Abstract:
:Systemic lupus erythematosus (SLE), a disorder of the immune system, is potentially curable by allogeneic bone marrow transplantation (alloBMT). Until recently, alloBMT was limited by donor availability and toxicity. Reduced intensity conditioning (RIC) combined with post-transplantation cyclophosphamide (PTCy) has improved the availability and safety of alloBMT permitting its exploration in severe-refractory autoimmune illnesses. We report the six-year follow-up of a young female whose refractory SLE-associated nephrosis resolved after RIC alloBMT with PTCy.
journal_name
Lupusjournal_title
Lupusauthors
Gladstone DE,Petri M,Bolaños-Meade J,Dezern AE,Jones RJ,Fine D,Brodsky RAdoi
10.1177/0961203316669242subject
Has Abstractpub_date
2017-06-01 00:00:00pages
773-776issue
7eissn
0961-2033issn
1477-0962pii
0961203316669242journal_volume
26pub_type
杂志文章相关文献
LUPUS文献大全abstract::Although challenging, developing evidence-based approaches to an early and accurate diagnosis of systemic lupus erythematosus is a key approach to preventing disease and lupus-associated morbidity and mortality. Advances in our understanding of preclinical and incomplete lupus erythematosus have enabled the identifica...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203316640367
更新日期:2016-07-01 00:00:00
abstract::Controversy exists concerning the prevalence of headache in systemic lupus erythematosus (SLE) and its importance as a neuropsychiatric manifestation, especially when it occurs independently of disease activity and with the typical characteristics of primary chronic headache. Most reports to date have either studied b...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/096120399678847443
更新日期:1999-01-01 00:00:00
abstract::The p53 tumour suppressor is the central regulator of apoptosis. Previously, the functional TP53 Arg72Pro polymorphism was found to be associated with systemic lupus erythematosus (SLE) in Koreans but not Spaniards. MDM2 is the major negative regulator of p53. An intronic polymorphism in MDM2, the SNP309, attenuates p...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203308094558
更新日期:2009-01-01 00:00:00
abstract::We report the case of a fetus with proliferative glomerulonephritis in the context of maternal systemic lupus erythematosus (SLE). The pattern of the renal lesions correspond to the class III of revisited WHO classification of glomerulonephritis in SLE. Amniotic fluid analysis showed a high level of albumin and the pr...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203303lu2045cr
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVES:The objective of this paper is to perform the cross-cultural validation of the French version of the LupusPRO, a disease-targeted patient-reported outcome measure, among systemic lupus erythematosus (SLE) patients in Canada. METHODS:The French version of the LupusPRO and the MOS SF-36 were administered; dem...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314543921
更新日期:2014-12-01 00:00:00
abstract::This study was conducted to determine kidney transplantation (KTx) outcomes for Greek patients with renal failure caused by lupus nephritis (LN) compared with matched controls, kidney recipients with other causes of end-stage renal disease (ESRD). Twenty-six patients with systemic lupus erythematosus (SLE) subjected t...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203308089430
更新日期:2008-07-01 00:00:00
abstract::To determine if neurometabolic changes in the white matter (WM) of systemic lupus erythematosus (SLE) patients may predict the appearance of small hyperintense lesions on T2-weighted magnetic resonance imaging (MRI) inside the magnetic resonance spectroscopy (MRS) region of interest (ROI). We included 30 SLE patients ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203307084723
更新日期:2007-01-01 00:00:00
abstract::Recent studies have suggested an association between primary antiphospholipid syndrome (PAPS), antiphospholipid antibodies and some major histocompatibility complex (MHC) antigens. We have studied the relationship between MHC class II antigens and PAPS in 19 patients from the south of Spain. Univariant analysis showed...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339500400111
更新日期:1995-02-01 00:00:00
abstract::Perinatal thrombosis in infants born to mothers with antiphospholipid antibodies (aPL) is a rare event, but with risk of death or severe sequelae. We analysed 16 infants with such perinatal thrombosis reported in the literature in the last 20 years. Thromboses were arterial (13/16), mostly strokes (8/16). Hydrops feta...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203307079039
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:To investigate the prevalence and characteristics of anti-endothelial cell antibodies (AECA) in a large cohort of patients with several well defined systemic autoimmune diseases, in order to determine their relationship with the clinical and laboratory features of these diseases. METHODS:Clinical and laborat...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339700600608
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVE:Studies have been conducted to determine the causal factors and clinical consequences of non-adherence to treatment in systemic lupus erythematosus (SLE). However, no interventions have been performed to increase drug adherence. Our objective was to assess the effectiveness of pharmaceutical care (PC) for dru...
