Disease activity, cumulative damage and quality of life in systematic lupus erythematosus: results of a cross-sectional study.

abstract：:In 1964, Miyoshi reported a series of patients with diverse symptoms after receiving treatment with silicone or paraffin fillers. Miyoshi named this condition 'human adjuvant disease'. Since then, the literature has been flooded with case reports and case series of granulomatous and systemic autoimmune disorders relat...

journal_title：Lupus

authors： Alijotas-Reig J

更新日期：2015-09-01 00:00:00

abstract：:Prognosis of pregnancies in women with antiphospholipid syndrome has dramatically improved over the past two decades using conventional treatment with low molecular weight heparin and low-dose aspirin. However, despite this regimen, 10-15% of antiphospholipid syndrome patients experience pregnancy losses. Several stud...

journal_title：Lupus

authors： Tabacco S,Giannini A,Garufi C,Botta A,Salvi S,Del Sordo G,Benedetti Panici P,Lanzone A,De Carolis S

更新日期：2019-11-01 00:00:00

abstract：:SLE is an autoimmune and polygenic disorder characterized by an accumulation and deposition of immune complexes. Several studies have indicated differential impact of FcgammaR polymorphism genotypes in different ethnic groups studied. The Fc receptor for IgG class IIA gene (FcgammaRIIA) occurs in two allelic forms. Th...

journal_title：Lupus

authors： Yap SN,Phipps ME,Manivasagar M,Tan SY,Bosco JJ

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVE:To investigate the predictive value of serum C3 and C4 complement component levels in relation to pregnancy outcome in patients with antiphospholipid syndrome (APS). MATERIALS AND METHODS:A prospective study of 47 pregnancies associated with APS was performed. Pregnancy outcome was analyzed in terms of: feta...

journal_title：Lupus

authors： De Carolis S,Botta A,Santucci S,Salvi S,Moresi S,Di Pasquo E,Del Sordo G,Martino C

更新日期：2012-06-01 00:00:00

abstract：:A special interaction is established during pregnancy between the maternal immune system and fetal cells to allow the survival and the normal growth of the fetus. Fetal cells expressing paternal alloantigens are not recognized as foreign by the mother because of an efficient anatomic barrier and a local immunosuppress...

journal_title：Lupus

authors： Bulla R,Fischetti F,Bossi F,Tedesco F

更新日期：2004-01-01 00:00:00

abstract：:A dose-dependent combination of environmental exposures, estrogenic hormones and genetic predisposition is thought to be required for lupus to develop and flare, but how the environment modifies the immune system in genetically predisposed people is unclear. Current evidence indicates that environmental agents that in...

journal_title：Lupus

authors： Somers EC,Richardson BC

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVE:Anti-α-enolase antibody (Ab) combined with β2 microglobulin (β2-MG) were investigated to predict the incidence of nephritis in systemic lupus erythematosus (SLE) patients. METHODS:Levels of serum anti-α-enolase Ab and urinary β2-MG were detected in 115 SLE patients, 29 SLE patients with nephritis and 70 heal...

journal_title：Lupus

authors： Huang Y,Chen L,Chen K,Huang F,Feng Y,Xu Z,Wang W

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Systemic lupus erythematosus (SLE) is a complex autoimmune disease that can involve multiple organ systems. Exposure to ultraviolet radiation (UVR) can exacerbate pre-existing SLE, and can even induce systemic manifestations. This study aimed to investigate the photoprotective habits of children with SLE and...

journal_title：Lupus

authors： Janthongsri T,Wisuthsarewong W,Nitiyarom R

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:There is no report about the association between GATA3 rs3824662 polymorphism and systemic lupus erythematosus (SLE). OBJECTIVE:To investigate the possible role of GATA3 rs3824662 polymorphism as a susceptibility risk factor for either adult SLE (aSLE) or pediatric SLE (pSLE) and to evaluate its role in the...

journal_title：Lupus

authors： Mosaad YM,Hammad A,Elghzaly AA,Tawhid ZME,Hammad EM,Showma A,Abdelsalam R,Elmoughy A,Fawzy IM,Anber N

更新日期：2018-11-01 00:00:00

abstract：:One hundred and twenty-nine patients with systemic lupus erythematosus were screened for thyroid function tests. Of these, 8.9% had hyperthyroidism and 3.9% Hashimoto's thyroiditis. Euthyroid sick syndrome was present in 47.8% of patients. There was a high prevalence of antimicrosomal and antithyroglobulin antibodies ...

