Abstract:
:For the first time, juvenile toxicity of inorganic arsenic (As) was investigated in male rats, focusing on reproductive effects. As is a metalloid naturally occurring in the environment, being the inorganic forms the most toxics. Contaminated drinking water and agricultural products are the main prospectors of intoxication for general population. In the present study, Wistar male rats (21 days old) were distributed into three groups (n = 10/group): control (received vehicle-filtered drinking water), As1 (received AsNaO2 at 0.01 mg L-1 ) and As2 (received AsNaO2 at 10 mg L-1 ). The animals were euthanized on PND 53. Testicular damages increased in As1 and As2 compared to control (ie, presence of vacuolization, acidophilic cells, and epithelium degeneration). Testicular interstitium of As1 and As2 presented fluid's increase and intense inflammatory infiltration. In the epididymis there was reduction of sperm amount in the lumen, besides epithelium areas presenting cribriform aspect in As1 and As2, exfoliation of cells in the light (in As1) and vacuoles (in As2). In epididymis interstitium, inflammatory infiltrates were observed in initial segment of As1 and As2. AsNaO2 changed immunolabeling pattern for androgen receptor in epididymis of As2, although serum testosterone levels was statistically comparable to control. Mass spectrometry revealed higher As concentrations in testis and epididymis of As2 compared to As1 and Control. These results indicate compromise of spermatogenesis and epididymal histophysiology in AsNaO2 -treated animals, possibly impairing sperm quality and fertility in long-term, even at low levels of exposure. Investigations about the reversibility of reproductive damages are necessary to better understand the mechanisms of As reproductive toxicity.
journal_name
Environ Toxicoljournal_title
Environmental toxicologyauthors
da Cunha de Medeiros P,Samelo RR,Silva APG,da Silva Araujo Santiago M,Duarte FA,de Castro ÍB,Perobelli JEdoi
10.1002/tox.22660subject
Has Abstractpub_date
2019-01-01 00:00:00pages
83-91issue
1eissn
1520-4081issn
1522-7278journal_volume
34pub_type
杂志文章abstract::Toxicity of lead on male reproductive functions has raised wide public concern as environmental lead contamination remains common worldwide. Conflicting and controversial data are available regarding effects of lead on male fertility. More importantly, our knowledge on effects of lead on sperm DNA integrity is signifi...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22545
更新日期:2018-05-01 00:00:00
abstract::Tributyltin (TBT), a well-known endocrine disruptor, is an omnipresent environmental pollutant and is explicitly used in many industrial applications. Previously we have shown its neurotoxic potential on cerebral cortex of male Wistar rats. As the effect of TBT on other brain regions is not known, we planned this stud...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22009
更新日期:2015-12-01 00:00:00
abstract::Cardiomyocyte apoptosis is the major risk factor for the development of heart failure (HF). The purpose of this study was to evaluate the effects of Gamma-aminobutyric acid (GABA) tea on hypertension-induced cardiac apoptotic pathways in spontaneously hypertensive rats (SHR). In order to reveal the mechanisms, 36 male...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22565
更新日期:2018-07-01 00:00:00
abstract::Sulfur dioxide (SO2 ) is a ubiquitous air pollutant. The previous studies have documented the adverse effects of SO2 on nervous system health, suggesting that acutely SO2 inhalation at high concentration may be associated with neurotoxicity and increase risk of hospitalization and mortality of many brain disorders. Ho...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22093
更新日期:2016-07-01 00:00:00
abstract::Melamine is a heterocyclic, aromatic amine and nitrogen-enriched environmental toxicant, found in not only adulterated foodstuffs but also industrial household tableware and paints. Previous studies demonstrated adverse effects of high-dose melamine on human infants and pregnant animals, but effects of low-dose melami...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22218
更新日期:2017-01-01 00:00:00
abstract::Crude extract of Rheum palmatum L (CERP) has been used to treat different diseases in the Chinese population for decades. In this study, we investigated the effects of CERP on LS1034 human colorectal cancer cells in vitro and also examined possible mechanisms of cell death. Flow cytometric assays were used to measure ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21827
更新日期:2014-09-01 00:00:00
abstract::Particulate matter 2.5 (PM2.5)-induced pulmonary inflammation has become a public concern in recent years. In which, the activation of the NLRP3/caspase-1 pathway was closely related to the inflammatory response of various diseases. However, the promotion effect of the NLRP3/caspase-1 pathway on PM2.5-induced pulmonar...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.23035
