Abstract:
:Systemic lupus erythematosus is a chronic, relapsing autoimmune disease that can affect multiple organ systems. An increased prevalence of drug allergy has been reported in lupus patients compared with the general population. Using a cohort of 417 lupus patients, we found a history of sulpha allergy in 27.3% of patients. European-American lupus patients with sulpha allergy are about two times more likely to suffer from lymphopenia, two times more likely to have anti-Ro autoantibody, and four times less likely to have anti-nRNP antibodies compared with lupus patients without a reported sulpha allergy (P = 0.0075, 0.025, and 0.032, respectively). In African-American lupus patients, a history of sulpha allergy was associated with over three times increased odds of developing pericarditis (P = 0.005).
journal_name
Lupusjournal_title
Lupusauthors
Jeffries M,Bruner G,Glenn S,Sadanandan P,Carson CW,Harley JB,Sawalha AHdoi
10.1177/0961203307086640subject
Has Abstractpub_date
2008-03-01 00:00:00pages
202-5issue
3eissn
0961-2033issn
1477-0962pii
0961203307086640journal_volume
17pub_type
杂志文章相关文献
LUPUS文献大全abstract::Previous studies in our laboratory showed a dose-dependent and hormone-specific increase in CD154 expression in T cells from females with systemic lupus erythematosus (SLE). This present study investigates if the estrogen-dependent increase in CD154 expression is due to stabilization of the messenger RNA. T cells from...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203306071314
更新日期:2006-01-01 00:00:00
abstract::Tumor necrosis factor alpha (TNF alpha) and interleukin-6 (IL-6) play a main role in inducing acute phase protein production by hepatocytes. This study describes the serum levels of TNF alpha and IL-6 in relation to serum levels of C-reactive protein (CRP) and alpha 1-acid glycoprotein (alpha 1AG) in three systemic lu...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339300200605
更新日期:1993-12-01 00:00:00
abstract:OBJECTIVES:Impaired function of polymorphonuclear cells (PMNs) in systemic lupus erythematosus (SLE) leads to severe gram-positive and gram-negative bacterial infection, and to major morbidity and mortality. Few studies have focused on the association of impaired function of PMNs and SLE patients' susceptibility to inf...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203312474704
更新日期:2013-03-01 00:00:00
abstract::Cardio-pulmonary manifestations of systemic lupus erythematosus (SLE) are well recognized in adults. We report the occurrence of clinically significant cardio-pulmonary disease in a cohort of predominantly Caucasian children with SLE. All children with SLE attending the Royal Liverpool Children's NHS Trust between 199...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203305lu2073oa
更新日期:2005-01-01 00:00:00
abstract::The presence of antibodies against the complex of prothrombin and phosphatidylserine (aPS/PT) more significantly correlates with manifestations of antiphospholipid syndrome (APS) and with the presence of lupus anticoagulants (LA) than antibodies against prothrombin bound to oxygenated polystyrene (aPT-A). To investiga...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203307078680
更新日期:2007-01-01 00:00:00
abstract::The purpose of the present study was to evaluate patients with the antiphospholipid syndrome with particular attention to their initial clinical features, final diagnoses and the course of thrombotic events in association with therapy. The methodology applied was the following: retrospective analysis of 30 patient fil...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339400300206
更新日期:1994-04-01 00:00:00
abstract::To evaluate the efficacy of hydroxychloroquine (HCQ) and quinacrine (Qn) association, at two different dosages, in treatment of lupus skin lesions not responding to HCQ alone. Thirty-four patients, affected by cutaneous and systemic lupus erythematosus, were retrospectively analysed. They were treated by HCQ (5 mg/Kg/...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203308101714
更新日期:2009-07-01 00:00:00
abstract::Vaccination has been perhaps the most important achievement in medicine of the last century. A hoard of infectious diseases that used to claim the lives of many, especially children, have been prevented and some even eradicated. However, it is possible that within this gift there is hidden a 'Trojan Horse'. During the...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1191/096120301673085478
更新日期:2001-01-01 00:00:00
