Non-stroke neurological syndromes associated with antiphospholipid antibodies: evaluation of clinical and experimental studies.

abstract：:Although the importance of the anticardiolipin test in diagnosis of antiphospholipid syndrome (APS) is widely accepted, there remains much misunderstanding about the strengths and weaknesses of this assay. Several disorders result in formation of low levels of the antibody, hence the anticardiolipin test is not specif...

journal_title：Lupus

authors： Harris EN,Pierangeli SS

更新日期：2002-01-01 00:00:00

abstract：:Pulmonary hypertension (PH) can occur at any time during the course of systemic lupus erythematosus (SLE), and can be independent of lupus disease activity in other systems. The pathogenesis of PH in SLE can be multifactorial, but pulmonary arterial hypertension (PAH) is the commonest cause of PH in SLE. The internati...

journal_title：Lupus

authors： Prabu A,Gordon C

更新日期：2013-10-01 00:00:00

abstract：:Cells traffic in both directions between the fetus and the mother during pregnancy. Recent studies indicate that a low level of fetal cells commonly persists in the maternal circulation for years after pregnancy completion. The harboring of DNA or cells from another individual at low levels is called microchimerism. C...

journal_title：Lupus

authors： Nelson JL

更新日期：2002-01-01 00:00:00

abstract：:Female B6.MRLc1(82-100) congenic mice develop more severe autoimmune glomerulonephritis (AGN) than males. We assessed the effects of gonadectomy on the pathogenesis of AGN in these mice. One-month-old male and female mice were divided into sham-operated group (SG) and gonadectomized group (GG), and the pathological ch...

journal_title：Lupus

authors： Ichii O,Konno A,Sasaki N,Endoh D,Hashimoto Y,Kon Y

更新日期：2009-05-01 00:00:00

abstract：OBJECTIVE:The feed-forward loop of type I interferons (IFNs) production and subsequent immunopathology of systemic lupus erythematosus (SLE) has been hypothesised to be disrupted with inhibition of IFNα or type I IFN receptor subunit 1 (IFNAR). This systematic review and meta-analysis present the treatment efficacy and...

journal_title：Lupus

authors： Koh JWH,Ng CH,Tay SH

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Complement activation plays a role in pathogenesis of the antiphospholipid syndrome (APS), but the involvement of the C5b-9 membrane attack complex (MAC) is unknown. Here we studied the effects of human polyclonal antiphospholipid (aPL) antibodies on thrombosis and tissue factor (TF) up-regulation in C6 defi...

journal_title：Lupus

authors： Carrera-Marín A,Romay-Penabad Z,Papalardo E,Reyes-Maldonado E,García-Latorre E,Vargas G,Shilagard T,Pierangeli S

更新日期：2012-12-01 00:00:00

abstract：:Recent studies on epigenetics, including DNA methylation and its regulatory enzymes, seem likely to contribute to elucidation of the pathogenesis of autoimmune diseases such as systemic lupus erythematosus (SLE), although the relationship between DNA methylation and SLE has long been the subject of investigation. To o...

journal_title：Lupus

authors： Sekigawa I,Okada M,Ogasawara H,Kaneko H,Hishikawa T,Hashimoto H

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:We established a multi-centre online registry for primary Sjögren's syndrome (pSS) in China, and compared Chinese patients with those from other countries. METHODS:Data were from 87 rheumatology centres in 27 provinces. All 2986 patients had pSS according to the 2002 American-European Consensus Group or the...

journal_title：Lupus

authors： Xu D,Zhao S,Li Q,Wang YH,Zhao JL,Li MT,Zhao Y,Zeng XF

更新日期：2020-01-01 00:00:00

abstract：:Neonatal antiphospholipid syndrome (neonatal APS) seems to be exceedingly rare, as the antiphospholipid antibodies (aPL) related thrombosis in the neonatal period. The pathogenesis of perinatal aPL related thrombosis may be explained both by the transplacental passage of the maternal antibodies and by the production o...

journal_title：Lupus

authors： De Carolis MP,Salvi S,Botta A,Cocca C,Garufi C,Lanzone A,De Carolis S

更新日期：2015-03-01 00:00:00

abstract：:Objective The objectives of this paper are to objectively measure habitual physical activity levels in patients with primary Sjögren's syndrome (pSS) with mild disease activity and to determine to which extent it may be associated with physical capacity and function and clinical features. Methods In this cross-section...

journal_title：Lupus

authors： Dassouki T,Benatti FB,Pinto AJ,Roschel H,Lima FR,Augusto K,Pasoto S,Pereira RMR,Gualano B,de Sá Pinto AL

