Acute exposure to bisphenol A and cadmium causes changes in the morphology of gerbil ventral prostates and promotes alterations in androgen-dependent proliferation and cell death.


:Bisphenol A (BPA) and cadmium (Cd) are environmental pollutants that are implicated in potential reproductive effects, including damage to the prostate gland. Their action during puberty requires analysis to determine the relationship of these compounds with the testosterone peak that occurs during this phase. This study evaluated whether exposure to BPA and Cd during puberty can cause changes in the morphology, proliferation and cell death and androgen receptor (AR) immunostaining of the ventral prostates of normal and castrated male gerbils (Meriones unguiculatus), considering an acute exposure to the chemicals and evaluation after short (52d) and long (120d) periods. Generally, morphometric-stereological results demonstrated that administration of BPA and Cd (individually or in combination) increased epithelial height, smooth muscle layer (SML) thickness and nuclear area and perimeter, and that these parameters were reduced in castrated animals. In addition, these groups showed important inflammatory processes but not prostate lesions. The proliferation/death rates of prostatic cells obtained by PCNA and TUNEL immunostaining demonstrated increased cell death in the 52d groups; in contrast, the gland acquired a more proliferative nature in the 120d groups. AR immunostaining showed that BPA and Cd compounds interact with ARs in different ways depending on the evaluated period and the hormonal profile of the animal. We conclude that BPA and cadmium are important agents in changing the morphology, proliferation and death of prostatic cells, in addition to interacting with ARs in different patterns. © 2015 Wiley Periodicals, Inc. Environ Toxicol 32: 48-61, 2017.


Environ Toxicol


Environmental toxicology


Colleta SJ,Antoniassi JQ,Zanatelli M,Santos FC,Góes RM,Vilamaior PS,Taboga SR




Has Abstract


2017-01-01 00:00:00












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    abstract::Polychlorinated biphenyls (PCBs) are a class of organic pollutants that have been linked to pancreatic disease. However, their role in affecting the exocrine function of pancreas and the underlying mechanism remains elusive. In the present study, male C57 mice were treated with Aroclor 1254, a commercially available P...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Lin M,Wu T,Sun L,Lin JJ,Zuo Z,Wang C

    更新日期:2016-06-01 00:00:00

  • Effects of cypermethrin on Allium cepa.

    abstract::In this study, toxic effects of the cypermethrin in Allium cepa L. cells were investigated. For this aim, we investigated the changes in pigment contents, antioxidant enzymes, mitotic index and chromosomal abnormalities as indicators of toxicity. The seeds were treated with different doses (1.5, 3.0, 6.0 ppm) of cyper...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Çavuşoğlu K,Kaya A,Yilmaz F,Yalçin E

    更新日期:2012-10-01 00:00:00

  • Bacterial biosensors for evaluating potential impacts of estrogenic endocrine disrupting compounds in multiple species.

    abstract::To study the effects and possible mechanisms of suspected endocrine disrupting compounds (EDCs), a wide variety of assays have been developed. In this work, we generated engineered Escherichia coli biosensor strains that incorporate the ligand-binding domains (LBDs) of the β-subtype estrogen receptors (ERβ) from Solea...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Gierach I,Shapero K,Eyster TW,Wood DW

    更新日期:2013-04-01 00:00:00

  • Non destructive in vivo measurement of ethoxyresorufin biotransformation by zebrafish prolarva: development and application.

    abstract::Biotransformation enzymatic activities, such as the cytochrome P450 one, have been used as biomarkers for pollution assessment for a long time. Nevertheless, such biochemical tools are destructive processes, because they are performed on fish liver or total larvae homogenates. Moreover, the adaptation of this bioassay...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Noury P,Geffard O,Tutundjian R,Garric J

    更新日期:2006-08-01 00:00:00

  • Inflammatory airway responses by nasal inoculation of suspended particulate matter in NC/Nga mice.

    abstract::To evaluate the allergic effect of airborne particulate matter (PM) on the airway, separated soluble supernatant (Sup) and insoluble precipitate (Pre) in suspended PM were inoculated into NC/Nga mice with a high sensitivity for mite allergens. Sup, Pre, or both Sup and Pre with or without pronase treatment were inocul...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Ogino K,Takahashi N,Kubo M,Takeuchi A,Nakagiri M,Fujikura Y

    更新日期:2014-06-01 00:00:00

  • Gene expression profile changes induced by acute toxicity of [C16 mim]Cl in loach (Paramisgurnus dabryanus).

