TiO2 nanoparticle-induced neurotoxicity may be involved in dysfunction of glutamate metabolism and its receptor expression in mice.

abstract：:The microbial assay for risk assessment (MARA) is an innovative system based on an array of 11 different microbial species freeze-dried in a 96-well micro-titer plate. Developed for testing the toxicity of chemicals, mixtures, and environmental samples, the assay employs species of a taxonomically diverse range. In ad...

journal_title：Environmental toxicology

authors： Wadhia K

更新日期：2008-10-01 00:00:00

abstract：:Numerous studies have shown that rutin has anticancer effects. We have previously reported that rutin induced cell cycle arrest and apoptosis in murine leukemia WEHI-3 cells in vitro and in vivo. However, there are no data showing that rutin inhibits human leukemia HL-60 cells in vivo in a murine xenograft animal mode...

journal_title：Environmental toxicology

authors： Lin JP,Yang JS,Lin JJ,Lai KC,Lu HF,Ma CY,Sai-Chuen Wu R,Wu KC,Chueh FS,Gibson Wood W,Chung JG

更新日期：2012-08-01 00:00:00

abstract：:Domestic exposure to biomass smoke represents the second cause of chronic obstructive lung disease. Previous studies have shown that exposure of guinea pigs to wood smoke is capable of generating oxidative stress in lung tissue, and this may involve a failure at a mitochondrial level, given its close relation with the...

journal_title：Environmental toxicology

authors： Granados-Castro LF,Rodríguez-Rangel DS,Montaño M,Ramos C,Pedraza-Chaverri J

更新日期：2015-04-01 00:00:00

abstract：:To evaluate the allergic effect of airborne particulate matter (PM) on the airway, separated soluble supernatant (Sup) and insoluble precipitate (Pre) in suspended PM were inoculated into NC/Nga mice with a high sensitivity for mite allergens. Sup, Pre, or both Sup and Pre with or without pronase treatment were inocul...

journal_title：Environmental toxicology

authors： Ogino K,Takahashi N,Kubo M,Takeuchi A,Nakagiri M,Fujikura Y

更新日期：2014-06-01 00:00:00

abstract：:There is emerging evidence suggesting that oxidative stress and DNA methylation can alter miRNA expression. However, little is known on the mechanism of miR-17-5p expression changes in paraquat (PQ)-induced nerve cell damage. In the present study, neuro-2a cells were pretreated with antioxidant N-acetylcysteine (NAC) ...

journal_title：Environmental toxicology

authors： Zhan Y,Guo Z,Zheng F,Zhang Z,Li K,Wang Q,Wang L,Cai Z,Chen N,Wu S,Li H

更新日期：2020-12-01 00:00:00

abstract：:Acute severe carbon monoxide (CO) poisoning induces hypoxia that leads to cardiovascular and nervous systems disturbances. Different complex mechanisms lead to CO neurotoxicity including lipid peroxidation, inflammatory and immune-mediated reactions, myelin degeneration and finally neuronal apoptosis and necrosis. Gra...

journal_title：Environmental toxicology

authors： Ghorbani M,Mohammadpour AH,Abnous K,Movassaghi AR,Sarshoori JR,Shahsavand S,Hashemzaei M,Moallem SA

更新日期：2017-01-01 00:00:00

abstract：:The 8-hydroxy-2'-deoxyguanosine (8-OHdG), an oxidized nucleoside of DNA, not only is a widely used biomarker for the measurement of endogenous oxidative DNA damage, but might also be a risk factor for many diseases including cancer. Elevated level of urinary 8-OHdG has been detected in patients with various malignanci...

journal_title：Environmental toxicology

authors： Yang Y,Tian Y,Yan C,Jin X,Tang J,Shen X

更新日期：2009-10-01 00:00:00

abstract：:The herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) has been widely used in agriculture and forestry since the 1940s. 2,4-D has been shown to produce a wide range of adverse effects-from embryotoxicity and teratogenicity to neurotoxicity-on animal and human health. The purpose of this study was to determine the possi...

journal_title：Environmental toxicology

authors： Pochettino AA,Bongiovanni B,Duffard RO,Evangelista de Duffard AM

更新日期：2013-01-01 00:00:00

abstract：:The environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is known to affect bone metabolism. We evaluated the protective effects of the triterpene glycoside actein from the herb black cohosh against TCDD-induced toxicity in MC3T3-E1 osteoblastic cells. We found that TCDD significantly reduced cell viabil...

journal_title：Environmental toxicology

authors： Choi EM,Suh KS,Jung WW,Park SY,Chin SO,Rhee SY,Pak YK,Chon S

更新日期：2017-12-01 00:00:00

abstract：:Throughout life, the human eye is continuously exposed to sunlight and artificial lighting. Ambient light exposure can lead to visual impairment and transient or permanent blindness. To mimic benign light stress conditions, Mus musculus eyes were exposed to low-energy UVB radiation, ensuring no severe morphological ch...

