Chloroquine treatment influences proinflammatory cytokine levels in systemic lupus erythematosus patients.


:Systemic lupus erythematosus (SLE) is an autoimmune disease with a complex pathogenesis. Published data have revealed that serum levels of proinflammatory cytokines are increased in SLE patients. The aim of our study was to evaluate whether monotherapy with chloroquine phosphate affects IL-1beta, IL-6, IL-18 and TNF-alpha serum levels in SLE patients. The study group consisted of 25 SLE patients with mild or moderate disease activity and 25 age- and sex-matched healthy control subjects. In SLE patients the cytokine levels were measured just before and three months after starting chloroquine treatment at a dose of 125 mg twice daily. Although the majority of SLE patients had a low systemic lupus activity measure (SLAM) index, the levels of IL-6, IL-18 and TNF-alpha were significantly higher than in the control group. After three-months of chloroquine therapy the mean level of IL-6, IL-18 and TNF-alpha decreased significantly. Minimal erythema doses (MEDs) were significantly increased in SLE patients after three months of chloroquine therapy. The results indicate that chloroquine treatment lowers some proinflammatory cytokines and may provide a photoprotective effect.






Wozniacka A,Lesiak A,Narbutt J,McCauliffe DP,Sysa-Jedrzejowska A




Has Abstract


2006-01-01 00:00:00














  • Impairment of quality of life in patients with antiphospholipid syndrome.

    abstract:OBJECTIVES:Health-related quality of life (HRQoL) has not been fully explored in antiphospholipid syndrome (APS); therefore, we compared HRQoL between APS patients and the general population and assessed the impact of thromboembolic history. METHODS:HRQoL was measured in a multicentre cohort study by the Medical Outco...


    pub_type: 杂志文章,多中心研究


    authors: Zuily S,Rat AC,Regnault V,Kaminsky P,Mismetti P,Ninet J,Baillet N,Magy-Bertrand N,Pasquali JL,Lambert M,Pasquier E,Lorcerie B,Lecompte T,Guillemin F,Wahl D,TAC(I)T investigators.

    更新日期:2015-10-01 00:00:00

  • Naturally occurring anti-idiotypic antibodies reactive with anti-DNA antibodies in systemic lupus erythematosus.

    abstract::The levels of 'putative' anti-idiotypic antibodies reactive with F(ab')2 fragments of affinity purified DNA binding antibodies from five SLE patients were measured in the serum of active and inactive systemic lupus erythematosus (SLE) patients, their relatives, spouses and healthy non-related individuals. Serum anti-i...


    pub_type: 杂志文章


    authors: Williams WM,Isenberg DA

    更新日期:1998-01-01 00:00:00

  • Unusual neurologic manifestations (I): Parkinsonism in juvenile SLE.

    abstract::A girl with neuropsychiatric lupus demonstrated Parkinsonian features soon after commencing risperidone. The single photon emission computed tomography scan showed hyperperfusion of the basal ganglia. Symptoms abated with the addition of dopaminergic agents to immunosuppressive therapy. The literature on juvenile Park...


    pub_type: 杂志文章


    authors: Khubchandani RP,Viswanathan V,Desai J

    更新日期:2007-01-01 00:00:00

  • Safety and efficacy of thrombopoeitin mimetics for refractory immune thrombocytopenia purpura in patients with systemic lupus erythematosus or antiphospholipid syndrome: a case series.

    abstract::Background While thrombopoeitin (TPO) agonists that act to simulate platelet production have been approved for use in steroid-refractory chronic immune thrombocytopenia purpura (ITP), there are few data on the safety and efficacy of these medications in patients with concurrent systemic lupus erythematosus (SLE) or an...


    pub_type: 杂志文章


    authors: Lusa A,Carlson A

    更新日期:2018-09-01 00:00:00

  • False-positive IgM for CMV in pregnant women with autoimmune disease: a novel prognostic factor for poor pregnancy outcome.

