Defective cerebral gamma-aminobutyric acid-A receptor density in patients with systemic lupus erythematosus and central nervous system involvement. An observational study.

abstract：:Consanguineous marriage is quite prevalent in the Sultanate of Oman, with up to 45% of marriages being consanguineous. The aim of this study was to determine demographic, clinical and serological characteristics between familial and non-familial cases of juvenile systemic lupus erythematosus (SLE) in a highly consangu...

journal_title：Lupus

authors： Abdwani R,Hira M,Al-Nabhani D,Al-Zakwani I

更新日期：2011-03-01 00:00:00

abstract：:The Framingham risk score is widely used to identify patients at increased cardiovascular risk, and women with systemic lupus erythematosus (SLE) have a marked increased prevalence of cardiovascular events. Thus, we examined the hypothesis that cardiovascular risk scores would identify women with SLE who had asymptoma...

journal_title：Lupus

authors： Chung CP,Oeser A,Avalos I,Raggi P,Stein CM

更新日期：2006-01-01 00:00:00

abstract：:This prospective multicentric register was initiated by the European Forum of Antiphospholipid Antibodies (APL) in 2003 after approval by local ethic committees. This register allows the investigation of infants after written informed parental consent. It collects mothers' clinical pattern of antiphospholipid syndrome...

journal_title：Lupus

authors： Boffa MC,Aurousseau MH,Lachassinne E,Dauphin H,Fain O,Le Toumelin P,Uzan M,Piette JC,Derenne S,Boinot C,Avcin T,Motta M,Faden D,Tincani A

更新日期：2004-01-01 00:00:00

abstract：:Systemic lupus erythematosus is the prototypic multi-system autoimmune disease characterized by the production of multiple autoantibodies. The development of disease depends on a genetic predisposition and exposure to environmental factors including UV light, drugs, and infections. The association of parasitic infecti...

journal_title：Lupus

authors： Zandman-Goddard G,Shoenfeld Y

更新日期：2009-11-01 00:00:00

abstract：:Cutaneous manifestations of lupus erythematosus (LE) are, usually, characteristic enough to permit an easy diagnosis. However, some patients may present less typical lesions, associated or not to the classic ones. Therefore, irrespectively of the variety of LE (acute, subacute and chronic), in absence of the typical b...

journal_title：Lupus

authors： Mascaro JM,Herrero C,Hausmann G

更新日期：1997-01-01 00:00:00

abstract：:HIN200 is a human IFN-inducible gene and homologous to murine IFI202 gene, which was identified as a candidate gene for SLE susceptibility in lupus mouse model. We determined these gene expressions in leukocytes from 20 SLE patients and 10 healthy controls and in renal biopsies from 29 SLE patients and 15 kidney donor...

journal_title：Lupus

authors： Kimkong I,Avihingsanon Y,Hirankarn N

更新日期：2009-10-01 00:00:00

abstract：:Choroidal involvement in systemic lupus erythematosus (SLE) occurs infrequently. We report a 45-y-old woman with bilateral chorioretinopathy associated with SLE. Diagnosis was performed using indirect ophthalmoscopy, retinal fluorescein angiography (FA) and green indocianin angiography (ICG). In this patient chorioret...

journal_title：Lupus

authors： Paroli MP,Riso D,Pinca M,Pivetti-Pezzi P

更新日期：2001-01-01 00:00:00

abstract：:Nodular or pseudomembranous tracheobronchitis due to infection by Aspergillus species is an uncommon presentation of invasive aspergillosis. Most cases have been described in severely immunocompromised hosts. We describe the case of a 23-year-old woman, with recently diagnosed systemic lupus erythematosus, who develop...

journal_title：Lupus

authors： Angelotti T,Krishna G,Scott J,Berry G,Weinacker A

更新日期：2002-01-01 00:00:00

abstract：:Although osteoporosis has traditionally been considered a disease of women, men also incur substantial bone loss with aging, and elderly men have age-specific hip fracture incidence rates and vertebral fracture prevalence rates that are at least half those in women. Early postmenopausal bone loss (which results in the...

journal_title：Lupus

authors： Khosla S,Melton LJ 3rd,Riggs BL

更新日期：1999-01-01 00:00:00

abstract：:Vitamin D deficiency has been described in systemic lupus erythematosus (SLE). BsmI VDR (vitamin D receptor) gene polymorphism was associated with SLE in Asian patients. Studies in Brazilian populations have not been realized. A case-control study with 195 SLE patients and 201 healthy controls was conducted to investi...

