A clinical and serological comparison of familial and non-familial systemic lupus erythematosus in Ireland.

abstract：INTRODUCTION:The objective of this study is to determine whether serum concentrations of B cell activating factor from the tumour necrosis factor family (BAFF) and/or a proliferation-inducing ligand (APRIL) are associated with clinical manifestations of systemic lupus erythematosus (SLE). METHODS:BAFF and APRIL concen...

journal_title：Lupus

authors： Vincent FB,Northcott M,Hoi A,Mackay F,Morand EF

更新日期：2013-08-01 00:00:00

abstract：OBJECTIVES:We aimed to determine 1) ultrasound (US) abnormalities in patients with systemic lupus erythematosus (SLE) with and without hand arthralgia at the day of examination compared with clinical evaluation and healthy controls, and 2) inter-observer reliability of the US abnormalities. METHODS:Thirty-three female...

journal_title：Lupus

authors： Dreyer L,Jacobsen S,Juul L,Terslev L

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:GlycA is a novel marker of systemic inflammation detected by nuclear magnetic resonance (NMR) spectroscopy. In the general population, GlycA is correlated with inflammatory markers such as C-reactive protein (CRP) and associated with coronary heart disease and diabetes. The utility of GlycA in patients with ...

journal_title：Lupus

authors： Chung CP,Ormseth MJ,Connelly MA,Oeser A,Solus JF,Otvos JD,Raggi P,Stein CM

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Patients with systemic lupus erythematosus (SLE) are at a high risk for cardiovascular disease (CVD) due to increased prevalence of traditional and nontraditional CVD risks factors. OBJECTIVE:To evaluate the effect of patient-centered nutrition counseling methods on changes in select nutrient, anthropometri...

journal_title：Lupus

authors： Everett ST,Wolf R,Contento I,Haiduc V,Richey M,Erkan D

更新日期：2015-10-01 00:00:00

abstract：:Poly(ADP-ribose) metabolism is altered in patients with SLE. In order to localize the defect, the levels of poly(ADP-ribose) polymerase-specific mRNA were measured from dot blots of total RNA from peripheral blood lymphocytes. In this preliminary study, eleven patients with SLE and two with antiphospholipid syndrome w...

journal_title：Lupus

authors： Lee JS,Haug BL,Sibley JT

更新日期：1994-04-01 00:00:00

abstract：INTRODUCTION:The International Society of Nephrology/Renal Pathology Society (ISN/RPS) pathological classification criteria of lupus nephritis are limited to glomerular injury. Although the tubulointerstitium is commonly involved, the importance of such involvement is not well defined. The major objective of this study...

journal_title：Lupus

authors： Alsuwaida AO

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVE:The aim of our study was to investigate the efficacy of adipose-derived stem cells (ADSC) transplantation in systemic lupus erythematosus (SLE) and to determine the mechanism of ADSC transplantation. METHODS:B6.MRL/lpr mice were administered ADSC intravenously every week from age 28 to 31 weeks, while the lu...

journal_title：Lupus

authors： Wei S,Xie S,Yang Z,Peng X,Gong L,Zhao K,Zeng K,Lai K

更新日期：2019-02-01 00:00:00

abstract：:The F(1) progeny of the (SWR × NZB) cross develop a lupus-like disease with high serum titers of autoantibodies, and increased frequency and severity of immune complex-mediated glomerulonephritis in females. In previous work, we found that an idiotypic peptide corresponding to aa62-73 (p62-73) of the heavy chain varia...

journal_title：Lupus

authors： Nyland JF,Stoll ML,Jiang F,Feng F,Gavalchin J

更新日期：2012-12-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE), a disorder of the immune system, is potentially curable by allogeneic bone marrow transplantation (alloBMT). Until recently, alloBMT was limited by donor availability and toxicity. Reduced intensity conditioning (RIC) combined with post-transplantation cyclophosphamide (PTCy) has im...

journal_title：Lupus

authors： Gladstone DE,Petri M,Bolaños-Meade J,Dezern AE,Jones RJ,Fine D,Brodsky RA

更新日期：2017-06-01 00:00:00

abstract：:Designing successful randomized controlled trials (RCTs) in systemic lupus erythematosus (SLE) poses many challenges. It remains difficult to correlate alterations in biologic markers with clinical outcome, especially when signs and symptoms are intermittent and broadly variable between patients. Disease activity indi...

