解剖学和形态学
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听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
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神经系统科学
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营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
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药理学和药剂学
生理学
基本医疗保健
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放射学,核医学和医学成像
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热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::In prospective studies, increased levels of cardiolipin-biding antibodies and autoantibodies to oxidized low-density lipoprotein (LDL) have been observed in patients with myocardial infarction (MI). These findings suggest that antiphospholipid antibodies may contribute to the development of MI. The 'oxidative-modifica...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/096120339800700229
更新日期:1998-01-01 00:00:00
abstract::With the use of low-dose heparin, fetal survival of aPL pregnancies is 70-80%, but prematurity and intrauterine growth restriction are common. It is likely, but not proven, that dysregulated placental coagulation and resultant vasculopathy are the cause of fetal loss. Details of dysregulated coagulation remain to be d...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/096120339800700219
更新日期:1998-01-01 00:00:00
abstract::Prothrombin is a common antigenic target of antiphospholipid antibodies, since anti-prothrombin antibodies are detected in about 50-90% of the patients. To allow proper immune recognition, prothrombin must be adsorbed on suitable anionic surfaces. The epitope(s) have not yet been identified: the majority of anti-proth...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/096120339800700209
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVE:To investigate the prevalence and characteristics of anti-endothelial cell antibodies (AECA) in a large cohort of patients with several well defined systemic autoimmune diseases, in order to determine their relationship with the clinical and laboratory features of these diseases. METHODS:Clinical and laborat...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339700600608
更新日期:1997-01-01 00:00:00
abstract::With a cross sectional study of 465 consecutive systemic lupus erythematosus (SLE) patients tested for 13 autoantibodies (Aab) and two idiotypes we determined the prevalence of Aab according to disease activity, both general and at particular organ systems. Seventy seven percent of SLE sera had at least one Aab and 56...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339700600503
更新日期:1997-01-01 00:00:00
abstract::We describe a case of active systemic lupus erythematosus (SLE) complicated with a large amount of pericardial effusion with diastolic collapse of right ventricle suggestive of tamponade. Isolates from surgical drainage of pericardial fluid showed Acinetobacter baumannii exhibiting multiple antibiotics resistance. Des...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/096120339700600513
更新日期:1997-01-01 00:00:00
abstract::We studied IgG and IgM anticardiolipin antibodies (aCL) by an ELISA method in 80 Mexican systemic lupus erythematosus (SLE) patients and 378 of their first degree relatives. Sixty five percent of SLE patients and 16% of their relatives were positive for aCL. We also determined allele and haplotype frequencies of Major...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339700600108
更新日期:1997-01-01 00:00:00
abstract::The effect of beta 2glycoprotein I (beta 2GPI) and human monoclonal anticardiolipin antibody (aCL) on the protein S/C4b-binding protein (C4BP) system was evaluated. The binding of C4BP to protein S was assessed by ELISA in the presence of beta 2GPI with/without human monoclonal aCL. beta 2GPI downregulated the binding...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339700600403
更新日期:1997-01-01 00:00:00
abstract::The pathogenesis and therapy of shrinking lungs syndrome in patients with systemic lupus erythematosus remains controversial. It has been previously reported that corticosteroid treatment can be effective. We report a patient with shrinking lungs syndrome who presented a good response to inhaled beta-agonist therapy. ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339700600413
更新日期:1997-01-01 00:00:00
abstract::We describe a patient with rheumatoid arthritis (RA) whose sera contained a high titre of an antibody targeting cytoplasmic ribosomal P proteins (anti-P). This association preceded by 6 years the development of serological and clinical manifestations of systemic lupus erythematosus (SLE). The clinical significance of ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339700600910
更新日期:1997-01-01 00:00:00
abstract::Cutaneous manifestations of lupus erythematosus (LE) are, usually, characteristic enough to permit an easy diagnosis. However, some patients may present less typical lesions, associated or not to the classic ones. Therefore, irrespectively of the variety of LE (acute, subacute and chronic), in absence of the typical b...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/096120339700600207
