Abstract:
:The effect of synthetic CpG-oligodeoxynucleotides (CpG-ODN) on the development of lupus nephritis during preactive phase (within seven months of age) in autoimmune lupus NZB x NZWF1 (B/WF1) mice was examined. Treatment of CpG-ODN was started at the age of 2.75 months and continued until 6.25 months. Overt disease began at the age of six months and progressed linearly at the age of 6.75 months in CpG-ODN-treated, but not control ODN-treated (control) groups. Also compared to control group, CpG-ODN-treated mice exhibited a severe glomerulonephritis (GN), with prominent deposits of IgG2a and C3, which paralleled increased titre of IgG2a type anti-nuclear antibody in the blood. Among several cytokines (interleukin, IL-6, IL-4, IL-1alpha, IL-10, interferon-gamma and tumor necrosis factor-alpha) in blood, IL-6 production paralleled the development of lupus nephritis. The present study suggests that CpG-ODN may enhance IL-6 production. The role of IL-6 in the development of GN will be discussed.
journal_name
Lupusjournal_title
Lupusauthors
Hasegawa K,Hayashi Tdoi
10.1191/0961203303lu483oasubject
Has Abstractpub_date
2003-01-01 00:00:00pages
838-45issue
11eissn
0961-2033issn
1477-0962journal_volume
12pub_type
杂志文章相关文献
LUPUS文献大全abstract::XRCC1 plays a central role in mammalian DNA repair processes. Two polymorphisms of XRCC1, rs1799782 (Arg > Trp at codon 194) and rs25487 (Arg > Gln at codon 399), are common in the Han Chinese population. Our objective was to analyze the relationship between these two functional single-nucleotide polymorphisms (SNPs) ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203309345777
更新日期:2009-12-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is an autoreactive T cell mediated autoimmune disease. Immunization with inactivated autoreactive T cells may induce idiotype anti-idiotypic reaction to deplete specific subsets of autoreactive T cells involved in SLE. Six SLE patients unsuitable or refused to use immunosuppressants ...
journal_title:Lupus
pub_type: 临床试验,杂志文章
doi:10.1191/0961203305lu2239oa
更新日期:2005-01-01 00:00:00
abstract::A 26-year-old Japanese woman developed autoimmune pulmonary alveolar proteinosis (PAP) during glucocorticoid therapy for systemic lupus erythematosus (SLE). Intensive immunosuppressive therapy worsened the PAP. De-escalation of immunosuppressive therapy improved the PAP. Autoimmune PAP is rarely associated with system...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203313498798
更新日期:2013-09-01 00:00:00
abstract::Perinatal thrombosis in infants born to mothers with antiphospholipid antibodies (aPL) is a rare event, but with risk of death or severe sequelae. We analysed 16 infants with such perinatal thrombosis reported in the literature in the last 20 years. Thromboses were arterial (13/16), mostly strokes (8/16). Hydrops feta...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203307079039
更新日期:2007-01-01 00:00:00
abstract::Abnormalities of the lipid profile partly explain the atherogenic tendency of systemic lupus erythematosus but the picture is unclear in thrombotic primary antiphospholipid syndrome (PAPS). Herein we compare the lipid profile, high-density lipoprotein (HDL), low-density lipoprotein (LDL), total cholesterol (CHO), apol...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203309357765
更新日期:2010-05-01 00:00:00
abstract::The aim of this study was to use transthoracic Doppler echocardiographic (TTE) imaging methods to identify cardiac dysfunction, an indicator of subclinical atherosclerosis in asymptomatic systemic lupus erythematosus (SLE) patients in terms of cardiac effects. This study involved 80 patients: a study group (n = 50) an...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203315570164
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:Patients with systemic lupus erythematosus (SLE) are at a high risk for cardiovascular disease (CVD) due to increased prevalence of traditional and nontraditional CVD risks factors. OBJECTIVE:To evaluate the effect of patient-centered nutrition counseling methods on changes in select nutrient, anthropometri...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203315582284
更新日期:2015-10-01 00:00:00
abstract::The occurrence of ataxic sensory neuronopathy (ASN) is rare in patients with connective tissue diseases (CTDs). ASN has been described in case reports and case series in patients with CTDs, mostly Sjögren's syndrome, and most often occurring during middle or old age. ASN in association with systemic lupus erythematosu...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203311434105
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND:We established a multi-centre online registry for primary Sjögren's syndrome (pSS) in China, and compared Chinese patients with those from other countries. METHODS:Data were from 87 rheumatology centres in 27 provinces. All 2986 patients had pSS according to the 2002 American-European Consensus Group or the...