更新日期:2020-09-30 00:00:00
abstract::Oral cancer is one of the cancer-related diseases in human populations and its incidence rates are rising worldwide. Fisetin, a flavonoid from natural products, has been shown to exhibit anticancer activities in many human cancer cell lines but the molecular mechanism of fisetin-induced apoptosis in human oral cancer ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22396
更新日期:2017-06-01 00:00:00
abstract::Andrographolide, the main bioactive component of the medicinal plant Andrographis paniculata, has been shown to possess potent anti-inflammatory activity. Endothelin 1 (ET-1), a potent vasoconstrictor peptide produced by vascular endothelial cells, displays proinflammatory property. Hypoxia-inducible factor 1α (HIF-1α...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22293
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVES:We evaluated the role of oxidative stress in Sudan IV-induced DNA damage, using human liver-derived HepG2 cells. METHODS:The DNA damaging effects of Sudan IV in HepG2 cells were evaluated by alkaline single cell gel electrophoresis assay and micronucleus test (MNT). To clarify the underlying mechanisms, we ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20558
更新日期:2011-06-01 00:00:00
abstract::Aspartame is one of the most common consumed artificial sweeteners utilized in many food products and beverages. It has been indicated that long-term consumption of aspartame leads to reproductive toxicity but its mechanism is not well-clear. In this study we investigated mechanism of aspartame-induced reproductive to...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.23028
更新日期:2021-02-01 00:00:00
abstract::Modulation of microcystin production has been extensively studied in both batch and continuous cultures. Positive correlations with medium nitrogen, medium phosphorous, light intensity, inorganic carbon availability, and growth rate have been reported. Negative correlations have been reported between microcystin conte...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20106
更新日期:2005-06-01 00:00:00
abstract::Renal cell carcinoma (RCC) is the most common type of kidney cancer in adults and the major cause of mortality in urological cancer. Most patients with RCC are asymptomatic until the disease is advanced and unresectable. In this situation, systemic therapy with immunotherapy or molecularly targeted therapy agents play...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22411
更新日期:2017-07-01 00:00:00
abstract::Metals such as lead (Pb), magnesium (Mg), and iron (Fe) are ubiquitous in the environment as a result of natural occurrence and anthropogenic activities. Although Mg, Fe, and others are considered essential elements, high level of exposure has been associated with severe adverse health effects including cardiovascular...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22014
更新日期:2015-12-01 00:00:00
abstract::As a widely used plasticizer in industry, di-2-ethylhexylphthalate (DEHP) can cause testicular toxicity, yet little is known about the potential mechanism. In this study, DEHP exposure dramatically inhibited cellviability and induced apoptosis of mouse GC-1 spg cells. Furthermore, DEHP significantly increased the leve...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22866
更新日期:2020-02-01 00:00:00
abstract::Tributyltin (TBT) and dibutyltin (DBT) are widespread environmental contaminants found in food, beverages, and human blood samples. Both of these butyltins (BTs) interfere with the ability of human natural killer (NK) cells to lyse target cells and alter secretion of the pro-inflammatory cytokine tumor necrosis factor...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21932
更新日期:2015-05-01 00:00:00
abstract::Increasing use of pesticides all over the world makes it necessary to reveal the toxic risk in populations of nontargeted organisms. Bendiocarb is one of the 12 insecticides recommended by the World Health Organization for use in malaria control in Africa, and is used against a variety of insects. The liver has an imp...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21887
更新日期:2015-02-01 00:00:00
abstract::Adrenomedullin (AdM) is synthesized and secreted by a number of cells and tissue. AdM is a potent vasodilator but it is also considered a neuromodulator, an angiogenic factor, and a hormone regulator. AdM possess antiapoptotic, antioxidant, and antimicrobial properties. Heavy metals such as cadmium and lead are found ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20430
更新日期:2009-06-01 00:00:00