journal_title：Environmental toxicology

authors： An MJ,Kim CH,Nam GY,Kim DH,Rhee S,Cho SJ,Kim JW

更新日期：2018-01-01 00:00:00

abstract：:The effect of the heavy metal copper on the expression of a wide spectrum of genes was analyzed by using a DNA microarray. The gene expression profile of baker's yeast Saccharomyces cerevisiae grown in a medium containing a sublethal concentration of cupric sulfate was compared with that of yeast grown in a normal med...

journal_title：Environmental toxicology

authors： Yasokawa D,Murata S,Kitagawa E,Iwahashi Y,Nakagawa R,Hashido T,Iwahashi H

更新日期：2008-10-01 00:00:00

abstract：:Lead ions (Pb(2+) ) are toxic industrial pollutants associated with chronic inflammatory diseases in humans and animals. Previously, we found that Pb(2+) ions induce COX-2 gene expression via the EGF receptor/nuclear factor-κB signal transduction pathway in epidermoid carcinoma cell line A431. In this study, to see wh...

journal_title：Environmental toxicology

authors： Tsai YT,Chang CM,Wang JY,Hou MF,Wang JM,Shiurba R,Chang WC,Chang WC

更新日期：2015-09-01 00:00:00

abstract：:8-Hydroxy-2'-deoxyguanosine (8-OHdG) is the most common biomarker of oxidative DNA damage, it is formed by chemical carcinogens and can be measured in any species. Perfluorooctanoic acid (PFOA) and perfluorononanoic acid (PFNA) are suspected genotoxic carcinogens through induction of reactive oxygen species that are r...

journal_title：Environmental toxicology

authors： Yahia D,Haruka I,Kagashi Y,Tsuda S

更新日期：2016-02-01 00:00:00

abstract：:The aim of this research was to analyze the effects and the modes of action of elemental sulfur (S(0)) in bioluminescence and respiration of Vibrio fischeri cells and the enzymes crude luciferase, pure catalase, and alcohol dehydrogenase (ADH). Metallic copper removed sulfur and reduced the toxicity of acetone extract...

journal_title：Environmental toxicology

authors： Cetkauskaite A,Pessala P,Södergren A

更新日期：2004-08-01 00:00:00

abstract：:The toxicity and chemical quality of surface water and sediment in the River Traun in Austria were studied because of recurrent fish mortality in some alpine rivers over the last few years. The analyses were carried out on samples collected during winter and summer upstream and downstream of two municipal wastewater t...

journal_title：Environmental toxicology

authors： Latif M,Licek E

更新日期：2004-08-01 00:00:00

abstract：:Benchmark dose (BMD) and the lower confidence limit on the benchmark dose (BMDL) of blood lead were estimated to explore the biologic exposure limits for renal dysfunction caused by lead. One hundred thirty-five workers from one storage battery plant were selected as lead exposure group while 143 mechanics as the cont...

journal_title：Environmental toxicology

authors： Lin T,Tai-Yi J

更新日期：2007-06-01 00:00:00

abstract：:Colorectal cancer (CRC) is one of the most common cancers and causes of cancer-related death. There are several first-line chemotherapeutic drugs used to treat CRC. Oxaliplatin (OXA) is an alkylating cytotoxic agent that is usually combined with other chemotherapeutic drugs to treat stage II and stage III CRC. However...

journal_title：Environmental toxicology

authors： Chen MC,Hsu HH,Chu YY,Cheng SF,Shen CY,Lin YJ,Chen RJ,Viswanadha VP,Lin YM,Huang CY

更新日期：2018-05-01 00:00:00

abstract：:We cloned the full-length cDNA sequence of xenobiotic metabolizing cytochrome P4501A (CYP1A) gene from the yellow catfish (Pelteobagrus fulvidraco, Siluriformes, Bagridae). P. fulvidraco is a commercially important fish generally distributed in Southeast Asian countries and Korea. This is the first report of any xenob...

journal_title：Environmental toxicology

authors： Kim JH,Hwang DS,Son KH,Raisuddin S,Ki JS,Lee JS,Han KN

更新日期：2008-06-01 00:00:00

abstract：:Indium, a rare earth metal characterized by high plasticity, corrosion resistance, and a low melting point, is widely used in the electronics industry, but has been reported to be an environmental pollutant and a health hazard. We designed a study to investigate the effects of subacute exposure of indium compounds on ...

journal_title：Environmental toxicology

authors： Lee KH,Chen HL,Leung CM,Chen HP,Hsu PC

更新日期：2016-01-01 00:00:00

abstract：:Melanoma is the leading cause of death from skin disease due to its propensity for metastasis. Studies have shown that integrin-mediated focal adhesion kinase (FAK) signal pathway is implicated in cell proliferation, survival and metastasis of tumor cells. Our previous results indicated that diallyl trisulfide (DATS) ...