    abstract::Our aims were to assess the frequency of false-positive IgM antibodies for cytomegalovirus in pregnant women with autoimmune diseases and in healthy women (controls) and to determine their relationship with pregnancy outcome. Data from 133 pregnancies in 118 patients with autoimmune diseases and from 222 pregnancies i...


    pub_type: 杂志文章


    authors: De Carolis S,Santucci S,Botta A,Garofalo S,Martino C,Perrelli A,Salvi S,Degennaro V,de Belvis A,Ferrazzani S,Scambia G

    更新日期:2010-06-01 00:00:00

  • Characteristics of Chinese patients with primary Sjögren's syndrome: preliminary report of a multi-centre registration study.

    abstract:BACKGROUND:We established a multi-centre online registry for primary Sjögren's syndrome (pSS) in China, and compared Chinese patients with those from other countries. METHODS:Data were from 87 rheumatology centres in 27 provinces. All 2986 patients had pSS according to the 2002 American-European Consensus Group or the...


    pub_type: 杂志文章,多中心研究


    authors: Xu D,Zhao S,Li Q,Wang YH,Zhao JL,Li MT,Zhao Y,Zeng XF

    更新日期:2020-01-01 00:00:00

  • Thiazolidinediones and inflammation.

    abstract::Thiazolidinediones (TZDs) are selective ligands of peroxisome-proliferator-activated receptor gamma increasingly used in the treatment of type 2 diabetes. Both in vitro and in vivo studies provide evidence that TZDs have anti-inflammatory properties. TZDs inhibit macrophage activation and decrease inflammatory cytokin...


    pub_type: 杂志文章,评审


    authors: Consoli A,Devangelio E

    更新日期:2005-01-01 00:00:00

  • Factors associated with increased white matter hyperintense lesion (WMHI) load in patients with systemic lupus erythematosus (SLE).

    abstract::Introduction White matter hyperintense (WMHI) lesions are the most common finding in magnetic resonance imaging (MRI) of the brain in patients with systemic lupus erythematosus (SLE). Objective The objective of this article is to determine the clinical factors associated with an increase in WMHI lesion load among SLE ...


    pub_type: 杂志文章


    authors: Shaharir SS,Osman SS,Md Rani SA,Sakthiswary R,Said MSM

    更新日期:2018-01-01 00:00:00

  • The dual role of innate immunity in antiphospholipid syndrome and systemic lupus erythematosus.

    abstract::Antiphospholipid syndrome (APS), as a primary disease or a secondary syndrome in systemic lupus erythematosus (SLE), is characterized by the presence of antiphospholipid antibodies (aPL) and a clinical event. It is likely that both genetic and environmental factors lead to the development of aPL and progression to dis...


    pub_type: 杂志文章


    authors: Salem D,Subang R,Laplante P,Levine JS,Rauch J

    更新日期:2014-10-01 00:00:00

  • Coxiella burnetii infection (Q fever) mimicking systemic lupus erythematosus: two cases.

    abstract::Q fever has extremely polymorphic features, and has been reported to be associated with positivity of several autoimmune antibodies. We report two cases of atypical Q fever with a clinical presentation highly suggestive of an inflammatory systemic disease with positivity of autoimmune antibodies, mimicking systemic lu...


    pub_type: 杂志文章


    authors: Durupt S,Puget M,Lega JC,Durieu I,Reynaud Q

    更新日期:2017-01-01 00:00:00

  • Feto-maternal immune interaction at the placental level.

    abstract::A special interaction is established during pregnancy between the maternal immune system and fetal cells to allow the survival and the normal growth of the fetus. Fetal cells expressing paternal alloantigens are not recognized as foreign by the mother because of an efficient anatomic barrier and a local immunosuppress...


