Abstract:
:Lupus nephritis (LN) is usually associated with widespread effacement of the podocytes' foot processes leading to proteinuria. Induction of urokinase receptor (uPAR) signaling in podocytes leads to foot process effacement and urinary protein loss via promoting podocytes' motility and kidney permeability in the glomerulus. Very little is known about uPAR signaling in LN. Mycophenolate mofetil (MMF), an immunosuppressive agent, efficiently modulates the development of LN in humans and mice, but there are no data concerning the direct uPAR involvement on podocytes in LN. The MMF efficiency and uPAR involvement signaling in NZB×NZW F1 lupus-prone mice were examined by proteinuria, renal function and pathology, immune complex deposits, and uPAR expression of podocytes by immunofluorescence staining and quantitative RT-PCR. After MMF treatment, the proteinuria (p < 0.01), BUN level (p < 0.05) and immunodeposition in glomeruli (p < 0.001) were significantly improved. Most important, the renal uPAR mRNA levels (p < 0.001) and uPAR protein level of podocytes (p < 0.001) were significantly reduced. The beneficial effect of MMF on LN could be attributed, at least in part, to the inhibition of uPAR expression in podocytes. These findings demonstrated uPAR could have potential as a predictive index for response to LN therapeutics.
journal_name
Lupusjournal_title
Lupusauthors
Cheng CC,Lee YF,Lan JL,Wu MJ,Hsieh TY,Lin NN,Wang JM,Chiu YTdoi
10.1177/0961203313480398subject
Has Abstractpub_date
2013-05-01 00:00:00pages
554-61issue
6eissn
0961-2033issn
1477-0962pii
0961203313480398journal_volume
22pub_type
杂志文章相关文献
LUPUS文献大全abstract:OBJECTIVE:We compared the 1997 update of the 1982 American College of Rheumatology (ACR-97) and the 2012 Systemic Lupus International Collaborating Clinics (SLICC-12) criteria, for earlier classification of systemic lupus erythematosus (SLE) in a multiethnic urban Asian SLE population. METHODS:Patients from a retrospe...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203318811599
更新日期:2019-01-01 00:00:00
abstract::It is well known that women with systemic lupus erythematosus (SLE) who have antiphospholipid antibodies (aPL) are at increased risk for pregnancy loss. Additionally, other reproductive processes, such as unexplained infertility and implantation failure after in vitro fertilization and embryo transfer may be affected ...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1191/0961203302lu237ra
更新日期:2002-01-01 00:00:00
abstract::Objective The lupus impact tracker (LIT) is a 10-item patient reported outcome tool to measure the impact of systemic lupus erythematosus or its treatment on patients' daily lives. Herein, we describe the responsiveness of the LIT and LupusQoL to changes in disease activity, using the systemic lupus erythematosus resp...
journal_title:Lupus
pub_type: 杂志文章,多中心研究
doi:10.1177/0961203316667494
更新日期:2017-04-01 00:00:00
abstract::The disease activity of patients suffering from lupus nephritis usually becomes quiescent after the onset of end stage renal failure. Reactivation of lupus activity, especially after a long period of dialysis, is uncommon. Factors that might trigger off lupus reactivation after dialysis have not been well defined. We ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203302lu096cr
更新日期:2002-01-01 00:00:00
abstract::Objective The objective of this report is to evaluate the prevalence and clinico-serological correlations of anti-α-enolase antibody (Ab) in patients with systemic lupus erythematosus (SLE). Methods Thirty-two untreated patients with SLE and 20 age- and sex-matched healthy controls were evaluated by rheumatologic exam...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203317721752
更新日期:2018-01-01 00:00:00
abstract::We report an infant with anticardiolipin (aCL) antibodies who presented with erythematous nodular skin lesions and elevated liver enzyme levels. The cutaneous manifestation was histologically lymphocytic lobular panniculitis with vasculitic and hemorrhagic changes. The infant also had low levels of anti-double strande...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/096120300678828721
更新日期:2000-01-01 00:00:00
abstract::This study investigates specificity, sensitivity and concomitant presence of antibodies against histone H1 (H1), nucleosomes (NUC), chromatin (CHR) and dsDNA in patients with systemic lupus erythematosus (SLE), analyses their association with SLE disease activity and characterizes the immunodominant epitope reactivity...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203302lu247oa
更新日期:2002-01-01 00:00:00
