Abstract:
:Azathioprine-induced aplastic anemia and fatal myelosuppression is a rare occurrence in patients with systemic lupus erythematosus (SLE). We report a case of a 53-year-old female with a normal thiopurine S-methyltransferase (TPMT) level who developed aplastic anemia within 4 weeks of azathioprine initiation, resulting in death. Physicians should be vigilant in monitoring routine blood work when administering azathioprine, a relatively common drug, in patients with SLE.
journal_name
Lupusjournal_title
Lupusauthors
Yeter KC,Afkhami M,Brynes RK,Quismorio FP Jrdoi
10.1177/0961203313504636subject
Has Abstractpub_date
2013-12-01 00:00:00pages
1526-8issue
14eissn
0961-2033issn
1477-0962pii
0961203313504636journal_volume
22pub_type
杂志文章,评审相关文献
LUPUS文献大全abstract::Nephropathy of antiphospholipid antibody syndrome (NAPS) is an increasingly well-recognized aspect of antiphospholipid syndrome. The most characteristic histopathology is that of thrombotic microangiopathy, and thrombosis occurring in the renal vasculature is thought to be the initiating event. Other less common patho...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203308098629
更新日期:2009-05-01 00:00:00
abstract::Objective The objective of this report is to evaluate the prevalence and clinico-serological correlations of anti-α-enolase antibody (Ab) in patients with systemic lupus erythematosus (SLE). Methods Thirty-two untreated patients with SLE and 20 age- and sex-matched healthy controls were evaluated by rheumatologic exam...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203317721752
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Systemic lupus erythematosus (SLE) is a complex autoimmune disease that can involve multiple organ systems. Exposure to ultraviolet radiation (UVR) can exacerbate pre-existing SLE, and can even induce systemic manifestations. This study aimed to investigate the photoprotective habits of children with SLE and...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203320930098
更新日期:2020-07-01 00:00:00
abstract::We describe seven patients who developed malignancy before, after or at the onset of systemic lupus erythematosus (SLE). They comprise three cases of breast adenocarcinoma, two cases of Hodgkin's lymphoma, and one each of cholangiocarcinoma and thymoma. Only one of this group had been treated with cytotoxic agents, an...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339300200309
更新日期:1993-06-01 00:00:00
abstract::Structural and metabolic abnormalities in the hippocampus have been associated with the pathophysiological mechanism of central nervous system involvement in primary Sjögren syndrome (pSS). Nevertheless, how hippocampal function is altered in pSS remains unknown. The purpose of our study is to investigate the alterati...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203320908936
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVE:To investigate the prevalence and characteristics of anti-endothelial cell antibodies (AECA) in a large cohort of patients with several well defined systemic autoimmune diseases, in order to determine their relationship with the clinical and laboratory features of these diseases. METHODS:Clinical and laborat...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339700600608
更新日期:1997-01-01 00:00:00
abstract::Women's treatment preferences for lupus nephritis vary widely even after adjusting for sociodemographic factors and disease severity. Attitude toward risk may partially explain interpatient variability in treatment preference. The objective of this study was to examine the association between 'risk-attitude' and patie...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203303lu371oa
更新日期:2003-01-01 00:00:00
abstract::Peripheral T cell apoptosis is upregulated in active SLE, in parallel with high expression of both membrane-bound and soluble (s) Fas. Previous studies postulated that sFas down-regulates apoptosis in vitro through its blockade of the Fas-L of cytotoxic cells. We have investigated the extent of apoptosis and sFas leve...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203303lu250oa
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVE:Studies have been conducted to determine the causal factors and clinical consequences of non-adherence to treatment in systemic lupus erythematosus (SLE). However, no interventions have been performed to increase drug adherence. Our objective was to assess the effectiveness of pharmaceutical care (PC) for dru...
journal_title:Lupus
pub_type: 杂志文章,随机对照试验
doi:10.1177/0961203319877237
更新日期:2019-10-01 00:00:00
abstract::This work describes the development of sideroblastic anemia (SA) during the clinical activity of systemic lupus erythematosus (SLE) in two patients. The cases refer to two women with SLE who developed SA during a relapse of the illness. Both patients fulfilled at least four criteria of the American Association of Rheu...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339400300305
更新日期:1994-06-01 00:00:00
abstract::Tumor necrosis factor alpha (TNF alpha) and interleukin-6 (IL-6) play a main role in inducing acute phase protein production by hepatocytes. This study describes the serum levels of TNF alpha and IL-6 in relation to serum levels of C-reactive protein (CRP) and alpha 1-acid glycoprotein (alpha 1AG) in three systemic lu...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339300200605
更新日期:1993-12-01 00:00:00
abstract:OBJECTIVES:We aimed to determine 1) ultrasound (US) abnormalities in patients with systemic lupus erythematosus (SLE) with and without hand arthralgia at the day of examination compared with clinical evaluation and healthy controls, and 2) inter-observer reliability of the US abnormalities. METHODS:Thirty-three female...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314561666
更新日期:2015-06-01 00:00:00
abstract::Although challenging, developing evidence-based approaches to an early and accurate diagnosis of systemic lupus erythematosus is a key approach to preventing disease and lupus-associated morbidity and mortality. Advances in our understanding of preclinical and incomplete lupus erythematosus have enabled the identifica...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203316640367
更新日期:2016-07-01 00:00:00
abstract::Cardio-pulmonary manifestations of systemic lupus erythematosus (SLE) are well recognized in adults. We report the occurrence of clinically significant cardio-pulmonary disease in a cohort of predominantly Caucasian children with SLE. All children with SLE attending the Royal Liverpool Children's NHS Trust between 199...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203305lu2073oa
更新日期:2005-01-01 00:00:00
