Antiphospholipid antibodies in an in vivo thrombosis model in mice.

abstract：:The effect of beta 2glycoprotein I (beta 2GPI) and human monoclonal anticardiolipin antibody (aCL) on the protein S/C4b-binding protein (C4BP) system was evaluated. The binding of C4BP to protein S was assessed by ELISA in the presence of beta 2GPI with/without human monoclonal aCL. beta 2GPI downregulated the binding...

journal_title：Lupus

authors： Atsumi T,Khamashta MA,Ames PR,Ichikawa K,Koike T,Hughes GR

更新日期：1997-01-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an immune-mediated disease that is responsive to suppression or modulation of the immune system. Patients with SLE who experience persistent multiorgan dysfunction, despite standard doses of intravenous cyclophosphamide (Cy), represent a subset of patients at high risk of early de...

journal_title：Lupus

authors： Lisukov IA,Sizikova SA,Kulagin AD,Kruchkova IV,Gilevich AV,Konenkova LP,Zonova EV,Chernykh ER,Leplina OY,Sentyakova TN,Demin AA,Kozlov VA

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:We analyzed data of lupus nephritis (LN) patients to find parameters that can predict remission. METHODS:Sixty-four LN patients who were diagnosed with class III, IV, V or V + III/IV by renal biopsy and were followed up for more than six months in our center were enrolled retrospectively. Receiver operating ...

journal_title：Lupus

authors： Liu G,Wang H,Le J,Lan L,Xu Y,Yang Y,Chen J,Han F

更新日期：2019-03-01 00:00:00

abstract：:This study investigates specificity, sensitivity and concomitant presence of antibodies against histone H1 (H1), nucleosomes (NUC), chromatin (CHR) and dsDNA in patients with systemic lupus erythematosus (SLE), analyses their association with SLE disease activity and characterizes the immunodominant epitope reactivity...

journal_title：Lupus

authors： Schett G,Smole J,Zimmermann C,Hiesberger H,Hoefler E,Fournel S,Muller S,Rubin RL,Steiner G

更新日期：2002-01-01 00:00:00

abstract：:Congenital heart block occurs in fetuses of Ro/SSA and La/SSB positive women. To investigate the stability of maternal autoantibody levels during pregnancy, we followed Ro52, Ro60 and La autoantibody IgG level variation and Ro52 subclass profiles longitudinally in selected congenital heart block risk pregnancies. Seru...

journal_title：Lupus

authors： Strandberg L,Salomonsson S,Bremme K,Sonesson S,Wahren-Herlenius M

更新日期：2006-01-01 00:00:00

abstract：:Autoantibodies against prothrombin, including lupus anticoagulant antibodies (LAC), have been identified in patients with systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS). To identify the epitopes of LAC in patients with SLE and APS, we analyzed B cell epitopes of anti-prothrombin Abs. Prothrombi...

journal_title：Lupus

authors： Akimoto T,Akama T,Kono I,Sumida T

更新日期：1999-01-01 00:00:00

abstract：:To assess bladder function in systemic lupus erythematosus (SLE) patients with recurrent urinary tract infections (UTIs). A convenience sample of consecutive patients with SLE (American College of Rheumatology criteria), with recurrent UTIs (>/=3 events in the preceding 12 months), without history of central nervous s...

journal_title：Lupus

authors： Duran-Barragan S,Ruvalcaba-Naranjo H,Rodriguez-Gutierrez L,Solano-Moreno H,Hernandez-Rios G,Sanchez-Ortiz A,Ramos-Remus C

更新日期：2008-12-01 00:00:00

abstract：:The objective of this study was to determine the HLA class II associations of the anticardiolipin (aCL) and anti-beta2GPI (abeta2GPI) antibodies in a large series of European patients with systemic lupus erythematosus (SLE). A cohort of 577 European SLE patients was enrolled. aCL and abeta2GPI were measured by ELISA m...

journal_title：Lupus

authors： Galeazzi M,Sebastiani GD,Tincani A,Piette JC,Allegri F,Morozzi G,Bellisai F,Scorza R,Ferrara GB,Carcassi C,Font J,Passiu G,Smolen J,Papasteriades C,Houssiau F,Nebro AF,Ramon Garrido ED,Jedryka-Goral A,Marcolongo R

更新日期：2000-01-01 00:00:00

abstract：:Recent accumulated evidence suggests that prolactin (PRL) is an important immunomodulator and might have a role in the pathogenesis of systemic lupus erythematosus (SLE). Our aim was to assess the frequency of hyperprolactinemia in women with SLE and to evaluate its correlation with disease activity. PRL plasma levels...

journal_title：Lupus

authors： Jimena P,Aguirre MA,López-Curbelo A,de Andrés M,Garcia-Courtay C,Cuadrado MJ

更新日期：1998-01-01 00:00:00

abstract：:The objective of this study is to determine if digital vasculitis (DV), a clinical manifestation with a high systemic lupus erythematosus disease activity index (SLEDAI) score, is associated with lupus severity. DV and other clinical manifestations defined according to the SLEDAI were evaluated in 168 consecutive pati...