journal_title:Lupus
pub_type: 杂志文章,随机对照试验
doi:10.1177/0961203319877237
更新日期:2019-10-01 00:00:00
abstract::Designing successful randomized controlled trials (RCTs) in systemic lupus erythematosus (SLE) poses many challenges. It remains difficult to correlate alterations in biologic markers with clinical outcome, especially when signs and symptoms are intermittent and broadly variable between patients. Disease activity indi...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1191/0961203303lu1034oa
更新日期:2004-01-01 00:00:00
abstract::Antiphospholipid syndrome (APS), as a primary disease or a secondary syndrome in systemic lupus erythematosus (SLE), is characterized by the presence of antiphospholipid antibodies (aPL) and a clinical event. It is likely that both genetic and environmental factors lead to the development of aPL and progression to dis...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314548248
更新日期:2014-10-01 00:00:00
abstract::Cutaneous manifestations of lupus erythematosus (LE) are, usually, characteristic enough to permit an easy diagnosis. However, some patients may present less typical lesions, associated or not to the classic ones. Therefore, irrespectively of the variety of LE (acute, subacute and chronic), in absence of the typical b...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/096120339700600207
更新日期:1997-01-01 00:00:00
abstract:INTRODUCTION:The International Society of Nephrology/Renal Pathology Society (ISN/RPS) pathological classification criteria of lupus nephritis are limited to glomerular injury. Although the tubulointerstitium is commonly involved, the importance of such involvement is not well defined. The major objective of this study...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203313507986
更新日期:2013-12-01 00:00:00
abstract::There has been limited success defining environmental factors important to the development of connective tissue diseases such as systemic lupus erythematosus (SLE). Recent work has suggested that the perinatal environment may be important. To investigate this we measured antinuclear antibodies (ANA) in a general popul...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203306lu2286oa
更新日期:2006-01-01 00:00:00
abstract::We retrospectively analysed the prevalence and clinical features associated to anti-Ku antibodies in patients affected by different autoimmune diseases. Anti-Ku antibodies are detected in 147 sera out of 7239 anti-ENA positive sera (2%). They are found in 2% of patients with systemic sclerosis (SSc) (8 out of 379), 1....
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203308089442
更新日期:2008-08-01 00:00:00
abstract::Mesenchymal stem cells have been applied to treat graft versus host disease as they have immunosuppressive ability and can overcome the major histocompatibility complex-histocompatibility barrier. The potential of allogeneic mesenchymal stem cells in treating systemic lupus erythematosus (SLE) was investigated in this...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203320928419
更新日期:2020-07-01 00:00:00
abstract::We report a case of a patient with clinical features of progressive supranuclear palsy and raised titres of anticardiolipin antibodies in blood, thrombocytopenia and livedo reticularis on skin. Magnetic resonance imaging of brain and isotope scan of brain were distinctive of vascular disorder. ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203303lu242CR
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVE:Since enhanced cardiac magnetic resonance imaging (cMRI) signals have been associated with lupus disease activity in humans prior to renal failure and novel, cardiac-focused therapeutic strategies could be investigated with an associated animal model, autoimmune myocarditis was characterized in murine lupus n...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203320948959
更新日期:2020-11-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) often coexists with other diseases. Diabetes mellitus (DM) is an example and patients with overlap SLE-DM can present with clinical features common to both disorders. In this review, we describe the patients with overlap SLE-DM, focussing on the clinical features common to both disea...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203308091539
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVE:The objective of this paper is to investigate the incidence of both non-vertebral and vertebral fracture in female patients with systemic lupus erythematosus (SLE) and to identify risk factors for incident fracture. METHODS:In a five-year prospective study of 127 female Chinese SLE patients with an average a...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314528555
更新日期:2014-08-01 00:00:00
abstract::Cardiac involvement in systemic lupus erythematosus (SLE) is well documented. The pericardium, myocardium and endocardium, as well as the coronary arteries, the valves and the conduction system can all be affected. While pericarditis is common, arrythmias are less frequently described.We present a 13-year-old male, wh...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203320974091
更新日期:2020-11-20 00:00:00
abstract:BACKGROUND:Current non-invasive methods of assessing disease activity in systemic lupus erythematosus (SLE) are of limited sensitivity and specificity. Testing includes acute phase markers, autoantibodies and complement levels. Although measurements of dsDNA antibodies and complement C3/C4 levels are routine, they rema...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203319845487
更新日期:2019-05-01 00:00:00
abstract::Chronic intestinal pseudo-obstruction (CIPO) is a rare clinical syndrome of ineffective intestinal motility characterised by clinical and radiological evidence of intestinal obstruction with no identifiable mechanical lesion. CIPO can either be idiopathic or secondary to a systemic disease, like systemic lupus erythem...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203313492873
更新日期:2013-08-01 00:00:00
abstract::The effect of synthetic CpG-oligodeoxynucleotides (CpG-ODN) on the development of lupus nephritis during preactive phase (within seven months of age) in autoimmune lupus NZB x NZWF1 (B/WF1) mice was examined. Treatment of CpG-ODN was started at the age of 2.75 months and continued until 6.25 months. Overt disease bega...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203303lu483oa
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVES:To examine the immune cell profile in the bone marrow of systemic lupus erythematosus (SLE) patients and to assess its clinical relevance. METHODS:Sixteen bone marrow samples from 14 SLE patients were compared with seven healthy control samples. The numbers of immune cells and apoptotic cells in the bone ma...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314531634
更新日期:2014-09-01 00:00:00
abstract::Systemic lupus erythematosus is a chronic, relapsing autoimmune disease that can affect multiple organ systems. An increased prevalence of drug allergy has been reported in lupus patients compared with the general population. Using a cohort of 417 lupus patients, we found a history of sulpha allergy in 27.3% of patien...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203307086640
更新日期:2008-03-01 00:00:00
abstract:OBJECTIVE:To describe clinical effectiveness of belimumab for systemic lupus erythematosus (SLE) in real-world practice in Argentina. METHODS:This retrospective, observational study analysed medical record data of patients with SLE treated with belimumab in 15 centres in Argentina. Primary endpoint: overall clinical r...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203320947814
更新日期:2020-10-01 00:00:00
abstract::The metabolism of radioiodinated mouse IgG was studied in mice with lupus-like syndrome before and after the onset of the disease. Before the onset of the disease, the pharmacokinetic parameters of IgG in MLR-1pr and Pristane-primed Balb/c mice were within the normal range of values. After the onset of the disease a c...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203305lu2129oa
更新日期:2005-01-01 00:00:00