Abstract:
:The Framingham risk score is widely used to identify patients at increased cardiovascular risk, and women with systemic lupus erythematosus (SLE) have a marked increased prevalence of cardiovascular events. Thus, we examined the hypothesis that cardiovascular risk scores would identify women with SLE who had asymptomatic coronary atherosclerosis. Ninety-three women with SLE and 65 control subjects were studied. The Framingham score and a score for younger populations developed from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study were compared in both groups. Coronary atherosclerosis was ascertained by electron beam computed tomography. There were no significant differences in the median (interquartile range) Framingham [5 (2-10) compared to 7 (0-10), P = 0.88] and PDAY [15 (14-18) compared to 16 (13-18), P = 0.99] scores in patients with SLE and controls, respectively. Coronary atherosclerosis was associated with higher Framingham [12 (3-15) compared to 4 (1-8), P = 0.008] and PDAY [17 (15-19 compared to 15 (12-18), P = 0.03)] scores in patients with SLE; however, 99% of patients were classified as low-risk with a 10-year predicted risk of 1% (<1-3%). Our data indicate that cardiovascular risk scores are not adequate for risk stratification in women with SLE. Measurement of coronary calcification may add information to identify asymptomatic women with lupus who might benefit from aggressive preventive measures.
journal_name
Lupusjournal_title
Lupusauthors
Chung CP,Oeser A,Avalos I,Raggi P,Stein CMdoi
10.1177/0961203306071870subject
Has Abstractpub_date
2006-01-01 00:00:00pages
562-9issue
9eissn
0961-2033issn
1477-0962journal_volume
15pub_type
杂志文章相关文献
LUPUS文献大全abstract:BACKGROUND AND OBJECTIVES:Pregnancies in women with systemic lupus erythematosus (SLE) and lupus nephritis are considered high-risk due to high rates of maternal and fetal complications. However, there has not been a formal analysis addressing the issue of maternal deaths in these women. The aim of this study was to pe...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203311434939
更新日期:2012-04-01 00:00:00
abstract:OBJECTIVES:Sexual dysfunction in systemic lupus erythematous (SLE) patients is an important issue to be tackled. We aimed to study the prevalence of sexual dysfunction in SLE women and detect its association with depression, functional disability and quality of life. METHODS:This study included 94 SLE females. Ninety-...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203320935518
更新日期:2020-08-01 00:00:00
abstract::Introduction Osteoprotegerin (OPG) is a member of the tumor necrosis factor (TNF) receptor family. It has recently been demonstrated that OPG is produced by a variety of tissues, including the cardiovascular system (heart, arteries, veins), lung, kidney, immune tissues, and bone. The OPG-RANKL signaling pathway is str...
journal_title:Lupus
pub_type: 杂志文章,随机对照试验
doi:10.1177/0961203316682101
更新日期:2017-07-01 00:00:00
abstract::A 7-year-old boy presented with adrenal insufficiency. He subsequently developed venous thrombosis in the limbs and was diagnosed with primary antiphospholipid syndrome (PAPS) based on clinical and laboratory parameters. Both adrenals were normal on imaging. He required thrombolysis and anticoagulation. The progressiv...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203310397965
更新日期:2011-10-01 00:00:00
abstract::The purpose of the present study was to evaluate patients with the antiphospholipid syndrome with particular attention to their initial clinical features, final diagnoses and the course of thrombotic events in association with therapy. The methodology applied was the following: retrospective analysis of 30 patient fil...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339400300206
更新日期:1994-04-01 00:00:00
abstract::Controversy exists concerning the prevalence of headache in systemic lupus erythematosus (SLE) and its importance as a neuropsychiatric manifestation, especially when it occurs independently of disease activity and with the typical characteristics of primary chronic headache. Most reports to date have either studied b...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/096120399678847443
更新日期:1999-01-01 00:00:00
abstract::Tissue damage associated with a severe injury can result in profound inflammatory responses that may trigger autoimmune development in lupus-prone individuals. In this study, we investigated the role of a large full-thickness cutaneous burn injury on the early onset of autoimmune disease in lupus-prone MRL/++ mice. MR...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203308097479