journal_title：Lupus

authors： Gomes C,Carvalho JF,Borba EF,Borges CT,Vendramini MB,Bueno C,Costa LP,Bonfá E

更新日期：2009-10-01 00:00:00

abstract：:The aim of this study was to evaluate traditional risk factors for coronary artery disease (CAD), homocysteine, anti-oxidized low-density lipoprotein (anti-oxLDL), anti-lipoprotein lipase (anti-LPL) and endothelin-1 (ET-1) in patients with primary anti-phospholipid syndrome (APS), furthermore verify possible associati...

journal_title：Lupus

authors： de Souza AW,Silva NP,de Carvalho JF,D'Almeida V,Noguti MA,Sato EI

更新日期：2007-01-01 00:00:00

abstract：:Objectives The carotid intima-media thickness (CIMT) and carotid arterial stiffness index (CASI) act as the surrogate markers of atherosclerosis. We aim to assess CIMT and CASI in pediatric systemic lupus erythematosus (SLE). Methods Patients ≤ 20 years old fulfilling diagnostic criteria for SLE were enrolled. Patient...

journal_title：Lupus

authors： Su-Angka N,Khositseth A,Vilaiyuk S,Tangnararatchakit K,Prangwatanagul W

更新日期：2017-08-01 00:00:00

abstract：:It is well known that women with systemic lupus erythematosus (SLE) who have antiphospholipid antibodies (aPL) are at increased risk for pregnancy loss. Additionally, other reproductive processes, such as unexplained infertility and implantation failure after in vitro fertilization and embryo transfer may be affected ...

journal_title：Lupus

authors： Balasch J,Cervera R

更新日期：2002-01-01 00:00:00

abstract：:A 26-year-old Japanese woman developed autoimmune pulmonary alveolar proteinosis (PAP) during glucocorticoid therapy for systemic lupus erythematosus (SLE). Intensive immunosuppressive therapy worsened the PAP. De-escalation of immunosuppressive therapy improved the PAP. Autoimmune PAP is rarely associated with system...

journal_title：Lupus

authors： Nagasawa J,Kurasawa K,Maezawa R,Owada T,Hanaoka R,Fukuda T

更新日期：2013-09-01 00:00:00

abstract：:The antiphospholipid syndrome (APS) is characterized by thrombosis and/or pregnancy morbidity in the presence of antiphospholipid antibodies (aPL). Among the thrombogenic mechanisms proposed, it has been suggested that aPL can stimulate tissue factor (TF) expression by endothelial cells (ECs) and monocytes. Moreover, ...

journal_title：Lupus

authors： López-Pedrera Ch,Buendía P,Aguirre MA,Velasco F,Cuadrado MJ

更新日期：2006-01-01 00:00:00

abstract：:Utilizing this unique animal model of thrombosis we demonstrated that human (IgG, IgM or IgA) polyclonal and monoclonal antiphospholipid antibodies derived from APS patients have a significant enhancing effect on thrombus formation. This effect is reversed by treatment of the mice with hydroxychloroquine (plaquenil). ...

journal_title：Lupus

authors： Pierangeli SS,Harris EN

更新日期：1996-10-01 00:00:00

abstract：:Systemic lupus erythematosus is the prototypic multi-system autoimmune disease characterized by the production of multiple autoantibodies. The development of disease depends on a genetic predisposition and exposure to environmental factors including UV light, drugs, and infections. The association of parasitic infecti...

journal_title：Lupus

authors： Zandman-Goddard G,Shoenfeld Y

更新日期：2009-11-01 00:00:00

abstract：:Intravenous immunoglobulin (IVIG) has a therapeutic potential in many autoimmune diseases. Based on its immune modulating and complement inhibiting effects, IVIG has been tested in systemic lupus erythematosus (SLE), but due to osmotic tubular injury caused by immunoglobulin-stabilizing sugar components, lupus nephrit...

journal_title：Lupus

authors： Racz Z,Nagy E,Rosivall L,Szebeni J,Hamar P

更新日期：2010-04-01 00:00:00

abstract：:Only recently Bartonella species have been recognized as important human pathogens. Cat scratch disease (CSD), caused by infection with Bartonella henselae, shows a steady increase in the number of cases throughout the world. We report a case of an 18-year-old woman with systemic lupus erythematosus (SLE) who presente...

journal_title：Lupus

authors： Gaubitz M,Herrmann M,Shahin M,Schotte H,Willeke P,Domschke W

更新日期：2001-01-01 00:00:00

abstract：INTRODUCTION:Complement activation is central to the pathogenesis of lupus nephritis (LN). Low serum complement C3 and C4, are traditionally used as markers of lupus disease activity in general and LN in particular. In this study we prospectively measured plasma and urine C3d and C4d, degradation products of C3 and C4 ...