journal_title：Environmental toxicology

authors： Wang HC,Chu YL,Hsieh SC,Sheen LY

更新日期：2017-11-01 00:00:00

abstract：:Casticin, a polymethoxyflavone, is one of the major active components obtained from Fructus viticis, which have been shown to have anticancer activities including induce cell apoptosis in human cancer cells. The aim of this study was to investigate the molecular mechanisms by which casticin inhibits cell migration and...

journal_title：Environmental toxicology

authors： Shih YL,Chou HM,Chou HC,Lu HF,Chu YL,Shang HS,Chung JG

更新日期：2017-09-01 00:00:00

abstract：:Long non-coding RNA (lncRNA) plays a critical role in male germline development. Atrazine (AZ) as an environmental endocrine disrupting chemical (EDCs) can induce male reproductive toxicity in amphibians. Our previous studies demonstrated that AZ can alter gene and circular RNA (circRNA) expression of damaged testes i...

journal_title：Environmental toxicology

authors： Sai L,Qu B,Zhang J,Liu J,Jia Q,Bo C,Zhang Y,Yu G,Han R,Peng C

更新日期：2019-04-01 00:00:00

abstract：:Although triphenyltin (TPT) compounds are ubiquitous pollutants in urbanised coastal environments in Asian regions, their toxicities to marine organisms are still poorly known. This study was designed to investigate the toxicity of triphenyltin chloride (TPTCl) on the rotifer Brachionus koreanus across different level...

journal_title：Environmental toxicology

authors： Yi AX,Han J,Lee JS,Leung KM

更新日期：2016-01-01 00:00:00

abstract：:Toxicity of lead on male reproductive functions has raised wide public concern as environmental lead contamination remains common worldwide. Conflicting and controversial data are available regarding effects of lead on male fertility. More importantly, our knowledge on effects of lead on sperm DNA integrity is signifi...

journal_title：Environmental toxicology

authors： Li C,Zhao K,Zhang H,Liu L,Xiong F,Wang K,Chen B

更新日期：2018-05-01 00:00:00

abstract：:Environmental stress factors may be responsible for biological changes in living species that are able to overcome deleterious effects depending on their detoxifying capacities. Defense systems present in every living species are involved in elimination of reactive chemical species of endogenous or exogenous origin, n...

journal_title：Environmental toxicology

authors： Vasseur P,Leguille C

更新日期：2004-08-01 00:00:00

abstract：:Liver is one of the major target organs of arsenic toxicity and carcinogenesis. Nuclear factor (erythroid-2 related) factor 2 (Nrf2) is a redox-sensitive transcription factor, regulating critically cellular defense responses against the toxic metallic arsenic in many cell types and tissues. This study was conducted to...

journal_title：Environmental toxicology

authors： Li B,Li X,Zhu B,Zhang X,Wang Y,Xu Y,Wang H,Hou Y,Zheng Q,Sun G

更新日期：2013-07-01 00:00:00

abstract：:The prostate is an accessory reproductive gland that is sensitive to the action of exogenous compounds known as endocrine disrupters that alter normal hormonal function. Finasteride is a widely used chemical that acts to inhibit the conversion of testosterone in its most active form, dihydrotestosterone. It is known t...

journal_title：Environmental toxicology

authors： Maldarine JS,Sanches BDA,Santos VA,Amaro GM,Calmon MF,Rahal P,Góes RM,Vilamaior PSL,Taboga SR

更新日期：2020-01-01 00:00:00

abstract：:Effects of perchlorate on sodium-iodide symporter (NIS) and pendrin gene expression in deer mice kidney and stomach were investigated. This was accomplished by isolating a partial cDNA sequence of deer mice NIS gene of 425 bps, and quantitatively analyzing NIS mRNA expression in various deer mouse tissues. The highest...

journal_title：Environmental toxicology

authors： Cheng Q,Smith EE,Liu F,Gentle A,Hooper MJ,Anderson TA

更新日期：2007-08-01 00:00:00

abstract：:7,12-Dimethylbenz[α]anthracene (DMBA) is a hazardous component present in polluted environments. DMBA has been used as an experimental tool for in vivo tumor formation owing to its carcinogenic effects, but the detailed molecular mechanism of DMBA has not been fully established. To comprehend the carcinogenic mechanis...

journal_title：Environmental toxicology

authors： Kwon YJ,Ye DJ,Baek HS,Chun YJ

更新日期：2018-07-01 00:00:00

abstract：:The chronic effect of p-nonylphenol on survival and reproduction for two generations of the freshwater cladoceran Daphnia galeata was examined by life table experiments. The effects on survival and reproduction were used as the intrinsic rate of natural increase, r, with the Euler-Lotka equation and were analyzed with...

journal_title：Environmental toxicology

authors： Tanaka Y,Nakanishi J

更新日期：2002-10-01 00:00:00