The dual role of innate immunity in antiphospholipid syndrome and systemic lupus erythematosus.

abstract：:Systemic lupus erythematosus (SLE) is a prototype inflammatory autoimmune disease resulting from autoimmune responses against nuclear autoantigens. During apoptosis many lupus autoantigens congregate inside the cells and are susceptible to modifications. Modified nuclear constituents are considered foreign and dangero...

journal_title：Lupus

authors： Munoz LE,van Bavel C,Franz S,Berden J,Herrmann M,van der Vlag J

更新日期：2008-05-01 00:00:00

abstract：:Pericardial effusions causing pericardial tamponade are rare in patients with systemic lupus erythematosus (SLE). The goal of this study is to describe in detail the clinical and laboratory characteristics of a group of patients with pericardial effusions and pericardial tamponade secondary to SLE. We retrospectively ...

journal_title：Lupus

authors： Rosenbaum E,Krebs E,Cohen M,Tiliakos A,Derk CT

更新日期：2009-06-01 00:00:00

abstract：:Gastrointestinal manifestations of systemic lupus erythematosus (SLE) are common, occurring in about 50% of cases. They are usually mild, in the form of mouth ulcers, nausea, heartburn and mild abdominal pain, but they can be severe in cases of gastrointestinal vasculitis. In this report we describe an unusual combina...

journal_title：Lupus

authors： Bedaiwi M,Alkubeyyer MA,Al Arfaj AS

更新日期：2014-02-01 00:00:00

abstract：:The purpose of the present study was to evaluate patients with the antiphospholipid syndrome with particular attention to their initial clinical features, final diagnoses and the course of thrombotic events in association with therapy. The methodology applied was the following: retrospective analysis of 30 patient fil...

journal_title：Lupus

authors： Vlachoyiannopoulos PG,Tsiakou E,Chalevelakis G,Raptis SA,Moutsopoulos HM

更新日期：1994-04-01 00:00:00

abstract：:Prothrombin is a common antigenic target of antiphospholipid antibodies, since anti-prothrombin antibodies are detected in about 50-90% of the patients. To allow proper immune recognition, prothrombin must be adsorbed on suitable anionic surfaces. The epitope(s) have not yet been identified: the majority of anti-proth...

journal_title：Lupus

authors： Galli M,Barbui T

更新日期：1998-01-01 00:00:00

abstract：:This work describes the development of sideroblastic anemia (SA) during the clinical activity of systemic lupus erythematosus (SLE) in two patients. The cases refer to two women with SLE who developed SA during a relapse of the illness. Both patients fulfilled at least four criteria of the American Association of Rheu...

journal_title：Lupus

authors： Jiménez-Balderas FJ,Morales-Polanco MR,Gutierrez L

更新日期：1994-06-01 00:00:00

abstract：:Criteria of organ-specific autoimmunity are fulfilled in a subset of patients with myocarditis/dilated cardiomyopathy (DCM). In particular, circulating heart-reactive autoantibodies are found in patients and symptom-free relatives. These autoantibodies are directed against multiple antigens, some of which are expresse...

journal_title：Lupus

authors： Caforio AL,Daliento L,Angelini A,Bottaro S,Vinci A,Dequal G,Tona F,Iliceto S,Thiene G,McKenna WJ

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:This study aimed to explore whether TYK2 polymorphisms are associated with susceptibility to autoimmune rheumatic diseases. METHODS:We conducted a meta-analysis on the association between TYK2 polymorphisms and autoimmune rheumatic diseases. RESULTS:Twelve studies with a total of 16,335 patients and 30,065 ...

journal_title：Lupus

authors： Lee YH,Bae SC

更新日期：2016-10-01 00:00:00

abstract：:Detection of antineutrophil cytoplasmic antibodies (ANCA) for ANCA-associated vasculitides (AAV) is based on indirect immunofluorescence (IIF) on ethanol-fixed neutrophils and reactivity toward myeloperoxidase (MPO) and proteinase 3 (PR3). According to the international consensus for ANCA testing, presence of ANCA sho...

journal_title：Lupus

authors： Avery TY,Bons J,van Paassen P,Damoiseaux J

更新日期：2016-07-01 00:00:00

abstract：:Several studies have investigated the potential of various autoantibody tests in the diagnosis of systemic lupus erythematosus (SLE). Many lupus patients initially present with glomerulonephritis. In that clinical situation the main differential diagnosis are other forms of glomerulonephritis. In this study the diagno...

journal_title：Lupus

authors： Heidenreich U,Mayer G,Herold M,Klotz W,Stempfl Al-Jazrawi K,Lhotta K

更新日期：2009-12-01 00:00:00

abstract：:Antiphospholipid syndrome (APS) is a distinct autoimmune prothrombotic disorder due to pathogenic autoantibodies directed against proteins that bind to phospholipids. APS is characterized by arterial and venous thrombosis and their clinical sequelae. Catastrophic antiphospholipid syndrome (CAPS) is a rare and often fa...

