Clinical profile of Chinese patients with systemic lupus erythematosus.

abstract：:Renal involvement is one of the main complications of systemic lupus erythematosus, causing a significant impact on patients' morbidity and mortality. Renal biopsy is still the gold standard of diagnosis, but it has many limitations. In this sense, several recent studies aim to identify biomarkers that not only predic...

journal_title：Lupus

authors： Gasparin AA,Pamplona Bueno de Andrade N,Hax V,Tres GL,Veronese FV,Monticielo OA

更新日期：2019-03-01 00:00:00

abstract：:Integrin very late antigen-4 (VLA4) is induced during inflammation and can regulate monocyte migration. It has been implicated in atherogenesis, a significant concern in systemic lupus erythematosus (SLE). The aim of this study was to define VLA4 expression in SLE monocytes. Flow cytometry, reverse transcription polym...

journal_title：Lupus

authors： Rahimi H,Maurer K,Song L,Akhter E,Petri M,Sullivan KE

更新日期：2013-03-01 00:00:00

abstract：:Rheumatoid Arthritis (RA) is a chronic disease with significant morbidity and functional disability. The traditional treatment for RA relied on the use of NSAIDs early in the disease course, followed by disease-modifying agents later. More recently, the disease-modifying anti-rheumatic drugs (DMARDs) have become the m...

journal_title：Lupus

authors： Khraishi MM,Singh G

更新日期：1996-06-01 00:00:00

abstract：:Background and objective African-Americans and Hispanic-Americans with lupus are the two most common minority groups who receive kidney transplants in the USA. It is unknown if African-Americans and Hispanic-Americans with lupus have similar outcomes after kidney transplantation. In this study, we assessed whether Afr...

journal_title：Lupus

authors： Gonzalez-Suarez ML,Contreras G

更新日期：2017-10-01 00:00:00

abstract：OBJECTIVE:Anti-α-enolase antibody (Ab) combined with β2 microglobulin (β2-MG) were investigated to predict the incidence of nephritis in systemic lupus erythematosus (SLE) patients. METHODS:Levels of serum anti-α-enolase Ab and urinary β2-MG were detected in 115 SLE patients, 29 SLE patients with nephritis and 70 heal...

journal_title：Lupus

authors： Huang Y,Chen L,Chen K,Huang F,Feng Y,Xu Z,Wang W

更新日期：2019-03-01 00:00:00

abstract：:One hundred and fifty-eight patients with SLE were prospectively studied at a tertiary referral centre in India to ascertain the prevalence and clinical profile of fibromyalgia (FM) in Indian patients with lupus. An attempt was made to determine whether socio-demographic factors or disease characteristics differ in SL...

journal_title：Lupus

authors： Handa R,Aggarwal P,Wali JP,Wig N,Dwivedi SN

更新日期：1998-01-01 00:00:00

abstract：:Background Systemic lupus erythematosus (SLE) is an autoimmune disease marked by the disruption of the immune homeostasis. Patients exhibit a wide range of clinical manifestations, and environmental and genetic factors are involved in SLE pathogenesis. Evidence suggests that abnormalities in the cellular and molecular...

journal_title：Lupus

authors： Glesse N,Vianna P,Paim LMG,Matte MCC,Aguiar AKK,Palhano PL,Monticielo OA,Brenol CV,Xavier RM,Chies JAB

更新日期：2017-06-01 00:00:00

abstract：:Pancreatitis is a relatively rare complication in systemic lupus erythematosus (SLE). Here we present a case of SLE associated with autoimmune pancreatitis. A 37-year old woman was admitted to our hospital because of fever, skin rash, proteinuria and abdominal pain. A diagnosis of SLE was made based on her clinical, l...

journal_title：Lupus

authors： Kobayashi S,Yoshida M,Kitahara T,Abe Y,Tsuchida A,Nojima Y

更新日期：2007-01-01 00:00:00

abstract：:We report an infant with anticardiolipin (aCL) antibodies who presented with erythematous nodular skin lesions and elevated liver enzyme levels. The cutaneous manifestation was histologically lymphocytic lobular panniculitis with vasculitic and hemorrhagic changes. The infant also had low levels of anti-double strande...

journal_title：Lupus

authors： Miyagawa S,Uchida Y,Taira K,Higuchi M,Hashimoto K,Yoshioka A,Shirai T

更新日期：2000-01-01 00:00:00

abstract：:Our aims were to assess the frequency of false-positive IgM antibodies for cytomegalovirus in pregnant women with autoimmune diseases and in healthy women (controls) and to determine their relationship with pregnancy outcome. Data from 133 pregnancies in 118 patients with autoimmune diseases and from 222 pregnancies i...

