Abstract:
:Neonatal lupus erythematosus (NLE) is an uncommon condition usually associated with maternal anti-Ro autoantibodies. The cutaneous lesions of NLE are usually transient, disappearing about six months after birth, but telangiectasia is a rare complication of NLE which persists. Telangiectasias are small focal red macules and papules created by abnormally prominent capillaries, venules, and arterioles and are a characteristic marker of connective tissue diseases. We report the case of an infant diagnosed with NLE presenting typical annular lesions, positive ANA and positive anti-Ro antibodies. By five months of age, both ANA and anti-Ro antibodies were negative and the annular cutaneous lesions had gradually faded, but small scattered focal red macules appeared on the face, especially in the peri-orbital area and scalp. The cutaneous lupus disappeared but the telangiectasia persisted. We would like to suggest that the diagnosis of NLE should be considered when cutaneous telangiectasias are observed in infants.
journal_name
Lupusjournal_title
Lupusauthors
Guinovart RM,Vicente A,Rovira C,Suñol M,González-Enseñat MAdoi
10.1177/0961203311430701subject
Has Abstractpub_date
2012-04-01 00:00:00pages
552-5issue
5eissn
0961-2033issn
1477-0962pii
0961203311430701journal_volume
21pub_type
杂志文章相关文献
LUPUS文献大全abstract::Coming from Hans Wigzell's laboratory in Uppsala, Sweden, I joined the Kunkel laboratory in 1981 to spend a post-doctoral fellowship period financed by the German Research Organization. While I initially worked with Nick Chiorazzi in an attempt to generate monoclonal antibody-secreting human B-cell hybridomas, I later...
journal_title:Lupus
pub_type: 传,历史文章,杂志文章
doi:10.1191/0961203303lu355xx
更新日期:2003-01-01 00:00:00
abstract::The effect of synthetic CpG-oligodeoxynucleotides (CpG-ODN) on the development of lupus nephritis during preactive phase (within seven months of age) in autoimmune lupus NZB x NZWF1 (B/WF1) mice was examined. Treatment of CpG-ODN was started at the age of 2.75 months and continued until 6.25 months. Overt disease bega...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203303lu483oa
更新日期:2003-01-01 00:00:00
abstract::Gastrointestinal manifestations of systemic lupus erythematosus (SLE) are common, occurring in about 50% of cases. They are usually mild, in the form of mouth ulcers, nausea, heartburn and mild abdominal pain, but they can be severe in cases of gastrointestinal vasculitis. In this report we describe an unusual combina...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203313517150
更新日期:2014-02-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) has preponderance in women in their childbearing years; consequently pregnancy has always been an important issue of concern for the patient and the treating physician. Based upon numerous reports on successful pregnancy outcomes in the past decades, the initial advice against pregna...
journal_title:Lupus
pub_type: 评论,杂志文章
doi:10.1177/0961203315627201
更新日期:2016-04-01 00:00:00
abstract::Women's treatment preferences for lupus nephritis vary widely even after adjusting for sociodemographic factors and disease severity. Attitude toward risk may partially explain interpatient variability in treatment preference. The objective of this study was to examine the association between 'risk-attitude' and patie...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203303lu371oa
更新日期:2003-01-01 00:00:00
abstract::HIN200 is a human IFN-inducible gene and homologous to murine IFI202 gene, which was identified as a candidate gene for SLE susceptibility in lupus mouse model. We determined these gene expressions in leukocytes from 20 SLE patients and 10 healthy controls and in renal biopsies from 29 SLE patients and 15 kidney donor...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203309106699
更新日期:2009-10-01 00:00:00
abstract::Perinatal thrombosis in infants born to mothers with antiphospholipid antibodies (aPL) is a rare event, but with risk of death or severe sequelae. We analysed 16 infants with such perinatal thrombosis reported in the literature in the last 20 years. Thromboses were arterial (13/16), mostly strokes (8/16). Hydrops feta...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203307079039
更新日期:2007-01-01 00:00:00
abstract::We conducted an open-labeled, prospective study to determine the efficacy and safety of tacrolimus as an alternative therapeutic option for those patients with refractory lupus nephritis. The study population comprised one male and eight female patients with diffuse proliferative lupus nephritis. All patients had fail...
