Antiphospholipid syndrome in northwest Italy (APS Piedmont Cohort): demographic features, risk factors, clinical and laboratory profile.

abstract：OBJECTIVE:The objective of our study was to determine the incidence rates and risk factors of aortic aneurysm and aortic dissection among patients with systemic lupus erythematosus (SLE) using a nationwide population-based data set. METHODS:We conducted a retrospective cohort study using data from the Taiwan National ...

journal_title：Lupus

authors： Wang SH,Chang YS,Liu CJ,Lai CC,Chen TJ,Chen WS

更新日期：2014-06-01 00:00:00

abstract：:Twelve systemic lupus erythematosus (SLE) patients with mild to moderate disease activity (SLEDAI of > or = 6 and on prednisolone < 0.5 mg/kg/day) were included in a prospective, randomized, double-blind, placebo-controlled pilot study for 24 weeks. Six were randomized to receive oral leflunomide and six received plac...

journal_title：Lupus

authors： Tam LS,Li EK,Wong CK,Lam CW,Szeto CC

更新日期：2004-01-01 00:00:00

abstract：:A girl with neuropsychiatric lupus demonstrated Parkinsonian features soon after commencing risperidone. The single photon emission computed tomography scan showed hyperperfusion of the basal ganglia. Symptoms abated with the addition of dopaminergic agents to immunosuppressive therapy. The literature on juvenile Park...

journal_title：Lupus

authors： Khubchandani RP,Viswanathan V,Desai J

更新日期：2007-01-01 00:00:00

abstract：:The immunopathogenesis of systemic lupus erythematosus has been thoroughly investigated recently, and genome-wide association studies have identified genes statistically associated with lupus. However, the progression to overt disease is dependent on the activation of environmental factors ('triggers'), among which oe...

journal_title：Lupus

authors： Catania G,Rossi E,Marmont A

更新日期：2012-05-01 00:00:00

abstract：:The objective of this article was to evaluate whether serum uric acid (SUA) correlates with arterial stiffness and inflammation markers in a cohort of women with systemic lupus erythematosus (SLE) without overt atherosclerotic cardiovascular diseases, who attended a community hospital. One hundred and two women with S...

journal_title：Lupus

authors： Sabio JM,Vargas-Hitos JA,Mediavilla JD,Navarrete-Navarrete N,Zamora-Posadas M,Pérez-Vicente S,Hidalgo-Tenorio C,Díaz-Chamorro A,Jáimez L,Jiménez-Alonso J,Grupo Lupus Virgen de las Nieves.

更新日期：2010-04-01 00:00:00

abstract：OBJECTIVE:This study aimed to explore whether TYK2 polymorphisms are associated with susceptibility to autoimmune rheumatic diseases. METHODS:We conducted a meta-analysis on the association between TYK2 polymorphisms and autoimmune rheumatic diseases. RESULTS:Twelve studies with a total of 16,335 patients and 30,065 ...

journal_title：Lupus

authors： Lee YH,Bae SC

更新日期：2016-10-01 00:00:00

abstract：:The effect of beta 2glycoprotein I (beta 2GPI) and human monoclonal anticardiolipin antibody (aCL) on the protein S/C4b-binding protein (C4BP) system was evaluated. The binding of C4BP to protein S was assessed by ELISA in the presence of beta 2GPI with/without human monoclonal aCL. beta 2GPI downregulated the binding...

journal_title：Lupus

authors： Atsumi T,Khamashta MA,Ames PR,Ichikawa K,Koike T,Hughes GR

更新日期：1997-01-01 00:00:00

abstract：:Neuropsychiatric manifestations of systemic lupus erythematosus are common and disabling yet their pathogenesis is poorly understood. We investigated the role of cerebrovascular endothelial dysfunction in systemic lupus erythematosus and its neuropsychiatric manifestations. Subjects with systemic lupus erythematosus w...

journal_title：Lupus

authors： Davey R,Bamford J,Emery P

更新日期：2010-06-01 00:00:00

abstract：:The objective of this study was to observe the clinical and pathologic features of digital lesions in a cohort of 50 patients with systemic lupus erythematosus (SLE). Biopsy and pictures of digital lesions were performed in 50 consecutive patients with SLE and digital lesions. A clinical diagnosis of vasculitis was pr...

journal_title：Lupus

authors： Bouaziz JD,Barete S,Le Pelletier F,Amoura Z,Piette JC,Francès C

更新日期：2007-01-01 00:00:00

abstract：:Analyses of the medical and economic burden of chronic disorders such as systemic lupus erythematosus (SLE) are valuable for clinical and health policy decisions. We performed a chart-based review of 215 adult SLE patients with active autoantibody-positive disease at the predefined ratio of 30% severe (involvement of ...

