Abstract:
:Results for lupus anticoagulant (LA) are expressed as ratio of patient-to-normal clotting times (LA-ratio) according to the equation LA-ratio = (Patient(Clotting time)/Normal(Clotting time)). However, numerical results vary according to the method used for testing, thus making difficult the between-method and between-laboratory comparison of results. The hypothesis that the standardization model currently employed for the international normalized ratio for patients on warfarin is valid also for LA standardization has been taken into consideration. The model calls for the determination of a LA-sensitivity index (LASI) for each commercial method for LA detection against a common standard method. The LASI is then used to convert the LA-ratio into a scale called standardized LA-ratio (SLA-ratio) according to the equation SLA-ratio = (LA-ratio)(LASI). The model proved effective in minimizing the between-method variability of results for LA detection. If implemented it could be a valuable tool to improve the comparability of results obtained in different laboratories, to quantify the LA potency and thus pave the way to the organization of collaborative clinical trials aimed at assessing whether the potency of LA is a risk factor for clinical events.
journal_name
Lupusjournal_title
Lupusauthors
Tripodi A,Chantarangkul V,Pengo Vdoi
10.1177/0961203312438114subject
Has Abstractpub_date
2012-06-01 00:00:00pages
715-7issue
7eissn
0961-2033issn
1477-0962pii
21/7/715journal_volume
21pub_type
杂志文章相关文献
LUPUS文献大全abstract:OBJECTIVE:To examine the potential immunologic mechanism and involvement of antiphospholipid antibodies in the pathogenesis of heart valve lesions in patients with the antiphospholipid syndrome (APS). METHODS:Immunoperoxidase and immunofluorescence staining methods were used to evaluate 13 heart valve specimens derive...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339600500306
更新日期:1996-06-01 00:00:00
abstract::Structural and metabolic abnormalities in the hippocampus have been associated with the pathophysiological mechanism of central nervous system involvement in primary Sjögren syndrome (pSS). Nevertheless, how hippocampal function is altered in pSS remains unknown. The purpose of our study is to investigate the alterati...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203320908936
更新日期:2020-04-01 00:00:00
abstract::Objective We aimed to evaluate the relationship between telomere length and systemic lupus erythematosus (SLE). Methods PUBMED and EMBASE databases were searched; meta-analyses were performed comparing telomere length in SLE patients and healthy controls, and on SLE patients in subgroups based on ethnicity, sample typ...
journal_title:Lupus
pub_type: 杂志文章,meta分析
doi:10.1177/0961203316662721
更新日期:2017-03-01 00:00:00
abstract::The outcome, quality of life and prognosis of lupus patients can be enhanced with close follow up and coordination between the individual's primary care physician and rheumatologist. Rheumatologists usually do not act as primary care physicians and leave health care maintenance to practitioners who need to be reminded...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203307086267
更新日期:2008-02-01 00:00:00
abstract::We studied the effect of beta 2-GPI on binding of antibodies in sera from patients with leprosy and patients with the antiphospholipid syndrome (APS) to CL in enzyme-linked immunosorbent assays (ELISAs). Increased levels of IgG aCL were detected in 59 of 61 leprosy patients' sera by the standard aCL-ELISA in the prese...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339400300615
更新日期:1994-12-01 00:00:00
abstract::With a cross sectional study of 465 consecutive systemic lupus erythematosus (SLE) patients tested for 13 autoantibodies (Aab) and two idiotypes we determined the prevalence of Aab according to disease activity, both general and at particular organ systems. Seventy seven percent of SLE sera had at least one Aab and 56...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339700600503
更新日期:1997-01-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is an autoimmune disease with a complex pathogenesis. Published data have revealed that serum levels of proinflammatory cytokines are increased in SLE patients. The aim of our study was to evaluate whether monotherapy with chloroquine phosphate affects IL-1beta, IL-6, IL-18 and TNF-a...