    abstract::Ionic liquids (ILs) are widely used as reaction media in various commercial applications. Many reports have indicated that most ILs are poorly decomposed by microorganisms and are toxic to aquatic organisms. In this study, differential gene expression profiling was conducted using a suppression subtraction hybridizati...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Nan P,Yan S,Wang Y,Du Q,Chang Z

    更新日期:2017-02-01 00:00:00

  • Effects of a pre-incubation period on the photoinduced toxicity of polycyclic aromatic hydrocarbons to the luminescent bacterium Vibrio fischeri.

    abstract::Irradiation of polycyclic aromatic hydrocarbons (PAHs) in aqueous solution with simulated solar radiation (SSR; a light source with a visible light: UV-A:UV-B ratio similar to that of sunlight) can greatly enhance their toxicity. Two microbial toxicity tests with Vibrio fischeri were used to investigate the effect of ...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: el-Alawi YS,Dixon DG,Greenberg BM

    更新日期:2001-06-01 00:00:00

  • Inflammatory activity in river-water samples.

    abstract::Contamination of the urban aquatic environment with chemical and biological substances could have a long-term impact on human health because these substances threaten the integrity of the urban ecosystem and the availability of high-quality water for recreation and consumption. In light of this, the aim of the present...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Wichmann G,Daegelmann C,Herbarth O,Strauch G,Schirmer K,Wöstemeyer J,Lehmann I

    更新日期:2004-12-01 00:00:00

  • 7,12-Dimethylbenz[α]anthracene increases cell proliferation and invasion through induction of Wnt/β-catenin signaling and EMT process.

    abstract::7,12-Dimethylbenz[α]anthracene (DMBA) is a hazardous component present in polluted environments. DMBA has been used as an experimental tool for in vivo tumor formation owing to its carcinogenic effects, but the detailed molecular mechanism of DMBA has not been fully established. To comprehend the carcinogenic mechanis...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Kwon YJ,Ye DJ,Baek HS,Chun YJ

    更新日期:2018-07-01 00:00:00

  • Biomarker responses in caged carp (Cyprinuscarpio) and native collected fish (Leporinus obtusidens) in the Río de la Plata Estuary, Argentina.

    abstract::Punta Lara is located in the Río de la Plata estuary near industrial areas contaminated mainly by organic pollutants. In this work, the responses and status of hepatic biomarkers were studied in juvenile carp (Cyprinus carpio) by means of a 21-day field exposure in cages and collection of juvenile native fish (Leporin...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Scarcia P,Calamante G,de la Torre F

    更新日期:2014-08-01 00:00:00

  • Rutin inhibits human leukemia tumor growth in a murine xenograft model in vivo.

    abstract::Numerous studies have shown that rutin has anticancer effects. We have previously reported that rutin induced cell cycle arrest and apoptosis in murine leukemia WEHI-3 cells in vitro and in vivo. However, there are no data showing that rutin inhibits human leukemia HL-60 cells in vivo in a murine xenograft animal mode...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Lin JP,Yang JS,Lin JJ,Lai KC,Lu HF,Ma CY,Sai-Chuen Wu R,Wu KC,Chueh FS,Gibson Wood W,Chung JG

    更新日期:2012-08-01 00:00:00

  • Protective effects of Ziziphora tenuior extract against chlorpyrifos induced liver and lung toxicity in rat: Mechanistic approaches in subchronic study.

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    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Yazdinezhad A,Abbasian M,Hojjat Hosseini S,Naserzadeh P,Agh-Atabay AH,Hosseini MJ

    更新日期:2017-09-01 00:00:00

  • Assessment of DNA damage and oxidative stress in juvenile Channa punctatus (Bloch) after exposure to multi-walled carbon nanotubes.

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    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Ali D,Falodah FA,Almutairi B,Alkahtani S,Alarifi S

    更新日期:2020-03-01 00:00:00

  • Toxic effect on tissues and differentially expressed genes in hepatopancreas identified by suppression subtractive hybridization of freshwater pearl mussel (Hyriopsis cumingii) following microcystin-LR challenge.