abstract::The antiphospholipid syndrome (APS) is characterized by thrombosis and/or pregnancy morbidity in the presence of antiphospholipid antibodies (aPL). Among the thrombogenic mechanisms proposed, it has been suggested that aPL can stimulate tissue factor (TF) expression by endothelial cells (ECs) and monocytes. Moreover, ...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1191/0961203306lu2276rr
更新日期:2006-01-01 00:00:00
abstract::Women's treatment preferences for lupus nephritis vary widely even after adjusting for sociodemographic factors and disease severity. Attitude toward risk may partially explain interpatient variability in treatment preference. The objective of this study was to examine the association between 'risk-attitude' and patie...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203303lu371oa
更新日期:2003-01-01 00:00:00
abstract::Neuropsychiatric manifestations of systemic lupus erythematosus are common and disabling yet their pathogenesis is poorly understood. We investigated the role of cerebrovascular endothelial dysfunction in systemic lupus erythematosus and its neuropsychiatric manifestations. Subjects with systemic lupus erythematosus w...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203309359780
更新日期:2010-06-01 00:00:00
abstract::A 22-year-old female with history of systemic lupus erythematosus (SLE) was referred for evaluation of decreased visual acuity in her right eye. Her best-corrected visual acuity (BCVA) at the time of presentation was 20/160. Widespread cotton wool spots and macular edema were seen on biomicroscopy. Fluorescein angiogr...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203311422095
更新日期:2012-03-01 00:00:00
abstract::Cytomegalovirus (CMV) is particularly dangerous in systemic lupus erythematosus (SLE), being a problem both for the differential diagnosis with disease flare and for the management of SLE flare with immunosuppressive drugs. We report on four cases of SLE with concomitant CMV infection, having some common clinical and ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203319825570
更新日期:2019-03-01 00:00:00
abstract::To determine if neurometabolic changes in the white matter (WM) of systemic lupus erythematosus (SLE) patients may predict the appearance of small hyperintense lesions on T2-weighted magnetic resonance imaging (MRI) inside the magnetic resonance spectroscopy (MRS) region of interest (ROI). We included 30 SLE patients ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203307084723
更新日期:2007-01-01 00:00:00
abstract::One hundred and twenty-nine patients with systemic lupus erythematosus were screened for thyroid function tests. Of these, 8.9% had hyperthyroidism and 3.9% Hashimoto's thyroiditis. Euthyroid sick syndrome was present in 47.8% of patients. There was a high prevalence of antimicrosomal and antithyroglobulin antibodies ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339300200109
更新日期:1993-02-01 00:00:00
abstract::Due to recent acquisitions, diagnostic criteria for the antiphospholipid/cofactors syndrome need to be improved. In the absence of a "common biological denominator", the best approach should be based on a scoring system mixing clinical and immunological items. APS might be composed of different biological subsets char...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/096120339600500504
更新日期:1996-10-01 00:00:00
abstract::Objective The objective of this article is to examine the quality, content, and readability of information and resources in the English language and accessible on the internet by pediatric patients with systemic lupus erythematosus (SLE) and their families in North America. Methods Keywords relevant to SLE were genera...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203317746246
更新日期:2018-04-01 00:00:00
abstract::Background Antimalarials (AMs) are widely used in the treatment of connective tissue diseases. Their main side effect is retinal damage, while heart disease has been described in isolated cases. The aim of this study is to systematically review the existing literature on AM-induced cardiomyopathy (AMIC). Methods The P...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203317734922
更新日期:2018-04-01 00:00:00
abstract::Our aims were to assess the frequency of false-positive IgM antibodies for cytomegalovirus in pregnant women with autoimmune diseases and in healthy women (controls) and to determine their relationship with pregnancy outcome. Data from 133 pregnancies in 118 patients with autoimmune diseases and from 222 pregnancies i...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203310361350