journal_title:Lupus
pub_type: 临床试验,杂志文章
doi:10.1191/0961203306lu2299oa
更新日期:2006-01-01 00:00:00
abstract::Renal involvement is one of the main complications of systemic lupus erythematosus, causing a significant impact on patients' morbidity and mortality. Renal biopsy is still the gold standard of diagnosis, but it has many limitations. In this sense, several recent studies aim to identify biomarkers that not only predic...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203319826695
更新日期:2019-03-01 00:00:00
abstract::Studies have demonstrated considerable variability in systemic lupus erythematosus (SLE) incidence and prevalence estimates. Lack of reliable epidemiological data may hinder evidence-based health care planning. The aim of the present study was to estimate the prevalence and incidence of SLE in the Estonian adult popul...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316686705
更新日期:2017-09-01 00:00:00
abstract::A dose-dependent combination of environmental exposures, estrogenic hormones and genetic predisposition is thought to be required for lupus to develop and flare, but how the environment modifies the immune system in genetically predisposed people is unclear. Current evidence indicates that environmental agents that in...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203313499419
更新日期:2014-05-01 00:00:00
abstract::Tumor necrosis factor alpha (TNF alpha) and interleukin-6 (IL-6) play a main role in inducing acute phase protein production by hepatocytes. This study describes the serum levels of TNF alpha and IL-6 in relation to serum levels of C-reactive protein (CRP) and alpha 1-acid glycoprotein (alpha 1AG) in three systemic lu...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339300200605
更新日期:1993-12-01 00:00:00
abstract::Immune-mediated sensorineural hearing loss may complicate systemic autoimmune diseases. We have previously reported the presence of antibodies directed against inner ear antigens in patients with Cogan syndrome, a disease characterized by sudden hearing loss and interstitial keratitis. Such autoantibodies cross-react ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316682099
更新日期:2017-07-01 00:00:00
abstract::The aim of this study was to evaluate traditional risk factors for coronary artery disease (CAD), homocysteine, anti-oxidized low-density lipoprotein (anti-oxLDL), anti-lipoprotein lipase (anti-LPL) and endothelin-1 (ET-1) in patients with primary anti-phospholipid syndrome (APS), furthermore verify possible associati...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203307081847
更新日期:2007-01-01 00:00:00
abstract::Neonatal antiphospholipid syndrome (neonatal APS) seems to be exceedingly rare, as the antiphospholipid antibodies (aPL) related thrombosis in the neonatal period. The pathogenesis of perinatal aPL related thrombosis may be explained both by the transplacental passage of the maternal antibodies and by the production o...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203314560207
更新日期:2015-03-01 00:00:00
abstract::We examined the prevalence of clinical and immunologic features of systemic lupus erythematosus (SLE) by race, sex and age in a population-based study of 265 SLE patients. Patients fulfilled the American College of Rheumatology classification criteria. The median time between diagnosis and study enrollment was 13 mont...
journal_title:Lupus
pub_type: 杂志文章,多中心研究
doi:10.1191/0961203302lu161oa
更新日期:2002-01-01 00:00:00
abstract::The registry is a prospective, European, multicentric, longitudinal study, which follows a cohort of children born to mothers with antiphospholipid syndrome (APS). It was started in 2003. In this report, we update the results obtained from the study of 110 mothers and 112 children (two twin births). Eighty per cent of...
