Acute exposure to bisphenol A and cadmium causes changes in the morphology of gerbil ventral prostates and promotes alterations in androgen-dependent proliferation and cell death.


:Bisphenol A (BPA) and cadmium (Cd) are environmental pollutants that are implicated in potential reproductive effects, including damage to the prostate gland. Their action during puberty requires analysis to determine the relationship of these compounds with the testosterone peak that occurs during this phase. This study evaluated whether exposure to BPA and Cd during puberty can cause changes in the morphology, proliferation and cell death and androgen receptor (AR) immunostaining of the ventral prostates of normal and castrated male gerbils (Meriones unguiculatus), considering an acute exposure to the chemicals and evaluation after short (52d) and long (120d) periods. Generally, morphometric-stereological results demonstrated that administration of BPA and Cd (individually or in combination) increased epithelial height, smooth muscle layer (SML) thickness and nuclear area and perimeter, and that these parameters were reduced in castrated animals. In addition, these groups showed important inflammatory processes but not prostate lesions. The proliferation/death rates of prostatic cells obtained by PCNA and TUNEL immunostaining demonstrated increased cell death in the 52d groups; in contrast, the gland acquired a more proliferative nature in the 120d groups. AR immunostaining showed that BPA and Cd compounds interact with ARs in different ways depending on the evaluated period and the hormonal profile of the animal. We conclude that BPA and cadmium are important agents in changing the morphology, proliferation and death of prostatic cells, in addition to interacting with ARs in different patterns. © 2015 Wiley Periodicals, Inc. Environ Toxicol 32: 48-61, 2017.


Environ Toxicol


Environmental toxicology


Colleta SJ,Antoniassi JQ,Zanatelli M,Santos FC,Góes RM,Vilamaior PS,Taboga SR




Has Abstract


2017-01-01 00:00:00












  • Response of antioxidant enzymes, ascorbate and glutathione metabolism towards cadmium in hyperaccumulator and nonhyperaccumulator ecotypes of Sedum alfredii H.

    abstract::Hydroponics studies were conducted to investigate the antioxidant adaptations, ascorbate and glutathione metabolism in hyperaccumulating ecotype of Sedum alfredii (HE) exposed to high Cd environment, when compared with its nonhyperaccumulating ecotype (NHE). Exposure to Cd induced a burst of oxidative stress in both e...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Jin X,Yang X,Mahmood Q,Islam E,Liu D,Li H

    更新日期:2008-08-01 00:00:00

  • Andrographolide inhibits hypoxia-induced HIF-1α-driven endothelin 1 secretion by activating Nrf2/HO-1 and promoting the expression of prolyl hydroxylases 2/3 in human endothelial cells.

    abstract::Andrographolide, the main bioactive component of the medicinal plant Andrographis paniculata, has been shown to possess potent anti-inflammatory activity. Endothelin 1 (ET-1), a potent vasoconstrictor peptide produced by vascular endothelial cells, displays proinflammatory property. Hypoxia-inducible factor 1α (HIF-1α...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Lin HC,Su SL,Lu CY,Lin AH,Lin WC,Liu CS,Yang YC,Wang HM,Lii CK,Chen HW

    更新日期:2017-03-01 00:00:00

  • cDNA cloning and expression of a xenobiotic metabolizing cytochrome P4501A (CYP1A) from the yellow catfish, Pelteobagrus fulvidraco (Siluriformes).

    abstract::We cloned the full-length cDNA sequence of xenobiotic metabolizing cytochrome P4501A (CYP1A) gene from the yellow catfish (Pelteobagrus fulvidraco, Siluriformes, Bagridae). P. fulvidraco is a commercially important fish generally distributed in Southeast Asian countries and Korea. This is the first report of any xenob...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Kim JH,Hwang DS,Son KH,Raisuddin S,Ki JS,Lee JS,Han KN

    更新日期:2008-06-01 00:00:00

  • Telmisartan ameliorates carbon tetrachloride-induced acute hepatotoxicity in rats.

    abstract::This study assessed the potential hepatoprotective effect of telmisartan (TLM), a selective angiotensin II type 1 (AT1 ) receptor blocker, on carbon tetrachloride (CCl4 )-induced acute hepatotoxity in rats. Intraperitoneal injection of male Wistar rats with CCl4 1 mL kg-1 , 1:1 mixture with corn oil for 3 days increas...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Atawia RT,Esmat A,Elsherbiny DA,El-Demerdash E

    更新日期:2017-02-01 00:00:00

  • Toxicity profiles of four metals and 17 xenobiotics in the human hepatoma cell line HepG2 and the protozoa Tetrahymena pyriformis--a comparison.