更新日期：2017-06-01 00:00:00

abstract：:Novel risk factors for the progression of atherosclerosis such as C-reactive protein (CRP) and adhesion molecules have stimulated much recent interest in the role of inflammation in atherosclerotic disease. There is also evidence emerging that autoimmunity may have a role in the pathogenesis of atherosclerosis. In thi...

journal_title：Lupus

authors： Gordon PA,George J,Khamashta MA,Harats D,Hughes G,Shoenfeld Y

更新日期：2001-01-01 00:00:00

abstract：:Designing successful randomized controlled trials (RCTs) in systemic lupus erythematosus (SLE) poses many challenges. It remains difficult to correlate alterations in biologic markers with clinical outcome, especially when signs and symptoms are intermittent and broadly variable between patients. Disease activity indi...

journal_title：Lupus

authors： Strand V

更新日期：2004-01-01 00:00:00

abstract：:The aim of this study was to investigate two patients with antiphospholipid syndrome (APS) who suffered from multiple repeated pregnancy losses of probably genetically impaired embryos. Sera from these patients contained high levels of IgG antibodies against cardiolipin, IgG and IgM phosphatidyl inositol, IgG phosphat...

journal_title：Lupus

authors： Ulcova-Gallova Z

更新日期：2012-06-01 00:00:00

abstract：:The disease activity of patients suffering from lupus nephritis usually becomes quiescent after the onset of end stage renal failure. Reactivation of lupus activity, especially after a long period of dialysis, is uncommon. Factors that might trigger off lupus reactivation after dialysis have not been well defined. We ...

journal_title：Lupus

authors： Lui SL,Lam MF,Tse KC,Lo WK

更新日期：2002-01-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) can affect all heart structures including the conduction system, with either reversible or permanent derangement. However, only a few cases of adult SLE and complete atrioventricular (AV) block have been reported. We describe a young pregnant woman who initially presented with comple...

journal_title：Lupus

authors： Lo CH,Wei JCC,Tsai CF,Li LC,Huang SW,Su CH

更新日期：2018-09-01 00:00:00

abstract：:Several studies have investigated the potential of various autoantibody tests in the diagnosis of systemic lupus erythematosus (SLE). Many lupus patients initially present with glomerulonephritis. In that clinical situation the main differential diagnosis are other forms of glomerulonephritis. In this study the diagno...

journal_title：Lupus

authors： Heidenreich U,Mayer G,Herold M,Klotz W,Stempfl Al-Jazrawi K,Lhotta K

更新日期：2009-12-01 00:00:00

abstract：:Antiphospholipid antibodies (aPL), the majority of which are directed against beta(2)-glycoprotein I (beta(2)GPI), are associated with an increased incidence of venous and arterial thrombosis. The pathogenesis of antiphospholipid/anti-beta(2)GPI-associated thrombosis has not been defined, and is likely multifactorial....

journal_title：Lupus

authors： Cockrell E,Espinola RG,McCrae KR

更新日期：2008-10-01 00:00:00

abstract：:Patients with systemic lupus erythematosus (SLE) frequently have gastrointestinal (GI) symptoms. These are usually self-limiting and related to treatment side-effects or concurrent illness. However, abdominal pain may be due to bowel ischaemia which can lead to infarction and perforation. The likelihood of these serio...

journal_title：Lupus

authors： Lian TY,Edwards CJ,Chan SP,Chng HH

更新日期：2003-01-01 00:00:00

abstract：PURPOSE:To describe the ocular and systemic manifestations associated with systemic lupus erythematosus (SLE) choroidopathy. METHODS:Three new cases of choroidopathy in patients with active SLE were described. Twenty-five published cases of lupus choroidopathy were summarized. RESULTS:There have been 28 cases of lupu...

journal_title：Lupus

authors： Nguyen QD,Uy HS,Akpek EK,Harper SL,Zacks DN,Foster CS

更新日期：2000-01-01 00:00:00

abstract：:Objective We aimed to evaluate the relationship between telomere length and systemic lupus erythematosus (SLE). Methods PUBMED and EMBASE databases were searched; meta-analyses were performed comparing telomere length in SLE patients and healthy controls, and on SLE patients in subgroups based on ethnicity, sample typ...

journal_title：Lupus

authors： Lee YH,Jung JH,Seo YH,Kim JH,Choi SJ,Ji JD,Song GG

更新日期：2017-03-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoreactive T cell mediated autoimmune disease. Immunization with inactivated autoreactive T cells may induce idiotype anti-idiotypic reaction to deplete specific subsets of autoreactive T cells involved in SLE. Six SLE patients unsuitable or refused to use immunosuppressants ...