journal_title:Lupus
pub_type: 杂志文章,多中心研究
doi:10.1177/0961203319889666
更新日期:2020-01-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is a highly heterogeneous disorder in which multiple immunologic abnormalities have been described. In this review, we thoroughly analyse the impaired T cell production of, and response to, interleukin-2 (IL-2) characteristic of patients with SLE. Since it was first reported, several...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1191/096120398678920028
更新日期:1998-01-01 00:00:00
abstract::Legionnaire's disease (LD) is most commonly caused by Legionella pneumophila (L. pneumophila). In immunocompromised patients LD can cause necrosis of the lung parenchyma with abscess formation and cavitation. Systemic lupus erythematosus (SLE) is an autoimmune disorder with features of both primary and secondary immun...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203321990102
更新日期:2021-01-26 00:00:00
abstract::Proteinuria is the hallmark of clinical manifestation of disease activity in lupus nephritis (LN) patients, which arises from direct or indirect podocyte injury. This study is to explore the relationship between intrarenal T cell infiltration and podocyte injury in lupus nephritis (LN), and to understand the potential...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316646861
更新日期:2016-12-01 00:00:00
abstract:OBJECTIVE:Further prospective study is needed to elucidate the etiology and natural history of systemic lupus erythematosus development. The clinical complexity of this heterogeneous disease makes study design challenging. Our objective was to ascertain useful screening factors for identifying at-risk individuals for f...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203319834675
更新日期:2019-04-01 00:00:00
abstract::The aim of this study was to investigate two patients with antiphospholipid syndrome (APS) who suffered from multiple repeated pregnancy losses of probably genetically impaired embryos. Sera from these patients contained high levels of IgG antibodies against cardiolipin, IgG and IgM phosphatidyl inositol, IgG phosphat...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203312442581
更新日期:2012-06-01 00:00:00
abstract::We have previously shown that elevation of anticardiolipin antibodies (aCL) at the first prenatal visit is associated with increased fetal loss in normal pregnancy. The variation in aCL levels during normal pregnancy has not been established. To examine this question we measured IgG, IgM and IgA aCL levels five times ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339500400506
更新日期:1995-10-01 00:00:00
abstract::Background While thrombopoeitin (TPO) agonists that act to simulate platelet production have been approved for use in steroid-refractory chronic immune thrombocytopenia purpura (ITP), there are few data on the safety and efficacy of these medications in patients with concurrent systemic lupus erythematosus (SLE) or an...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203318770023
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVE:The objective of our study was to determine the incidence rates and risk factors of aortic aneurysm and aortic dissection among patients with systemic lupus erythematosus (SLE) using a nationwide population-based data set. METHODS:We conducted a retrospective cohort study using data from the Taiwan National ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314523868
更新日期:2014-06-01 00:00:00
abstract::Monoclonal antiphospholipid antibodies (aPL) have been utilized to dissect the relationship between their sequence, structure, binding and biological properties relevant to the pathogenesis of the antiphospholipid syndrome. In particular, sequence analysis of aPL has highlighted the clustering of certain amino acid re...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203309360809
更新日期:2010-04-01 00:00:00
abstract::The objective of this study was to identify risk factors associated with flare during pregnancy in women with systemic lupus erythematosus (SLE). We performed a retrospective analysis of pregnant women with SLE in a referral hospital. Flare was considered according to predetermined definitions. We analyzed 15 clinical...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314552116
更新日期:2015-02-01 00:00:00