journal_title：Lupus

authors： De Carolis S,Santucci S,Botta A,Garofalo S,Martino C,Perrelli A,Salvi S,Degennaro V,de Belvis A,Ferrazzani S,Scambia G

更新日期：2010-06-01 00:00:00

abstract：:CD27 is a useful marker in assessing the number of circulating B cells and B cell subsets because it permits one step identification of the major B cell compartments, CD27- naïve and CD27+ memory B cells as well as CD27high plasma cells. Abnormalities in the distribution ofCD27+ B cell subsets are useful in assessing ...

journal_title：Lupus

authors： Dörner T,Lipsky PE

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Although the survival rate has considerably improved, many patients with systemic lupus erythematosus (SLE) develop irreversible organ damage. OBJECTIVES:The objectives of this paper are to characterize cumulative damage in SLE patients and identify variables associated with its presence and severity. METH...

journal_title：Lupus

authors： Gonçalves MJ,Sousa S,Inês LS,Duarte C,Borges J,Silva C,Romão VC,Terroso G,Bernardes M,Cerqueira M,Raposo A,Sequeira G,Barcelos A,Macieira C,Canas da Silva J,Costa L,Pereira da Silva JA,Cunha-Miranda L,Da Silva JA,Ca

更新日期：2015-03-01 00:00:00

abstract：:The complement system contributes to the pathogenesis of systemic lupus erythematosus (SLE). Mannose-binding lectin (MBL) is a key molecule of the lectin pathway of complement and seems to be related to the clinical manifestations of this disease. We evaluated the serum levels of MBL and its relationship with disease ...

journal_title：Lupus

authors： Cieslinski JZ,Skare TL,Nisihara R,De Messias-Reason IJ,Utiyama SRR

更新日期：2018-03-01 00:00:00

abstract：:Coming from Hans Wigzell's laboratory in Uppsala, Sweden, I joined the Kunkel laboratory in 1981 to spend a post-doctoral fellowship period financed by the German Research Organization. While I initially worked with Nick Chiorazzi in an attempt to generate monoclonal antibody-secreting human B-cell hybridomas, I later...

journal_title：Lupus

authors： Kabelitz D

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:Systemic lupus erythematosus (SLE), an autoimmune condition with diverse clinical manifestations, is reported to have different expression in populations of different ancestry. Most previous studies compared patients of different ethnic groups from geographically distinct cohorts. In our study, we aimed to ch...

journal_title：Lupus

authors： Golder V,Connelly K,Staples M,Morand E,Hoi A

更新日期：2013-11-01 00:00:00

abstract：:Seventeen families, in which the diagnosis of SLE could be verified in two relatives, were included in the study. The diagnosis was made according to the revised 1982 ARA criteria. We compared the 34 cases of familial SLE in these 17 families with 34 non-familial SLE controls matched for age, sex, ethnicity and durati...

journal_title：Lupus

authors： Gourley IS,Cunnane G,Bresnihan B,FitzGerald O,Bell AL

更新日期：1996-08-01 00:00:00

abstract：:The effect of synthetic CpG-oligodeoxynucleotides (CpG-ODN) on the development of lupus nephritis during preactive phase (within seven months of age) in autoimmune lupus NZB x NZWF1 (B/WF1) mice was examined. Treatment of CpG-ODN was started at the age of 2.75 months and continued until 6.25 months. Overt disease bega...

journal_title：Lupus

authors： Hasegawa K,Hayashi T

更新日期：2003-01-01 00:00:00

abstract：:One hundred and twenty-nine patients with systemic lupus erythematosus were screened for thyroid function tests. Of these, 8.9% had hyperthyroidism and 3.9% Hashimoto's thyroiditis. Euthyroid sick syndrome was present in 47.8% of patients. There was a high prevalence of antimicrosomal and antithyroglobulin antibodies ...

journal_title：Lupus

authors： Boey ML,Fong PH,Lee JS,Ng WY,Thai AC

更新日期：1993-02-01 00:00:00

abstract：:Estrogens and their receptors may play a role in the pathogenesis of systemic lupus erythematosus. Genetic alterations in the exon 8-coding region of the estrogen receptor alpha alter the intracellular signalling of estrogens, leading in enhanced or diminished activity. We investigated whether genetic alterations in e...

journal_title：Lupus

authors： Kassi E,Vlachoyiannopoulos PG,Kominakis A,Kiaris H,Moutsopoulos HM,Moutsatsou P