abstract::Glycans (sugars or carbohydrates) are predominant surface components of cells such as erythrocytes, immune cells and microorganisms. As such, they give rise to high levels of anti-glycan antibodies of all classes. Antibodies to certain defined mono, di and oligosaccharides that are common in bacterial, fungal and para...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1191/0961203306lu2331oa
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVES:Sexual dysfunction in systemic lupus erythematous (SLE) patients is an important issue to be tackled. We aimed to study the prevalence of sexual dysfunction in SLE women and detect its association with depression, functional disability and quality of life. METHODS:This study included 94 SLE females. Ninety-...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203320935518
更新日期:2020-08-01 00:00:00
abstract::The aim of this study is to determine prevalence, clinical significance of antiphospholipid antibodies (aPL) including anticardiolipin antibodies (aCL), anti-beta2GP1 and lupus anticoagulant (LA) in a cohort of 74 patients with primary Sjögren's syndrome (pSS) according to revised European criteria. aPL were found in ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203304lu1006oa
更新日期:2004-01-01 00:00:00
abstract::High levels of serum and/or plasma circulating DNA (cDNA) have been described in patients with systemic autoimmune diseases (SADs). However, the role of this molecule has not been clarified. Our aim was to evaluate plasma cDNA levels in 48 systemic lupus erythematosus (SLE) and 44 primary Sjögren's syndrome (SS) patie...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203311399606
更新日期:2011-08-01 00:00:00
abstract::The objective of this study was to determine whether there are differences in the prevalence, clinical and laboratory manifestations, and morbidity and mortality of systemic lupus erythematosus (SLE) between Aborigines and Caucasians in Central Australia. The medical records of all patients diagnosed with SLE upto Dec...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/096120301678646191
更新日期:2001-01-01 00:00:00
abstract::With an increasing number of international journeys occurring daily, there is also an increase in the need for appropriate medical advice for patients who will undertake such travel. In this context, the lupus patient presents a great challenge to the rheumatologist. However, the demand for such information by patient...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203319888688
更新日期:2019-12-01 00:00:00
abstract::Lymphocytic vasculitis (LV) characterises systemic lupus erythematosus (SLE) and this potentially reversible lesion, which may be subclinical, may imply overt systemic disease activity. Needle quadriceps muscle biopsy was performed in 26 unselected patients with SLE and the presence of LV in these muscle specimens was...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339500400213
更新日期:1995-04-01 00:00:00
abstract::Neonatal lupus erythematosus (NLE) is an uncommon condition usually associated with maternal anti-Ro autoantibodies. The cutaneous lesions of NLE are usually transient, disappearing about six months after birth, but telangiectasia is a rare complication of NLE which persists. Telangiectasias are small focal red macule...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203311430701
更新日期:2012-04-01 00:00:00
abstract::The main objective of this study is to describe the presence of infections in patients with pulmonary haemorrhage and systemic lupus erythematosus. Patients with systemic lupus erythematosus and pulmonary haemorrhage were thoroughly evaluated in the first 48 hours with imaging plus bronchoscopy and bronchoalveolar flu...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203307086930
更新日期:2008-04-01 00:00:00
abstract::Neonatal antiphospholipid syndrome (neonatal APS) seems to be exceedingly rare, as the antiphospholipid antibodies (aPL) related thrombosis in the neonatal period. The pathogenesis of perinatal aPL related thrombosis may be explained both by the transplacental passage of the maternal antibodies and by the production o...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203314560207
更新日期:2015-03-01 00:00:00
abstract::This study was designed to investigate whether Foxp3( +) regulatory T (Treg) cells play a role in the histopathologic changes of primary Sjögren's Syndrome (pSS) and to evaluate other factors possibly associated with Foxp3(+) Treg cells in pSS patients. The number of FoxP3-expressing T cells in peripheral blood (PB) o...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203309348234
更新日期:2010-02-01 00:00:00
abstract::Systemic lupus erythematosus is a chronic, relapsing autoimmune disease that can affect multiple organ systems. An increased prevalence of drug allergy has been reported in lupus patients compared with the general population. Using a cohort of 417 lupus patients, we found a history of sulpha allergy in 27.3% of patien...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203307086640
