Anticardiolipin antibodies in infections are heterogenous in their dependency on beta 2-glycoprotein I: analysis of anticardiolipin antibodies in leprosy.

abstract：:The immunopathogenesis of systemic lupus erythematosus has been thoroughly investigated recently, and genome-wide association studies have identified genes statistically associated with lupus. However, the progression to overt disease is dependent on the activation of environmental factors ('triggers'), among which oe...

journal_title：Lupus

authors： Catania G,Rossi E,Marmont A

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVE:We analyzed data of lupus nephritis (LN) patients to find parameters that can predict remission. METHODS:Sixty-four LN patients who were diagnosed with class III, IV, V or V + III/IV by renal biopsy and were followed up for more than six months in our center were enrolled retrospectively. Receiver operating ...

journal_title：Lupus

authors： Liu G,Wang H,Le J,Lan L,Xu Y,Yang Y,Chen J,Han F

更新日期：2019-03-01 00:00:00

abstract：:The aim of our study was to determine whether the SLEDAI-2K calculated using a timeframe of 30 days prior to a visit for clinical and laboratory variables was equivalent to the prescribed 10-day period. One hundred forty nine consecutive lupus patients seen over 9 weeks at the University of Toronto Lupus Clinic enroll...

journal_title：Lupus

authors： Touma Z,Urowitz MB,Gladman DD

更新日期：2010-01-01 00:00:00

abstract：:Abnormalities of the lipid profile partly explain the atherogenic tendency of systemic lupus erythematosus but the picture is unclear in thrombotic primary antiphospholipid syndrome (PAPS). Herein we compare the lipid profile, high-density lipoprotein (HDL), low-density lipoprotein (LDL), total cholesterol (CHO), apol...

journal_title：Lupus

authors： Ames PR,Matsuura E,Batuca JR,Ciampa A,Lopez LL,Ferrara F,Iannaccone L,Alves JD

更新日期：2010-05-01 00:00:00

abstract：OBJECTIVE:The objective of this paper is to assess whether pulmonary hypertension (PH) may be detected at one point in time or longitudinally predicted by serum uric acid (sUA) levels in systemic lupus erythematosus (SLE). METHODS:We conducted a post-hoc analysis of a long-term followed cohort of Mexican SLE patients....

journal_title：Lupus

authors： Castillo-Martínez D,Marroquín-Fabián E,Lozada-Navarro AC,Mora-Ramírez M,Juárez M,Sánchez-Muñoz F,Vargas-Barrón J,Sandoval J,Amezcua-Guerra LM

更新日期：2016-01-01 00:00:00

abstract：:SLE is an autoimmune and polygenic disorder characterized by an accumulation and deposition of immune complexes. Several studies have indicated differential impact of FcgammaR polymorphism genotypes in different ethnic groups studied. The Fc receptor for IgG class IIA gene (FcgammaRIIA) occurs in two allelic forms. Th...

journal_title：Lupus

authors： Yap SN,Phipps ME,Manivasagar M,Tan SY,Bosco JJ

更新日期：1999-01-01 00:00:00

abstract：:We report a case of bilateral choroidopathy in a 35-year-old woman with systemic lupus erythematosus (SLE) diagnosed 3 years previously, and treated with hydroxychloroquine and steroids that ceased 6 months before ocular signs. She complained about rapid bilateral blurred vision with a severe loss of visual acuity. Fl...

journal_title：Lupus

authors： Edouard S,Douat J,Sailler L,Arlet P,Astudillo L

更新日期：2011-10-01 00:00:00

abstract：:Cytomegalovirus (CMV) is particularly dangerous in systemic lupus erythematosus (SLE), being a problem both for the differential diagnosis with disease flare and for the management of SLE flare with immunosuppressive drugs. We report on four cases of SLE with concomitant CMV infection, having some common clinical and ...

journal_title：Lupus

authors： Sebastiani GD,Iuliano A,Canofari C,Bracci M

更新日期：2019-03-01 00:00:00

abstract：:The relationship between disease activity, cumulative damage and self-reported quality of life was examined in 96 patients with Systematic Lupus Erythematosus (SLE). Disease activity was measured by the SLE Disease Activity Index (SLEDAI) and cumulative damage by the Systematic Lupus International Cooperating Clinics/...

journal_title：Lupus

authors： Hanly JG

更新日期：1997-01-01 00:00:00

abstract：:Antiphospholipid antibodies (aPL), the majority of which are directed against beta(2)-glycoprotein I (beta(2)GPI), are associated with an increased incidence of venous and arterial thrombosis. The pathogenesis of antiphospholipid/anti-beta(2)GPI-associated thrombosis has not been defined, and is likely multifactorial....

