Long noncoding RNA MACC1-AS1 promotes the stemness of nonsmall cell lung cancer cells through promoting UPF1-mediated destabilization of LATS1/2.

abstract：:Environmental estrogens are major cause of endocrine disruption in vertebrates, including aquatic organisms. Teleosts are valuable and popular models for studying the effects of endocrine disrupting chemicals (EDCs) in the environment. In the present study, we investigated the changes caused by exposure to the synthet...

journal_title：Environmental toxicology

authors： Sridevi P,Chaitanya RK,Prathibha Y,Balakrishna SL,Dutta-Gupta A,Senthilkumaran B

更新日期：2015-04-01 00:00:00

abstract：:Long non-coding RNA (lncRNA) plays a critical role in male germline development. Atrazine (AZ) as an environmental endocrine disrupting chemical (EDCs) can induce male reproductive toxicity in amphibians. Our previous studies demonstrated that AZ can alter gene and circular RNA (circRNA) expression of damaged testes i...

journal_title：Environmental toxicology

authors： Sai L,Qu B,Zhang J,Liu J,Jia Q,Bo C,Zhang Y,Yu G,Han R,Peng C

更新日期：2019-04-01 00:00:00

abstract：OBJECTIVES:We evaluated the role of oxidative stress in Sudan IV-induced DNA damage, using human liver-derived HepG2 cells. METHODS:The DNA damaging effects of Sudan IV in HepG2 cells were evaluated by alkaline single cell gel electrophoresis assay and micronucleus test (MNT). To clarify the underlying mechanisms, we ...

journal_title：Environmental toxicology

authors： Zhang Y,An Y,Jiang L,Geng C,Cao J,Jiang L,Zhong L

更新日期：2011-06-01 00:00:00

abstract：:Crude extract of Rheum palmatum L (CERP) has been used to treat different diseases in the Chinese population for decades. In this study, we investigated the effects of CERP on LS1034 human colorectal cancer cells in vitro and also examined possible mechanisms of cell death. Flow cytometric assays were used to measure ...

journal_title：Environmental toxicology

authors： Ma YS,Hsu SC,Weng SW,Yu CC,Yang JS,Lai KC,Lin JP,Lin JG,Chung JG

更新日期：2014-09-01 00:00:00

abstract：:Doxorubicin (DOX)-induced cardiomyopathy is a lethal disease. DOX-induced cardiotoxic effects are attributed towards increased redox status and apoptotic signaling. In this study, we show that genistein offers protection against DOX-induced cardio toxicity in the mice model. DOX-mediated increase in serum cardiac trop...

journal_title：Environmental toxicology

authors： Bai Z,Wang Z

更新日期：2019-05-01 00:00:00

abstract：:Fascinating super paramagnetic uniqueness of iron oxide particles at nano-scale level make them extremely useful in the state of the art therapies, equipments, and techniques. Cobalt ferrite (CoFe2 O4 ) magnetic nanoparticles (MNPs) are extensively used in nano-based medicine and electronics, results in extensive disc...

journal_title：Environmental toxicology

authors： Ahmad F,Liu X,Zhou Y,Yao H,Zhao F,Ling Z,Xu C

更新日期：2016-12-01 00:00:00

abstract：:Sulfur dioxide (SO2 ) is a ubiquitous air pollutant. The previous studies have documented the adverse effects of SO2 on nervous system health, suggesting that acutely SO2 inhalation at high concentration may be associated with neurotoxicity and increase risk of hospitalization and mortality of many brain disorders. Ho...

journal_title：Environmental toxicology

authors： Yao G,Yun Y,Sang N

更新日期：2016-07-01 00:00:00

abstract：:Micronucleus induction by the diarrhetic shellfish toxin okadaic acid (OA) was investigated in two intestinal models, cultured human Caco-2 cells and colon epithelial cells of mice treated in vivo. Exposure to OA for 4 and 24 h induced dose-responsive increases in the frequency of micronucleated Caco-2 cells; the mini...

journal_title：Environmental toxicology

authors： Le Hégarat L,Jacquin AG,Bazin E,Fessard V

更新日期：2006-02-01 00:00:00

abstract：:Environmental stress factors may be responsible for biological changes in living species that are able to overcome deleterious effects depending on their detoxifying capacities. Defense systems present in every living species are involved in elimination of reactive chemical species of endogenous or exogenous origin, n...

journal_title：Environmental toxicology

authors： Vasseur P,Leguille C

更新日期：2004-08-01 00:00:00

abstract：:Fluoride exposure is widespread, with drinking water commonly containing natural and artificially added sources of the ion. Ingested fluoride undergoes absorption across the gastric and intestinal epithelia. Previous studies have reported adverse gastrointestinal effects with high levels of fluoride exposure. Here, we...

journal_title：Environmental toxicology

authors： Amadeu de Oliveira F,MacVinish LJ,Amin S,Herath D,Jeggle P,Mela I,Pieri M,Sharma C,Jarvis GE,Levy FM,Santesso MR,Khan ZN,Leite AL,Oliveira RC,Buzalaf MAR,Edwardson JM