journal_title：Lupus

authors： Monticielo OA,Brenol JC,Chies JA,Longo MG,Rucatti GG,Scalco R,Xavier RM

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:The objective of this paper is to assess the role of gender on survival rate and causes of death and organ damage in systemic lupus erythematosus (SLE) patients in China from 2009 to 2015. METHODS:We conducted a multicenter cohort study to analyze the differences in outcome data between male and female SLE p...

journal_title：Lupus

authors： Zhang S,Ye Z,Li C,Li Z,Li X,Wu L,Liu S,Zuo X,Zhu P,Wang Z,Wang Y,Wang Z,Zhao J,Wang Q,Tian X,Li M,Zeng X

更新日期：2019-04-01 00:00:00

abstract：:Cytotoxic therapy is a cornerstone for patients with severe systemic lupus erythematosus (SLE). High-dose cyclophosphamide, 200 mg/kg, can induce a complete remission without the need for stem cell rescue in patients with autoimmune illnesses. Here we report on our first four patients treated for severe SLE with this ...

journal_title：Lupus

authors： Gladstone DE,Prestrud AA,Pradhan A,Styler MJ,Topolsky DL,Crilley PA,Hoch S,Huppert A,Brodsky I

更新日期：2002-01-01 00:00:00

abstract：:We report clinical and histopathological features, treatment and outcome of 37 Croatian children with biopsy-proven lupus nephritis seen over a 30-year period. The mean age at lupus nephritis presentation was 12.11 ± 2.59 years (range 4.66-17.0). The most frequent histopathological finding was class IV (37.8%), follow...

journal_title：Lupus

authors： Batinić D,Milošević D,Čorić M,Topalović-Grković M,Jelušić M,Turudić D

更新日期：2015-03-01 00:00:00

abstract：:This study was conducted to determine kidney transplantation (KTx) outcomes for Greek patients with renal failure caused by lupus nephritis (LN) compared with matched controls, kidney recipients with other causes of end-stage renal disease (ESRD). Twenty-six patients with systemic lupus erythematosus (SLE) subjected t...

journal_title：Lupus

authors： Lionaki S,Kapitsinou PP,Iniotaki A,Kostakis A,Moutsopoulos HM,Boletis JN

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:Environmental factors appear to play a role in the pathogenesis of lupus erythematosus (LE). OBJECTIVE:To determine the association between cigarette smoking and various types of cutaneous LE. DESIGN:Retrospective descriptive study at a dermatology clinic of a tertiary referral hospital. METHODS:All patie...

journal_title：Lupus

authors： Böckle BC,Sepp NT

更新日期：2015-06-01 00:00:00

abstract：:There is an increasing body of literature suggesting the efficacy and tolerability of mycophenolate mofetil (MMF) for the treatment of lupus nephritis. The rationale for its use is based upon its successful profile as an immunosuppressive agent for prevention of allograft rejection, as well as studies in murine models...

journal_title：Lupus

authors： Ginzler EM,Aranow C

更新日期：2005-01-01 00:00:00

abstract：:To determine if neurometabolic changes in the white matter (WM) of systemic lupus erythematosus (SLE) patients may predict the appearance of small hyperintense lesions on T2-weighted magnetic resonance imaging (MRI) inside the magnetic resonance spectroscopy (MRS) region of interest (ROI). We included 30 SLE patients ...

journal_title：Lupus

authors： Appenzeller S,Li LM,Costallat LT,Cendes F

更新日期：2007-01-01 00:00:00

abstract：:Objectives The objective of this paper is to study the time trend and risk factors of avascular bone necrosis (AVN) in patients with systemic lupus erythematosus (SLE). Methods Between 1999 and 2014, patients who fulfilled the ACR criteria for SLE and developed symptomatic AVN were identified from our cohort database ...

journal_title：Lupus

authors： Tse SM,Mok CC

更新日期：2017-06-01 00:00:00

abstract：:There has been limited success defining environmental factors important to the development of connective tissue diseases such as systemic lupus erythematosus (SLE). Recent work has suggested that the perinatal environment may be important. To investigate this we measured antinuclear antibodies (ANA) in a general popul...

journal_title：Lupus

authors： Edwards CJ,Syddall H,Goswami R,Goswami P,Dennison EM,Cooper C

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Plasma mycophenolic acid (MPA) concentrations may predict therapeutic response in active lupus nephritis (LN). We determined the efficacy and safety of a concentration-controlled MPA regime in the treatment of severely active LN. METHODS:In this prospective study, 19 biopsy-proven class III/IV LN patients w...

journal_title：Lupus

authors： Kittanamongkolchai W,Rukrung C,Supasiri T,Lertjirachai I,Somparn P,Chariyavilaskul P,Avihingsanon Y

