Massive ovarian haemorrhage complicating oral anticoagulation in the antiphospholipid syndrome: a report of three cases.

abstract：:Lupus nephritis (LN) is usually associated with widespread effacement of the podocytes' foot processes leading to proteinuria. Induction of urokinase receptor (uPAR) signaling in podocytes leads to foot process effacement and urinary protein loss via promoting podocytes' motility and kidney permeability in the glomeru...

journal_title：Lupus

authors： Cheng CC,Lee YF,Lan JL,Wu MJ,Hsieh TY,Lin NN,Wang JM,Chiu YT

更新日期：2013-05-01 00:00:00

abstract：:Intravenous immunoglobulin (IVIG) has a therapeutic potential in many autoimmune diseases. Based on its immune modulating and complement inhibiting effects, IVIG has been tested in systemic lupus erythematosus (SLE), but due to osmotic tubular injury caused by immunoglobulin-stabilizing sugar components, lupus nephrit...

journal_title：Lupus

authors： Racz Z,Nagy E,Rosivall L,Szebeni J,Hamar P

更新日期：2010-04-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease with chronic systemic inflammation. Oxidative stress may play a role in the pathogenesis of SLE. An increase in free radicals or an impaired antioxidant defense system in SLE causes oxidative stress. Therefore, oxidative damage plays an important role in the ...

journal_title：Lupus

authors： Zaieni SH,Derakhshan Z,Sariri R

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:Complement activation plays a role in pathogenesis of the antiphospholipid syndrome (APS), but the involvement of the C5b-9 membrane attack complex (MAC) is unknown. Here we studied the effects of human polyclonal antiphospholipid (aPL) antibodies on thrombosis and tissue factor (TF) up-regulation in C6 defi...

journal_title：Lupus

authors： Carrera-Marín A,Romay-Penabad Z,Papalardo E,Reyes-Maldonado E,García-Latorre E,Vargas G,Shilagard T,Pierangeli S

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:The main vitamin D source is exposure to ultraviolet radiation, which aggravates cutaneous lupus erythematosus (CLE). OBJECTIVES:The aims of this study were to identify variables associated with lower serum 25-hydroxyvitamin D [25(OH)D] levels in CLE patients and assess the effect of vitamin D restoration o...

journal_title：Lupus

authors： Cutillas-Marco E,Marquina-Vila A,Grant WB,Vilata-Corell JJ,Morales-Suárez-Varela MM

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVES:To determine the rates of induced abortions in women with systemic lupus erythematosus (SLE) compared to women from the general population and assess disease-related predictors of induced abortion in women with SLE. METHODS:We identified women with SLE (15-45 years) and determined the number of induced abor...

journal_title：Lupus

authors： Venne K,Scott S,Bernatsky S,Vinet E

更新日期：2020-12-15 00:00:00

abstract：OBJECTIVES:Poor adherence to immunosuppressive treatment is common in patients with systemic lupus erythematosus and may identify those with lupus nephritis (LN) who have a poorer prognosis. Non-adherence has also been reported to be a potential adverse outcome predictor in renal transplantation (rTp). We investigated ...

journal_title：Lupus

authors： Ntatsaki E,Vassiliou VS,Velo-Garcia A,Salama AD,Isenberg DA

更新日期：2019-04-01 00:00:00

abstract：:We investigated obstetric outcomes and comorbidities during pregnancy in females with preexisting lupus nephritis (LN) and identified predictors for renal flare. In cases of renal flare during pregnancy, we assessed the long-term post-delivery renal outcome. We performed a retrospective analysis of 183 systemic lupus ...

journal_title：Lupus

authors： Koh JH,Ko HS,Lee J,Jung SM,Kwok SK,Ju JH,Park SH

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Cognitive dysfunction (CD) is among the most common neuropsychiatric manifestations of systemic lupus erythematosus (SLE). There are two methods which have been used to detect CD in patients with SLE: traditional neuropsychological tests (NPT) and the Automated Neuropsychological Assessment Metrics (ANAM). B...

journal_title：Lupus

authors： Adhikari T,Piatti A,Luggen M

更新日期：2011-10-01 00:00:00

abstract：:Coming from Hans Wigzell's laboratory in Uppsala, Sweden, I joined the Kunkel laboratory in 1981 to spend a post-doctoral fellowship period financed by the German Research Organization. While I initially worked with Nick Chiorazzi in an attempt to generate monoclonal antibody-secreting human B-cell hybridomas, I later...