更新日期:1997-01-01 00:00:00
abstract::The relationship between disease activity, cumulative damage and self-reported quality of life was examined in 96 patients with Systematic Lupus Erythematosus (SLE). Disease activity was measured by the SLE Disease Activity Index (SLEDAI) and cumulative damage by the Systematic Lupus International Cooperating Clinics/...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339700600305
更新日期:1997-01-01 00:00:00
abstract::Atherosclerosis may represent a significant cause of death and morbidity in patients with systemic lupus erythematosus. Coronary involvement is more premature in lupus patients. We present the case of a young woman diagnosed with SLE at the age of 20 years who had a myocardial infarction at age 29 years. We review the...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339700600704
更新日期:1997-01-01 00:00:00
abstract::Sera from healthy individuals, relatives of lupus patients, and lupus patients with active disease and in remission were screened for IgG and IgM antibodies to ssDNA and dsDNA. The serum samples were also separated into IgG and IgM fractions which were screened for DNA reactivity at dilutions equivalent to those used ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339600500604
更新日期:1996-12-01 00:00:00
abstract::Due to recent acquisitions, diagnostic criteria for the antiphospholipid/cofactors syndrome need to be improved. In the absence of a "common biological denominator", the best approach should be based on a scoring system mixing clinical and immunological items. APS might be composed of different biological subsets char...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/096120339600500504
更新日期:1996-10-01 00:00:00
abstract::Endothelial and/or platelet activation likely initiates thrombus formation. Whether antiphospholipid antibody (aPL) is an activator, a toxic response, or a protective response is not clear, nor is it certain whether aPL is germ-line encoded or antigen-driven. The pregnancy model is particularly informative. Alternativ...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/096120339600500514
更新日期:1996-10-01 00:00:00
abstract::Utilizing this unique animal model of thrombosis we demonstrated that human (IgG, IgM or IgA) polyclonal and monoclonal antiphospholipid antibodies derived from APS patients have a significant enhancing effect on thrombus formation. This effect is reversed by treatment of the mice with hydroxychloroquine (plaquenil). ...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/096120339600500524
更新日期:1996-10-01 00:00:00
abstract::Autoantibodies to phospholipids other than cardiolipin have received less attention, to date, than anti-cardiolipin antibodies. This review focuses on these antibodies and potential roles for both phospholipid and protein in their reactivity. We review data in the literature indicating that antibodies to phosphatidyle...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/096120339600500534
更新日期:1996-10-01 00:00:00
abstract::Seventeen families, in which the diagnosis of SLE could be verified in two relatives, were included in the study. The diagnosis was made according to the revised 1982 ARA criteria. We compared the 34 cases of familial SLE in these 17 families with 34 non-familial SLE controls matched for age, sex, ethnicity and durati...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339600500408
更新日期:1996-08-01 00:00:00
abstract:OBJECTIVE:To examine the potential immunologic mechanism and involvement of antiphospholipid antibodies in the pathogenesis of heart valve lesions in patients with the antiphospholipid syndrome (APS). METHODS:Immunoperoxidase and immunofluorescence staining methods were used to evaluate 13 heart valve specimens derive...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339600500306
更新日期:1996-06-01 00:00:00
abstract::Rheumatoid Arthritis (RA) is a chronic disease with significant morbidity and functional disability. The traditional treatment for RA relied on the use of NSAIDs early in the disease course, followed by disease-modifying agents later. More recently, the disease-modifying anti-rheumatic drugs (DMARDs) have become the m...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:
更新日期:1996-06-01 00:00:00
abstract::'Antiphospholipid' (aPL) antibodies are of clinical importance because of their strong association with vascular thrombosis, recurrent pregnancy loss, thrombocytopenia and other clinical manifestations like livedo reticularis, chorea and cardiac valvular disease. While aPL antibodies have traditionally been thought to...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/096120339600500212
更新日期:1996-04-01 00:00:00
abstract::The metabolism of poly(ADP-ribose) in peripheral blood mononuclear (PBM) cells was studied in 13 patients with systemic lupus erythematosus (SLE) and in 12 age and sex matched controls. Poly(ADP-ribose) polymerase activity was measured as the net accumulation of ADP-ribose polymers during the conversion of 32P-NAD to ...