journal_title:Lupus
pub_type: 临床试验,杂志文章
doi:10.1177/0961203310366573
更新日期:2010-07-01 00:00:00
abstract::Objective People affected by chronic rheumatic conditions, such as systemic lupus erythematosus (SLE), frequently rely on the Internet and search engines to look for terms related to their disease and its possible causes, symptoms and treatments. 'Infodemiology' and 'infoveillance' are two recent terms created to desc...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203317691372
更新日期:2017-07-01 00:00:00
abstract::Objective The main aim of this study was to investigate the ovarian reserve, menstruation, and lymphocyte subpopulation in systemic lupus erythematosus (SLE) patients of childbearing age. Methods We enrolled 40 SLE patients of childbearing age and 40 age-matched healthy controls. Anti-Müllerian hormone (AMH) was teste...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203317726378
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVES:To determine the rates of induced abortions in women with systemic lupus erythematosus (SLE) compared to women from the general population and assess disease-related predictors of induced abortion in women with SLE. METHODS:We identified women with SLE (15-45 years) and determined the number of induced abor...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203320979741
更新日期:2020-12-15 00:00:00
abstract::Variations at the ITGAM gene, which encodes for the CD11b chain of the Mac-1 (alphaMbeta2; CD11b/CD18; complement receptor-3) integrin, is one of the strongest genetic risk factors for systemic lupus erythematosus (SLE). More specifically, a genetic variant (rs1143679) which results in an arginine to histidine substit...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203313491851
更新日期:2013-06-01 00:00:00
abstract::We examined the prevalence of clinical and immunologic features of systemic lupus erythematosus (SLE) by race, sex and age in a population-based study of 265 SLE patients. Patients fulfilled the American College of Rheumatology classification criteria. The median time between diagnosis and study enrollment was 13 mont...
journal_title:Lupus
pub_type: 杂志文章,多中心研究
doi:10.1191/0961203302lu161oa
更新日期:2002-01-01 00:00:00
abstract::Studies have demonstrated considerable variability in systemic lupus erythematosus (SLE) incidence and prevalence estimates. Lack of reliable epidemiological data may hinder evidence-based health care planning. The aim of the present study was to estimate the prevalence and incidence of SLE in the Estonian adult popul...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316686705
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVE:Studies have been conducted to determine the causal factors and clinical consequences of non-adherence to treatment in systemic lupus erythematosus (SLE). However, no interventions have been performed to increase drug adherence. Our objective was to assess the effectiveness of pharmaceutical care (PC) for dru...
journal_title:Lupus
pub_type: 杂志文章,随机对照试验
doi:10.1177/0961203319877237
更新日期:2019-10-01 00:00:00
abstract:OBJECTIVES:To examine the immune cell profile in the bone marrow of systemic lupus erythematosus (SLE) patients and to assess its clinical relevance. METHODS:Sixteen bone marrow samples from 14 SLE patients were compared with seven healthy control samples. The numbers of immune cells and apoptotic cells in the bone ma...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314531634
更新日期:2014-09-01 00:00:00
abstract::Endothelial and/or platelet activation likely initiates thrombus formation. Whether antiphospholipid antibody (aPL) is an activator, a toxic response, or a protective response is not clear, nor is it certain whether aPL is germ-line encoded or antigen-driven. The pregnancy model is particularly informative. Alternativ...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/096120339600500514
更新日期:1996-10-01 00:00:00
abstract:OBJECTIVE:The objective of our study was to determine the incidence rates and risk factors of aortic aneurysm and aortic dissection among patients with systemic lupus erythematosus (SLE) using a nationwide population-based data set. METHODS:We conducted a retrospective cohort study using data from the Taiwan National ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314523868
更新日期:2014-06-01 00:00:00
abstract::Despite strongly held opinions, a trustworthy scientific basis for most statements about autoimmunity, autoimmune diseases and assisted reproductive technologies (ART) does not exist. It is not likely that autoimmunity causes infertility, nor that patients with autoimmune diseases are unusually infertile. When careful...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203304lu2000oa
更新日期:2004-01-01 00:00:00
abstract::Objectives The objective of this study was to determine whether advanced MRI could provide biomarkers for diagnosis and prognosis in neuropsychiatric systemic lupus erythematosus (NPSLE). Methods Our prospective study included 28 systemic lupus erythematosus (SLE) patients with primary central NPSLE, 22 patients witho...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316674820
更新日期:2017-04-01 00:00:00
abstract::Severe systemic lupus erythematosus often requires the use of cyclophosphamide in women of reproductive age. As cyclophosphamide is generally avoided during pregnancy because of its teratogenic risk, its impact on fetal survival is poorly understood. This is a case series of lupus patients exposed to cyclophosphamide ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203305lu2169oa
更新日期:2005-01-01 00:00:00
abstract::Introduction Osteoprotegerin (OPG) is a member of the tumor necrosis factor (TNF) receptor family. It has recently been demonstrated that OPG is produced by a variety of tissues, including the cardiovascular system (heart, arteries, veins), lung, kidney, immune tissues, and bone. The OPG-RANKL signaling pathway is str...