journal_title：Lupus

authors： Kabelitz D

更新日期：2003-01-01 00:00:00

abstract：:Results for lupus anticoagulant (LA) are expressed as ratio of patient-to-normal clotting times (LA-ratio) according to the equation LA-ratio = (Patient(Clotting time)/Normal(Clotting time)). However, numerical results vary according to the method used for testing, thus making difficult the between-method and between-...

journal_title：Lupus

authors： Tripodi A,Chantarangkul V,Pengo V

更新日期：2012-06-01 00:00:00

abstract：:Antiphospholipid syndrome (APS), as a primary disease or a secondary syndrome in systemic lupus erythematosus (SLE), is characterized by the presence of antiphospholipid antibodies (aPL) and a clinical event. It is likely that both genetic and environmental factors lead to the development of aPL and progression to dis...

journal_title：Lupus

authors： Salem D,Subang R,Laplante P,Levine JS,Rauch J

更新日期：2014-10-01 00:00:00

abstract：:Systemic lupus erythematosus is a chronic, relapsing autoimmune disease that can affect multiple organ systems. An increased prevalence of drug allergy has been reported in lupus patients compared with the general population. Using a cohort of 417 lupus patients, we found a history of sulpha allergy in 27.3% of patien...

journal_title：Lupus

authors： Jeffries M,Bruner G,Glenn S,Sadanandan P,Carson CW,Harley JB,Sawalha AH

更新日期：2008-03-01 00:00:00

abstract：:Multiple sources were used to identify 325 systemic lupus erythematosus (SLE) patients within the city of Oslo during 1999-2009 who met ≥ 4 of the American College of Rheumatology (ACR) criteria. The survival, standard mortality rate (SMR), years of potential life loss before 60 years of age (YPLL60) and causes of dea...

journal_title：Lupus

authors： Lerang K,Gilboe IM,Steinar Thelle D,Gran JT

更新日期：2014-12-01 00:00:00

abstract：OBJECTIVE:To investigate the predictive value of serum C3 and C4 complement component levels in relation to pregnancy outcome in patients with antiphospholipid syndrome (APS). MATERIALS AND METHODS:A prospective study of 47 pregnancies associated with APS was performed. Pregnancy outcome was analyzed in terms of: feta...

journal_title：Lupus

authors： De Carolis S,Botta A,Santucci S,Salvi S,Moresi S,Di Pasquo E,Del Sordo G,Martino C

更新日期：2012-06-01 00:00:00

abstract：:Recent studies on epigenetics, including DNA methylation and its regulatory enzymes, seem likely to contribute to elucidation of the pathogenesis of autoimmune diseases such as systemic lupus erythematosus (SLE), although the relationship between DNA methylation and SLE has long been the subject of investigation. To o...

journal_title：Lupus

authors： Sekigawa I,Okada M,Ogasawara H,Kaneko H,Hishikawa T,Hashimoto H

更新日期：2003-01-01 00:00:00

abstract：:Objectives Avascular necrosis (AVN) is one of the most common causes of organ damage in patients with systemic lupus erythematosus (SLE) and often causes serious physical disability. The aims of this study were to investigate clinical risk factors associated with symptomatic AVN and to analyze their synergistic effect...

journal_title：Lupus

authors： Kwon HH,Bang SY,Won S,Park Y,Yi JH,Joo YB,Lee HS,Bae SC

更新日期：2018-09-01 00:00:00

abstract：:We retrospectively analysed the prevalence and clinical features associated to anti-Ku antibodies in patients affected by different autoimmune diseases. Anti-Ku antibodies are detected in 147 sera out of 7239 anti-ENA positive sera (2%). They are found in 2% of patients with systemic sclerosis (SSc) (8 out of 379), 1....

journal_title：Lupus

authors： Cavazzana I,Ceribelli A,Quinzanini M,Scarsi M,Airò P,Cattaneo R,Franceschini F

更新日期：2008-08-01 00:00:00

abstract：:To determine if neurometabolic changes in the white matter (WM) of systemic lupus erythematosus (SLE) patients may predict the appearance of small hyperintense lesions on T2-weighted magnetic resonance imaging (MRI) inside the magnetic resonance spectroscopy (MRS) region of interest (ROI). We included 30 SLE patients ...

journal_title：Lupus

authors： Appenzeller S,Li LM,Costallat LT,Cendes F

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:To investigate the prevalence and characteristics of anti-endothelial cell antibodies (AECA) in a large cohort of patients with several well defined systemic autoimmune diseases, in order to determine their relationship with the clinical and laboratory features of these diseases. METHODS:Clinical and laborat...

journal_title：Lupus

authors： Navarro M,Cervera R,Font J,Reverter JC,Monteagudo J,Escolar G,López-Soto A,Ordinas A,Ingelmo M

