Abstract:
:Neonatal antiphospholipid syndrome (neonatal APS) seems to be exceedingly rare, as the antiphospholipid antibodies (aPL) related thrombosis in the neonatal period. The pathogenesis of perinatal aPL related thrombosis may be explained both by the transplacental passage of the maternal antibodies and by the production of de novo antibodies by the neonate. However, few cases of neonatal APS are reported in the literature, especially regarding arterial thrombotic events. In particular, only two cases of neonatal aPL related isolated cerebral sinovenous thrombosis (CSVT) are described in the literature. Despite its frequency, CSVT results in significant mortality and morbidity, probably also due to the difficulty in early diagnosis and then in correct managing in the neonatal period. A diagnosis of neonatal APS should be considered in the evaluation of neonates with CSVT, as well as in any case of neonatal thrombosis, to correctly manage the affected neonates and counsel the mother for future pregnancies.
journal_name
Lupusjournal_title
Lupusauthors
De Carolis MP,Salvi S,Botta A,Cocca C,Garufi C,Lanzone A,De Carolis Sdoi
10.1177/0961203314560207subject
Has Abstractpub_date
2015-03-01 00:00:00pages
231-4issue
3eissn
0961-2033issn
1477-0962pii
0961203314560207journal_volume
24pub_type
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