    pub_type: 杂志文章,评审


    authors: Bulla R,Fischetti F,Bossi F,Tedesco F

    更新日期:2004-01-01 00:00:00

  • Familial SLE: sustained drug-free remission in a mother successfully treated for anal cancer, but development of SLE in a 16-year old daughter.

    abstract::The immunopathogenesis of systemic lupus erythematosus has been thoroughly investigated recently, and genome-wide association studies have identified genes statistically associated with lupus. However, the progression to overt disease is dependent on the activation of environmental factors ('triggers'), among which oe...


    pub_type: 杂志文章


    authors: Catania G,Rossi E,Marmont A

    更新日期:2012-05-01 00:00:00

  • Improvement in health-related quality of life in systemic lupus erythematosus patients enrolled in a randomized clinical trial comparing LJP 394 treatment with placebo.

    abstract::In a 76-week, randomized controlled trial, patients received 100 mg LJP 394 or placebo weekly for 16 weeks followed by three 12-week treatment cycles of 50 mg LJP 394 or placebo weekly each separated by eight-week periods when no therapy was administered. Health-related quality of life (HRQOL) was assessed using SF-36...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Strand V,Aranow C,Cardiel MH,Alarcón-Segovia D,Furie R,Sherrer Y,Tumlin J,Wallace DJ,Crawford B,LJP 394 Investigator Consortium.

    更新日期:2003-01-01 00:00:00

  • Skeletal muscle lymphocytic vasculitis in systemic lupus erythematosus: relation to disease activity.

    abstract::Lymphocytic vasculitis (LV) characterises systemic lupus erythematosus (SLE) and this potentially reversible lesion, which may be subclinical, may imply overt systemic disease activity. Needle quadriceps muscle biopsy was performed in 26 unselected patients with SLE and the presence of LV in these muscle specimens was...


    pub_type: 杂志文章


    authors: Lim KL,Lowe J,Powell RJ

    更新日期:1995-04-01 00:00:00

  • Diabetes mellitus complicating systemic lupus erythematosus - analysis of the UCL lupus cohort and review of the literature.

    abstract::Systemic lupus erythematosus (SLE) often coexists with other diseases. Diabetes mellitus (DM) is an example and patients with overlap SLE-DM can present with clinical features common to both disorders. In this review, we describe the patients with overlap SLE-DM, focussing on the clinical features common to both disea...


    pub_type: 杂志文章,评审


    authors: Cortes S,Chambers S,Jerónimo A,Isenberg D

    更新日期:2008-11-01 00:00:00

  • Mycophenolate mofetil in lupus nephritis.

    abstract::There is an increasing body of literature suggesting the efficacy and tolerability of mycophenolate mofetil (MMF) for the treatment of lupus nephritis. The rationale for its use is based upon its successful profile as an immunosuppressive agent for prevention of allograft rejection, as well as studies in murine models...


    pub_type: 杂志文章,评审


    authors: Ginzler EM,Aranow C

    更新日期:2005-01-01 00:00:00

  • Efficacy and safety of creatine supplementation in childhood-onset systemic lupus erythematosus: a randomized, double-blind, placebo-controlled, crossover trial.

    abstract:INTRODUCTION:Creatine supplementation has emerged as a promising non-pharmacological therapeutic strategy to counteract muscle dysfunction and low lean mass in a variety of conditions, including in pediatric and rheumatic diseases. The objective of this study was to examine the efficacy and safety of creatine supplemen...


    pub_type: 杂志文章,随机对照试验


    authors: Hayashi AP,Solis MY,Sapienza MT,Otaduy MC,de Sá Pinto AL,Silva CA,Sallum AM,Pereira RM,Gualano B

    更新日期:2014-12-01 00:00:00

  • Antimalarials as a risk factor for elevated muscle enzymes in systemic lupus erythematosus.