journal_title：Lupus

authors： Cockrell E,Espinola RG,McCrae KR

更新日期：2008-10-01 00:00:00

abstract：:Tissue damage associated with a severe injury can result in profound inflammatory responses that may trigger autoimmune development in lupus-prone individuals. In this study, we investigated the role of a large full-thickness cutaneous burn injury on the early onset of autoimmune disease in lupus-prone MRL/++ mice. MR...

journal_title：Lupus

authors： Anam K,Amare M,Naik S,Szabo KA,Davis TA

更新日期：2009-04-01 00:00:00

abstract：:Background Patients with systemic lupus erythematosus (SLE) may form clusters with clinical manifestations and autoantibodies. Objective The objective of this report is to study whether SLE patients with positive rheumatoid factor (RF) have a special clinical and/or serological profile. Methods A retrospective study o...

journal_title：Lupus

authors： Fedrigo A,Dos Santos TAFG,Nisihara R,Skare T

更新日期：2018-07-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an immune-mediated disease that is responsive to suppression or modulation of the immune system. Patients with SLE who experience persistent multiorgan dysfunction, despite standard doses of intravenous cyclophosphamide (Cy), represent a subset of patients at high risk of early de...

journal_title：Lupus

authors： Lisukov IA,Sizikova SA,Kulagin AD,Kruchkova IV,Gilevich AV,Konenkova LP,Zonova EV,Chernykh ER,Leplina OY,Sentyakova TN,Demin AA,Kozlov VA

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:The aim of our study was to investigate the efficacy of adipose-derived stem cells (ADSC) transplantation in systemic lupus erythematosus (SLE) and to determine the mechanism of ADSC transplantation. METHODS:B6.MRL/lpr mice were administered ADSC intravenously every week from age 28 to 31 weeks, while the lu...

journal_title：Lupus

authors： Wei S,Xie S,Yang Z,Peng X,Gong L,Zhao K,Zeng K,Lai K

更新日期：2019-02-01 00:00:00

abstract：INTRODUCTION:Children with systemic lupus erythematosus (SLE) have an increased prevalence of kidney disease compared to their adult counterparts. Our goal was to identify potential clinical and laboratory predictors of renal disease. METHODS:We performed a cohort study of incident and prevalent patients with SLE aged...

journal_title：Lupus

authors： Sule SD,Moodalbail DG,Burnham J,Fivush B,Furth SL

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVES:To estimate the prevalence of pulmonary arterial hypertension (PAH) and risk factors for PAH in patients registered in the Chinese SLE Treatment and Research group (CSTAR) database, the first online registry of Chinese patients with systemic lupus erythematosus (SLE). METHODS:A prospective cross-sectional s...

journal_title：Lupus

authors： Li M,Wang Q,Zhao J,Li Z,Ye Z,Li C,Li X,Zhu P,Wang Z,Zheng Y,Li X,Zhang M,Tian Z,Liu Y,He J,Zhang F,Zhao Y,Zeng X,CSTAR co-authors.

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVE:YB current affiliation: Department of Pediatrics, Hadassah-Hebrew University Medical Center, Mount Scopus, Israel YB and MJS contributed equally to the study and should be regarded as joint first authors on this manuscript. Antiphospholipid syndrome (APS) may present with thrombosis and persistently elevated ...

journal_title：Lupus

authors： Berkun Y,Simchen MJ,Strauss T,Menashcu S,Padeh S,Kenet G

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVE:Fatigue in systemic lupus erythematosus (SLE) is burdensome and must be assessed using validated scales. Although the psychometric properties of the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-Fatigue) scale in SLE have been evaluated previously, its content validity in this disease remain...

journal_title：Lupus

authors： Kosinski M,Gajria K,Fernandes AW,Cella D

更新日期：2013-04-01 00:00:00

abstract：:Obstetric antiphospholipid syndrome (APS) remains a clinical challenge for practitioners, with several controversial points that have not been answered so far. This Obstetric APS Task Force met on the 16th International Congress on Antiphospholipid Antibodies in Manchester, England, to discuss about treatment, diagnos...

journal_title：Lupus

authors： de Jesús GR,Benson AE,Chighizola CB,Sciascia S,Branch DW

更新日期：2020-10-01 00:00:00

abstract：:This study investigates specificity, sensitivity and concomitant presence of antibodies against histone H1 (H1), nucleosomes (NUC), chromatin (CHR) and dsDNA in patients with systemic lupus erythematosus (SLE), analyses their association with SLE disease activity and characterizes the immunodominant epitope reactivity...

journal_title：Lupus

authors： Schett G,Smole J,Zimmermann C,Hiesberger H,Hoefler E,Fournel S,Muller S,Rubin RL,Steiner G

