Abstract:
:The complement system contributes to the pathogenesis of systemic lupus erythematosus (SLE). Mannose-binding lectin (MBL) is a key molecule of the lectin pathway of complement and seems to be related to the clinical manifestations of this disease. We evaluated the serum levels of MBL and its relationship with disease onset and clinical findings in SLE patients. Serum samples were analysed in 195 patients and 145 healthy controls from southern Brazil. Patients with high MBL levels (above 2000 ng/ml) showed a significant increase in the frequency of thrombocytopaenia ( p = 0.007; OR = 2.71; 95% CI = 1.32-5.55); and seizures ( p = 0.034; OR = 2.61; 95% CI = 1.07-6.37). A positive correlation between disease activity and MBL levels (>2000 ng/ml; p = 0.031, rho = 0.279) as well as of MBL concentration with accumulated organ damage ( p = 0.021; rho = 0.232) was observed. Our results suggest a role for MBL in the development of clinical manifestations such as thrombocytopaenia and seizures in SLE patients. These findings corroborate the participation of the lectin pathway of complement in the pathophysiologic mechanisms underlying clinical manifestations of SLE.
journal_name
Lupusjournal_title
Lupusauthors
Cieslinski JZ,Skare TL,Nisihara R,De Messias-Reason IJ,Utiyama SRRdoi
10.1177/0961203317722846subject
Has Abstractpub_date
2018-03-01 00:00:00pages
372-379issue
3eissn
0961-2033issn
1477-0962journal_volume
27pub_type
杂志文章相关文献
LUPUS文献大全abstract::Herein, we investigated the risk of juvenile-onset systemic lupus erythematosus (JSLE) in children with atopic dermatitis (AD). From 2000 to 2007, 192,357 children with newly diagnosed AD and 769,428 matched non-AD controls were identified. By the end of 2008, incidences and hazard ratios (HRs) of JSLE were measured. ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314543920
更新日期:2014-12-01 00:00:00
abstract::Skin involvement in systemic lupus erythematosus (SLE) occurs in varied forms. Lupus erythematosus tumidus (LET) is not known to occur with SLE. In our patient presented below, LET occurred in a patient with SLE. Some of the lesions progressed to scarring discoid lesions, while others responded very well to hydoxychlo...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203304lu473cr
更新日期:2004-01-01 00:00:00
abstract::Tissue damage associated with a severe injury can result in profound inflammatory responses that may trigger autoimmune development in lupus-prone individuals. In this study, we investigated the role of a large full-thickness cutaneous burn injury on the early onset of autoimmune disease in lupus-prone MRL/++ mice. MR...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203308097479
更新日期:2009-04-01 00:00:00
abstract::Neuropsychiatric manifestations of systemic lupus erythematosus are common and disabling yet their pathogenesis is poorly understood. We investigated the role of cerebrovascular endothelial dysfunction in systemic lupus erythematosus and its neuropsychiatric manifestations. Subjects with systemic lupus erythematosus w...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203309359780
更新日期:2010-06-01 00:00:00
abstract::We examined the prevalence of clinical and immunologic features of systemic lupus erythematosus (SLE) by race, sex and age in a population-based study of 265 SLE patients. Patients fulfilled the American College of Rheumatology classification criteria. The median time between diagnosis and study enrollment was 13 mont...
journal_title:Lupus
pub_type: 杂志文章,多中心研究
doi:10.1191/0961203302lu161oa
更新日期:2002-01-01 00:00:00
abstract::Intestinal pseudo-obstruction (IpsO) occurs in a small subgroup of patients with systemic lupus erythematosus (SLE), and has been under-recognized. The etiology and mechanisms are unclear. Herein, we report two cases. In case 1, IpsO occurred as the complication in a previously diagnosed SLE patient. In case 2, IpsO w...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203311405702
更新日期:2011-10-01 00:00:00
abstract::Although many types of neurological disorders and events have been described in association with antiphospholipid antibodies (aPL) and the antiphospholipid syndrome (APS), only ischaemic stroke is reasonably well established and accepted as a diagnostic criterion for the syndrome. We propose to evaluate, classify and ...
