Abstract:
:Utilizing this unique animal model of thrombosis we demonstrated that human (IgG, IgM or IgA) polyclonal and monoclonal antiphospholipid antibodies derived from APS patients have a significant enhancing effect on thrombus formation. This effect is reversed by treatment of the mice with hydroxychloroquine (plaquenil). In addition murine polyclonal and monoclonal anticardiolipin antibodies induced by active immunization with human beta 2-GP1 or human anticardiolipin antibodies showed to have thrombogenic properties in CD1 mice. Antibodies with antihuman beta 2-GP1 activity alone did not seem to affect thrombus formation.
journal_name
Lupusjournal_title
Lupusauthors
Pierangeli SS,Harris ENdoi
10.1177/096120339600500524subject
Has Abstractpub_date
1996-10-01 00:00:00pages
451-5issue
5eissn
0961-2033issn
1477-0962journal_volume
5pub_type
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