Abstract:
:Structural and metabolic abnormalities in the hippocampus have been associated with the pathophysiological mechanism of central nervous system involvement in primary Sjögren syndrome (pSS). Nevertheless, how hippocampal function is altered in pSS remains unknown. The purpose of our study is to investigate the alterations in hippocampal functional connectivity (FC) in pSS by using resting-state functional magnetic resonance imaging (rs-fMRI). Thirty-eight patients with pSS and 38 age- and education level-matched healthy controls (HCs) underwent magnetic resonance imaging examination. Prior to each MRI examination, neuropsychological tests were performed. Left and right hippocampal FCs were analyzed by using seed-based whole-brain correlation and compared between pSS and HCs. Spearman correlation analysis was performed between the z-value of hippocampal FC in brain regions with significant difference between the two groups and neuropsychological tests/clinical data in pSS. Compared with the controls, the patients with pSS showed decreased hippocampal FC between the left hippocampus and the right inferior occipital gray (IOG)/inferior temporal gray (ITG), as well as between the right hippocampus and right IOG/middle occipital gray (MOG), left MOG, and left middle temporal gray. In addition, increased hippocampal FCs were detected between the left hippocampus and left putamen, as well as between the right hippocampus and right cerebellum posterior lobe. Moreover, the visual reproduction score positively correlated with the FC between right hippocampus and right IOG/MOG. The white matter hyperintensity score negatively correlated with the FC between left hippocampus and right IOG/ITG. In conclusion, patients with pSS suffered decreased hippocampal FC mainly sited in the occipital and temporal cortex with right hippocampal laterality. Altered hippocampal FC might be a potential biomarker in detecting brain function changes and guiding neuroprotection in pSS.
journal_name
Lupusjournal_title
Lupusauthors
Zhang XD,Zhao LR,Zhou JM,Su YY,Ke J,Cheng Y,Li JL,Shen Wdoi
10.1177/0961203320908936subject
Has Abstractpub_date
2020-04-01 00:00:00pages
446-454issue
5eissn
0961-2033issn
1477-0962journal_volume
29pub_type
杂志文章相关文献
LUPUS文献大全abstract::Cardiac involvement in systemic lupus erythematosus (SLE) is well documented. The pericardium, myocardium and endocardium, as well as the coronary arteries, the valves and the conduction system can all be affected. While pericarditis is common, arrythmias are less frequently described.We present a 13-year-old male, wh...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203320974091
更新日期:2020-11-20 00:00:00
abstract::The purpose of this study was to determine the prevalence and correlates of fibromyalgia (FM) in a prospective, multiethnic systemic lupus (SLE) cohort. A total of 266 SLE patients with disease duration of < or = 5 years at study entry were evaluated longitudinally for the presence of FM (per ACR criteria). Sociodemog...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203303lu330oa
更新日期:2003-01-01 00:00:00
abstract::Glycans (sugars or carbohydrates) are predominant surface components of cells such as erythrocytes, immune cells and microorganisms. As such, they give rise to high levels of anti-glycan antibodies of all classes. Antibodies to certain defined mono, di and oligosaccharides that are common in bacterial, fungal and para...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1191/0961203306lu2331oa
更新日期:2006-01-01 00:00:00
abstract::Although the importance of the anticardiolipin test in diagnosis of antiphospholipid syndrome (APS) is widely accepted, there remains much misunderstanding about the strengths and weaknesses of this assay. Several disorders result in formation of low levels of the antibody, hence the anticardiolipin test is not specif...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203302lu202cr
更新日期:2002-01-01 00:00:00
abstract::The metabolism of poly(ADP-ribose) in peripheral blood mononuclear (PBM) cells was studied in 13 patients with systemic lupus erythematosus (SLE) and in 12 age and sex matched controls. Poly(ADP-ribose) polymerase activity was measured as the net accumulation of ADP-ribose polymers during the conversion of 32P-NAD to ...