    abstract::We performed an interspecies comparison for the human hepatoma cell line HepG2 and the eukaryotic single cell organism Tetrahymena pyriformis (T. pyriformis) for 17 xenobiotics with diverse structures and four metals. The cytotoxicity was assessed by four different cell viability assays (3-[4,5-dimethylthiazol-2-yl]-2...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Rudzok S,Krejči S,Graebsch C,Herbarth O,Mueller A,Bauer M

    更新日期:2011-04-01 00:00:00

  • Cellular and molecular hypoxic response in common carp (Cyprinus carpio) exposed to linear alkylbenzene sulfonate at sublethal concentrations.

    abstract::Linear alkylbenzene sulfonate (LAS) is an anionic surfactant commonly used in cleaning agents such as laundry detergents. Trace amounts of LAS are released into environmental waters after processing in wastewater treatment plants after the use of this chemical. Acute toxicity of LAS has been well-studied using various...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Tasaki J,Nakayama K,Shimizu I,Yamada H,Suzuki T,Nishiyama N,Yamane M

    更新日期:2017-01-01 00:00:00

  • Determining the mechanisms of toxic action of phenols to Tetrahymena pyriformis.

    abstract::Phenols are environmentally important compounds that are widely used in agriculture and industry. Thus, phenols are of interest to environmental toxicologists, which has led to the development of several quantitative structure-activity relationship (QSAR) models. The most successful QSARs have been established for com...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Ren S

    更新日期:2002-01-01 00:00:00

  • Acute toxicity and bioaccumulation of aqueous and sediment-bound metals in the estuarine amphipod Melita plumulosa.

    abstract::The sensitivities of juvenile and adult amphipods to metals (Cd, Cu, Ni, Pb, and Zn) in whole sediment and water-only exposures were compared using a newly developed acute test with the estuarine species Melita plumulosa. Endpoints included survival and bioaccumulation in adults, and survival and growth (body length) ...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: King CK,Gale SA,Stauber JL

    更新日期:2006-10-01 00:00:00

  • Mouse toxicity of Anabaena flos-aquae from Lake Dianchi, China.

    abstract::Some species of the genera Anabaena can produce various kinds of cyanotoxins, which may pose risks to environment and human health. Anabaena has frequently been observed in eutrophic freshwater of China in recent years, but its toxicity has been reported only in a few studies. In the present study, the toxicity of an ...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Pan X,Chang F,Liu Y,Li D,Xu A,Shen Y,Huang Z

    更新日期:2009-02-01 00:00:00

  • Allelopathic effects of the toxic cyanobacterium Microcystis aeruginosa on duckweed, Lemna gibba L.

    abstract::Cyanotoxins are a group of compounds produced by cyanobacteria that can have severe physiological effects on other organisms, including humans. The potential allelopathic effects of Microcystis aeruginosa, a toxic cyanobacterium, on the duckweed plant, Lemna gibba L., were examined using three experimental methods: (1...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: LeBlanc S,Pick FR,Aranda-Rodriguez R

    更新日期:2005-02-01 00:00:00

  • Early exposure of 17α-ethynylestradiol and diethylstilbestrol induces morphological changes and alters ovarian steroidogenic pathway enzyme gene expression in catfish, Clarias gariepinus.

    abstract::Environmental estrogens are major cause of endocrine disruption in vertebrates, including aquatic organisms. Teleosts are valuable and popular models for studying the effects of endocrine disrupting chemicals (EDCs) in the environment. In the present study, we investigated the changes caused by exposure to the synthet...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Sridevi P,Chaitanya RK,Prathibha Y,Balakrishna SL,Dutta-Gupta A,Senthilkumaran B

    更新日期:2015-04-01 00:00:00

  • Hepatic oxidative stress, DNA damage and apoptosis in adult zebrafish following sub-chronic exposure to BDE-47 and BDE-153.

    abstract::Polybrominated diphenyl ethers (PBDEs) are ubiquitous and prolific contaminant in both the abiotic and biotic environment because of the wide industrial applications of these chemicals. In the present study, the effects of 2,2',4,4'-tetrabrominateddiphenyl ether (BDE-47) and 2,2',4,4',5,5'-hexabromodiphenyl ether (BDE...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Meng S,Chen X,Gyimah E,Xu H,Chen J

    更新日期:2020-11-01 00:00:00

  • Seasonal dynamics of the hepatotoxic microcystins in various organs of four freshwater bivalves from the large eutrophic lake Taihu of subtropical China and the risk to human consumption.

    abstract::So far, little is known on the distribution of hepatotoxic microcystin (MC) in various organs of bivalves, and there is no study on MC accumulation in bivalves from Chinese waters. Distribution pattern and seasonal dynamics of MC-LR, -YR and -RR in various organs (hepatopancreas, intestine, visceral mass, gill, foot, ...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Chen J,Xie P