    abstract:OBJECTIVE:To investigate the relationship between antimalarials (AM) and elevated muscle enzymes in systemic lupus erythematosus (SLE). PATIENTSMETHODS:325 lupus patients with abnormal creatine phosphokinase (CPK) for at least two consecutive clinic visits were enrolled; 54 patients on statins/fibrates (n = 43) and/or...


    pub_type: 杂志文章


    authors: Tselios K,Gladman DD,Su J,Urowitz MB

    更新日期:2016-04-01 00:00:00

  • Long-term systemic lupus erythematosus disease control after allogeneic bone marrow transplantation.

    abstract::Systemic lupus erythematosus (SLE), a disorder of the immune system, is potentially curable by allogeneic bone marrow transplantation (alloBMT). Until recently, alloBMT was limited by donor availability and toxicity. Reduced intensity conditioning (RIC) combined with post-transplantation cyclophosphamide (PTCy) has im...


    pub_type: 杂志文章


    authors: Gladstone DE,Petri M,Bolaños-Meade J,Dezern AE,Jones RJ,Fine D,Brodsky RA

    更新日期:2017-06-01 00:00:00

  • 1996 diagnostic and classification criteria for the antiphospholipid/cofactors syndrome: a "mission impossible'?

    abstract::Due to recent acquisitions, diagnostic criteria for the antiphospholipid/cofactors syndrome need to be improved. In the absence of a "common biological denominator", the best approach should be based on a scoring system mixing clinical and immunological items. APS might be composed of different biological subsets char...


    pub_type: 杂志文章,评审


    authors: Piette JC

    更新日期:1996-10-01 00:00:00

  • Pulmonary thromboendarterectomy is a curative resolution for chronic thromboembolic pulmonary hypertension associated with antiphospholipid syndrome: a retrospective cohort study.

    abstract:BACKGROUND:Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare and life-threatening condition with poor prognosis in patients with antiphospholipid syndrome (APS). Pulmonary thromboendarterectomy (PTE) is the optimal surgical option for CTEPH. OBJECTIVES:This retrospective cohort study aimed to evaluate th...


    pub_type: 杂志文章


    authors: Li C,Zhao J,Liu S,Song W,Zhu J,Hua L,Wang Q,Li M,Zeng X,Zhao Y

    更新日期:2018-12-01 00:00:00

  • Pathogenesis of the antiphospholipid antibody syndrome.

    abstract::Endothelial and/or platelet activation likely initiates thrombus formation. Whether antiphospholipid antibody (aPL) is an activator, a toxic response, or a protective response is not clear, nor is it certain whether aPL is germ-line encoded or antigen-driven. The pregnancy model is particularly informative. Alternativ...


    pub_type: 杂志文章,评审


    authors: Lockshin MD

    更新日期:1996-10-01 00:00:00

  • Ethnic differences in the epidemiology of cutaneous lupus erythematosus in New Zealand.

    abstract::Background The prevalence and variation by ethnicity of cutaneous lupus in New Zealand is not known. Therefore, a cross-sectional study to determine the prevalence and variation by ethnicity of cutaneous lupus in the ethnically diverse community of South Auckland, New Zealand, was undertaken. Methods Multiple sources ...


    pub_type: 杂志文章


    authors: Jarrett P,Thornley S,Scragg R

    更新日期:2016-11-01 00:00:00

  • GATA3 rs3824662 gene polymorphism as possible risk factor for systemic lupus erythematosus.

    abstract:BACKGROUND:There is no report about the association between GATA3 rs3824662 polymorphism and systemic lupus erythematosus (SLE). OBJECTIVE:To investigate the possible role of GATA3 rs3824662 polymorphism as a susceptibility risk factor for either adult SLE (aSLE) or pediatric SLE (pSLE) and to evaluate its role in the...


    pub_type: 杂志文章


    authors: Mosaad YM,Hammad A,Elghzaly AA,Tawhid ZME,Hammad EM,Showma A,Abdelsalam R,Elmoughy A,Fawzy IM,Anber N