journal_title：Lupus

authors： Rangel ML,Alghamdi I,Contreras G,Harrington T,Thomas DB,Barisoni L,Andrews D,Wolf M,Asif A,Nayer A

更新日期：2013-07-01 00:00:00

abstract：:Legionnaire's disease (LD) is most commonly caused by Legionella pneumophila (L. pneumophila). In immunocompromised patients LD can cause necrosis of the lung parenchyma with abscess formation and cavitation. Systemic lupus erythematosus (SLE) is an autoimmune disorder with features of both primary and secondary immun...

journal_title：Lupus

authors： Khokher W,Kesireddy N,Adunse J,Mudiyanselage PH,Iftikhar S,Assaly R

更新日期：2021-01-26 00:00:00

abstract：OBJECTIVE:The aim of this study was to determine whether the functional CD40 rs4810485 G/T polymorphism is associated with susceptibility to rheumatoid arthritis (RA) or with susceptibility to systemic lupus erythematosus (SLE). METHODS:A series of meta-analyses were conducted to test for association between the CD40 ...

journal_title：Lupus

authors： Lee YH,Bae SC,Choi SJ,Ji JD,Song GG

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to analyse autoantibodies' titres modulation during belimumab treatment in 50 patients with systemic lupus erythematosus (SLE). METHODS:Sera were collected at belimumab start (T0) and every six months until the 24th month. Disease activity index (SLEDAI-2K) was analysed at eve...

journal_title：Lupus

authors： Cavazzana I,Kumar R,Pozzari C,Ottaviani R,Fredi M,Piantoni S,Andreoli L,Tincani A,Franceschini F

更新日期：2019-08-01 00:00:00

abstract：:Diagnosing vulvar intraepithelial neoplasia in a young woman presenting mainly with skin manifestations of lupus and with no other risk factors is a major challenge. The case of a 27-year-old woman with systemic lupus erythematosus and vulvar intraepithelial neoplasia is described. Although progression of vulvar intra...

journal_title：Lupus

authors： Stepanić V,Corusić A,Matković V,Sentić M,Bosnić D,Mahovlić V

更新日期：2010-01-01 00:00:00

abstract：:XRCC1 plays a central role in mammalian DNA repair processes. Two polymorphisms of XRCC1, rs1799782 (Arg > Trp at codon 194) and rs25487 (Arg > Gln at codon 399), are common in the Han Chinese population. Our objective was to analyze the relationship between these two functional single-nucleotide polymorphisms (SNPs) ...

journal_title：Lupus

authors： Lin YJ,Wan L,Huang CM,Chen SY,Huang YC,Lai CH,Lin WY,Liu HP,Wu YS,Chen CM,Tsai YH,Tsai CH,Sheu JJ,Tsai FJ

更新日期：2009-12-01 00:00:00

abstract：:Coming from Hans Wigzell's laboratory in Uppsala, Sweden, I joined the Kunkel laboratory in 1981 to spend a post-doctoral fellowship period financed by the German Research Organization. While I initially worked with Nick Chiorazzi in an attempt to generate monoclonal antibody-secreting human B-cell hybridomas, I later...

journal_title：Lupus

authors： Kabelitz D

更新日期：2003-01-01 00:00:00

abstract：:Anti-phospholipid antibodies are common in patients in the Hopkins' Lupus Cohort: 47% have anti-cardiolipin, 32.5% anti-beta(2)-glycoprotein I and 26% lupus anticoagulant (by dRVVT confirmatory testing). Systemic lupus erythematosus patients with the lupus anticoagulant at baseline have a 50% chance of a deep venous t...

journal_title：Lupus

authors： Petri M

更新日期：2010-04-01 00:00:00

abstract：:We report clinical and histopathological features, treatment and outcome of 37 Croatian children with biopsy-proven lupus nephritis seen over a 30-year period. The mean age at lupus nephritis presentation was 12.11 ± 2.59 years (range 4.66-17.0). The most frequent histopathological finding was class IV (37.8%), follow...

journal_title：Lupus

authors： Batinić D,Milošević D,Čorić M,Topalović-Grković M,Jelušić M,Turudić D

更新日期：2015-03-01 00:00:00

abstract：:The purpose of this study was to determine the prevalence and correlates of fibromyalgia (FM) in a prospective, multiethnic systemic lupus (SLE) cohort. A total of 266 SLE patients with disease duration of < or = 5 years at study entry were evaluated longitudinally for the presence of FM (per ACR criteria). Sociodemog...

journal_title：Lupus

authors： Friedman AW,Tewi MB,Ahn C,McGwin G Jr,Fessler BJ,Bastian HM,Baethge BA,Reveille JD,Alarcón GS,LUMINA Study Group.