更新日期：2013-06-01 00:00:00

abstract：OBJECTIVES:The aims of this study were to clarify the activation of complement pathways in patients with lupus nephritis (LN), and to elucidate the association between these complement activation types and clinical outcomes. METHODS:We enrolled 115 patients with biopsy-proven LN from 2003 to 2016 from the lupus cohort...

journal_title：Lupus

authors： Kim H,Kim T,Kim M,Lee HY,Kim Y,Kang MS,Kim J

更新日期：2020-07-01 00:00:00

abstract：:The purpose of the present study was to evaluate patients with the antiphospholipid syndrome with particular attention to their initial clinical features, final diagnoses and the course of thrombotic events in association with therapy. The methodology applied was the following: retrospective analysis of 30 patient fil...

journal_title：Lupus

authors： Vlachoyiannopoulos PG,Tsiakou E,Chalevelakis G,Raptis SA,Moutsopoulos HM

更新日期：1994-04-01 00:00:00

abstract：:With a cross sectional study of 465 consecutive systemic lupus erythematosus (SLE) patients tested for 13 autoantibodies (Aab) and two idiotypes we determined the prevalence of Aab according to disease activity, both general and at particular organ systems. Seventy seven percent of SLE sera had at least one Aab and 56...

journal_title：Lupus

authors： Villarreal GM,Drenkard C,Villa AR,Slor H,Shafrir S,Bakimer R,Shoenfeld Y,Alarcón-Segovia D

更新日期：1997-01-01 00:00:00

abstract：:The objective of this study was to observe the clinical and pathologic features of digital lesions in a cohort of 50 patients with systemic lupus erythematosus (SLE). Biopsy and pictures of digital lesions were performed in 50 consecutive patients with SLE and digital lesions. A clinical diagnosis of vasculitis was pr...

journal_title：Lupus

authors： Bouaziz JD,Barete S,Le Pelletier F,Amoura Z,Piette JC,Francès C

更新日期：2007-01-01 00:00:00

abstract：:This work describes the development of sideroblastic anemia (SA) during the clinical activity of systemic lupus erythematosus (SLE) in two patients. The cases refer to two women with SLE who developed SA during a relapse of the illness. Both patients fulfilled at least four criteria of the American Association of Rheu...

journal_title：Lupus

authors： Jiménez-Balderas FJ,Morales-Polanco MR,Gutierrez L

更新日期：1994-06-01 00:00:00

abstract：:Neurological involvement in antiphospholipid antibody syndrome (APS) is common, and its occurrence increases morbidity and mortality. Patients may present variable neurological involvement, such as cerebrovascular disease, cognitive dysfunction, headache, seizures, movement disorders, multiple sclerosis-like syndrome,...

journal_title：Lupus

authors： Ricarte IF,Dutra LA,Abrantes FF,Toso FF,Barsottini OGP,Silva GS,de Souza AWS,Andrade D

更新日期：2018-08-01 00:00:00

abstract：:The aim of this study was to evaluate traditional risk factors for coronary artery disease (CAD), homocysteine, anti-oxidized low-density lipoprotein (anti-oxLDL), anti-lipoprotein lipase (anti-LPL) and endothelin-1 (ET-1) in patients with primary anti-phospholipid syndrome (APS), furthermore verify possible associati...

journal_title：Lupus

authors： de Souza AW,Silva NP,de Carvalho JF,D'Almeida V,Noguti MA,Sato EI

更新日期：2007-01-01 00:00:00

abstract：:Coming from Hans Wigzell's laboratory in Uppsala, Sweden, I joined the Kunkel laboratory in 1981 to spend a post-doctoral fellowship period financed by the German Research Organization. While I initially worked with Nick Chiorazzi in an attempt to generate monoclonal antibody-secreting human B-cell hybridomas, I later...

journal_title：Lupus

authors： Kabelitz D

更新日期：2003-01-01 00:00:00

abstract：:Poly(ADP-ribose) metabolism is altered in patients with SLE. In order to localize the defect, the levels of poly(ADP-ribose) polymerase-specific mRNA were measured from dot blots of total RNA from peripheral blood lymphocytes. In this preliminary study, eleven patients with SLE and two with antiphospholipid syndrome w...

journal_title：Lupus

authors： Lee JS,Haug BL,Sibley JT

更新日期：1994-04-01 00:00:00

abstract：:Azathioprine-induced aplastic anemia and fatal myelosuppression is a rare occurrence in patients with systemic lupus erythematosus (SLE). We report a case of a 53-year-old female with a normal thiopurine S-methyltransferase (TPMT) level who developed aplastic anemia within 4 weeks of azathioprine initiation, resulting...

journal_title：Lupus

authors： Yeter KC,Afkhami M,Brynes RK,Quismorio FP Jr

更新日期：2013-12-01 00:00:00