    更新日期:2018-11-01 00:00:00

  • Apoptosis in the pathogenesis of systemic lupus erythematosus.

    abstract::Systemic lupus erythematosus (SLE) is a prototype inflammatory autoimmune disease resulting from autoimmune responses against nuclear autoantigens. During apoptosis many lupus autoantigens congregate inside the cells and are susceptible to modifications. Modified nuclear constituents are considered foreign and dangero...


    pub_type: 杂志文章,评审


    authors: Munoz LE,van Bavel C,Franz S,Berden J,Herrmann M,van der Vlag J

    更新日期:2008-05-01 00:00:00

  • Chinese SLE Treatment and Research group (CSTAR) registry: II. Prevalence and risk factors of pulmonary arterial hypertension in Chinese patients with systemic lupus erythematosus.

    abstract:OBJECTIVES:To estimate the prevalence of pulmonary arterial hypertension (PAH) and risk factors for PAH in patients registered in the Chinese SLE Treatment and Research group (CSTAR) database, the first online registry of Chinese patients with systemic lupus erythematosus (SLE). METHODS:A prospective cross-sectional s...


    pub_type: 杂志文章


    authors: Li M,Wang Q,Zhao J,Li Z,Ye Z,Li C,Li X,Zhu P,Wang Z,Zheng Y,Li X,Zhang M,Tian Z,Liu Y,He J,Zhang F,Zhao Y,Zeng X,CSTAR co-authors.

    更新日期:2014-09-01 00:00:00

  • Evaluation of early cardiac dysfunction in patients with systemic lupus erythematosus with or without anticardiolipin antibodies.

    abstract::The aim of this study was to use transthoracic Doppler echocardiographic (TTE) imaging methods to identify cardiac dysfunction, an indicator of subclinical atherosclerosis in asymptomatic systemic lupus erythematosus (SLE) patients in terms of cardiac effects. This study involved 80 patients: a study group (n = 50) an...


    pub_type: 杂志文章


    authors: Barutcu A,Aksu F,Ozcelik F,Barutcu CA,Umit GE,Pamuk ON,Altun A

    更新日期:2015-09-01 00:00:00

  • Antiphospholipid syndrome and tissue factor: a thrombotic couple.

    abstract::The antiphospholipid syndrome (APS) is characterized by thrombosis and/or pregnancy morbidity in the presence of antiphospholipid antibodies (aPL). Among the thrombogenic mechanisms proposed, it has been suggested that aPL can stimulate tissue factor (TF) expression by endothelial cells (ECs) and monocytes. Moreover, ...


    pub_type: 杂志文章,评审


    authors: López-Pedrera Ch,Buendía P,Aguirre MA,Velasco F,Cuadrado MJ

    更新日期:2006-01-01 00:00:00

  • Bilateral choroidopathy in systemic lupus erythematosus.

    abstract::We report a case of bilateral choroidopathy in a 35-year-old woman with systemic lupus erythematosus (SLE) diagnosed 3 years previously, and treated with hydroxychloroquine and steroids that ceased 6 months before ocular signs. She complained about rapid bilateral blurred vision with a severe loss of visual acuity. Fl...


    pub_type: 杂志文章,评审


    authors: Edouard S,Douat J,Sailler L,Arlet P,Astudillo L

    更新日期:2011-10-01 00:00:00

  • Recurrent cerebral infarctions in polyarteritis nodosa with circulating antiphospholipid antibodies and mitral valve disease.

    abstract::A case of recurrent cerebral infarctions in a 42-year-old woman affected by polyarteritis nodosa and antiphospholipid syndrome is reported. Two-dimensional echocardiography revealed grossly thickened mitral valve leaflets, possibly related to the presence of antiphospholipid antibodies. Thus, an embolic source at mitr...


    pub_type: 杂志文章


    authors: Morelli S,Perrone C,Paroli M

    更新日期:1998-01-01 00:00:00