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:The aim of our study was to investigate the efficacy of adipose-derived stem cells (ADSC) transplantation in systemic lupus erythematosus (SLE) and to determine the mechanism of ADSC transplantation. METHODS:B6.MRL/lpr mice were administered ADSC intravenously every week from age 28 to 31 weeks, while the lu...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203318819131
更新日期:2019-02-01 00:00:00
abstract::XRCC1 plays a central role in mammalian DNA repair processes. Two polymorphisms of XRCC1, rs1799782 (Arg > Trp at codon 194) and rs25487 (Arg > Gln at codon 399), are common in the Han Chinese population. Our objective was to analyze the relationship between these two functional single-nucleotide polymorphisms (SNPs) ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203309345777
更新日期:2009-12-01 00:00:00
abstract::Thymus-derived CD4(+)CD25(high)Foxp3(+) T-regulatory cells (Tregs) have an important role in the mechanisms of peripheral immune tolerance and in the prevention of pathogenic autoimmunity through the suppression of proliferation and production of pro-inflammatory cytokines in effector immune cells. Some studies have s...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203308090028
更新日期:2008-05-01 00:00:00
abstract::Acquired C1q deficiency secondary to anti C1q auto-antibodies may result in the hypocomplementaemic urticarial vasculitis syndrome and may also be seen in active systemic lupus erythematosus. Some patients with acquired C1 inhibitor deficiency are found to have an underlying malignancy, most commonly lymphoma. We repo...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120330000900113
更新日期:2000-01-01 00:00:00
abstract::We studied IgG and IgM anticardiolipin antibodies (aCL) by an ELISA method in 80 Mexican systemic lupus erythematosus (SLE) patients and 378 of their first degree relatives. Sixty five percent of SLE patients and 16% of their relatives were positive for aCL. We also determined allele and haplotype frequencies of Major...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339700600108
更新日期:1997-01-01 00:00:00
abstract::Female B6.MRLc1(82-100) congenic mice develop more severe autoimmune glomerulonephritis (AGN) than males. We assessed the effects of gonadectomy on the pathogenesis of AGN in these mice. One-month-old male and female mice were divided into sham-operated group (SG) and gonadectomized group (GG), and the pathological ch...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203308098989
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVE:The objective of this paper is to evaluate whether the different International Society of Nephrology/Renal Pathology Society (ISN/RPS) classes of proliferative lupus nephritis (LN) have a distinct baseline presentation, short-term response to immunosuppression (IS) and long-term prognosis. METHODS:Ninety-eig...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203313514623
更新日期:2014-02-01 00:00:00
abstract::Renal involvement is one of the main complications of systemic lupus erythematosus, causing a significant impact on patients' morbidity and mortality. Renal biopsy is still the gold standard of diagnosis, but it has many limitations. In this sense, several recent studies aim to identify biomarkers that not only predic...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203319826695
更新日期:2019-03-01 00:00:00
abstract::Endothelial and/or platelet activation likely initiates thrombus formation. Whether antiphospholipid antibody (aPL) is an activator, a toxic response, or a protective response is not clear, nor is it certain whether aPL is germ-line encoded or antigen-driven. The pregnancy model is particularly informative. Alternativ...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/096120339600500514
更新日期:1996-10-01 00:00:00
abstract::Intravenous immunoglobulin (IVIG) has a therapeutic potential in many autoimmune diseases. Based on its immune modulating and complement inhibiting effects, IVIG has been tested in systemic lupus erythematosus (SLE), but due to osmotic tubular injury caused by immunoglobulin-stabilizing sugar components, lupus nephrit...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203309355299
更新日期:2010-04-01 00:00:00
abstract::Herein, we investigated the risk of juvenile-onset systemic lupus erythematosus (JSLE) in children with atopic dermatitis (AD). From 2000 to 2007, 192,357 children with newly diagnosed AD and 769,428 matched non-AD controls were identified. By the end of 2008, incidences and hazard ratios (HRs) of JSLE were measured. ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314543920
更新日期:2014-12-01 00:00:00
abstract::In prospective studies, increased levels of cardiolipin-biding antibodies and autoantibodies to oxidized low-density lipoprotein (LDL) have been observed in patients with myocardial infarction (MI). These findings suggest that antiphospholipid antibodies may contribute to the development of MI. The 'oxidative-modifica...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/096120339800700229