journal_title：Lupus

authors： Bertsias G,Karampli E,Sidiropoulos P,Gergianaki I,Drosos A,Sakkas L,Garyfallos A,Tzioufas A,Vassilopoulos D,Tsalapaki C,Sfikakis P,Panopoulos S,Athanasakis K,Perna A,Psomali D,Kyriopoulos J,Boumpas D

更新日期：2016-10-01 00:00:00

abstract：:One hundred and fifty-eight patients with SLE were prospectively studied at a tertiary referral centre in India to ascertain the prevalence and clinical profile of fibromyalgia (FM) in Indian patients with lupus. An attempt was made to determine whether socio-demographic factors or disease characteristics differ in SL...

journal_title：Lupus

authors： Handa R,Aggarwal P,Wali JP,Wig N,Dwivedi SN

更新日期：1998-01-01 00:00:00

abstract：:Cardio-pulmonary manifestations of systemic lupus erythematosus (SLE) are well recognized in adults. We report the occurrence of clinically significant cardio-pulmonary disease in a cohort of predominantly Caucasian children with SLE. All children with SLE attending the Royal Liverpool Children's NHS Trust between 199...

journal_title：Lupus

authors： Beresford MW,Cleary AG,Sills JA,Couriel J,Davidson JE

更新日期：2005-01-01 00:00:00

abstract：:Objective The main aim of this study was to investigate the ovarian reserve, menstruation, and lymphocyte subpopulation in systemic lupus erythematosus (SLE) patients of childbearing age. Methods We enrolled 40 SLE patients of childbearing age and 40 age-matched healthy controls. Anti-Müllerian hormone (AMH) was teste...

journal_title：Lupus

authors： Gao H,Ma J,Wang X,Lv T,Liu J,Ren Y,Li Y,Zhang Y

更新日期：2018-03-01 00:00:00

abstract：:Although osteoporosis has traditionally been considered a disease of women, men also incur substantial bone loss with aging, and elderly men have age-specific hip fracture incidence rates and vertebral fracture prevalence rates that are at least half those in women. Early postmenopausal bone loss (which results in the...

journal_title：Lupus

authors： Khosla S,Melton LJ 3rd,Riggs BL

更新日期：1999-01-01 00:00:00

abstract：:Nephropathy of antiphospholipid antibody syndrome (NAPS) is an increasingly well-recognized aspect of antiphospholipid syndrome. The most characteristic histopathology is that of thrombotic microangiopathy, and thrombosis occurring in the renal vasculature is thought to be the initiating event. Other less common patho...

journal_title：Lupus

authors： Lin YQ,Lakshminarayanan S,Yamase H,Palmisano J,Parke A

更新日期：2009-05-01 00:00:00

abstract：:Progressive multifocal leukoencephalopathy (PML) is a rare, deadly demyelinating disease of the central nervous system, which is caused by a reactivation of the DNA polyomavirus JC and occurs in immunosuppressed individuals. So far, only 25 cases have been described in patients with SLE and none survived without antiv...

journal_title：Lupus

authors： Nived O,Bengtsson AA,Jönsen A,Sturfelt G

更新日期：2008-11-01 00:00:00

abstract：:Lupus nephritis during pregnancy increases morbidity and mortality for mother and baby. Flares are difficult to treat as many therapeutic options are teratogenic or fetotoxic. Steroids alone may be unable to control disease activity and are associated with higher rates of preterm delivery, sepsis and gestational diabe...

journal_title：Lupus

authors： Webster P,Wardle A,Bramham K,Webster L,Nelson-Piercy C,Lightstone L

更新日期：2014-10-01 00:00:00

abstract：:The SLICC/ACR damage index for SLE was developed to assess accumulated damage since the onset of the disease. The damage includes non-reversible changes in organs and systems affected by the disease process itself, its therapy, or inter-current illness. This paper describes the development of the damage index, its val...

journal_title：Lupus

authors： Gladman DD,Urowitz MB

更新日期：1999-01-01 00:00:00

abstract：:This report considers the rare situation in which primary antiphospholipid syndrome (PAPS) is linked with thrombotic thrombocytopenic purpura (TTP). It describes the case of a young lady with PAPS, characterized by recurring cerebro-vascular abnormalities and marked livedo reticularis, combined with circulating antica...

journal_title：Lupus

authors： de Carvalho JF,Freitas CA,Lima IV,Leite CC,Lage LV

更新日期：2009-08-01 00:00:00

abstract：:A 26-year-old Japanese female presented to us with a 2-year history of multiple arc-shaped erythematous lesions on her scalp and the right side of her forehead. Histopathological examination of two of the lesions showed lobular and septal panniculitis with deposits of IgG in the basement membrane zone. We diagnosed th...