    更新日期:2005-12-01 00:00:00

  • Cantharidin induces DNA damage and inhibits DNA repair-associated protein levels in NCI-H460 human lung cancer cells.

    abstract::Cantharidin is one of the major compounds from mylabris and it has cytotoxic effects in many different types of human cancer cells. Previously, we found that cantharidin induced cell death through cell cycle arrest and apoptosis induction in human lung cancer NCI-H460 cells. However, cantharidin-affected DNA damage, r...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Hsia TC,Lin JH,Hsu SC,Tang NY,Lu HF,Wu SH,Lin JG,Chung JG

    更新日期:2015-09-01 00:00:00

  • Physiological responses of Microcystis aeruginosa PCC7806 to nonanoic acid stress.

    abstract::A recent study has shown that nonanoic acid (NA) is one of the strongest allelochemicals to a cyanobacterium Microcystis aeruginosa, but the physiological responses of M. aeruginosa to NA stress remain unknown. In this study, physiological characters such as the growth rate, photosynthetic processes, phosphorus and ni...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Shao JH,Wu XQ,Li RH

    更新日期:2009-12-01 00:00:00

  • Everolimus suppresses invasion and migration of renal cell carcinoma by inhibiting FAK activity and reversing epithelial to mesenchymal transition in vitro and in vivo.

    abstract::Renal cell carcinoma (RCC) is the most common type of kidney cancer in adults and the major cause of mortality in urological cancer. Most patients with RCC are asymptomatic until the disease is advanced and unresectable. In this situation, systemic therapy with immunotherapy or molecularly targeted therapy agents play...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Wu SW,Chen PN,Lin CY,Hsieh YS,Chang HR

    更新日期:2017-07-01 00:00:00

  • Mechanism of bisphenol AF-induced progesterone inhibition in human chorionic gonadotrophin-stimulated mouse Leydig tumor cell line (mLTC-1) cells.

    abstract::Bisphenol AF (BPAF) has been shown to inhibit testicular steroidogenesis in male rats. However, the precise mechanisms related to the toxic effects of BPAF on reproduction remain poorly understood. In the present study, a mouse Leydig tumor cell line (mLTC-1) was used as a model to investigate the mechanism of steroid...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Feng Y,Shi J,Jiao Z,Duan H,Shao B

    更新日期:2018-06-01 00:00:00

  • Pivotal role of cAMP-PKA-CREB signaling pathway in manganese-induced neurotoxicity in PC12 cells.

    abstract::Manganese (Mn) plays a critical role in individual growth and development, yet excessive exposure can result in neurotoxicity, especially cognitive impairment. Neuronal apoptosis is considered as one of the mechanisms of Mn-induced neurotoxicity. Recent evidence suggests that cAMP-PKA-CREB signaling regulates apoptosi...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Yang Y,Ma S,Wei F,Liang G,Yang X,Huang Y,Wang J,Zou Y

    更新日期:2019-09-01 00:00:00

  • Inflammatory airway responses by nasal inoculation of suspended particulate matter in NC/Nga mice.

    abstract::To evaluate the allergic effect of airborne particulate matter (PM) on the airway, separated soluble supernatant (Sup) and insoluble precipitate (Pre) in suspended PM were inoculated into NC/Nga mice with a high sensitivity for mite allergens. Sup, Pre, or both Sup and Pre with or without pronase treatment were inocul...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Ogino K,Takahashi N,Kubo M,Takeuchi A,Nakagiri M,Fujikura Y

    更新日期:2014-06-01 00:00:00

  • Differential effects between one week and four weeks exposure to same mass of SO2 on synaptic plasticity in rat hippocampus.

    abstract::Sulfur dioxide (SO2 ) is a ubiquitous air pollutant. The previous studies have documented the adverse effects of SO2 on nervous system health, suggesting that acutely SO2 inhalation at high concentration may be associated with neurotoxicity and increase risk of hospitalization and mortality of many brain disorders. Ho...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Yao G,Yun Y,Sang N

    更新日期:2016-07-01 00:00:00

  • Gene expression profile changes induced by acute toxicity of [C16 mim]Cl in loach (Paramisgurnus dabryanus).

    abstract::Ionic liquids (ILs) are widely used as reaction media in various commercial applications. Many reports have indicated that most ILs are poorly decomposed by microorganisms and are toxic to aquatic organisms. In this study, differential gene expression profiling was conducted using a suppression subtraction hybridizati...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Nan P,Yan S,Wang Y,Du Q,Chang Z

    更新日期:2017-02-01 00:00:00

  • Ameliorative effect of N-acetyl cysteine on alpha-cypermethrin-induced pulmonary toxicity in male rats.

