Infant perinatal thrombosis and antiphospholipid antibodies: a review.

abstract：:Objectives The carotid intima-media thickness (CIMT) and carotid arterial stiffness index (CASI) act as the surrogate markers of atherosclerosis. We aim to assess CIMT and CASI in pediatric systemic lupus erythematosus (SLE). Methods Patients ≤ 20 years old fulfilling diagnostic criteria for SLE were enrolled. Patient...

journal_title：Lupus

authors： Su-Angka N,Khositseth A,Vilaiyuk S,Tangnararatchakit K,Prangwatanagul W

更新日期：2017-08-01 00:00:00

abstract：:CD27 is a useful marker in assessing the number of circulating B cells and B cell subsets because it permits one step identification of the major B cell compartments, CD27- naïve and CD27+ memory B cells as well as CD27high plasma cells. Abnormalities in the distribution ofCD27+ B cell subsets are useful in assessing ...

journal_title：Lupus

authors： Dörner T,Lipsky PE

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:We aimed to develop a model of the illness experience for youth with systemic lupus erythematosus (SLE)/mixed connective tissue disease (MCTD). METHODS:We conducted 32 semi-structured interviews with 16 outpatient youth with SLE/MCTD, age 11 to 22 years, and their parents. We qualitatively defined key featur...

journal_title：Lupus

authors： Knight A,Vickery M,Fiks AG,Barg FK

更新日期：2016-08-01 00:00:00

abstract：:We studied IgG and IgM anticardiolipin antibodies (aCL) by an ELISA method in 80 Mexican systemic lupus erythematosus (SLE) patients and 378 of their first degree relatives. Sixty five percent of SLE patients and 16% of their relatives were positive for aCL. We also determined allele and haplotype frequencies of Major...

journal_title：Lupus

authors： Granados J,Vargas-Alarcón G,Drenkard C,Andrade F,Melín-Aldana H,Alcocer-Varela J,Alarcón-Segovia D

更新日期：1997-01-01 00:00:00

abstract：:The relationship between disease activity, cumulative damage and self-reported quality of life was examined in 96 patients with Systematic Lupus Erythematosus (SLE). Disease activity was measured by the SLE Disease Activity Index (SLEDAI) and cumulative damage by the Systematic Lupus International Cooperating Clinics/...

journal_title：Lupus

authors： Hanly JG

更新日期：1997-01-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease with a suggested genetic basis. The newly identified human programmed cell death 1 gene could be associated with SLE susceptibility. We aimed to investigate the association between programmed cell death 1 polymorphism (PD1.3G/A (rs11568821) and PD1...

journal_title：Lupus

authors： Abo El-Khair SM,Sameer W,Awadallah N,Shaalan D

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Patients with systemic lupus erythematosus (SLE) are at a high risk for cardiovascular disease (CVD) due to increased prevalence of traditional and nontraditional CVD risks factors. OBJECTIVE:To evaluate the effect of patient-centered nutrition counseling methods on changes in select nutrient, anthropometri...

journal_title：Lupus

authors： Everett ST,Wolf R,Contento I,Haiduc V,Richey M,Erkan D

更新日期：2015-10-01 00:00:00

abstract：:Mycobacterial infections can cause a variety of different manifestations. The increasing incidence of these infections worldwide brought another medical dilemma: immunological manifestations characterized by the presence of many autoantibodies and concomitant presence of autoimmune diseases. The burden of tuberculosis...

journal_title：Lupus

authors： Machado Ribeiro F,Goldenberg T

更新日期：2015-04-01 00:00:00

abstract：:The aim of this study was to use transthoracic Doppler echocardiographic (TTE) imaging methods to identify cardiac dysfunction, an indicator of subclinical atherosclerosis in asymptomatic systemic lupus erythematosus (SLE) patients in terms of cardiac effects. This study involved 80 patients: a study group (n = 50) an...

journal_title：Lupus

authors： Barutcu A,Aksu F,Ozcelik F,Barutcu CA,Umit GE,Pamuk ON,Altun A

更新日期：2015-09-01 00:00:00

abstract：:In search of markers of disease activity in patients with SLE we have investigated blood lymphocyte subsets from a large cohort of patient. Seventy-one patients were studied using a well-defined panel of fluorescent monoclonal antibodies which recognize the major T, B and NK lymphocyte subsets and activated cells. Flo...

journal_title：Lupus

authors： Erkeller-Yüsel F,Hulstaart F,Hannet I,Isenberg D,Lydyard P

更新日期：1993-08-01 00:00:00

abstract：:XRCC1 plays a central role in mammalian DNA repair processes. Two polymorphisms of XRCC1, rs1799782 (Arg > Trp at codon 194) and rs25487 (Arg > Gln at codon 399), are common in the Han Chinese population. Our objective was to analyze the relationship between these two functional single-nucleotide polymorphisms (SNPs) ...

journal_title：Lupus

authors： Lin YJ,Wan L,Huang CM,Chen SY,Huang YC,Lai CH,Lin WY,Liu HP,Wu YS,Chen CM,Tsai YH,Tsai CH,Sheu JJ,Tsai FJ

更新日期：2009-12-01 00:00:00

abstract：:Renal involvement in systemic lupus erythematosus is a common complication that significantly worsens morbidity and mortality. Although treatment with corticosteroids and cytotoxic drugs may be useful in many cases, morbidity associated with these drugs and the relapsing nature of the disease make it necessary to deve...

journal_title：Lupus

authors： Alperovich G,Rama I,Lloberas N,Franquesa M,Poveda R,Gomà M,Herrero-Fresneda I,Cruzado JM,Bolaños N,Carrera M,Grinyó JM,Torras J