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    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Yang Z,Wu H,Li Y

    更新日期:2012-07-01 00:00:00

  • Wood smoke exposure induces a decrease in respiration parameters and in the activity of respiratory complexes I and IV in lung mitochondria from guinea pigs.

    abstract::Domestic exposure to biomass smoke represents the second cause of chronic obstructive lung disease. Previous studies have shown that exposure of guinea pigs to wood smoke is capable of generating oxidative stress in lung tissue, and this may involve a failure at a mitochondrial level, given its close relation with the...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Granados-Castro LF,Rodríguez-Rangel DS,Montaño M,Ramos C,Pedraza-Chaverri J

    更新日期:2015-04-01 00:00:00

  • Lupeol alters ER stress-signaling pathway by downregulating ABCG2 expression to induce Oxaliplatin-resistant LoVo colorectal cancer cell apoptosis.

    abstract::Colorectal cancer (CRC) is one of the most common cancers and causes of cancer-related death. There are several first-line chemotherapeutic drugs used to treat CRC. Oxaliplatin (OXA) is an alkylating cytotoxic agent that is usually combined with other chemotherapeutic drugs to treat stage II and stage III CRC. However...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Chen MC,Hsu HH,Chu YY,Cheng SF,Shen CY,Lin YJ,Chen RJ,Viswanadha VP,Lin YM,Huang CY

    更新日期:2018-05-01 00:00:00

  • l-Carnitine protects against 1,4-benzoquinone-induced apoptosis and DNA damage by suppressing oxidative stress and promoting fatty acid oxidation in K562 cells.

    abstract::Widespread occupational and environmental exposure to benzene is unavoidable and poses a public health threat. Studies of potential interventions to prevent or relieve benzene toxicity are, thus, essential. Research has shown l-carnitine (LC) has beneficial effects against various pathological processes and diseases. ...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Sun R,Man Z,Ji J,Ji S,Xu K,Pu Y,Yu L,Zhang J,Yin L,Pu Y

    更新日期:2020-10-01 00:00:00

  • Direct and interactive effects of ecologically relevant concentrations of organic wastewater contaminants on Rana pipiens tadpoles.

    abstract::Organic wastewater contaminants (OWCs) have recently been documented in several aquatic ecosystems. We examined the effects of three OWCs (caffeine, acetaminophen, and triclosan) on the activity level, startle response, survivorship, and growth of northern leopard frog (Rana pipiens) tadpoles. We conducted two experim...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Fraker SL,Smith GR

    更新日期:2004-06-01 00:00:00

  • Adverse reproductive effects of maternal low-dose melamine exposure during pregnancy in rats.

    abstract::Melamine is a heterocyclic, aromatic amine and nitrogen-enriched environmental toxicant, found in not only adulterated foodstuffs but also industrial household tableware and paints. Previous studies demonstrated adverse effects of high-dose melamine on human infants and pregnant animals, but effects of low-dose melami...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Chu CY,Tang LY,Li L,Shum AS,Fung KP,Wang CC

    更新日期:2017-01-01 00:00:00

  • cDNA cloning and expression of a xenobiotic metabolizing cytochrome P4501A (CYP1A) from the yellow catfish, Pelteobagrus fulvidraco (Siluriformes).

    abstract::We cloned the full-length cDNA sequence of xenobiotic metabolizing cytochrome P4501A (CYP1A) gene from the yellow catfish (Pelteobagrus fulvidraco, Siluriformes, Bagridae). P. fulvidraco is a commercially important fish generally distributed in Southeast Asian countries and Korea. This is the first report of any xenob...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Kim JH,Hwang DS,Son KH,Raisuddin S,Ki JS,Lee JS,Han KN

    更新日期:2008-06-01 00:00:00

  • Development of a free beta-galactosidase in vitro test for the assessment of heavy metal toxicity.

    abstract::The effect of heavy metals and organic compounds on the activity of the enzyme beta-galactosidase in a standardized bioassay has been evaluated, considering future applications in environmental monitoring. The tests were done using a commercial extract of a hydrolase from the eukaryote yeast Kluyveromyces lactis and o...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Apartin C,Ronco A

    更新日期:2001-01-01 00:00:00

  • More serious autophagy can be induced by ZnO nanoparticles than single-walled carbon nanotubes in rat tracheal epithelial cells.

    abstract::Metal oxide nanoparticles and carbon nanoparticles, as common nanoparticles (NPs), can cause autophagy in certain cells, which will lead to biohealth risk issues. This study determined the difference in autophagy induced by zinc oxide nanoparticles (ZnO NPs) and single-walled carbon nanotubes (SWCNTs) in respiratory e...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Zhang H,Chen F,Li Y,Shan X,Yin L,Hao X,Zhong Y

    更新日期:2021-02-01 00:00:00

  • A comparison of hepatocyte cytotoxic mechanisms for thallium (I) and thallium (III).

