:00:00
abstract::As a widely used plasticizer in industry, di-2-ethylhexylphthalate (DEHP) can cause testicular toxicity, yet little is known about the potential mechanism. In this study, DEHP exposure dramatically inhibited cellviability and induced apoptosis of mouse GC-1 spg cells. Furthermore, DEHP significantly increased the leve...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22866
更新日期:2020-02-01 00:00:00
abstract::Previous studies indicate that exposure to perfluorooctanesulfonate (PFOS), a ubiquitous and highly persistent environmental contaminant, induces immunotoxicity in mice. However, few studies have specifically assessed the effects of PFOS on inflammation. This study utilized a standard 60-day oral exposure period to as...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20642
更新日期:2012-05-01 00:00:00
abstract::Bisphenol A (BPA) has been widely reported to exert endocrine disrupting effects, including the induction of adipogenesis in cultured preadipocytes and intact animals. Because of the potential harm to human health, BPA is being substituted by structurally related bisphenols. Whether or not such BPA analogues are safe ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22889
更新日期:2020-05-01 00:00:00