更新日期:2008-03-01 00:00:00
abstract::The immunopathogenesis of systemic lupus erythematosus has been thoroughly investigated recently, and genome-wide association studies have identified genes statistically associated with lupus. However, the progression to overt disease is dependent on the activation of environmental factors ('triggers'), among which oe...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203311433138
更新日期:2012-05-01 00:00:00
abstract::Pulmonary hypertension (PH) can occur at any time during the course of systemic lupus erythematosus (SLE), and can be independent of lupus disease activity in other systems. The pathogenesis of PH in SLE can be multifactorial, but pulmonary arterial hypertension (PAH) is the commonest cause of PH in SLE. The internati...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203313505010
更新日期:2013-10-01 00:00:00
abstract::This review briefly defines the heat shock proteins (hsps), their classification and their functions. The hypothesis that links hsps to the development of autoimmunity is explored, together with the rationale for investigation of the relationship between hsps and systemic lupus erythematosus (SLE). Thus, published wor...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/096120339100100102
更新日期:1991-11-01 00:00:00
abstract:BACKGROUND:Systemic lupus erythematosus (SLE) is regarded as a prototype autoimmune disease because it can serve as a means for studying differences between ethnic minorities and sex. Traditionally, all Hispanics have been bracketed within the same ethnic group, but there are differences between Hispanics from Spain an...
journal_title:Lupus
pub_type: 杂志文章,多中心研究
doi:10.1177/0961203319889667
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:For patients with chronic illnesses the global burden of illness is a crucial health measure hitherto neglected in research studies and clinical practice. We tested the application and validity of PRISM (Pictorial Representation of Illness and Self-Measure), a novel visual method for assessing the burden of i...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/096120300678828479
更新日期:2000-01-01 00:00:00
abstract::The contribution of the p53 Arg72Pro polymorphism in the development of systemic lupus erythematosus (SLE) remains controversial. We investigated the frequency of the p53 Arg72Pro genotype in patients with SLE (n = 155) and in controls (n = 150) in Poland. We found a weak contribution of the Arg/Arg genotype to the mo...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203307084722
更新日期:2008-02-01 00:00:00
abstract::In the 9-year period between 1982 and 1991, 137 patients attending a medical clinic of Queen Elizabeth Hospital, Hong Kong, were diagnosed as having systemic lupus erythematosus according to the American Rheumatism Association's criteria for classification. The female-to-male ratio was 16 to 1. Commonly the onset age ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339300200207
更新日期:1993-04-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) often coexists with other diseases. Diabetes mellitus (DM) is an example and patients with overlap SLE-DM can present with clinical features common to both disorders. In this review, we describe the patients with overlap SLE-DM, focussing on the clinical features common to both disea...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203308091539
更新日期:2008-11-01 00:00:00
abstract:BACKGROUND:Polyarthritis is common to both mixed connective tissue disease (MCTD) and systemic lupus erythematosus (SLE). Apart from being erosive and deforming in the former, we speculated that it was more common and the extent of joints involved would be higher in MCTD. METHODS:This was a cross-sectional study that ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203318804891
更新日期:2018-11-01 00:00:00
abstract::Diffuse alveolar hemorrhage (DAH) is a life-threatening complication of systemic lupus erythematosus (SLE). Cases complicated with DAH often have active SLE with multi-organ involvement, especially lupus nephritis. We describe a rare case of DAH as the first presenting manifestation of SLE in the absence of lupus neph...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203311411353
更新日期:2011-12-01 00:00:00
abstract::Wegener's granulomatosis (WG) belongs to the group of necrotizing primary systemic vasculitides of unknown etiology, that are associated with anti-neutrophil cytoplasmic antibodies. The pathological hallmark of WG is the coexistence of vasculitis and granuloma. Due to more sensitive diagnostic instruments, especially ...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1191/096120398678920118
更新日期:1998-01-01 00:00:00