    abstract::Alpha-cypermethrin (α-CYP) is one of the most widely used insecticides. It may become an air pollutant and adversely affect the health. The present study was designed to determine whether treatment with N-acetyl cysteine (NAC), a well-known antioxidant, can be useful for the management of the deleterious effects of α-...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Arafa MH,Mohamed DA,Atteia HH

    更新日期:2015-01-01 00:00:00

  • Prepubertal exposure to low doses of sodium arsenite impairs spermatogenesis and epididymal histophysiology in rats.

    abstract::For the first time, juvenile toxicity of inorganic arsenic (As) was investigated in male rats, focusing on reproductive effects. As is a metalloid naturally occurring in the environment, being the inorganic forms the most toxics. Contaminated drinking water and agricultural products are the main prospectors of intoxic...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: da Cunha de Medeiros P,Samelo RR,Silva APG,da Silva Araujo Santiago M,Duarte FA,de Castro ÍB,Perobelli JE

    更新日期:2019-01-01 00:00:00

  • Analysis of long non-coding RNA involved in atrazine-induced testicular degeneration of Xenopus laevis.

    abstract::Long non-coding RNA (lncRNA) plays a critical role in male germline development. Atrazine (AZ) as an environmental endocrine disrupting chemical (EDCs) can induce male reproductive toxicity in amphibians. Our previous studies demonstrated that AZ can alter gene and circular RNA (circRNA) expression of damaged testes i...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Sai L,Qu B,Zhang J,Liu J,Jia Q,Bo C,Zhang Y,Yu G,Han R,Peng C

    更新日期:2019-04-01 00:00:00

  • Identification of toxicants from marine sediment using effect-directed analysis.

    abstract::Effect-directed analysis (EDA) has been reported to be a powerful tool for the identification of the responsible toxicants in contaminated, hazardous environmental samples. The aim of this study was to investigate whether it also is possible to use currently available EDA methodology to identify potentially relevant t...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Grote M,Brack W,Altenburger R

    更新日期:2005-10-01 00:00:00

  • Suppression of reactive oxygen species-mediated ERK and JNK activation sensitizes dihydromyricetin-induced mitochondrial apoptosis in human non-small cell lung cancer.

    abstract::Nonsmall cell lung cancer (NSCLC) is the most common type of lung cancer with a high mortality rate and still remains a therapeutic challenge. A strategy for targeting NSCLC is to identify agents that are effective against NSCLC cells while sparing normal cells. Dihydromyricetin (DHM) is the major flavonoid component ...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Kao SJ,Lee WJ,Chang JH,Chow JM,Chung CL,Hung WY,Chien MH

    更新日期:2017-04-01 00:00:00

  • G-CSF administration attenuates brain injury in rats following carbon monoxide poisoning via different mechanisms.

    abstract::Acute severe carbon monoxide (CO) poisoning induces hypoxia that leads to cardiovascular and nervous systems disturbances. Different complex mechanisms lead to CO neurotoxicity including lipid peroxidation, inflammatory and immune-mediated reactions, myelin degeneration and finally neuronal apoptosis and necrosis. Gra...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Ghorbani M,Mohammadpour AH,Abnous K,Movassaghi AR,Sarshoori JR,Shahsavand S,Hashemzaei M,Moallem SA

    更新日期:2017-01-01 00:00:00

  • ISTA13-catecholamine toxicity and metabolism in the ciliated protozoan, Tetrahymena pyriformis.

    abstract::A high throughput culture methodology of unicellular eukaryote Tetrahymena pyriformis, strain GL were used for the determination of catecholamines toxicity and their metabolism. Catecholamines exhibited acute toxicity to Tetrahymena cells where dopamine and L-DOPA showed higher toxic potential of EC(10) (0.39 and 0.63...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Ud-Daula A,Pfister G,Schramm KW

    更新日期:2009-12-01 00:00:00

  • Hematotoxic and hepatotoxic effects of dichlorvos at sublethal dosages in rats.

    abstract::The present study was designed to understand the effects of sublethal concentrations of dichlorvos (DIC) on hematological constituent [red blood corpuscles, white blood corpuscles (WBC), mean cell volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, platelet counts, hemoglobin and hematocrit...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Celik I,Yilmaz Z,Turkoglu V

    更新日期:2009-04-01 00:00:00

  • Microcystin-LR induces protein phosphatase 2A alteration in a human liver cell line.

    abstract::Microcystin-LR (MC-LR) is a potent inhibitor of protein phosphatases 1 and 2A, and has potent hepatotoxicity and tumor promotion activity. Numerous studies on MC-LR toxicity have been conducted in rat hepatocytes, but few studies of the effects of microcystins on human hepatocytes have been done. In this study, HL7702...

    journal_title:Environmental toxicology

    pub_type: 杂志文章


    authors: Sun Y,Zheng Q,Sun YT,Huang P,Guo ZL,Xu LH

    更新日期:2014-11-01 00:00:00