journal_title:Lupus
pub_type: 临床试验,杂志文章
doi:10.1177/096120339600500105
更新日期:1996-02-01 00:00:00
abstract::The aim of the study is to investigate whether the functional p53 codon 72 polymorphism is associated with susceptibility to SLE and its clinical features. A polymerase chain reaction of genomic DNA-restriction fragment length polymorphism was used to determine genotypes of the p53 codon 72 in 90 SLE patients and 114 ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203305lu2224oa
更新日期:2005-01-01 00:00:00
abstract::Anti-tumor necrosis factor-alpha (TNF-α) immunotherapy is currently used in the treatment of various inflammatory diseases such as rheumatoid arthritis, psoriasis, psoriatic arthritis, ankylosing spondylitis and Crohn's disease. Infliximab is a chimeric monoclonal antibody that binds to transmembrane-bound and soluble...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203313479423
更新日期:2013-04-01 00:00:00
abstract:OBJECTIVE:This study aimed to explore the experience and impact of fatigue in adults with primary antiphospholipid syndrome (pAPS). METHODS:This sequential, explanatory mixed-methods study enrolled adults with a six-month or more history of pAPS. Consenting participants completed the Functional Assessment of Chronic I...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203320928421
更新日期:2020-07-01 00:00:00
abstract::Background Antimalarials (AMs) are widely used in the treatment of connective tissue diseases. Their main side effect is retinal damage, while heart disease has been described in isolated cases. The aim of this study is to systematically review the existing literature on AM-induced cardiomyopathy (AMIC). Methods The P...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203317734922
更新日期:2018-04-01 00:00:00
abstract::We investigated obstetric outcomes and comorbidities during pregnancy in females with preexisting lupus nephritis (LN) and identified predictors for renal flare. In cases of renal flare during pregnancy, we assessed the long-term post-delivery renal outcome. We performed a retrospective analysis of 183 systemic lupus ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203315572715
更新日期:2015-06-01 00:00:00
abstract::In search of markers of disease activity in patients with SLE we have investigated blood lymphocyte subsets from a large cohort of patient. Seventy-one patients were studied using a well-defined panel of fluorescent monoclonal antibodies which recognize the major T, B and NK lymphocyte subsets and activated cells. Flo...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339300200404
更新日期:1993-08-01 00:00:00
abstract::The aim of this study was to describe the clinical course of patients with lupus nephritis (LN) who attain a sustained remission (SR) and identify predictors of SR. A retrospective study of patients with biopsy-proven LN were followed for up to 10 years. SR was defined as normal renal function, urine protein <0.5g/day...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203306lu2271oa
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:Systemic lupus erythematosus (SLE), an autoimmune condition with diverse clinical manifestations, is reported to have different expression in populations of different ancestry. Most previous studies compared patients of different ethnic groups from geographically distinct cohorts. In our study, we aimed to ch...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203313500547
更新日期:2013-11-01 00:00:00
abstract::In 1964, Miyoshi reported a series of patients with diverse symptoms after receiving treatment with silicone or paraffin fillers. Miyoshi named this condition 'human adjuvant disease'. Since then, the literature has been flooded with case reports and case series of granulomatous and systemic autoimmune disorders relat...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203315579092
更新日期:2015-09-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to evaluate the correlation and agreement of spot urine protein/creatinine (P/C) ratio with 24 h proteinuria in patients with lupus nephritis (LN) under different scores of activity index (AI). METHODS:In total, 90 pairs of 24 h urine and spot urine samples from 90 patients with bi...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203315570688
更新日期:2015-08-01 00:00:00
abstract::Twelve systemic lupus erythematosus (SLE) patients with mild to moderate disease activity (SLEDAI of > or = 6 and on prednisolone < 0.5 mg/kg/day) were included in a prospective, randomized, double-blind, placebo-controlled pilot study for 24 weeks. Six were randomized to receive oral leflunomide and six received plac...