更新日期：2018-01-01 00:00:00

abstract：:Chlorpyrifos (CPF) is one of the most widely used organophosphorus, which has spurred renewed interest. This study was conducted to investigate the protective effect of ziziphora tenuior extract against CPF-induced liver and lung toxicity. This study conducted 8-week rat sub-chronic toxicity study and then the effect ...

journal_title：Environmental toxicology

authors： Yazdinezhad A,Abbasian M,Hojjat Hosseini S,Naserzadeh P,Agh-Atabay AH,Hosseini MJ

更新日期：2017-09-01 00:00:00

abstract：:Water bodies are routinely monitored for the presence of potentially toxic cyanobacteria; however, the methodology for confirming toxicity is currently complex and expensive. Here we describe the application of gene-based technology to rapidly identify cylindrospermopsin-producing cyanobacteria, specifically, Cylindro...

journal_title：Environmental toxicology

authors： Fergusson KM,Saint CP

更新日期：2003-04-01 00:00:00

abstract：:Lake Elphinstone is a tropical inland water body in the far north of the Fitzroy Catchment in Central Queensland, Australia, and has experienced recurrent toxic cyanoprokaryote blooms since 1997. This article reports on an examination of the environmental conditions of the lake and the concurrent cyanoprokaryote speci...

journal_title：Environmental toxicology

authors： White SH,Fabbro LD,Duivenvoorden LJ

更新日期：2003-12-01 00:00:00

abstract：:The effect of heavy metals and organic compounds on the activity of the enzyme beta-galactosidase in a standardized bioassay has been evaluated, considering future applications in environmental monitoring. The tests were done using a commercial extract of a hydrolase from the eukaryote yeast Kluyveromyces lactis and o...

journal_title：Environmental toxicology

authors： Apartin C,Ronco A

更新日期：2001-01-01 00:00:00

abstract：:Quinolines are aromatic nitrogen compounds with wide therapeutic potential to treat parasitic and microbial diseases. In this study, the genotoxicity of quinoline, 4-methylquinoline, 4-nitroquinoline-1-oxide (4-NQO), and diversely functionalized quinoline derivatives and the influence of the substituents (functional g...

journal_title：Environmental toxicology

authors： Duran LT,Rincón NO,Galvis CE,Kouznetsov VV,Lorenzo JL

更新日期：2015-03-01 00:00:00

abstract：:This study assessed the potential hepatoprotective effect of telmisartan (TLM), a selective angiotensin II type 1 (AT1 ) receptor blocker, on carbon tetrachloride (CCl4 )-induced acute hepatotoxity in rats. Intraperitoneal injection of male Wistar rats with CCl4 1 mL kg-1 , 1:1 mixture with corn oil for 3 days increas...

journal_title：Environmental toxicology

authors： Atawia RT,Esmat A,Elsherbiny DA,El-Demerdash E

更新日期：2017-02-01 00:00:00

abstract：:The aim of this study is to determine the chemical composition, and evaluate the genotoxic, and anti-growth potency of the methanol extracts of lichen species Hypogymnia physodes (L.) Nyl. (HPE). Anti-growth effect was tested in two different human breast cancer cell lines (MCF-7 and MDA-MB-231) by the MTT and ATP via...

journal_title：Environmental toxicology

authors： Ari F,Celikler S,Oran S,Balikci N,Ozturk S,Ozel MZ,Ozyurt D,Ulukaya E

更新日期：2014-05-01 00:00:00

abstract：:The toxicity of petroleum hydrocarbons to marine aquatic organisms has been widely investigated; however, the effects on freshwater environments have largely been ignored. Selected biomarkers were measured in a freshwater species, the crimson-spotted rainbowfish (Melanotaenia fluviatilis). Fish were exposed to either ...

journal_title：Environmental toxicology

authors： Pollino CA,Holdway DA

更新日期：2003-02-01 00:00:00

abstract：:In recent years, the protective effect of hydrogensulfide donor sodium hydrosulfide(NaHS) on multiple organs has been widely reported. The study aimed to explorethe effect of commonly used concentration of NaHS on theliver and its potential damage mechanism. Rats divided into 4 groups: control, NaHS I (1 mg/kg), II (3...

journal_title：Environmental toxicology

authors： Feng X,Zhang H,Shi M,Chen Y,Yang T,Fan H

更新日期：2020-03-01 00:00:00

abstract：:Within the last decade, numerous epidemiological studies have demonstrated that endocrine disruptors are a possible cause for a decline in semen quality. Cypermethrin is a widely used pyrethroid insecticide, but little is known about its potentially adverse effects on male reproduction. In the present study, we invest...

journal_title：Environmental toxicology

authors： Wang H,Wang SF,Ning H,Ji YL,Zhang C,Zhang Y,Yu T,Ma XH,Zhao XF,Wang Q,Liu P,Meng XH,Xu DX

