Mycobacteria and autoimmunity.

abstract：BACKGROUND:Antibodies to M-type phospholipase A2 receptor (a-PLA2R) have been identified in most patients with idiopathic membranous nephropathy, but the prevalence in membranous lupus nephritis (MLN) is still unclear. The objective of this study was to assess the prevalence of a-PLA2R antibodies in a large cohort of p...

journal_title：Lupus

authors： Garcia-Vives E,Solé C,Moliné T,Alvarez-Rios AM,Vidal M,Agraz I,Ordi-Ros J,Cortés-Hernández J

更新日期：2019-03-01 00:00:00

abstract：:The purpose of the present study was to evaluate patients with the antiphospholipid syndrome with particular attention to their initial clinical features, final diagnoses and the course of thrombotic events in association with therapy. The methodology applied was the following: retrospective analysis of 30 patient fil...

journal_title：Lupus

authors： Vlachoyiannopoulos PG,Tsiakou E,Chalevelakis G,Raptis SA,Moutsopoulos HM

更新日期：1994-04-01 00:00:00

abstract：:Anti-phospholipid antibodies are common in patients in the Hopkins' Lupus Cohort: 47% have anti-cardiolipin, 32.5% anti-beta(2)-glycoprotein I and 26% lupus anticoagulant (by dRVVT confirmatory testing). Systemic lupus erythematosus patients with the lupus anticoagulant at baseline have a 50% chance of a deep venous t...

journal_title：Lupus

authors： Petri M

更新日期：2010-04-01 00:00:00

abstract：:The use of TNF alpha (TNFalpha) inhibitors has made a strong impact on the management of rheumatoid and psoriatic arthritis, ankylosing spondylitis and Crohn disease. Side effects of these agents include the development of autoantibodies and a lupus-like syndrome (drug-related lupus, DRL). Here, a case of a patient wh...

journal_title：Lupus

authors： Kocharla L,Mongey AB

更新日期：2009-02-01 00:00:00

abstract：:Systemic lupus erythematosus may present with renal manifestations that frequently are difficult to categorize and lupus nephritis is an important predictor of poor outcome. The type and spectrum of renal injury may remain undiagnosed until full-blown nephritic and/or nephrotic syndrome appear with increased risk of e...

journal_title：Lupus

authors： Ortega LM,Schultz DR,Lenz O,Pardo V,Contreras GN

更新日期：2010-04-01 00:00:00

abstract：:In examining reasons for premature atherosclerosis in systemic lupus erythematosus (SLE), we previously reported low levels of the cholesterol transport protein apolipoprotein A1 (apoA1) in these patients, and specific antibodies to purified apoA1 were identified in the sera of 5 out of 30 lupus patients. The current ...

journal_title：Lupus

authors： Dinu AR,Merrill JT,Shen C,Antonov IV,Myones BL,Lahita RG

更新日期：1998-01-01 00:00:00

abstract：:The objective of this study was to determine whether there are differences in the prevalence, clinical and laboratory manifestations, and morbidity and mortality of systemic lupus erythematosus (SLE) between Aborigines and Caucasians in Central Australia. The medical records of all patients diagnosed with SLE upto Dec...

journal_title：Lupus

authors： Segasothy M,Phillips PA

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVES:To examine the immune cell profile in the bone marrow of systemic lupus erythematosus (SLE) patients and to assess its clinical relevance. METHODS:Sixteen bone marrow samples from 14 SLE patients were compared with seven healthy control samples. The numbers of immune cells and apoptotic cells in the bone ma...

journal_title：Lupus

authors： Park JW,Moon SY,Lee JH,Park JK,Lee DS,Jung KC,Song YW,Lee EB

更新日期：2014-09-01 00:00:00

abstract：:The Framingham risk score is widely used to identify patients at increased cardiovascular risk, and women with systemic lupus erythematosus (SLE) have a marked increased prevalence of cardiovascular events. Thus, we examined the hypothesis that cardiovascular risk scores would identify women with SLE who had asymptoma...

journal_title：Lupus

authors： Chung CP,Oeser A,Avalos I,Raggi P,Stein CM

更新日期：2006-01-01 00:00:00

abstract：PURPOSE:To describe the ocular and systemic manifestations associated with systemic lupus erythematosus (SLE) choroidopathy. METHODS:Three new cases of choroidopathy in patients with active SLE were described. Twenty-five published cases of lupus choroidopathy were summarized. RESULTS:There have been 28 cases of lupu...

journal_title：Lupus

authors： Nguyen QD,Uy HS,Akpek EK,Harper SL,Zacks DN,Foster CS

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Cognitive dysfunction (CD) is among the most common neuropsychiatric manifestations of systemic lupus erythematosus (SLE). There are two methods which have been used to detect CD in patients with SLE: traditional neuropsychological tests (NPT) and the Automated Neuropsychological Assessment Metrics (ANAM). B...