journal_title:Lupus
pub_type: 杂志文章,多中心研究
doi:10.1177/0961203309106951
更新日期:2009-09-01 00:00:00
abstract::Female B6.MRLc1(82-100) congenic mice develop more severe autoimmune glomerulonephritis (AGN) than males. We assessed the effects of gonadectomy on the pathogenesis of AGN in these mice. One-month-old male and female mice were divided into sham-operated group (SG) and gonadectomized group (GG), and the pathological ch...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203308098989
更新日期:2009-05-01 00:00:00
abstract:BACKGROUND:Systemic lupus erythematosus (SLE) is a complex autoimmune disease that can involve multiple organ systems. Exposure to ultraviolet radiation (UVR) can exacerbate pre-existing SLE, and can even induce systemic manifestations. This study aimed to investigate the photoprotective habits of children with SLE and...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203320930098
更新日期:2020-07-01 00:00:00
abstract::Neonatal lupus erythematosus (NLE) is an uncommon condition usually associated with maternal anti-Ro autoantibodies. The cutaneous lesions of NLE are usually transient, disappearing about six months after birth, but telangiectasia is a rare complication of NLE which persists. Telangiectasias are small focal red macule...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203311430701
更新日期:2012-04-01 00:00:00
abstract::The immunopathogenesis of systemic lupus erythematosus has been thoroughly investigated recently, and genome-wide association studies have identified genes statistically associated with lupus. However, the progression to overt disease is dependent on the activation of environmental factors ('triggers'), among which oe...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203311433138
更新日期:2012-05-01 00:00:00
abstract::Gamma-aminobutyric acid-A (GABA-A) receptors play a crucial role in regulating neuronal excitability and cognitive functions. Single-photon emission computerized tomography (SPECT) analysis of GABA-A receptors binding by (123)I-labelled Iomazenil ((123)I-IMZ) has been applied in some neuropsychiatric disorders to inve...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203310364398
更新日期:2010-07-01 00:00:00
abstract:OBJECTIVE:The objectives of this paper are to compare sexual function and distress in women with systemic lupus erythematosus (SLE) and in healthy controls; to determine the association between disease characteristics, quality of life, psychopathology and sexual function; and to compare sexual function and distress of ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203313500370
更新日期:2013-09-01 00:00:00
abstract::The mouse model described in this study offers a unique method of determining the characteristics and mechanism(s) of action of aCL antibodies in thrombosis in vivo. In addition, this animal model enables the study of the kinetics of formation and dissolution of thrombus, as well as clot area, to be studied in a dynam...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/096120339400300408
更新日期:1994-08-01 00:00:00
abstract::Anti-phospholipid antibodies are common in patients in the Hopkins' Lupus Cohort: 47% have anti-cardiolipin, 32.5% anti-beta(2)-glycoprotein I and 26% lupus anticoagulant (by dRVVT confirmatory testing). Systemic lupus erythematosus patients with the lupus anticoagulant at baseline have a 50% chance of a deep venous t...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203309360541
更新日期:2010-04-01 00:00:00
abstract::Atherosclerosis is an inflammatory disease, leading to the formation of pro-inflammatory and pro-oxidative lipids that generate an immune response. Several antigens have been shown to activate the immune response and affect the development of atherogenesis. Systemic lupus erythematosus is an autoimmune and inflammator...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203309345725
更新日期:2009-11-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is a connective tissue disease where inflammatory activity affects several organ systems. An increased risk of cardiovascular disease has been identified in these patients, even after correction for traditional risk factors. The aim of the present study was to evaluate arterial stiff...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203306071402
更新日期:2006-01-01 00:00:00
abstract::Involvement of the musculoskeletal system is common if not universal in the clinical course of systemic lupus erythematosus (SLE). Joint involvement on the whole does not cause major erosive disease, however, recent developments in musculoskeletal imaging show clearly the presence of significant bony and soft tissue i...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203303lu2021oa
更新日期:2004-01-01 00:00:00
abstract::We describe a patient with rheumatoid arthritis (RA) whose sera contained a high titre of an antibody targeting cytoplasmic ribosomal P proteins (anti-P). This association preceded by 6 years the development of serological and clinical manifestations of systemic lupus erythematosus (SLE). The clinical significance of ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339700600910
更新日期:1997-01-01 00:00:00
abstract:INTRODUCTION:The use of hydroxychloroquine (HCQ) in patients with systemic lupus erythematosus (SLE) offers a wide range of benefits. However, there are evidence in favour of cardiotoxicity, including heart conduction disturbances and congestive heart failure. OBJECTIVE:To determine the effects of HCQ in the resting h...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203315580870
更新日期:2015-10-01 00:00:00
abstract::Legionnaire's disease (LD) is most commonly caused by Legionella pneumophila (L. pneumophila). In immunocompromised patients LD can cause necrosis of the lung parenchyma with abscess formation and cavitation. Systemic lupus erythematosus (SLE) is an autoimmune disorder with features of both primary and secondary immun...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203321990102
更新日期:2021-01-26 00:00:00