journal_title：Lupus

authors： Li ZG,Mu R,Dai ZP,Gao XM

更新日期：2005-01-01 00:00:00

abstract：:Despite strongly held opinions, a trustworthy scientific basis for most statements about autoimmunity, autoimmune diseases and assisted reproductive technologies (ART) does not exist. It is not likely that autoimmunity causes infertility, nor that patients with autoimmune diseases are unusually infertile. When careful...

journal_title：Lupus

authors： Lockshin MD

更新日期：2004-01-01 00:00:00

abstract：:A girl with neuropsychiatric lupus demonstrated Parkinsonian features soon after commencing risperidone. The single photon emission computed tomography scan showed hyperperfusion of the basal ganglia. Symptoms abated with the addition of dopaminergic agents to immunosuppressive therapy. The literature on juvenile Park...

journal_title：Lupus

authors： Khubchandani RP,Viswanathan V,Desai J

更新日期：2007-01-01 00:00:00

abstract：:The levels of 'putative' anti-idiotypic antibodies reactive with F(ab')2 fragments of affinity purified DNA binding antibodies from five SLE patients were measured in the serum of active and inactive systemic lupus erythematosus (SLE) patients, their relatives, spouses and healthy non-related individuals. Serum anti-i...

journal_title：Lupus

authors： Williams WM,Isenberg DA

更新日期：1998-01-01 00:00:00

abstract：:The purpose of this study was to determine the prevalence and correlates of fibromyalgia (FM) in a prospective, multiethnic systemic lupus (SLE) cohort. A total of 266 SLE patients with disease duration of < or = 5 years at study entry were evaluated longitudinally for the presence of FM (per ACR criteria). Sociodemog...

journal_title：Lupus

authors： Friedman AW,Tewi MB,Ahn C,McGwin G Jr,Fessler BJ,Bastian HM,Baethge BA,Reveille JD,Alarcón GS,LUMINA Study Group.

更新日期：2003-01-01 00:00:00

abstract：:A 24 year old female with hereditary spastic paraplegia presented with intermittent headache for one year. She also had lower abdominal pain and vomiting for two months. She was pale, had icterus and mild splenomegaly. On diagnostic evaluation she was found to have hemolytic anemia, thrombocytopenia and bilateral adre...

journal_title：Lupus

authors： Abdulla MC,Alungal J,Hashim S,Ali MM,Musambil M

更新日期：2015-09-01 00:00:00

abstract：:The objective of this study was to observe the clinical and pathologic features of digital lesions in a cohort of 50 patients with systemic lupus erythematosus (SLE). Biopsy and pictures of digital lesions were performed in 50 consecutive patients with SLE and digital lesions. A clinical diagnosis of vasculitis was pr...

journal_title：Lupus

authors： Bouaziz JD,Barete S,Le Pelletier F,Amoura Z,Piette JC,Francès C

更新日期：2007-01-01 00:00:00

abstract：:Analyses of the medical and economic burden of chronic disorders such as systemic lupus erythematosus (SLE) are valuable for clinical and health policy decisions. We performed a chart-based review of 215 adult SLE patients with active autoantibody-positive disease at the predefined ratio of 30% severe (involvement of ...

journal_title：Lupus

authors： Bertsias G,Karampli E,Sidiropoulos P,Gergianaki I,Drosos A,Sakkas L,Garyfallos A,Tzioufas A,Vassilopoulos D,Tsalapaki C,Sfikakis P,Panopoulos S,Athanasakis K,Perna A,Psomali D,Kyriopoulos J,Boumpas D

更新日期：2016-10-01 00:00:00

abstract：OBJECTIVE:Arthritis is frequently seen in human lupus, but rarely in lupus models. Pristane-induced lupus (PIL) can be induced in various mouse strains such as BALB/c and C57BL/6. We herein characterize clinical and histological features of arthritis in the context of systemic lupus and provide a prudent comparison wit...

journal_title：Lupus

authors： Leiss H,Niederreiter B,Bandur T,Schwarzecker B,Blüml S,Steiner G,Ulrich W,Smolen JS,Stummvoll GH

更新日期：2013-07-01 00:00:00

abstract：:Objectives The objective of this study was to determine whether advanced MRI could provide biomarkers for diagnosis and prognosis in neuropsychiatric systemic lupus erythematosus (NPSLE). Methods Our prospective study included 28 systemic lupus erythematosus (SLE) patients with primary central NPSLE, 22 patients witho...

journal_title：Lupus

authors： Sarbu N,Toledano P,Calvo A,Roura E,Sarbu MI,Espinosa G,Lladó X,Cervera R,Bargalló N

更新日期：2017-04-01 00:00:00