abstract::Colorectal cancer (CC) is an important human malignancy with high cancer related death worldwide. The chemotherapy using doxorubicin hydrochloride is one of the most common cancer therapeutic methods. However, drug resistance lowers the treatment efficacy in CC patients. The combination therapies seem to be more promi...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.23105
更新日期:2021-01-28 00:00:00
abstract::Toxicants can perturb cellular homeostasis by modifying phosphorylation-based signaling. In the present study, we examined the effects of cerulein, an inducer of acute pancreatitis, on keratin 8 (K8) phosphorylation. We found that cerulein dose-dependently induced K8 phosphorylation and perinuclear reorganization in P...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22186
更新日期:2016-12-01 00:00:00
abstract::Females are born with a finite number of oocyte-containing follicles and ovary damage results in reduced fertility. Cadmium accumulates in the reproductive system, damaging it, and the cigarette smoke is a potential exposure route. Natural therapies are relevant to health benefits and disease prevention. This study ve...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22225
更新日期:2017-01-01 00:00:00
abstract::The aim of the study was to investigate the early effect of acute dichlorodiphenyltrichloroethane (DDT) exposure on the methylation status of the promoter region of two tumor suppressor genes: p53 and p16(INK4a) (p16) in rat liver. We analyzed their transcript and protein expression profiles concurrently with the exam...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22071
更新日期:2016-05-01 00:00:00
abstract::Liver is one of the major target organs of arsenic toxicity and carcinogenesis. Nuclear factor (erythroid-2 related) factor 2 (Nrf2) is a redox-sensitive transcription factor, regulating critically cellular defense responses against the toxic metallic arsenic in many cell types and tissues. This study was conducted to...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20731
更新日期:2013-07-01 00:00:00
abstract::Long non-coding RNA (lncRNA) plays a critical role in male germline development. Atrazine (AZ) as an environmental endocrine disrupting chemical (EDCs) can induce male reproductive toxicity in amphibians. Our previous studies demonstrated that AZ can alter gene and circular RNA (circRNA) expression of damaged testes i...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22704
更新日期:2019-04-01 00:00:00
abstract::To evaluate the allergic effect of airborne particulate matter (PM) on the airway, separated soluble supernatant (Sup) and insoluble precipitate (Pre) in suspended PM were inoculated into NC/Nga mice with a high sensitivity for mite allergens. Sup, Pre, or both Sup and Pre with or without pronase treatment were inocul...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21791
更新日期:2014-06-01 00:00:00
abstract::The risk presented by β-blockers on aquatic organisms remains uncertain, particularly given the enantiospecific differences in toxicity of chiral β-blockers. In this study, the toxicity of two β-blockers, propranolol and metoprolol, was determined. The 96-h LC50 of propranolol in the zebrafish larvae was 2.48 mg/L, wh...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21867
更新日期:2014-12-01 00:00:00
abstract::Sick building syndrome (SBS) is a set of several clinically recognizable symptoms reported by occupants of a building without a clear cause. Neuropathy target esterase (NTE) is a membrane bound serine esterase and its reaction with organophosphates (OPs) can lead to OP-induced delayed neuropathy (OPIDN) and nerve axon...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21839
更新日期:2014-10-01 00:00:00
abstract::Chlorpyrifos (CPF) is one of the most widely used organophosphorus, which has spurred renewed interest. This study was conducted to investigate the protective effect of ziziphora tenuior extract against CPF-induced liver and lung toxicity. This study conducted 8-week rat sub-chronic toxicity study and then the effect ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22432
更新日期:2017-09-01 00:00:00
abstract::Safrole is one of important food-borne phytotoxin that exhibits in many natural products such as oil of sassafras and spices such as anise, basil, nutmeg, and pepper. This study was performed to elucidate safrole-induced apoptosis in human tongue squamous carcinoma SCC-4 cells. The effect of safrole on apoptosis was m...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20658
更新日期:2012-07-01 00:00:00
abstract::Oral submucous fibrosis (OSF) has been indicated as one of the oral potentially malignant disorders. Epidemiological studies have attributed this pathological fibrosis to the habit of areca nuts chewing, which causes chronic inflammation and persistent activation of myofibroblasts in the oral cavity. Hence, it is cruc...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22489
更新日期:2018-01-01 00:00:00