journal_title：Lupus

authors： Ganguly S,Majumder S,Kumar S,Gupta R,Muhammed H,Shobha V,Aggarwal A,Misra R

更新日期：2020-11-01 00:00:00

abstract：:Lymphocytic vasculitis (LV) characterises systemic lupus erythematosus (SLE) and this potentially reversible lesion, which may be subclinical, may imply overt systemic disease activity. Needle quadriceps muscle biopsy was performed in 26 unselected patients with SLE and the presence of LV in these muscle specimens was...

journal_title：Lupus

authors： Lim KL,Lowe J,Powell RJ

更新日期：1995-04-01 00:00:00

abstract：:In 2012, the Systemic Lupus International Collaborating Clinics (SLICC) group published a new set of classification criteria for systemic lupus erythematosus (SLE). Studies applying these criteria to real-life scenarios have found either equal or greater sensitivity and equal or lower specificity to the 1997 ACR class...

journal_title：Lupus

authors： Ungprasert P,Sagar V,Crowson CS,Amin S,Makol A,Ernste FC,Osborn TG,Moder KG,Niewold TB,Maradit-Kremers H,Ramsey-Goldman R,Chowdhary VR

更新日期：2017-03-01 00:00:00

abstract：:The purpose of this study was to determine the prevalence and correlates of fibromyalgia (FM) in a prospective, multiethnic systemic lupus (SLE) cohort. A total of 266 SLE patients with disease duration of < or = 5 years at study entry were evaluated longitudinally for the presence of FM (per ACR criteria). Sociodemog...

journal_title：Lupus

authors： Friedman AW,Tewi MB,Ahn C,McGwin G Jr,Fessler BJ,Bastian HM,Baethge BA,Reveille JD,Alarcón GS,LUMINA Study Group.

更新日期：2003-01-01 00:00:00

abstract：:Q fever has extremely polymorphic features, and has been reported to be associated with positivity of several autoimmune antibodies. We report two cases of atypical Q fever with a clinical presentation highly suggestive of an inflammatory systemic disease with positivity of autoimmune antibodies, mimicking systemic lu...

journal_title：Lupus

authors： Durupt S,Puget M,Lega JC,Durieu I,Reynaud Q

更新日期：2017-01-01 00:00:00

abstract：:SLE is an autoimmune and polygenic disorder characterized by an accumulation and deposition of immune complexes. Several studies have indicated differential impact of FcgammaR polymorphism genotypes in different ethnic groups studied. The Fc receptor for IgG class IIA gene (FcgammaRIIA) occurs in two allelic forms. Th...

journal_title：Lupus

authors： Yap SN,Phipps ME,Manivasagar M,Tan SY,Bosco JJ

更新日期：1999-01-01 00:00:00

abstract：:The objective was to investigate the relation between serum levels of interferon-alpha (IFN-alpha), the activity of an endogenous IFN-alpha inducing factor (SLE-IIF), clinical and immunological disease activity as well as serum levels of antiretroviral antibodies in SLE. Serum levels of IFN-alpha were measured in seri...

journal_title：Lupus

authors： Bengtsson AA,Sturfelt G,Truedsson L,Blomberg J,Alm G,Vallin H,Rönnblom L

更新日期：2000-01-01 00:00:00

abstract：:The presence of antibodies against the complex of prothrombin and phosphatidylserine (aPS/PT) more significantly correlates with manifestations of antiphospholipid syndrome (APS) and with the presence of lupus anticoagulants (LA) than antibodies against prothrombin bound to oxygenated polystyrene (aPT-A). To investiga...

journal_title：Lupus

authors： Horita T,Ichikawa K,Kataoka H,Yasuda S,Atsumi T,Koike T

更新日期：2007-01-01 00:00:00

abstract：:Background Patients with systemic lupus erythematosus (SLE) may form clusters with clinical manifestations and autoantibodies. Objective The objective of this report is to study whether SLE patients with positive rheumatoid factor (RF) have a special clinical and/or serological profile. Methods A retrospective study o...

journal_title：Lupus

authors： Fedrigo A,Dos Santos TAFG,Nisihara R,Skare T

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVE:Systemic lupus erythematosus (SLE), an autoimmune condition with diverse clinical manifestations, is reported to have different expression in populations of different ancestry. Most previous studies compared patients of different ethnic groups from geographically distinct cohorts. In our study, we aimed to ch...

journal_title：Lupus

authors： Golder V,Connelly K,Staples M,Morand E,Hoi A

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare and life-threatening condition with poor prognosis in patients with antiphospholipid syndrome (APS). Pulmonary thromboendarterectomy (PTE) is the optimal surgical option for CTEPH. OBJECTIVES:This retrospective cohort study aimed to evaluate th...

journal_title：Lupus

authors： Li C,Zhao J,Liu S,Song W,Zhu J,Hua L,Wang Q,Li M,Zeng X,Zhao Y

更新日期：2018-12-01 00:00:00