journal_title:Lupus
pub_type: 临床试验,杂志文章
doi:10.1177/096120339600500105
更新日期:1996-02-01 00:00:00
abstract::The objective of this study was to determine whether anticardiolipin antibodies (ACL) in SLE patients are associated with a specific pattern of lupus nephritis and/or with renal microvascular changes. Patients with SLE, followed prospectively between June 1991-May 1994 at The Wellesley Hospital Lupus Clinic, who under...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339600500113
更新日期:1996-02-01 00:00:00
abstract::We investigated the clinical significance of IgG phospholipid-dependent anti-beta 2-glycoprotein I (beta 2-GPI) antibodies in patients with SLE. The study population consisted of 140 patients with SLE. Sera were examined for IgG phospholipid-dependent anti-beta 2-GPI antibodies by ELISA. IgG phospholipid-dependent ant...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339500400609
更新日期:1995-12-01 00:00:00
abstract::We have previously shown that elevation of anticardiolipin antibodies (aCL) at the first prenatal visit is associated with increased fetal loss in normal pregnancy. The variation in aCL levels during normal pregnancy has not been established. To examine this question we measured IgG, IgM and IgA aCL levels five times ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339500400506
更新日期:1995-10-01 00:00:00
abstract::We report a woman with systemic lupus erythematosus (SLE) with diffuse proliferative glomerulonephritis and anti-dsDNA antibodies whose serum contained autoantibodies specific for the phosphorylated form of RNA polymerase II (RNAP IIO), Su and ribosomal P antigen, as well as anti-topoisomerase I antibodies, a marker f...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339500400414
更新日期:1995-08-01 00:00:00
abstract::To study whether monoclonal anticardiolipin antibodies (aCL), derived from patients with antiphospholipid syndrome (APS), have similar pathogenic potential, we have employed an experimental model of antiphospholipid syndrome. Monoclonal aCL were produced by the combined method of EBV transformation and somatic cell hy...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339500400307
更新日期:1995-06-01 00:00:00
abstract::Lymphocytic vasculitis (LV) characterises systemic lupus erythematosus (SLE) and this potentially reversible lesion, which may be subclinical, may imply overt systemic disease activity. Needle quadriceps muscle biopsy was performed in 26 unselected patients with SLE and the presence of LV in these muscle specimens was...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339500400213
更新日期:1995-04-01 00:00:00
abstract::Recent studies have suggested an association between primary antiphospholipid syndrome (PAPS), antiphospholipid antibodies and some major histocompatibility complex (MHC) antigens. We have studied the relationship between MHC class II antigens and PAPS in 19 patients from the south of Spain. Univariant analysis showed...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339500400111
更新日期:1995-02-01 00:00:00
abstract::This brief review is focused on those heavy metals (cadmium, gold and mercury) that have strong associations with autoimmunity. Cadmium treatment of rats and mice results in autoimmune responses that vary with species and inbred strain of animals. However, there is no solid evidence demonstrating that the renal pathol...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/096120339400300604
更新日期:1994-12-01 00:00:00
abstract::We studied the effect of beta 2-GPI on binding of antibodies in sera from patients with leprosy and patients with the antiphospholipid syndrome (APS) to CL in enzyme-linked immunosorbent assays (ELISAs). Increased levels of IgG aCL were detected in 59 of 61 leprosy patients' sera by the standard aCL-ELISA in the prese...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339400300615
更新日期:1994-12-01 00:00:00
abstract::Valvular replacement was performed in a patient with primary antiphospholipid syndrome and severe mitral insufficiency. The valvular tissue presented thrombotic phenomena and fibrosis with minimum inflammatory component. ...
journal_title:Lupus
pub_type: 杂志文章
doi:
更新日期:1994-10-01 00:00:00
abstract::The mouse model described in this study offers a unique method of determining the characteristics and mechanism(s) of action of aCL antibodies in thrombosis in vivo. In addition, this animal model enables the study of the kinetics of formation and dissolution of thrombus, as well as clot area, to be studied in a dynam...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/096120339400300408
更新日期:1994-08-01 00:00:00
abstract::This work describes the development of sideroblastic anemia (SA) during the clinical activity of systemic lupus erythematosus (SLE) in two patients. The cases refer to two women with SLE who developed SA during a relapse of the illness. Both patients fulfilled at least four criteria of the American Association of Rheu...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339400300305
更新日期:1994-06-01 00:00:00
abstract::Poly(ADP-ribose) metabolism is altered in patients with SLE. In order to localize the defect, the levels of poly(ADP-ribose) polymerase-specific mRNA were measured from dot blots of total RNA from peripheral blood lymphocytes. In this preliminary study, eleven patients with SLE and two with antiphospholipid syndrome w...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339400300210
更新日期:1994-04-01 00:00:00
abstract::The purpose of the present study was to evaluate patients with the antiphospholipid syndrome with particular attention to their initial clinical features, final diagnoses and the course of thrombotic events in association with therapy. The methodology applied was the following: retrospective analysis of 30 patient fil...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339400300206
更新日期:1994-04-01 00:00:00
abstract::We describe a human monoclonal antibody designated WRI 176 beta and a common idiotype that it carries. This antibody was derived from the spleen of a patient with SLE. WRI 176 is an IgM kappa monoclonal reacting with ssDNA, dsDNA, poly(dT) and it is likely that mAb WRI 176 beta is a representative of the so-called nat...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339400300105
更新日期:1994-02-01 00:00:00
abstract::Anti-idiotypic antibody and its F(ab')2 fragments prepared from pooled normal human IgG had a partial inhibitory effect on the spontaneous in vitro secretion of anti-DNA antibodies from blood mononuclear cells of lupus patients. The inhibitory effect was specific for anti-DNA secretion as the anti-idiotype failed to i...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339300200607
更新日期:1993-12-01 00:00:00
abstract::Tumor necrosis factor alpha (TNF alpha) and interleukin-6 (IL-6) play a main role in inducing acute phase protein production by hepatocytes. This study describes the serum levels of TNF alpha and IL-6 in relation to serum levels of C-reactive protein (CRP) and alpha 1-acid glycoprotein (alpha 1AG) in three systemic lu...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339300200605
更新日期:1993-12-01 00:00:00