更新日期：1997-01-01 00:00:00

abstract：:The metabolism of poly(ADP-ribose) in peripheral blood mononuclear (PBM) cells was studied in 13 patients with systemic lupus erythematosus (SLE) and in 12 age and sex matched controls. Poly(ADP-ribose) polymerase activity was measured as the net accumulation of ADP-ribose polymers during the conversion of 32P-NAD to ...

journal_title：Lupus

authors： Chen HY,Pertusi RM,Kirkland JB,Rubin BR,Jacobson EL

更新日期：1996-02-01 00:00:00

abstract：:SLE is an autoimmune and polygenic disorder characterized by an accumulation and deposition of immune complexes. Several studies have indicated differential impact of FcgammaR polymorphism genotypes in different ethnic groups studied. The Fc receptor for IgG class IIA gene (FcgammaRIIA) occurs in two allelic forms. Th...

journal_title：Lupus

authors： Yap SN,Phipps ME,Manivasagar M,Tan SY,Bosco JJ

更新日期：1999-01-01 00:00:00

abstract：:Objective The main aim of this study was to investigate the ovarian reserve, menstruation, and lymphocyte subpopulation in systemic lupus erythematosus (SLE) patients of childbearing age. Methods We enrolled 40 SLE patients of childbearing age and 40 age-matched healthy controls. Anti-Müllerian hormone (AMH) was teste...

journal_title：Lupus

authors： Gao H,Ma J,Wang X,Lv T,Liu J,Ren Y,Li Y,Zhang Y

更新日期：2018-03-01 00:00:00

abstract：:Background Antimalarials (AMs) are widely used in the treatment of connective tissue diseases. Their main side effect is retinal damage, while heart disease has been described in isolated cases. The aim of this study is to systematically review the existing literature on AM-induced cardiomyopathy (AMIC). Methods The P...

journal_title：Lupus

authors： Tselios K,Deeb M,Gladman DD,Harvey P,Urowitz MB

更新日期：2018-04-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is one of the most heterogeneous autoimmune disorders known. There is production of a variety of autoantibodies and patients present with a wide range of symptoms due to multiple organ involvement by the disease process. The underlying cause is not fully understood but it may involve...

journal_title：Lupus

authors： Lau CS,Yin G,Mok MY

更新日期：2006-01-01 00:00:00

abstract：:The complexity of the therapeutic approach in systemic lupus erythematosus (SLE) is increased by the large number of patients who do not respond to the first-line therapies and by relapses after initial clinical remission. In these patients, second-line drugs are often prescribed according to individual clinical decis...

journal_title：Lupus

authors： Ramos-Casals M,Soto MJ,Cuadrado MJ,Khamashta MA

更新日期：2009-08-01 00:00:00

abstract：:Recent studies have suggested an association between primary antiphospholipid syndrome (PAPS), antiphospholipid antibodies and some major histocompatibility complex (MHC) antigens. We have studied the relationship between MHC class II antigens and PAPS in 19 patients from the south of Spain. Univariant analysis showed...

journal_title：Lupus

authors： Camps MT,Cuadrado MJ,Ocón P,Alonso A,Gutierrez A,Guil M,Grana MI,de Ramón E

更新日期：1995-02-01 00:00:00

abstract：OBJECTIVE:The objective of this paper is to examine some solid tumors incidence in patients with systemic lupus erythematosus (SLE) derived from population-based cohort studies by means of meta-analysis. METHODS:Relevant electronic databases were searched for studies characterizing the associated risk of overall malig...

journal_title：Lupus

authors： Ni J,Qiu LJ,Hu LF,Cen H,Zhang M,Wen PF,Wang XS,Pan HF,Ye DQ

更新日期：2014-03-01 00:00:00

abstract：:Systemic lupus erythematosus is the prototypic multi-system autoimmune disease characterized by the production of multiple autoantibodies. The development of disease depends on a genetic predisposition and exposure to environmental factors including UV light, drugs, and infections. The association of parasitic infecti...

journal_title：Lupus

authors： Zandman-Goddard G,Shoenfeld Y

更新日期：2009-11-01 00:00:00

abstract：:Nephropathy of antiphospholipid antibody syndrome (NAPS) is an increasingly well-recognized aspect of antiphospholipid syndrome. The most characteristic histopathology is that of thrombotic microangiopathy, and thrombosis occurring in the renal vasculature is thought to be the initiating event. Other less common patho...

journal_title：Lupus

authors： Lin YQ,Lakshminarayanan S,Yamase H,Palmisano J,Parke A

更新日期：2009-05-01 00:00:00