journal_title：Lupus

authors： Adhikari T,Piatti A,Luggen M

更新日期：2011-10-01 00:00:00

abstract：:It is well known that women with systemic lupus erythematosus (SLE) who have antiphospholipid antibodies (aPL) are at increased risk for pregnancy loss. Additionally, other reproductive processes, such as unexplained infertility and implantation failure after in vitro fertilization and embryo transfer may be affected ...

journal_title：Lupus

authors： Balasch J,Cervera R

更新日期：2002-01-01 00:00:00

abstract：:Tumor necrosis factor alpha (TNF alpha) and interleukin-6 (IL-6) play a main role in inducing acute phase protein production by hepatocytes. This study describes the serum levels of TNF alpha and IL-6 in relation to serum levels of C-reactive protein (CRP) and alpha 1-acid glycoprotein (alpha 1AG) in three systemic lu...

journal_title：Lupus

authors： Meijer C,Huysen V,Smeenk RT,Swaak AJ

更新日期：1993-12-01 00:00:00

abstract：:A 26-year-old Japanese female presented to us with a 2-year history of multiple arc-shaped erythematous lesions on her scalp and the right side of her forehead. Histopathological examination of two of the lesions showed lobular and septal panniculitis with deposits of IgG in the basement membrane zone. We diagnosed th...

journal_title：Lupus

authors： Tsuzaka S,Ishiguro N,Akashi R,Kawashima M

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:Systemic lupus erythematosus (SLE) is regarded as a prototype autoimmune disease because it can serve as a means for studying differences between ethnic minorities and sex. Traditionally, all Hispanics have been bracketed within the same ethnic group, but there are differences between Hispanics from Spain an...

journal_title：Lupus

authors： Hernández Cruz B,Alonso F,Calvo Alén J,Pego-Reigosa JM,López-Longo FJ,Galindo-Izquierdo M,Olivé A,Tomero E,Horcada L,Uriarte E,Erausquin C,Sánchez-Atrio A,Montilla C,Santos Soler G,Fernández-Nebro A,Blanco R,Rodríguez-Góm

更新日期：2020-01-01 00:00:00

abstract：:The contribution of the p53 Arg72Pro polymorphism in the development of systemic lupus erythematosus (SLE) remains controversial. We investigated the frequency of the p53 Arg72Pro genotype in patients with SLE (n = 155) and in controls (n = 150) in Poland. We found a weak contribution of the Arg/Arg genotype to the mo...

journal_title：Lupus

authors： Piotrowski P,Lianeri M,Mostowska M,Wudarski M,Chwalinska-Sadowska H,Jagodzinski PP

更新日期：2008-02-01 00:00:00

abstract：OBJECTIVE:YB current affiliation: Department of Pediatrics, Hadassah-Hebrew University Medical Center, Mount Scopus, Israel YB and MJS contributed equally to the study and should be regarded as joint first authors on this manuscript. Antiphospholipid syndrome (APS) may present with thrombosis and persistently elevated ...

journal_title：Lupus

authors： Berkun Y,Simchen MJ,Strauss T,Menashcu S,Padeh S,Kenet G

更新日期：2014-09-01 00:00:00

abstract：:Background Patients with systemic lupus erythematosus (SLE) may form clusters with clinical manifestations and autoantibodies. Objective The objective of this report is to study whether SLE patients with positive rheumatoid factor (RF) have a special clinical and/or serological profile. Methods A retrospective study o...

journal_title：Lupus

authors： Fedrigo A,Dos Santos TAFG,Nisihara R,Skare T

更新日期：2018-07-01 00:00:00

abstract：:In prospective studies, increased levels of cardiolipin-biding antibodies and autoantibodies to oxidized low-density lipoprotein (LDL) have been observed in patients with myocardial infarction (MI). These findings suggest that antiphospholipid antibodies may contribute to the development of MI. The 'oxidative-modifica...

journal_title：Lupus

authors： Vaarala O

更新日期：1998-01-01 00:00:00

abstract：:We report the case of a fetus with proliferative glomerulonephritis in the context of maternal systemic lupus erythematosus (SLE). The pattern of the renal lesions correspond to the class III of revisited WHO classification of glomerulonephritis in SLE. Amniotic fluid analysis showed a high level of albumin and the pr...

journal_title：Lupus

authors： Daïkha-Dahmane F,Bault JP,Molina-Gomes D,Hillion D,Ville Y

更新日期：2005-01-01 00:00:00

abstract：:Estrogens and their receptors may play a role in the pathogenesis of systemic lupus erythematosus. Genetic alterations in the exon 8-coding region of the estrogen receptor alpha alter the intracellular signalling of estrogens, leading in enhanced or diminished activity. We investigated whether genetic alterations in e...