journal_title：Lupus

authors： Boey ML,Fong PH,Lee JS,Ng WY,Thai AC

更新日期：1993-02-01 00:00:00

abstract：:Thalidomide has been shown to be an effective treatment for cutaneous forms of lupus erythematous refractory to other therapies. Thalidomide has very serious side effects, including teratogenicity and neuropathy, which limit its clinical use in lupus to such severe refractory cases. Efficacy has been confirmed in seve...

journal_title：Lupus

authors： Karim MY,Ruiz-Irastorza G,Khamashta MA,Hughes GR

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVE:This study aimed to explore the experience and impact of fatigue in adults with primary antiphospholipid syndrome (pAPS). METHODS:This sequential, explanatory mixed-methods study enrolled adults with a six-month or more history of pAPS. Consenting participants completed the Functional Assessment of Chronic I...

journal_title：Lupus

authors： Bearne LM,Bieles J,Georgopoulou S,Andrews J,Tully A,Stolarchuk-Prowting K,Williamson T,Suarez BS,Nel L,D'Cruz D,Lempp H

更新日期：2020-07-01 00:00:00

abstract：:The incidence and nature of headaches in 85 systemic lupus erythematosus (SLE) patients attending an outpatient clinic were studied and compared to those experienced by 61 nurses. The two groups were similar in age, sex and ethnicity. Test-retest assessment of reliability gave both groups 95% confidence limits of 0.09...

journal_title：Lupus

authors： Whitelaw DA,Hugo F,Spangenberg JJ,Rickman R

更新日期：2004-01-01 00:00:00

abstract：:Peripheral T cell apoptosis is upregulated in active SLE, in parallel with high expression of both membrane-bound and soluble (s) Fas. Previous studies postulated that sFas down-regulates apoptosis in vitro through its blockade of the Fas-L of cytotoxic cells. We have investigated the extent of apoptosis and sFas leve...

journal_title：Lupus

authors： Silvestris F,Grinello D,Tucci M,Cafforio P,Dammacco F

更新日期：2003-01-01 00:00:00

abstract：Background:Strongyloidiasis can be fatal in systemic lupus erythematosus (SLE) patients, but few epidemiological studies have investigated the burden of this tropical disease among the SLE population. This study aimed to assess the prevalence and associated factors of strongyloidiasis among SLE patients in Southern Tha...

journal_title：Lupus

authors： Juthong S,Geater AF,Dekumyoy P,Hortiwakul T,Siripaitoon B,Aiewruengsurat D,Thongbun N

更新日期：2020-05-01 00:00:00

abstract：:Diffuse alveolar hemorrhage (DAH) is a life-threatening complication of systemic lupus erythematosus (SLE). Cases complicated with DAH often have active SLE with multi-organ involvement, especially lupus nephritis. We describe a rare case of DAH as the first presenting manifestation of SLE in the absence of lupus neph...

journal_title：Lupus

authors： Al Rashidi A,Alajmi M,Hegazi MO

更新日期：2011-12-01 00:00:00

abstract：:Antiphospholipid antibodies (aPL) are associated with an increased incidence of fetal loss, but the pathophysiology remains unclear. One mechanism may involve the binding of aPL directly to the placenta where they may initiate placental thrombosis and infarction. We have developed an immunofluorescent technique to det...

journal_title：Lupus

authors： Donohoe S,Kingdom JC,Mackie IJ

更新日期：1999-01-01 00:00:00

abstract：:Lupus nephritis (LN) is usually associated with widespread effacement of the podocytes' foot processes leading to proteinuria. Induction of urokinase receptor (uPAR) signaling in podocytes leads to foot process effacement and urinary protein loss via promoting podocytes' motility and kidney permeability in the glomeru...

journal_title：Lupus

authors： Cheng CC,Lee YF,Lan JL,Wu MJ,Hsieh TY,Lin NN,Wang JM,Chiu YT

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:The prevalence and severity of systemic lupus erythematosus (SLE) differs between ethnic groups and geographical regions. Although initially reported as rare, there is growing evidence that SLE is prevalent and runs a severe course in Africa. There is a paucity of prospective studies on African SLE patients....

journal_title：Lupus

authors： Hodkinson B,Mapiye D,Jayne D,Kalla A,Tiffin N,Okpechi I

更新日期：2016-03-01 00:00:00

abstract：:There is an increasing body of literature suggesting the efficacy and tolerability of mycophenolate mofetil (MMF) for the treatment of lupus nephritis. The rationale for its use is based upon its successful profile as an immunosuppressive agent for prevention of allograft rejection, as well as studies in murine models...