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVE:This study aimed to explore the risk factors for 'severe' neuropsychiatric (NP) flare in patients with systemic lupus erythematosus (SLE). METHODS:This retrospective study comprised newly diagnosed 184 adult SLE patients who visited Hokkaido University Hospital between 2006 and 2017. In this study, severe NP...

journal_title：Lupus

authors： Aso K,Kono M,Kono M,Watanabe T,Shimizu Y,Ogata Y,Fujieda Y,Kato M,Oku K,Amengual O,Yasuda S,Atsumi T

更新日期：2020-09-01 00:00:00

abstract：INTRODUCTION:The International Society of Nephrology/Renal Pathology Society (ISN/RPS) pathological classification criteria of lupus nephritis are limited to glomerular injury. Although the tubulointerstitium is commonly involved, the importance of such involvement is not well defined. The major objective of this study...

journal_title：Lupus

authors： Alsuwaida AO

更新日期：2013-12-01 00:00:00

abstract：:Current management of primary or secondary antiphospholipid antibody (aPL) syndromes with known embolic phenomena requiring anticoagulation is empiric in the setting of elective orthopedic procedures. Short-term withdrawal of warfarin with continuance of aspirin and glucocorticoid therapy was undertaken for sequential...

journal_title：Lupus

authors： Schnitz WM,Lister KA,McCarty GA

更新日期：1992-05-01 00:00:00

abstract：:We retrospectively evaluated the clinical outcome of 45 female and 11 male patients with biopsy-proven lupus nephritis, followed at our hospital between February 1974 and February 1990. In the majority signs of nephritis were present at the time systemic lupus erythematosus was diagnosed (range: -42-156 months) and th...

journal_title：Lupus

authors： Derksen RH,Hené RJ,Kater L

更新日期：1992-02-01 00:00:00

abstract：:Although challenging, developing evidence-based approaches to an early and accurate diagnosis of systemic lupus erythematosus is a key approach to preventing disease and lupus-associated morbidity and mortality. Advances in our understanding of preclinical and incomplete lupus erythematosus have enabled the identifica...

journal_title：Lupus

authors： Choi MY,Barber MR,Barber CE,Clarke AE,Fritzler MJ

更新日期：2016-07-01 00:00:00

abstract：:Nephropathy of antiphospholipid antibody syndrome (NAPS) is an increasingly well-recognized aspect of antiphospholipid syndrome. The most characteristic histopathology is that of thrombotic microangiopathy, and thrombosis occurring in the renal vasculature is thought to be the initiating event. Other less common patho...

journal_title：Lupus

authors： Lin YQ,Lakshminarayanan S,Yamase H,Palmisano J,Parke A

更新日期：2009-05-01 00:00:00

abstract：OBJECTIVES:Poor adherence to immunosuppressive treatment is common in patients with systemic lupus erythematosus and may identify those with lupus nephritis (LN) who have a poorer prognosis. Non-adherence has also been reported to be a potential adverse outcome predictor in renal transplantation (rTp). We investigated ...

journal_title：Lupus

authors： Ntatsaki E,Vassiliou VS,Velo-Garcia A,Salama AD,Isenberg DA

更新日期：2019-04-01 00:00:00

abstract：:We report three cases of severe haemorrhagic rupture of luteal ovarian cyst requiring surgical haemostasis in young women treated with long-term oral anticoagulation for antiphospholipid syndrome (APS) who used no contraception. At the time of bleeding, the international normalized ratios were 3.78, 4.24, and 7.11. An...

journal_title：Lupus

authors： Crétel E,Cacoub P,Huong DL,Gompel A,Amoura Z,Piette JC

更新日期：1999-01-01 00:00:00

abstract：:Peripheral T cell apoptosis is upregulated in active SLE, in parallel with high expression of both membrane-bound and soluble (s) Fas. Previous studies postulated that sFas down-regulates apoptosis in vitro through its blockade of the Fas-L of cytotoxic cells. We have investigated the extent of apoptosis and sFas leve...

journal_title：Lupus

authors： Silvestris F,Grinello D,Tucci M,Cafforio P,Dammacco F

更新日期：2003-01-01 00:00:00

abstract：:Recent studies have revealed new populations of T/B cells, including central/effector memory, follicular T cells and CXCR3+ or CXCR4+ B cells. In the present study, changes in these populations of CD4+ T cells were examined on the basis of the expression of CD62L, CCR7 and CXCR5 in patients with systemic lupus erythem...

journal_title：Lupus

authors： Watanabe T,Suzuki J,Mitsuo A,Nakano S,Tamayama Y,Katagiri A,Amano H,Morimoto S,Tokano Y,Takasaki Y

更新日期：2008-01-01 00:00:00