journal_title:Lupus
pub_type: 共识发展会议,杂志文章,评审
doi:10.1191/0961203303lu392oa
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVE:To examine the potential immunologic mechanism and involvement of antiphospholipid antibodies in the pathogenesis of heart valve lesions in patients with the antiphospholipid syndrome (APS). METHODS:Immunoperoxidase and immunofluorescence staining methods were used to evaluate 13 heart valve specimens derive...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339600500306
更新日期:1996-06-01 00:00:00
abstract::The potential of oral treatment with AVEMAR (AVEMAR), a new benzoquinone-containing fermentation product of wheat germ, on features of experimental systemic lupus erythematosus (SLE) in naive mice, induced by idiotypic manipulation, was studied. We assessed the effect of AVEMAR on the profile of autoantibody productio...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/096120301682430203
更新日期:2001-01-01 00:00:00
abstract::Cardiac involvement in systemic lupus erythematosus (SLE) is well documented. The pericardium, myocardium and endocardium, as well as the coronary arteries, the valves and the conduction system can all be affected. While pericarditis is common, arrythmias are less frequently described.We present a 13-year-old male, wh...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203320974091
更新日期:2020-11-20 00:00:00
abstract::Atherosclerosis is an inflammatory disease, leading to the formation of pro-inflammatory and pro-oxidative lipids that generate an immune response. Several antigens have been shown to activate the immune response and affect the development of atherogenesis. Systemic lupus erythematosus is an autoimmune and inflammator...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203309345725
更新日期:2009-11-01 00:00:00
abstract::We have explored the relationship between possible hemostatic changes and clinical manifestation of the systemic lupus erythematosus (SLE) as a function of greater or lesser disease activity according to Systemic Lupus Erythematosus Disease Activity Index-2000 (SLEDAI-2K) criteria. Endothelial injury and hypercoagulab...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203319899478
更新日期:2020-02-01 00:00:00
abstract::Children born to women with systemic lupus erythematosus seem to have a potentially increased risk of neurodevelopmental disorders compared to children born to healthy women. Recent experimental data suggest in utero exposure to maternal antibodies and cytokines as important risk factors for neurodevelopmental disorde...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203314541691
更新日期:2014-10-01 00:00:00
abstract::Catastrophic antiphospholipid syndrome (CAPS) is an acutely devastating situation characterized by widespread thrombotic microangiopathy in the presence of elevated titers of antiphospholipid antibodies. We describe a 57-year old woman who underwent liver transplantation for primary sclerosing cholangitis and develope...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203303lu278cr
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVE:Systemic lupus erythematosus (SLE), an autoimmune condition with diverse clinical manifestations, is reported to have different expression in populations of different ancestry. Most previous studies compared patients of different ethnic groups from geographically distinct cohorts. In our study, we aimed to ch...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203313500547
更新日期:2013-11-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is an autoimmune disease with a complex pathogenesis. Published data have revealed that serum levels of proinflammatory cytokines are increased in SLE patients. The aim of our study was to evaluate whether monotherapy with chloroquine phosphate affects IL-1beta, IL-6, IL-18 and TNF-a...