journal_title:Lupus
pub_type: 杂志文章,随机对照试验
doi:10.1177/0961203316682101
更新日期:2017-07-01 00:00:00
abstract:OBJECTIVE:Arthritis is frequently seen in human lupus, but rarely in lupus models. Pristane-induced lupus (PIL) can be induced in various mouse strains such as BALB/c and C57BL/6. We herein characterize clinical and histological features of arthritis in the context of systemic lupus and provide a prudent comparison wit...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203313492869
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:The prevalence and severity of systemic lupus erythematosus (SLE) differs between ethnic groups and geographical regions. Although initially reported as rare, there is growing evidence that SLE is prevalent and runs a severe course in Africa. There is a paucity of prospective studies on African SLE patients....
journal_title:Lupus
pub_type: 杂志文章,多中心研究
doi:10.1177/0961203315606984
更新日期:2016-03-01 00:00:00
abstract::Therapeutic agents currently in use to treat systemic lupus erythematosus (SLE) are predominantly immunosuppressive agents with limited specificities. Multiple groups, including ours, have illustrated that inducing tolerance in SLE animal models ameliorates disease symptoms and increases survival. We examined if oral ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203311398509
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:GlycA is a novel marker of systemic inflammation detected by nuclear magnetic resonance (NMR) spectroscopy. In the general population, GlycA is correlated with inflammatory markers such as C-reactive protein (CRP) and associated with coronary heart disease and diabetes. The utility of GlycA in patients with ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203315617842
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVE:The objective of this paper is to assess whether pulmonary hypertension (PH) may be detected at one point in time or longitudinally predicted by serum uric acid (sUA) levels in systemic lupus erythematosus (SLE). METHODS:We conducted a post-hoc analysis of a long-term followed cohort of Mexican SLE patients....
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203315600539
更新日期:2016-01-01 00:00:00
abstract::Seventeen families, in which the diagnosis of SLE could be verified in two relatives, were included in the study. The diagnosis was made according to the revised 1982 ARA criteria. We compared the 34 cases of familial SLE in these 17 families with 34 non-familial SLE controls matched for age, sex, ethnicity and durati...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339600500408
更新日期:1996-08-01 00:00:00
abstract::Vitamin D deficiency has been described in systemic lupus erythematosus (SLE). BsmI VDR (vitamin D receptor) gene polymorphism was associated with SLE in Asian patients. Studies in Brazilian populations have not been realized. A case-control study with 195 SLE patients and 201 healthy controls was conducted to investi...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203311421798
更新日期:2012-01-01 00:00:00
abstract::Immune-mediated sensorineural hearing loss may complicate systemic autoimmune diseases. We have previously reported the presence of antibodies directed against inner ear antigens in patients with Cogan syndrome, a disease characterized by sudden hearing loss and interstitial keratitis. Such autoantibodies cross-react ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316682099
更新日期:2017-07-01 00:00:00