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVE:Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies. Recently, a specific highly activated T helper cell subset, follicular helper T (Tfh) cell, has emerged as a key immunoregulator of germinal center (GC) formation and high-affinity antibody productio...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314567750
更新日期:2015-08-01 00:00:00
abstract::We retrospectively evaluated the clinical outcome of 45 female and 11 male patients with biopsy-proven lupus nephritis, followed at our hospital between February 1974 and February 1990. In the majority signs of nephritis were present at the time systemic lupus erythematosus was diagnosed (range: -42-156 months) and th...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339200100207
更新日期:1992-02-01 00:00:00
abstract::CD27 is a useful marker in assessing the number of circulating B cells and B cell subsets because it permits one step identification of the major B cell compartments, CD27- naïve and CD27+ memory B cells as well as CD27high plasma cells. Abnormalities in the distribution ofCD27+ B cell subsets are useful in assessing ...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1191/0961203304lu1014oa
更新日期:2004-01-01 00:00:00
abstract::Prognosis of pregnancies in women with antiphospholipid syndrome has dramatically improved over the past two decades using conventional treatment with low molecular weight heparin and low-dose aspirin. However, despite this regimen, 10-15% of antiphospholipid syndrome patients experience pregnancy losses. Several stud...
journal_title:Lupus
pub_type: 社论
doi:10.1177/0961203319882507
更新日期:2019-11-01 00:00:00
abstract::Antiphospholipid antibodies (aPL) have been detected in various liver diseases, particularly cirrhosis. The role of alcoholic consumption per se has been suggested. The aim of our study was to assess the prevalence of aPL in patients with alcoholic liver disease at various states and to correlate the presence of aPL w...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/096120300678828659
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVE:Anti-α-enolase antibody (Ab) combined with β2 microglobulin (β2-MG) were investigated to predict the incidence of nephritis in systemic lupus erythematosus (SLE) patients. METHODS:Levels of serum anti-α-enolase Ab and urinary β2-MG were detected in 115 SLE patients, 29 SLE patients with nephritis and 70 heal...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203319828822
更新日期:2019-03-01 00:00:00
abstract::Mycophenolate mofetil (MMF) initially found widespread use in the immunoprophylaxis of rejection in organ transplantation. It has subsequently been used in lupus glomerulonephritis, where early studies have shown it to be effective in induction and maintenance therapy. The randomized studies have mostly studied small ...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1191/0961203305lu2116oa
更新日期:2005-01-01 00:00:00
abstract:INTRODUCTION:Anti-RNP autoantibodies occur either in mixed connective tissue disease (MCTD) (with a frequently favorable prognosis), or in systemic lupus erythematosus (SLE) cases with aggressive major organ disease. It is uncertain how to assess for the risk of severe disease in anti-RNP + patients. METHODS:Following...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203315575586
更新日期:2015-09-01 00:00:00
abstract::Several studies have investigated the potential of various autoantibody tests in the diagnosis of systemic lupus erythematosus (SLE). Many lupus patients initially present with glomerulonephritis. In that clinical situation the main differential diagnosis are other forms of glomerulonephritis. In this study the diagno...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203309345753
更新日期:2009-12-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is an autoreactive T cell mediated autoimmune disease. Immunization with inactivated autoreactive T cells may induce idiotype anti-idiotypic reaction to deplete specific subsets of autoreactive T cells involved in SLE. Six SLE patients unsuitable or refused to use immunosuppressants ...
journal_title:Lupus
pub_type: 临床试验,杂志文章
doi:10.1191/0961203305lu2239oa
更新日期:2005-01-01 00:00:00
abstract::Recent studies have suggested an association between primary antiphospholipid syndrome (PAPS), antiphospholipid antibodies and some major histocompatibility complex (MHC) antigens. We have studied the relationship between MHC class II antigens and PAPS in 19 patients from the south of Spain. Univariant analysis showed...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339500400111
更新日期:1995-02-01 00:00:00