abstract:INTRODUCTION:Anti-ganglioside antibodies (AGA) have been associated with several peripheral neuropathies, such as Miller-Fisher syndrome, Guillain-Barré syndrome and multifocal motor neuropathy. They have also been studied in patients with systemic lupus erythematosus (SLE), focusing on neuropsychiatric manifestations ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203312436856
更新日期:2012-05-01 00:00:00
abstract::The outcome, quality of life and prognosis of lupus patients can be enhanced with close follow up and coordination between the individual's primary care physician and rheumatologist. Rheumatologists usually do not act as primary care physicians and leave health care maintenance to practitioners who need to be reminded...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203307086267
更新日期:2008-02-01 00:00:00
abstract::Neurological involvement in antiphospholipid antibody syndrome (APS) is common, and its occurrence increases morbidity and mortality. Patients may present variable neurological involvement, such as cerebrovascular disease, cognitive dysfunction, headache, seizures, movement disorders, multiple sclerosis-like syndrome,...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203318776110
更新日期:2018-08-01 00:00:00
abstract::Peripheral T cell apoptosis is upregulated in active SLE, in parallel with high expression of both membrane-bound and soluble (s) Fas. Previous studies postulated that sFas down-regulates apoptosis in vitro through its blockade of the Fas-L of cytotoxic cells. We have investigated the extent of apoptosis and sFas leve...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203303lu250oa
更新日期:2003-01-01 00:00:00
abstract::Prothrombin is a common antigenic target of antiphospholipid antibodies, since anti-prothrombin antibodies are detected in about 50-90% of the patients. To allow proper immune recognition, prothrombin must be adsorbed on suitable anionic surfaces. The epitope(s) have not yet been identified: the majority of anti-proth...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/096120339800700209
更新日期:1998-01-01 00:00:00
abstract::To determine if neurometabolic changes in the white matter (WM) of systemic lupus erythematosus (SLE) patients may predict the appearance of small hyperintense lesions on T2-weighted magnetic resonance imaging (MRI) inside the magnetic resonance spectroscopy (MRS) region of interest (ROI). We included 30 SLE patients ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203307084723
更新日期:2007-01-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder that can have many cutaneous manifestations including malar rash, discoid rash or oral ulcer. Isolated unilateral involvement of face is uncommon in SLE. It lacks typical clinical features of LE, and may impose a diagnostic challenge for clinicians. H...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203320957739
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVES:Poor adherence to immunosuppressive treatment is common in patients with systemic lupus erythematosus and may identify those with lupus nephritis (LN) who have a poorer prognosis. Non-adherence has also been reported to be a potential adverse outcome predictor in renal transplantation (rTp). We investigated ...
journal_title:Lupus
pub_type: 杂志文章,多中心研究
doi:10.1177/0961203319842641
更新日期:2019-04-01 00:00:00
abstract:OBJECTIVE:Systemic lupus erythematosus (SLE) is a chronic, relapsing-remitting autoimmune disorder that involves multiple organ systems including the central nervous system. Among the items included in the nomenclature for neuropsychiatric SLE, mood disorders have been identified. The aim of this paper is to review the...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203313477227
更新日期:2013-04-01 00:00:00
abstract::The acute clinical syndrome of toxic epidermal necrolysis (TEN) is currently thought to be a distinct clinical-pathological entity typically resulting from drug hypersensitivity. We describe an adult woman who experienced a fulminate pattern of apoptotic epidermal cell injury following tanning bed exposure while takin...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1191/0961203304lu2037sa
更新日期:2004-01-01 00:00:00
abstract::Cutaneous manifestations of lupus erythematosus (LE) are, usually, characteristic enough to permit an easy diagnosis. However, some patients may present less typical lesions, associated or not to the classic ones. Therefore, irrespectively of the variety of LE (acute, subacute and chronic), in absence of the typical b...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/096120339700600207
更新日期:1997-01-01 00:00:00