journal_title：Lupus

authors： Tsuzaka S,Ishiguro N,Akashi R,Kawashima M

更新日期：2012-05-01 00:00:00

abstract：:Previous studies in our laboratory showed a dose-dependent and hormone-specific increase in CD154 expression in T cells from females with systemic lupus erythematosus (SLE). This present study investigates if the estrogen-dependent increase in CD154 expression is due to stabilization of the messenger RNA. T cells from...

journal_title：Lupus

authors： Li X,Rider V,Kimler BF,Abdou NI

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:Several studies have shown that Hispanic patients generally experience a worse renal prognosis than non-Hispanic white patients with lupus. To date, there is no report on American College of Rheumatology (ACR) renal response criteria (ACR-RRC) in patients from Latin America. OBJECTIVE:To evaluate treatmen...

journal_title：Lupus

authors： Vinicki JP,Paniego FM,De Rosa G,Dubinsky D,Laborde HA,Marini A,Nasswetter G

更新日期：2016-02-01 00:00:00

abstract：OBJECTIVE:For patients with chronic illnesses the global burden of illness is a crucial health measure hitherto neglected in research studies and clinical practice. We tested the application and validity of PRISM (Pictorial Representation of Illness and Self-Measure), a novel visual method for assessing the burden of i...

journal_title：Lupus

authors： Büchi S,Villiger P,Kauer Y,Klaghofer R,Sensky T,Stoll T

更新日期：2000-01-01 00:00:00

abstract：:Neuropsychiatric lupus is a well-recognized complication of systemic lupus erythematosus (SLE) and encompasses a wide variety of neurological manifestations. Although isolated cranial nerve involvement is rare, it can cause significant morbidity and disability. This report describes a case with isolated vagus nerve in...

journal_title：Lupus

authors： Yu KH,Yang CH,Chu CC

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVES:Health-related quality of life (HRQoL) has not been fully explored in antiphospholipid syndrome (APS); therefore, we compared HRQoL between APS patients and the general population and assessed the impact of thromboembolic history. METHODS:HRQoL was measured in a multicentre cohort study by the Medical Outco...

journal_title：Lupus

authors： Zuily S,Rat AC,Regnault V,Kaminsky P,Mismetti P,Ninet J,Baillet N,Magy-Bertrand N,Pasquali JL,Lambert M,Pasquier E,Lorcerie B,Lecompte T,Guillemin F,Wahl D,TAC(I)T investigators.

更新日期：2015-10-01 00:00:00

abstract：:The heart lesions of rheumatic fever and the heart involvement in antiphospholipid syndrome (APS), have different clinical pictures. Yet, there are several common characteristics linking both diseases: 1) central nervous system (CNS) and heart involvement; 2) molecular mimicry between the a pathogen and the origin of ...

journal_title：Lupus

authors： Blank M,Aron-Maor A,Shoenfeld Y

更新日期：2005-01-01 00:00:00

abstract：:Objective We aimed to evaluate the relationship between telomere length and systemic lupus erythematosus (SLE). Methods PUBMED and EMBASE databases were searched; meta-analyses were performed comparing telomere length in SLE patients and healthy controls, and on SLE patients in subgroups based on ethnicity, sample typ...

journal_title：Lupus

authors： Lee YH,Jung JH,Seo YH,Kim JH,Choi SJ,Ji JD,Song GG

更新日期：2017-03-01 00:00:00

abstract：:Gamma-aminobutyric acid-A (GABA-A) receptors play a crucial role in regulating neuronal excitability and cognitive functions. Single-photon emission computerized tomography (SPECT) analysis of GABA-A receptors binding by (123)I-labelled Iomazenil ((123)I-IMZ) has been applied in some neuropsychiatric disorders to inve...

journal_title：Lupus

authors： Mathieu A,Vacca A,Serra A,Cauli A,Piga M,Porru G,Marrosu F,Sanna G,Piga M

更新日期：2010-07-01 00:00:00

abstract：:Antiphospholipid syndrome (APS) is an autoimmune disease characterized by recurrent thrombotic events, miscarriages and thrombocytopenia with persistently positive antiphospholipid antibodies.( 1,2 ) APS may be isolated (primary APS) or associated to a connective tissue disease, most often systemic lupus erythematosus...

journal_title：Lupus

authors： Taipa R,Santos E

更新日期：2011-11-01 00:00:00

abstract：:Monoclonal antiphospholipid antibodies (aPL) have been utilized to dissect the relationship between their sequence, structure, binding and biological properties relevant to the pathogenesis of the antiphospholipid syndrome. In particular, sequence analysis of aPL has highlighted the clustering of certain amino acid re...

journal_title：Lupus

authors： Lambrianides A,Giles IP

更新日期：2010-04-01 00:00:00