更新日期：2011-08-01 00:00:00

abstract：:Airborne particulates, especially fine particles and bound chemical compounds, are a potential mediator of adverse health effects. In this study an analysis was done of the concentration and size distribution of air particulate matter, the content of bound polycyclic aromatic hydrocarbons (PAHs), and the biological ef...

journal_title：Environmental toxicology

authors： Massolo L,Müller A,Tueros M,Rehwagen M,Franck U,Ronco A,Herbarth O

更新日期：2002-01-01 00:00:00

abstract：:We cloned the full-length cDNA sequence of xenobiotic metabolizing cytochrome P4501A (CYP1A) gene from the yellow catfish (Pelteobagrus fulvidraco, Siluriformes, Bagridae). P. fulvidraco is a commercially important fish generally distributed in Southeast Asian countries and Korea. This is the first report of any xenob...

journal_title：Environmental toxicology

authors： Kim JH,Hwang DS,Son KH,Raisuddin S,Ki JS,Lee JS,Han KN

更新日期：2008-06-01 00:00:00

abstract：:So far, little is known on the distribution of hepatotoxic microcystin (MC) in various organs of bivalves, and there is no study on MC accumulation in bivalves from Chinese waters. Distribution pattern and seasonal dynamics of MC-LR, -YR and -RR in various organs (hepatopancreas, intestine, visceral mass, gill, foot, ...

journal_title：Environmental toxicology

authors： Chen J,Xie P

更新日期：2005-12-01 00:00:00

abstract：:The freshwater crabs Sinopotamon henanense were exposed to different concentrations of waterborne cadmium (Cd). The relationship between tissue-specific Cd accumulation and metallothionein (MT) induction was investigated using the Cd saturation assay and atomic absorption spectrophotometry method. The results showed t...

journal_title：Environmental toxicology

authors： Ma W,Wang L,He Y,Yan Y

更新日期：2008-06-01 00:00:00

abstract：:The mycotoxin citrinin (CTN), a natural contaminant in foodstuffs and animal feeds, exerts cytotoxic and genotoxic effects on various mammalian cells. CTN causes cell injury, including apoptosis. Previous studies by our group showed that CTN triggers apoptosis in mouse embryonic stem cells, as well as embryonic develo...

journal_title：Environmental toxicology

authors： Huang YT,Lai CY,Lou SL,Yeh JM,Chan WH

更新日期：2009-08-01 00:00:00

abstract：:Colorectal cancer (CRC) is one of the most common cancers and causes of cancer-related death. There are several first-line chemotherapeutic drugs used to treat CRC. Oxaliplatin (OXA) is an alkylating cytotoxic agent that is usually combined with other chemotherapeutic drugs to treat stage II and stage III CRC. However...

journal_title：Environmental toxicology

authors： Chen MC,Hsu HH,Chu YY,Cheng SF,Shen CY,Lin YJ,Chen RJ,Viswanadha VP,Lin YM,Huang CY

更新日期：2018-05-01 00:00:00

abstract：:The toxicity and chemical quality of surface water and sediment in the River Traun in Austria were studied because of recurrent fish mortality in some alpine rivers over the last few years. The analyses were carried out on samples collected during winter and summer upstream and downstream of two municipal wastewater t...

journal_title：Environmental toxicology

authors： Latif M,Licek E

更新日期：2004-08-01 00:00:00

abstract：:Andrographolide, the main bioactive component of the medicinal plant Andrographis paniculata, has been shown to possess potent anti-inflammatory activity. Endothelin 1 (ET-1), a potent vasoconstrictor peptide produced by vascular endothelial cells, displays proinflammatory property. Hypoxia-inducible factor 1α (HIF-1α...

journal_title：Environmental toxicology

authors： Lin HC,Su SL,Lu CY,Lin AH,Lin WC,Liu CS,Yang YC,Wang HM,Lii CK,Chen HW

更新日期：2017-03-01 00:00:00

abstract：:di-N-butylphthalate (DBP) is a ubiquitous environmental pollutant used for plastic coating and in the cosmetics industry. It has toxic effects on body health, especially the male reproductive system. Here, we investigated the effects of DBP on the male reproductive system of pubertal mice and explored the protective r...

journal_title：Environmental toxicology

authors： Jiang XP,Tang JY,Xu Z,Han P,Qin ZQ,Yang CD,Wang SQ,Tang M,Wang W,Qin C,Xu Y,Shen BX,Zhou WM,Zhang W

更新日期：2017-07-01 00:00:00

abstract：:The frequent occurrences of the toxic cyanobacterial (specifically Microcystis aeruginosa) bloom are becoming a global environmental issue. Lots of researches have been focused on the pure cyanobacterial toxins, but little on the natural cyanobacterial bloom. This study was undertaken to investigate the effect of the ...

journal_title：Environmental toxicology

authors： Huang P,Zheng YF,Xu LH

更新日期：2008-12-01 00:00:00