journal_title：Lupus

authors： Ginzler EM,Aranow C

更新日期：2005-01-01 00:00:00

abstract：:Up to 80% of patients with systemic lupus erythematosus (SLE) are treated with nonsteroidal anti-inflammatory drugs (NSAID) for musculoskeletal symptoms, serositis and headache. This survey reviews the literature on non-selective and selective inhibitors of cyclooxygenases, with an emphasis on the efficacy and safety ...

journal_title：Lupus

authors： Ostensen M,Villiger PM

更新日期：2000-01-01 00:00:00

abstract：:The pathogenesis and therapy of shrinking lungs syndrome in patients with systemic lupus erythematosus remains controversial. It has been previously reported that corticosteroid treatment can be effective. We report a patient with shrinking lungs syndrome who presented a good response to inhaled beta-agonist therapy. ...

journal_title：Lupus

authors： Muñoz-Rodríguez FJ,Font J,Badia JR,Miret C,Barberà JA,Cervera R,Ingelmo M

更新日期：1997-01-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a connective tissue disease where inflammatory activity affects several organ systems. An increased risk of cardiovascular disease has been identified in these patients, even after correction for traditional risk factors. The aim of the present study was to evaluate arterial stiff...

journal_title：Lupus

authors： Bjarnegråd N,Bengtsson C,Brodszki J,Sturfelt G,Nived O,Länne T

更新日期：2006-01-01 00:00:00

abstract：:A 26-year-old Japanese female presented to us with a 2-year history of multiple arc-shaped erythematous lesions on her scalp and the right side of her forehead. Histopathological examination of two of the lesions showed lobular and septal panniculitis with deposits of IgG in the basement membrane zone. We diagnosed th...

journal_title：Lupus

authors： Tsuzaka S,Ishiguro N,Akashi R,Kawashima M

更新日期：2012-05-01 00:00:00

abstract：:This study was conducted to determine kidney transplantation (KTx) outcomes for Greek patients with renal failure caused by lupus nephritis (LN) compared with matched controls, kidney recipients with other causes of end-stage renal disease (ESRD). Twenty-six patients with systemic lupus erythematosus (SLE) subjected t...

journal_title：Lupus

authors： Lionaki S,Kapitsinou PP,Iniotaki A,Kostakis A,Moutsopoulos HM,Boletis JN

更新日期：2008-07-01 00:00:00

abstract：OBJECTIVE:Systemic lupus erythematosus (SLE) is a chronic, relapsing-remitting autoimmune disorder that involves multiple organ systems including the central nervous system. Among the items included in the nomenclature for neuropsychiatric SLE, mood disorders have been identified. The aim of this paper is to review the...

journal_title：Lupus

authors： Palagini L,Mosca M,Tani C,Gemignani A,Mauri M,Bombardieri S

更新日期：2013-04-01 00:00:00

abstract：:Panniculitis rarely occurs in the course of systemic lupus erythematosus (SLE). When it occurs, it is thought to be mainly lupus erythematosus panniculitis (LEP). Here we describe a 32-year old Japanese woman with chronic SLE, who simultaneously presented facial lymphocytic lobular panniculitis and pancytopenia due to...

journal_title：Lupus

authors： Deji N,Sugimoto T,Fujimoto T,Aoyama M,Takeda N,Sakaguchi M,Uzu T,Kashiwagi A

更新日期：2007-01-01 00:00:00

abstract：:Objective People affected by chronic rheumatic conditions, such as systemic lupus erythematosus (SLE), frequently rely on the Internet and search engines to look for terms related to their disease and its possible causes, symptoms and treatments. 'Infodemiology' and 'infoveillance' are two recent terms created to desc...

journal_title：Lupus

authors： Radin M,Sciascia S

更新日期：2017-07-01 00:00:00

abstract：:Proteinuria is a well-known risk factor for the progression of renal dysfunction in chronic kidney disease; however, its importance for estimating the prognosis of lupus nephritis requires verification. Korean adult patients with renal biopsy-diagnosed diffuse proliferative lupus nephritis who had undergone three or m...

journal_title：Lupus

authors： Koo HS,Kim S,Chin HJ

更新日期：2016-01-01 00:00:00

abstract：:The objective of this study was to assess the incidence and risk factors of infections in 200 SLE outpatients. All outpatients with active or inactive SLE without infections in the previous month were included. They were assessed every 3 months. Major infections were those requiring hospitalization and parental antibi...

journal_title：Lupus

authors： Zonana-Nacach A,Camargo-Coronel A,Yañez P,Sánchez L,Jimenez-Balderas FJ,Fraga A

更新日期：2001-01-01 00:00:00