journal_title：Lupus

authors： Kassi E,Vlachoyiannopoulos PG,Kominakis A,Kiaris H,Moutsopoulos HM,Moutsatsou P

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:We established a multi-centre online registry for primary Sjögren's syndrome (pSS) in China, and compared Chinese patients with those from other countries. METHODS:Data were from 87 rheumatology centres in 27 provinces. All 2986 patients had pSS according to the 2002 American-European Consensus Group or the...

journal_title：Lupus

authors： Xu D,Zhao S,Li Q,Wang YH,Zhao JL,Li MT,Zhao Y,Zeng XF

更新日期：2020-01-01 00:00:00

abstract：:In a 76-week, randomized controlled trial, patients received 100 mg LJP 394 or placebo weekly for 16 weeks followed by three 12-week treatment cycles of 50 mg LJP 394 or placebo weekly each separated by eight-week periods when no therapy was administered. Health-related quality of life (HRQOL) was assessed using SF-36...

journal_title：Lupus

authors： Strand V,Aranow C,Cardiel MH,Alarcón-Segovia D,Furie R,Sherrer Y,Tumlin J,Wallace DJ,Crawford B,LJP 394 Investigator Consortium.

更新日期：2003-01-01 00:00:00

abstract：:Mesenchymal stem cells have been applied to treat graft versus host disease as they have immunosuppressive ability and can overcome the major histocompatibility complex-histocompatibility barrier. The potential of allogeneic mesenchymal stem cells in treating systemic lupus erythematosus (SLE) was investigated in this...

journal_title：Lupus

authors： Liu F,Chen H,Chen T,Lau CS,Yu FX,Chen K,Chen HP,Pan RS,Chan GC,Zhang XY,Nie YJ

更新日期：2020-07-01 00:00:00

abstract：:We performed a prospective study to evaluate the efficacy and safety of low-dose cyclosporine A (CSA) treatment in paediatric lupus nephritis refractory to conventional therapy. Seven children with biopsy-proven Class III-IV lupus nephritis were treated with CSA (2-4 mg/kg/day) combined with low-dose prednisone for on...

journal_title：Lupus

authors： Baca V,Catalán T,Villasís-Keever M,Ramón G,Morales AM,Rodríguez-Leyva F

更新日期：2006-01-01 00:00:00

abstract：:We have explored the relationship between possible hemostatic changes and clinical manifestation of the systemic lupus erythematosus (SLE) as a function of greater or lesser disease activity according to Systemic Lupus Erythematosus Disease Activity Index-2000 (SLEDAI-2K) criteria. Endothelial injury and hypercoagulab...

journal_title：Lupus

authors： Cicarini WB,Duarte RCF,Ferreira KS,Loures CMG,Consoli RV,Neiva CLS,de Pádua PM,Nunes FFC,Alves LCV,Reis EA,Moreira CC,Guimarães TMPD,de Toledo VPCP,Carvalho MDG

更新日期：2020-02-01 00:00:00

abstract：:Objective The objective of this study was to describe the clinical and immunological pattern and disease outcome in Egyptian systemic lupus erythematosus patients. Patients and methods The medical records of 770 systemic lupus erythematosus patients who were followed from 2002-2015 at Kasr Alainy Hospital, Cairo Unive...

journal_title：Lupus

authors： Mahmoud GA,Shahin AA,Zayed HS,Moghazy A,Eissa BM

更新日期：2018-08-01 00:00:00

abstract：:Objective Adherence to medication has a major impact on treatment control and success especially in chronic diseases but often remains unrecognized. Besides clinical, socioeconomic, disease-related and treatment-related parameters, general and personal health beliefs, as well as perception of health, can affect adhere...

journal_title：Lupus

authors： Chehab G,Sauer GM,Richter JG,Brinks R,Willers R,Fischer-Betz R,Winkler-Rohlfing B,Schneider M

更新日期：2018-09-01 00:00:00

abstract：:Several studies have investigated the potential of various autoantibody tests in the diagnosis of systemic lupus erythematosus (SLE). Many lupus patients initially present with glomerulonephritis. In that clinical situation the main differential diagnosis are other forms of glomerulonephritis. In this study the diagno...

journal_title：Lupus

authors： Heidenreich U,Mayer G,Herold M,Klotz W,Stempfl Al-Jazrawi K,Lhotta K

更新日期：2009-12-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease with a complex pathogenesis. Published data have revealed that serum levels of proinflammatory cytokines are increased in SLE patients. The aim of our study was to evaluate whether monotherapy with chloroquine phosphate affects IL-1beta, IL-6, IL-18 and TNF-a...

journal_title：Lupus

authors： Wozniacka A,Lesiak A,Narbutt J,McCauliffe DP,Sysa-Jedrzejowska A

更新日期：2006-01-01 00:00:00