更新日期：2003-01-01 00:00:00

abstract：:In examining reasons for premature atherosclerosis in systemic lupus erythematosus (SLE), we previously reported low levels of the cholesterol transport protein apolipoprotein A1 (apoA1) in these patients, and specific antibodies to purified apoA1 were identified in the sera of 5 out of 30 lupus patients. The current ...

journal_title：Lupus

authors： Dinu AR,Merrill JT,Shen C,Antonov IV,Myones BL,Lahita RG

更新日期：1998-01-01 00:00:00

abstract：:A case of recurrent cerebral infarctions in a 42-year-old woman affected by polyarteritis nodosa and antiphospholipid syndrome is reported. Two-dimensional echocardiography revealed grossly thickened mitral valve leaflets, possibly related to the presence of antiphospholipid antibodies. Thus, an embolic source at mitr...

journal_title：Lupus

authors： Morelli S,Perrone C,Paroli M

更新日期：1998-01-01 00:00:00

abstract：:Systemic lupus erythematosus may present with renal manifestations that frequently are difficult to categorize and lupus nephritis is an important predictor of poor outcome. The type and spectrum of renal injury may remain undiagnosed until full-blown nephritic and/or nephrotic syndrome appear with increased risk of e...

journal_title：Lupus

authors： Ortega LM,Schultz DR,Lenz O,Pardo V,Contreras GN

更新日期：2010-04-01 00:00:00

abstract：OBJECTIVES:To determine the frequency and the time to complete recovery identified by Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) and the time to partial recovery identified by the SLEDAI-2K Responder Index 50 (SRI-50) in three laboratory systems over 10 years. METHODS:This is a retrospective ...

journal_title：Lupus

authors： Touma Z,Gladman DD,Ibañez D,Urowitz MB

更新日期：2012-10-01 00:00:00

abstract：:Catastrophic antiphospholipid syndrome (CAPS) is an acutely devastating situation characterized by widespread thrombotic microangiopathy in the presence of elevated titers of antiphospholipid antibodies. We describe a 57-year old woman who underwent liver transplantation for primary sclerosing cholangitis and develope...

journal_title：Lupus

authors： Villamil A,Sorkin E,Basta MC,Mysler E,Macias S,Pekolj J,Ciardullo M,Eleta F,de Santibañes E,Allievi A,Gadano A

更新日期：2003-01-01 00:00:00

abstract：:We describe a patient with rheumatoid arthritis (RA) whose sera contained a high titre of an antibody targeting cytoplasmic ribosomal P proteins (anti-P). This association preceded by 6 years the development of serological and clinical manifestations of systemic lupus erythematosus (SLE). The clinical significance of ...

journal_title：Lupus

authors： Hamasaki K,Mimura T,Kanda H,Morino N,Yazaki Y,Nojima Y

更新日期：1997-01-01 00:00:00

abstract：:We describe a human monoclonal antibody designated WRI 176 beta and a common idiotype that it carries. This antibody was derived from the spleen of a patient with SLE. WRI 176 is an IgM kappa monoclonal reacting with ssDNA, dsDNA, poly(dT) and it is likely that mAb WRI 176 beta is a representative of the so-called nat...

journal_title：Lupus

authors： Blanco F,Longhurst C,Watts R,Kalsi J,Wiloch HW,Youinou P,Latchman DS,Isenberg DA

更新日期：1994-02-01 00:00:00

abstract：:The aim of this study was to determine if the measurement of anti-beta2-glycoprotein I antibodies (abeta2-GPI) in serum levels contributes to the better characterization of the clinical situation of patients with antiphospholipid syndrome (APS). For this purpose abeta2-GPI of both isotypes was measured in 42 patients ...

journal_title：Lupus

authors： Detkov,Gil-Aguado A,Lavilla P,Cuesta MV,Fontán G,Pascual-Salcedo D

更新日期：1999-01-01 00:00:00

abstract：:The p53 tumour suppressor is the central regulator of apoptosis. Previously, the functional TP53 Arg72Pro polymorphism was found to be associated with systemic lupus erythematosus (SLE) in Koreans but not Spaniards. MDM2 is the major negative regulator of p53. An intronic polymorphism in MDM2, the SNP309, attenuates p...

journal_title：Lupus

authors： Onel KB,Huo D,Hastings D,Fryer-Biggs J,Crow MK,Onel K

更新日期：2009-01-01 00:00:00

abstract：:Lupus nephritis is an important cause of morbidity and mortality in patients with systemic lupus erythematosus. Traditional outcome criteria such as doubling of serum creatinine, end-stage renal disease and death have been used in controlled therapeutic trials, but are limited by their low incidence and the extended p...

journal_title：Lupus

authors： Boumpas DT,Balow JE

更新日期：1998-01-01 00:00:00