    abstract::Thallium (Tl) is a highly toxic heavy metal though up to now its mechanisms are poorly understood. In this study, we comparatively investigated the cytotoxic mechanisms of Tl(I) and Tl(III) in isolated rat hepatocytes. Both Tl(I) and Tl(III) cytotoxicities were associated with reactive oxygen species (ROS) formation, ...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Pourahmad J,Eskandari MR,Daraei B

    更新日期:2010-10-01 00:00:00

  • Gas chromatography-mass spectrometry based metabolomics profile of hippocampus and cerebellum in mice after chronic arsenic exposure.

    abstract::Intake of arsenic (As) via drinking water has been a serious threat to global public health. Though there are numerous reports of As neurotoxicity, its pathogenesis mechanisms remain vague especially its chronic effects on metabolic network. Hippocampus is a renowned area in relation to learning and memory, whilst rec...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Mo TT,Dai H,Du H,Zhang RY,Chai KP,An Y,Chen JJ,Wang JK,Chen ZJ,Chen CZ,Jiang XJ,Tang R,Wang LP,Tan Q,Tang P,Miao XY,Meng P,Zhang LB,Cheng SQ,Peng B,Tu BJ,Han TL,Xia YY,Baker PN

    更新日期:2019-02-01 00:00:00

  • Yohimbine hydrochloride ameliorates collagen type-II-induced arthritis targeting oxidative stress and inflammatory cytokines in Wistar rats.

    abstract::Rheumatoid arthritis (RA) is the most common type of chronic inflammatory disease which is triggered by dysfunction in the immune system which in turn affects synovial joints. Current treatment of RA with NSAIDs and DMRDs is limited by their side effect. As a result, the interest in alternative, well tolerated anti-in...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Neha,Ansari MM,Khan HA

    更新日期:2017-02-01 00:00:00

  • Ouabain promotes immune responses in WEHI-3 cells to generate leukemia mice through enhancing phagocytosis and natural killer cell activities in vivo.

    abstract::Ouabain, a cardiotonic steroid, was used for the treatment of heart failure and atrial fibrillation and induces cancer cell apoptosis in many human cancer cells including human leukemia cells. However, there are no reports to show the effects on immune responses in a leukemia mouse model. In this study, WEHI-3 cell ge...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Shih YL,Shang HS,Chen YL,Hsueh SC,Chou HM,Lu HF,Lee MZ,Hou HT,Chuang YY,Lee MH,Chen KW,Chung JG

    更新日期:2019-05-01 00:00:00

  • Formation of MTBE-DNA adducts in mice measured with accelerator mass spectrometry.

    abstract::Methyl tert-butyl ether (MTBE) is a gasoline oxygenate and antiknock additive substituting for lead alkyls currently in use worldwide. Previous studies have shown that MTBE at very high doses induces tumors in rodents. The aim of the present study was to examine directly the binding ability of MTBE onto DNA, demonstra...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Du HF,Xu LH,Wang HF,Liu YF,Tang XY,Liu KX,Peng SX

    更新日期:2005-08-01 00:00:00

  • Toxicity and enantiospecific differences of two β-blockers, propranolol and metoprolol, in the embryos and larvae of zebrafish (Danio rerio).

    abstract::The risk presented by β-blockers on aquatic organisms remains uncertain, particularly given the enantiospecific differences in toxicity of chiral β-blockers. In this study, the toxicity of two β-blockers, propranolol and metoprolol, was determined. The 96-h LC50 of propranolol in the zebrafish larvae was 2.48 mg/L, wh...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Sun L,Xin L,Peng Z,Jin R,Jin Y,Qian H,Fu Z

    更新日期:2014-12-01 00:00:00

  • Retracted: Pulmonary fibrosis of mice and its molecular mechanism following chronic inhaled exposure to TiO2 nanoparticles.

    abstract::Nanoparticulate titanium dioxide (nano-TiO2 ) has been widely used in industry, medicine and daily life. However, assessment of nano-TiO2 toxicity on health is an important occupational safety issue. Numerous studies have demonstrated that nano-TiO2 can induced sustained pulmonary inflammation, but whether chronic exp...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Hong F,Ji L,Zhou Y,Wang L

    更新日期:2017-09-25 00:00:00

  • Cyst-based toxicity tests XIII--development of a short chronic sediment toxicity test with the ostracod crustacean Heterocypris incongruens: methodology and precision.

    abstract::Experiments were carried out with neonates of the freshwater ostracod Heterocypris incongruens to verify and complete previous choices of test parameters for a new culture/maintenance-free solid-phase microbiotest for freshwater sediments. From trials with increasing volumes of reference sediment, it was concluded tha...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Chial B,Persoone G

    更新日期:2002-12-01 00:00:00