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:GlycA is a novel marker of systemic inflammation detected by nuclear magnetic resonance (NMR) spectroscopy. In the general population, GlycA is correlated with inflammatory markers such as C-reactive protein (CRP) and associated with coronary heart disease and diabetes. The utility of GlycA in patients with ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203315617842
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVES:Impaired function of polymorphonuclear cells (PMNs) in systemic lupus erythematosus (SLE) leads to severe gram-positive and gram-negative bacterial infection, and to major morbidity and mortality. Few studies have focused on the association of impaired function of PMNs and SLE patients' susceptibility to inf...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203312474704
更新日期:2013-03-01 00:00:00
abstract::One hundred and twenty-nine patients with systemic lupus erythematosus were screened for thyroid function tests. Of these, 8.9% had hyperthyroidism and 3.9% Hashimoto's thyroiditis. Euthyroid sick syndrome was present in 47.8% of patients. There was a high prevalence of antimicrosomal and antithyroglobulin antibodies ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339300200109
更新日期:1993-02-01 00:00:00
abstract:OBJECTIVE:We sought to describe characteristics of children admitted with pericardial effusion (PCE) and systemic lupus erythematosus (SLE) and determine the association between PCE and outcomes of interest. METHODS:We performed a retrospective cohort study of the Pediatric Health Information System (PHIS). Patients w...
journal_title:Lupus
pub_type: 杂志文章,多中心研究
doi:10.1177/0961203319828523
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVE:YB current affiliation: Department of Pediatrics, Hadassah-Hebrew University Medical Center, Mount Scopus, Israel YB and MJS contributed equally to the study and should be regarded as joint first authors on this manuscript. Antiphospholipid syndrome (APS) may present with thrombosis and persistently elevated ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314531842
更新日期:2014-09-01 00:00:00
abstract:OBJECTIVE:We analyzed data of lupus nephritis (LN) patients to find parameters that can predict remission. METHODS:Sixty-four LN patients who were diagnosed with class III, IV, V or V + III/IV by renal biopsy and were followed up for more than six months in our center were enrolled retrospectively. Receiver operating ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203319826703
更新日期:2019-03-01 00:00:00
abstract::Systemic lupus erythematosus (SLE), a disorder of the immune system, is potentially curable by allogeneic bone marrow transplantation (alloBMT). Until recently, alloBMT was limited by donor availability and toxicity. Reduced intensity conditioning (RIC) combined with post-transplantation cyclophosphamide (PTCy) has im...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316669242
更新日期:2017-06-01 00:00:00
abstract:PURPOSE:To describe the ocular and systemic manifestations associated with systemic lupus erythematosus (SLE) choroidopathy. METHODS:Three new cases of choroidopathy in patients with active SLE were described. Twenty-five published cases of lupus choroidopathy were summarized. RESULTS:There have been 28 cases of lupu...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1191/096120300680199024
更新日期:2000-01-01 00:00:00
abstract::The metabolism of poly(ADP-ribose) in peripheral blood mononuclear (PBM) cells was studied in 13 patients with systemic lupus erythematosus (SLE) and in 12 age and sex matched controls. Poly(ADP-ribose) polymerase activity was measured as the net accumulation of ADP-ribose polymers during the conversion of 32P-NAD to ...
journal_title:Lupus
pub_type: 临床试验,杂志文章
doi:10.1177/096120339600500105
更新日期:1996-02-01 00:00:00
abstract:OBJECTIVE:Subepidermal bullous lesions and toxic epidermal necrolysis-like (TEN-like) lesions can occur in patients with systemic lupus erythematosus (SLE). In this report, we describe a case of a patient previously diagnosed with SLE who experienced TEN-like skin lesions with unusual subacute progression in the contex...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203313492242
更新日期:2013-07-01 00:00:00
abstract::In 2012, the Systemic Lupus International Collaborating Clinics (SLICC) group published a new set of classification criteria for systemic lupus erythematosus (SLE). Studies applying these criteria to real-life scenarios have found either equal or greater sensitivity and equal or lower specificity to the 1997 ACR class...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316657434
更新日期:2017-03-01 00:00:00