更新日期：2005-01-01 00:00:00

abstract：PURPOSE:To describe the ocular and systemic manifestations associated with systemic lupus erythematosus (SLE) choroidopathy. METHODS:Three new cases of choroidopathy in patients with active SLE were described. Twenty-five published cases of lupus choroidopathy were summarized. RESULTS:There have been 28 cases of lupu...

journal_title：Lupus

authors： Nguyen QD,Uy HS,Akpek EK,Harper SL,Zacks DN,Foster CS

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Polyarthritis is common to both mixed connective tissue disease (MCTD) and systemic lupus erythematosus (SLE). Apart from being erosive and deforming in the former, we speculated that it was more common and the extent of joints involved would be higher in MCTD. METHODS:This was a cross-sectional study that ...

journal_title：Lupus

authors： Gunashekar S,Prakash M,Minz RW,Sharma A,Sharma S,Dhir V

更新日期：2018-11-01 00:00:00

abstract：:The presence of antibodies against the complex of prothrombin and phosphatidylserine (aPS/PT) more significantly correlates with manifestations of antiphospholipid syndrome (APS) and with the presence of lupus anticoagulants (LA) than antibodies against prothrombin bound to oxygenated polystyrene (aPT-A). To investiga...

journal_title：Lupus

authors： Horita T,Ichikawa K,Kataoka H,Yasuda S,Atsumi T,Koike T

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Many studies in adult patients with systemic lupus erythematosus (SLE) have demonstrated that myocardial dysfunction was significantly associated with enhanced disease activity. However, similar studies in paediatric patients with SLE are limited. The aim of this study was to evaluate the role of speckle tra...

journal_title：Lupus

authors： Emara M,Hafez MA,El-Bendary A,Razaky OE

更新日期：2020-10-01 00:00:00

abstract：:Chronic intestinal pseudo-obstruction (CIPO) is a rare clinical syndrome of ineffective intestinal motility characterised by clinical and radiological evidence of intestinal obstruction with no identifiable mechanical lesion. CIPO can either be idiopathic or secondary to a systemic disease, like systemic lupus erythem...

journal_title：Lupus

authors： Khairullah S,Jasmin R,Yahya F,Cheah TE,Ng CT,Sockalingam S

更新日期：2013-08-01 00:00:00

abstract：:A girl with neuropsychiatric lupus demonstrated Parkinsonian features soon after commencing risperidone. The single photon emission computed tomography scan showed hyperperfusion of the basal ganglia. Symptoms abated with the addition of dopaminergic agents to immunosuppressive therapy. The literature on juvenile Park...

journal_title：Lupus

authors： Khubchandani RP,Viswanathan V,Desai J

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVES:We aimed to determine 1) ultrasound (US) abnormalities in patients with systemic lupus erythematosus (SLE) with and without hand arthralgia at the day of examination compared with clinical evaluation and healthy controls, and 2) inter-observer reliability of the US abnormalities. METHODS:Thirty-three female...

journal_title：Lupus

authors： Dreyer L,Jacobsen S,Juul L,Terslev L

更新日期：2015-06-01 00:00:00

abstract：:Neonatal antiphospholipid syndrome (neonatal APS) seems to be exceedingly rare, as the antiphospholipid antibodies (aPL) related thrombosis in the neonatal period. The pathogenesis of perinatal aPL related thrombosis may be explained both by the transplacental passage of the maternal antibodies and by the production o...

journal_title：Lupus

authors： De Carolis MP,Salvi S,Botta A,Cocca C,Garufi C,Lanzone A,De Carolis S

更新日期：2015-03-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a highly heterogeneous disorder in which multiple immunologic abnormalities have been described. In this review, we thoroughly analyse the impaired T cell production of, and response to, interleukin-2 (IL-2) characteristic of patients with SLE. Since it was first reported, several...

journal_title：Lupus

authors： Crispin JC,Alcocer-Varela J

更新日期：1998-01-01 00:00:00

abstract：:We report a case of bilateral choroidopathy in a 35-year-old woman with systemic lupus erythematosus (SLE) diagnosed 3 years previously, and treated with hydroxychloroquine and steroids that ceased 6 months before ocular signs. She complained about rapid bilateral blurred vision with a severe loss of visual acuity. Fl...

journal_title：Lupus

authors： Edouard S,Douat J,Sailler L,Arlet P,Astudillo L

更新日期：2011-10-01 00:00:00

abstract：:The relationship between disease activity, cumulative damage and self-reported quality of life was examined in 96 patients with Systematic Lupus Erythematosus (SLE). Disease activity was measured by the SLE Disease Activity Index (SLEDAI) and cumulative damage by the Systematic Lupus International Cooperating Clinics/...

journal_title：Lupus

authors： Hanly JG

更新日期：1997-01-01 00:00:00