abstract::Studies have demonstrated considerable variability in systemic lupus erythematosus (SLE) incidence and prevalence estimates. Lack of reliable epidemiological data may hinder evidence-based health care planning. The aim of the present study was to estimate the prevalence and incidence of SLE in the Estonian adult popul...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316686705
更新日期:2017-09-01 00:00:00
abstract::Autoantibodies against prothrombin, including lupus anticoagulant antibodies (LAC), have been identified in patients with systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS). To identify the epitopes of LAC in patients with SLE and APS, we analyzed B cell epitopes of anti-prothrombin Abs. Prothrombi...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/096120399678840963
更新日期:1999-01-01 00:00:00
abstract::To evaluate the efficacy of hydroxychloroquine (HCQ) and quinacrine (Qn) association, at two different dosages, in treatment of lupus skin lesions not responding to HCQ alone. Thirty-four patients, affected by cutaneous and systemic lupus erythematosus, were retrospectively analysed. They were treated by HCQ (5 mg/Kg/...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203308101714
更新日期:2009-07-01 00:00:00
abstract::Acquired C1q deficiency secondary to anti C1q auto-antibodies may result in the hypocomplementaemic urticarial vasculitis syndrome and may also be seen in active systemic lupus erythematosus. Some patients with acquired C1 inhibitor deficiency are found to have an underlying malignancy, most commonly lymphoma. We repo...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120330000900113
更新日期:2000-01-01 00:00:00
abstract:INTRODUCTION:The International Society of Nephrology/Renal Pathology Society (ISN/RPS) pathological classification criteria of lupus nephritis are limited to glomerular injury. Although the tubulointerstitium is commonly involved, the importance of such involvement is not well defined. The major objective of this study...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203313507986
更新日期:2013-12-01 00:00:00
abstract::Diagnosing vulvar intraepithelial neoplasia in a young woman presenting mainly with skin manifestations of lupus and with no other risk factors is a major challenge. The case of a 27-year-old woman with systemic lupus erythematosus and vulvar intraepithelial neoplasia is described. Although progression of vulvar intra...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203309345742
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVE:We aimed to develop a model of the illness experience for youth with systemic lupus erythematosus (SLE)/mixed connective tissue disease (MCTD). METHODS:We conducted 32 semi-structured interviews with 16 outpatient youth with SLE/MCTD, age 11 to 22 years, and their parents. We qualitatively defined key featur...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316646460
更新日期:2016-08-01 00:00:00
abstract::We report three cases of severe haemorrhagic rupture of luteal ovarian cyst requiring surgical haemostasis in young women treated with long-term oral anticoagulation for antiphospholipid syndrome (APS) who used no contraception. At the time of bleeding, the international normalized ratios were 3.78, 4.24, and 7.11. An...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339900800614
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:Environmental factors appear to play a role in the pathogenesis of lupus erythematosus (LE). OBJECTIVE:To determine the association between cigarette smoking and various types of cutaneous LE. DESIGN:Retrospective descriptive study at a dermatology clinic of a tertiary referral hospital. METHODS:All patie...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314559630
更新日期:2015-06-01 00:00:00
abstract::Data on the clinical and laboratory profiles of 83 children with SLE have been analysed and compared with data on 187 adults with the disease. The clinical features of childhood SLE are similar to those seen in adults, although clinical and laboratory parameters reflect propensity to a more severe form of the disease ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339300200204
更新日期:1993-04-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is an autoantibody and immune complex mediated disease. However, it is the ensuing inflammatory process that leads to irreversible organ damage. In fact several murine models of SLE suggest that this inflammatory organ damage can be prevented even in the presence of autoantibodies. G...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1191/0961203303lu1024oa
更新日期:2004-01-01 00:00:00
abstract::Patients with systemic lupus erythematosus (SLE) frequently have gastrointestinal (GI) symptoms. These are usually self-limiting and related to treatment side-effects or concurrent illness. However, abdominal pain may be due to bowel ischaemia which can lead to infarction and perforation. The likelihood of these serio...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203303lu433oa
更新日期:2003-01-01 00:00:00
abstract::Proteinuria is the hallmark of clinical manifestation of disease activity in lupus nephritis (LN) patients, which arises from direct or indirect podocyte injury. This study is to explore the relationship between intrarenal T cell infiltration and podocyte injury in lupus nephritis (LN), and to understand the potential...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316646861
更新日期:2016-12-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder that can have many cutaneous manifestations including malar rash, discoid rash or oral ulcer. Isolated unilateral involvement of face is uncommon in SLE. It lacks typical clinical features of LE, and may impose a diagnostic challenge for clinicians. H...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203320957739
更新日期:2020-12-01 00:00:00
abstract::The object of this study was to compare patients with familial versus sporadic systemic lupus erythematosus (SLE) with respect to clinical, laboratory variables and outcome. The familial SLE group comprised 12 patients while the comparative group comprised 24 patients selected by systemic sampling from our pediatric r...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120330607192
更新日期:2006-01-01 00:00:00
abstract::A 24 year old female with hereditary spastic paraplegia presented with intermittent headache for one year. She also had lower abdominal pain and vomiting for two months. She was pale, had icterus and mild splenomegaly. On diagnostic evaluation she was found to have hemolytic anemia, thrombocytopenia and bilateral adre...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203315573853
更新日期:2015-09-01 00:00:00