journal_title:Lupus
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1191/0961203304lu1067sr
更新日期:2004-01-01 00:00:00
abstract::C4d deposition in peritubular capillaries (PTC) has been used as a marker of antibody-mediated rejection (AMR). However, PTC C4d deposition is not described in patients with lupus nephritis (LN). C4d deposition in PTC was detected in 455 patients with biopsy proven LN in the present study. Renal tissues from 21 cases ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203307083279
更新日期:2007-01-01 00:00:00
abstract::To determine whether killer cell immunologlobulin-like receptor (KIR) genotypes are associated with vasculitis, vascular arterial events or anticardiolipin (aCL) antibodies in patients with lupus. A total of 304 patients followed prospectively at the University of Toronto Lupus Clinic were assessed for the occurrence ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203308089443
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND:Acute exercise increases IL-6, IL-10 and TNF-α levels in healthy subjects. There is no study evaluating the effect of exercise on cytokines level in systemic lupus erythematosus (SLE) patients. OBJECTIVE:Our aim was to assess IL-10, IL-6 and TNF-α levels at baseline and after acute physical exercise in pati...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203313508832
更新日期:2013-12-01 00:00:00
abstract::Intravenous immunoglobulin (IVIG) has a therapeutic potential in many autoimmune diseases. Based on its immune modulating and complement inhibiting effects, IVIG has been tested in systemic lupus erythematosus (SLE), but due to osmotic tubular injury caused by immunoglobulin-stabilizing sugar components, lupus nephrit...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203309355299
更新日期:2010-04-01 00:00:00
abstract:INTRODUCTION:The International Society of Nephrology/Renal Pathology Society (ISN/RPS) pathological classification criteria of lupus nephritis are limited to glomerular injury. Although the tubulointerstitium is commonly involved, the importance of such involvement is not well defined. The major objective of this study...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203313507986
更新日期:2013-12-01 00:00:00
abstract::We report clinical and histopathological features, treatment and outcome of 37 Croatian children with biopsy-proven lupus nephritis seen over a 30-year period. The mean age at lupus nephritis presentation was 12.11 ± 2.59 years (range 4.66-17.0). The most frequent histopathological finding was class IV (37.8%), follow...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314563133
更新日期:2015-03-01 00:00:00
abstract::The disease activity of patients suffering from lupus nephritis usually becomes quiescent after the onset of end stage renal failure. Reactivation of lupus activity, especially after a long period of dialysis, is uncommon. Factors that might trigger off lupus reactivation after dialysis have not been well defined. We ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203302lu096cr
更新日期:2002-01-01 00:00:00
abstract::Criteria of organ-specific autoimmunity are fulfilled in a subset of patients with myocarditis/dilated cardiomyopathy (DCM). In particular, circulating heart-reactive autoantibodies are found in patients and symptom-free relatives. These autoantibodies are directed against multiple antigens, some of which are expresse...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1191/0961203305lu2193oa
更新日期:2005-01-01 00:00:00
abstract::The SLICC/ACR damage index for SLE was developed to assess accumulated damage since the onset of the disease. The damage includes non-reversible changes in organs and systems affected by the disease process itself, its therapy, or inter-current illness. This paper describes the development of the damage index, its val...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/096120399680411335
更新日期:1999-01-01 00:00:00
abstract::Antiphospholipid antibodies (aPL), the majority of which are directed against beta(2)-glycoprotein I (beta(2)GPI), are associated with an increased incidence of venous and arterial thrombosis. The pathogenesis of antiphospholipid/anti-beta(2)GPI-associated thrombosis has not been defined, and is likely multifactorial....
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203308095329
更新日期:2008-10-01 00:00:00
abstract::Patients with chronic hepatitis C virus (HCV) infection frequently present with extrahepatic manifestations covering a large spectrum, involving different organ systems leading to the concept of systemic HCV infection. These manifestations include autoimmune phenomena and frank autoimmune and/or rheumatic diseases and...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203314556140
更新日期:2015-04-01 00:00:00
abstract::Choroidal involvement in systemic lupus erythematosus (SLE) occurs infrequently. We report a 45-y-old woman with bilateral chorioretinopathy associated with SLE. Diagnosis was performed using indirect ophthalmoscopy, retinal fluorescein angiography (FA) and green indocianin angiography (ICG). In this patient chorioret...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/096120301701549598
更新日期:2001-01-01 00:00:00
abstract::Background Systemic lupus erythematosus (SLE) is an autoimmune disease marked by the disruption of the immune homeostasis. Patients exhibit a wide range of clinical manifestations, and environmental and genetic factors are involved in SLE pathogenesis. Evidence suggests that abnormalities in the cellular and molecular...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316678671
更新日期:2017-06-01 00:00:00
abstract::Neonatal lupus erythematosus (NLE) is an uncommon condition usually associated with maternal anti-Ro autoantibodies. The cutaneous lesions of NLE are usually transient, disappearing about six months after birth, but telangiectasia is a rare complication of NLE which persists. Telangiectasias are small focal red macule...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203311430701
更新日期:2012-04-01 00:00:00