journal_title：Lupus

authors： Strand V

更新日期：2004-01-01 00:00:00

abstract：:Associations of polymorphisms in vitamin D receptor (VDR) with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) have already been explored by many studies. The aim of this meta-analysis was to better clarify associations between polymorphisms in VDR and RA/SLE by combing the results of all relevant stu...

journal_title：Lupus

authors： Zhang WT,Jin TF,Chen L

更新日期：2020-04-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease with a complex pathogenesis. Published data have revealed that serum levels of proinflammatory cytokines are increased in SLE patients. The aim of our study was to evaluate whether monotherapy with chloroquine phosphate affects IL-1beta, IL-6, IL-18 and TNF-a...

journal_title：Lupus

authors： Wozniacka A,Lesiak A,Narbutt J,McCauliffe DP,Sysa-Jedrzejowska A

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:This study aimed to investigate whether early eradication therapy influences systemic lupus erythematosus (SLE) risk in patients with Helicobacter pylori (HP) infection. METHODS:We identified 41,653 patients with HP infection in Taiwan from 2000 to 2013. The patient population was divided into early (within...

journal_title：Lupus

authors： Wu MC,Huang JY,Chen HH,Wei JC

更新日期：2020-06-01 00:00:00

abstract：:To study whether monoclonal anticardiolipin antibodies (aCL), derived from patients with antiphospholipid syndrome (APS), have similar pathogenic potential, we have employed an experimental model of antiphospholipid syndrome. Monoclonal aCL were produced by the combined method of EBV transformation and somatic cell hy...

journal_title：Lupus

authors： Bakimer R,Blank M,Kosashvilli D,Ichikawa K,Khamashta MA,Hughes GR,Koike T,Shoenfeld Y

更新日期：1995-06-01 00:00:00

abstract：INTRODUCTION:Complement activation is central to the pathogenesis of lupus nephritis (LN). Low serum complement C3 and C4, are traditionally used as markers of lupus disease activity in general and LN in particular. In this study we prospectively measured plasma and urine C3d and C4d, degradation products of C3 and C4 ...

journal_title：Lupus

authors： Ganguly S,Majumder S,Kumar S,Gupta R,Muhammed H,Shobha V,Aggarwal A,Misra R

更新日期：2020-11-01 00:00:00

abstract：:Thalidomide has been shown to be an effective treatment for cutaneous forms of lupus erythematous refractory to other therapies. Thalidomide has very serious side effects, including teratogenicity and neuropathy, which limit its clinical use in lupus to such severe refractory cases. Efficacy has been confirmed in seve...

journal_title：Lupus

authors： Karim MY,Ruiz-Irastorza G,Khamashta MA,Hughes GR

更新日期：2001-01-01 00:00:00

abstract：:Prothrombin is a common antigenic target of antiphospholipid antibodies, since anti-prothrombin antibodies are detected in about 50-90% of the patients. To allow proper immune recognition, prothrombin must be adsorbed on suitable anionic surfaces. The epitope(s) have not yet been identified: the majority of anti-proth...

journal_title：Lupus

authors： Galli M,Barbui T

更新日期：1998-01-01 00:00:00

abstract：:Valvular replacement was performed in a patient with primary antiphospholipid syndrome and severe mitral insufficiency. The valvular tissue presented thrombotic phenomena and fibrosis with minimum inflammatory component. ...

journal_title：Lupus

authors： Alvarez-Blanco A,Egurbide-Arberas MV,Aguirre-Errasti C

更新日期：1994-10-01 00:00:00

abstract：OBJECTIVES:Impaired function of polymorphonuclear cells (PMNs) in systemic lupus erythematosus (SLE) leads to severe gram-positive and gram-negative bacterial infection, and to major morbidity and mortality. Few studies have focused on the association of impaired function of PMNs and SLE patients' susceptibility to inf...

journal_title：Lupus

authors： Wu SA,Yeh KW,Lee WI,Yao TC,Kuo ML,Huang B,Huang JL

更新日期：2013-03-01 00:00:00

abstract：:This study investigates specificity, sensitivity and concomitant presence of antibodies against histone H1 (H1), nucleosomes (NUC), chromatin (CHR) and dsDNA in patients with systemic lupus erythematosus (SLE), analyses their association with SLE disease activity and characterizes the immunodominant epitope reactivity...

journal_title：Lupus

authors： Schett G,Smole J,Zimmermann C,Hiesberger H,Hoefler E,Fournel S,Muller S,Rubin RL,Steiner G