journal_title:Lupus
pub_type: 临床试验,杂志文章
doi:10.1191/0961203306lu2299oa
更新日期:2006-01-01 00:00:00
abstract::Lupus nephritis during pregnancy increases morbidity and mortality for mother and baby. Flares are difficult to treat as many therapeutic options are teratogenic or fetotoxic. Steroids alone may be unable to control disease activity and are associated with higher rates of preterm delivery, sepsis and gestational diabe...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314540353
更新日期:2014-10-01 00:00:00
abstract::There is an increasing body of literature suggesting the efficacy and tolerability of mycophenolate mofetil (MMF) for the treatment of lupus nephritis. The rationale for its use is based upon its successful profile as an immunosuppressive agent for prevention of allograft rejection, as well as studies in murine models...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1191/0961203305lu2061oa
更新日期:2005-01-01 00:00:00
abstract::The objective of this study is to determine if digital vasculitis (DV), a clinical manifestation with a high systemic lupus erythematosus disease activity index (SLEDAI) score, is associated with lupus severity. DV and other clinical manifestations defined according to the SLEDAI were evaluated in 168 consecutive pati...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203309106177
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND:Polyarthritis is common to both mixed connective tissue disease (MCTD) and systemic lupus erythematosus (SLE). Apart from being erosive and deforming in the former, we speculated that it was more common and the extent of joints involved would be higher in MCTD. METHODS:This was a cross-sectional study that ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203318804891
更新日期:2018-11-01 00:00:00
abstract::Monoclonal antiphospholipid antibodies (aPL) have been utilized to dissect the relationship between their sequence, structure, binding and biological properties relevant to the pathogenesis of the antiphospholipid syndrome. In particular, sequence analysis of aPL has highlighted the clustering of certain amino acid re...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203309360809
更新日期:2010-04-01 00:00:00
abstract::Central nervous system (CNS) involvement may occur in 20-70% of systemic lupus erythematosus (SLE) patients where neurological symptoms are overt; this is termed neuropsychiatric lupus or NPSLE. This review summarizes evidence that damage to the brain endothelium forming the blood-brain barrier (BBB) is a contributory...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1191/0961203303lu501oa
更新日期:2003-01-01 00:00:00
abstract::Immune-mediated sensorineural hearing loss may complicate systemic autoimmune diseases. We have previously reported the presence of antibodies directed against inner ear antigens in patients with Cogan syndrome, a disease characterized by sudden hearing loss and interstitial keratitis. Such autoantibodies cross-react ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316682099
更新日期:2017-07-01 00:00:00
abstract::Gastrointestinal manifestations of systemic lupus erythematosus (SLE) are common, occurring in about 50% of cases. They are usually mild, in the form of mouth ulcers, nausea, heartburn and mild abdominal pain, but they can be severe in cases of gastrointestinal vasculitis. In this report we describe an unusual combina...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203313517150
更新日期:2014-02-01 00:00:00
abstract:OBJECTIVE:The objective of our study was to determine the incidence rates and risk factors of aortic aneurysm and aortic dissection among patients with systemic lupus erythematosus (SLE) using a nationwide population-based data set. METHODS:We conducted a retrospective cohort study using data from the Taiwan National ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314523868
更新日期:2014-06-01 00:00:00
abstract::Autoantibodies against prothrombin, including lupus anticoagulant antibodies (LAC), have been identified in patients with systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS). To identify the epitopes of LAC in patients with SLE and APS, we analyzed B cell epitopes of anti-prothrombin Abs. Prothrombi...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/096120399678840963
更新日期:1999-01-01 00:00:00
abstract::The purpose of this study was to evaluate the clinical characteristics of women with systemic lupus erythematosus (SLE) sent for a dual energy X-ray absorptiometry (DEXA) study, and to analyse the factors associated with a lower bone mineral density in these patients. Women with SLE who had a DEXA done between 1 Janua...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203303lu1036oa
更新日期:2004-01-01 00:00:00
abstract::Cardio-pulmonary manifestations of systemic lupus erythematosus (SLE) are well recognized in adults. We report the occurrence of clinically significant cardio-pulmonary disease in a cohort of predominantly Caucasian children with SLE. All children with SLE attending the Royal Liverpool Children's NHS Trust between 199...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203305lu2073oa
更新日期:2005-01-01 00:00:00
abstract::Prothrombin is a common antigenic target of antiphospholipid antibodies, since anti-prothrombin antibodies are detected in about 50-90% of the patients. To allow proper immune recognition, prothrombin must be adsorbed on suitable anionic surfaces. The epitope(s) have not yet been identified: the majority of anti-proth...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/096120339800700209
更新日期:1998-01-01 00:00:00
abstract::The acute clinical syndrome of toxic epidermal necrolysis (TEN) is currently thought to be a distinct clinical-pathological entity typically resulting from drug hypersensitivity. We describe an adult woman who experienced a fulminate pattern of apoptotic epidermal cell injury following tanning bed exposure while takin...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1191/0961203304lu2037sa
更新日期:2004-01-01 00:00:00