更新日期：2002-01-01 00:00:00

abstract：:Legionnaire's disease (LD) is most commonly caused by Legionella pneumophila (L. pneumophila). In immunocompromised patients LD can cause necrosis of the lung parenchyma with abscess formation and cavitation. Systemic lupus erythematosus (SLE) is an autoimmune disorder with features of both primary and secondary immun...

journal_title：Lupus

authors： Khokher W,Kesireddy N,Adunse J,Mudiyanselage PH,Iftikhar S,Assaly R

更新日期：2021-01-26 00:00:00

abstract：:Azathioprine-induced aplastic anemia and fatal myelosuppression is a rare occurrence in patients with systemic lupus erythematosus (SLE). We report a case of a 53-year-old female with a normal thiopurine S-methyltransferase (TPMT) level who developed aplastic anemia within 4 weeks of azathioprine initiation, resulting...

journal_title：Lupus

authors： Yeter KC,Afkhami M,Brynes RK,Quismorio FP Jr

更新日期：2013-12-01 00:00:00

abstract：:The complexity of the therapeutic approach in systemic lupus erythematosus (SLE) is increased by the large number of patients who do not respond to the first-line therapies and by relapses after initial clinical remission. In these patients, second-line drugs are often prescribed according to individual clinical decis...

journal_title：Lupus

authors： Ramos-Casals M,Soto MJ,Cuadrado MJ,Khamashta MA

更新日期：2009-08-01 00:00:00

abstract：:The mouse model described in this study offers a unique method of determining the characteristics and mechanism(s) of action of aCL antibodies in thrombosis in vivo. In addition, this animal model enables the study of the kinetics of formation and dissolution of thrombus, as well as clot area, to be studied in a dynam...

journal_title：Lupus

authors： Pierangeli SS,Harris EN

更新日期：1994-08-01 00:00:00

abstract：:There has been limited success defining environmental factors important to the development of connective tissue diseases such as systemic lupus erythematosus (SLE). Recent work has suggested that the perinatal environment may be important. To investigate this we measured antinuclear antibodies (ANA) in a general popul...

journal_title：Lupus

authors： Edwards CJ,Syddall H,Goswami R,Goswami P,Dennison EM,Cooper C

更新日期：2006-01-01 00:00:00

abstract：:Panniculitis rarely occurs in the course of systemic lupus erythematosus (SLE). When it occurs, it is thought to be mainly lupus erythematosus panniculitis (LEP). Here we describe a 32-year old Japanese woman with chronic SLE, who simultaneously presented facial lymphocytic lobular panniculitis and pancytopenia due to...

journal_title：Lupus

authors： Deji N,Sugimoto T,Fujimoto T,Aoyama M,Takeda N,Sakaguchi M,Uzu T,Kashiwagi A

更新日期：2007-01-01 00:00:00

abstract：:Anti-idiotypic antibody and its F(ab')2 fragments prepared from pooled normal human IgG had a partial inhibitory effect on the spontaneous in vitro secretion of anti-DNA antibodies from blood mononuclear cells of lupus patients. The inhibitory effect was specific for anti-DNA secretion as the anti-idiotype failed to i...

journal_title：Lupus

authors： Evans M,Abdou NI

更新日期：1993-12-01 00:00:00

abstract：:Due to recent acquisitions, diagnostic criteria for the antiphospholipid/cofactors syndrome need to be improved. In the absence of a "common biological denominator", the best approach should be based on a scoring system mixing clinical and immunological items. APS might be composed of different biological subsets char...

journal_title：Lupus

authors： Piette JC

更新日期：1996-10-01 00:00:00

abstract：:The relationship between disease activity, cumulative damage and self-reported quality of life was examined in 96 patients with Systematic Lupus Erythematosus (SLE). Disease activity was measured by the SLE Disease Activity Index (SLEDAI) and cumulative damage by the Systematic Lupus International Cooperating Clinics/...

journal_title：Lupus

authors： Hanly JG

更新日期：1997-01-01 00:00:00

abstract：:Autoantibodies against prothrombin, including lupus anticoagulant antibodies (LAC), have been identified in patients with systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS). To identify the epitopes of LAC in patients with SLE and APS, we analyzed B cell epitopes of anti-prothrombin Abs. Prothrombi...

journal_title：Lupus

authors： Akimoto T,Akama T,Kono I,Sumida T

更新日期：1999-01-01 00:00:00