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVES:To determine the rates of induced abortions in women with systemic lupus erythematosus (SLE) compared to women from the general population and assess disease-related predictors of induced abortion in women with SLE. METHODS:We identified women with SLE (15-45 years) and determined the number of induced abor...

journal_title：Lupus

authors： Venne K,Scott S,Bernatsky S,Vinet E

更新日期：2020-12-15 00:00:00

abstract：:We describe seven patients who developed malignancy before, after or at the onset of systemic lupus erythematosus (SLE). They comprise three cases of breast adenocarcinoma, two cases of Hodgkin's lymphoma, and one each of cholangiocarcinoma and thymoma. Only one of this group had been treated with cytotoxic agents, an...

journal_title：Lupus

authors： Menon S,Snaith ML,Isenberg DA

更新日期：1993-06-01 00:00:00

abstract：OBJECTIVE:The objective of this paper is to assess whether pulmonary hypertension (PH) may be detected at one point in time or longitudinally predicted by serum uric acid (sUA) levels in systemic lupus erythematosus (SLE). METHODS:We conducted a post-hoc analysis of a long-term followed cohort of Mexican SLE patients....

journal_title：Lupus

authors： Castillo-Martínez D,Marroquín-Fabián E,Lozada-Navarro AC,Mora-Ramírez M,Juárez M,Sánchez-Muñoz F,Vargas-Barrón J,Sandoval J,Amezcua-Guerra LM

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVES:To compare and rank currently available pharmacological interventions for the prevention of recurrent miscarriage (RM) in women with antiphospholipid syndrome (APS). METHODS:A search was performed using PubMed, Embase, the Cochrane Central Register of Controlled Trials, Web of Science, CNKI, ClinicalTrials....

journal_title：Lupus

authors： Yang Z,Shen X,Zhou C,Wang M,Liu Y,Zhou L

更新日期：2021-01-01 00:00:00

abstract：:The p53 tumour suppressor is the central regulator of apoptosis. Previously, the functional TP53 Arg72Pro polymorphism was found to be associated with systemic lupus erythematosus (SLE) in Koreans but not Spaniards. MDM2 is the major negative regulator of p53. An intronic polymorphism in MDM2, the SNP309, attenuates p...

journal_title：Lupus

authors： Onel KB,Huo D,Hastings D,Fryer-Biggs J,Crow MK,Onel K

更新日期：2009-01-01 00:00:00

abstract：:Neonatal antiphospholipid syndrome (neonatal APS) seems to be exceedingly rare, as the antiphospholipid antibodies (aPL) related thrombosis in the neonatal period. The pathogenesis of perinatal aPL related thrombosis may be explained both by the transplacental passage of the maternal antibodies and by the production o...

journal_title：Lupus

authors： De Carolis MP,Salvi S,Botta A,Cocca C,Garufi C,Lanzone A,De Carolis S

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVE:To investigate the clinical characteristics, imaging changes and early diagnostic methods of neuropsychiatric systemic lupus erythematosus (NPSLE). METHODS:Thirty-five SLE patients, of which 16 had overt neuropsychiatric symptoms, underwent examination for multiple autoantibodies, including anti-double-stran...

journal_title：Lupus

authors： Jia J,Xie J,Li H,Wei H,Li X,Hu J,Meng D,Zhang Y,Zhang X

更新日期：2019-08-01 00:00:00

abstract：:To study whether monoclonal anticardiolipin antibodies (aCL), derived from patients with antiphospholipid syndrome (APS), have similar pathogenic potential, we have employed an experimental model of antiphospholipid syndrome. Monoclonal aCL were produced by the combined method of EBV transformation and somatic cell hy...

journal_title：Lupus

authors： Bakimer R,Blank M,Kosashvilli D,Ichikawa K,Khamashta MA,Hughes GR,Koike T,Shoenfeld Y

更新日期：1995-06-01 00:00:00

abstract：:A special interaction is established during pregnancy between the maternal immune system and fetal cells to allow the survival and the normal growth of the fetus. Fetal cells expressing paternal alloantigens are not recognized as foreign by the mother because of an efficient anatomic barrier and a local immunosuppress...

journal_title：Lupus

authors： Bulla R,Fischetti F,Bossi F,Tedesco F

更新日期：2004-01-01 00:00:00

abstract：:In the 9-year period between 1982 and 1991, 137 patients attending a medical clinic of Queen Elizabeth Hospital, Hong Kong, were diagnosed as having systemic lupus erythematosus according to the American Rheumatism Association's criteria for classification. The female-to-male ratio was 16 to 1. Commonly the onset age ...

journal_title：Lupus

authors： Lee SS,Li CS,Li PC

更新日期：1993-04-01 00:00:00

abstract：:Endothelial and/or platelet activation likely initiates thrombus formation. Whether antiphospholipid antibody (aPL) is an activator, a toxic response, or a protective response is not clear, nor is it certain whether aPL is germ-line encoded or antigen-driven. The pregnancy model is particularly informative. Alternativ...

journal_title：Lupus

authors： Lockshin MD

更新日期：1996-10-01 00:00:00

abstract：:Severe systemic lupus erythematosus often requires the use of cyclophosphamide in women of reproductive age. As cyclophosphamide is generally avoided during pregnancy because of its teratogenic risk, its impact on fetal survival is poorly understood. This is a case series of lupus patients exposed to cyclophosphamide ...

journal_title：Lupus

authors： Clowse ME,Magder L,Petri M

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the frequency of primary immunodeficiencies (PID) in juvenile systemic lupus erythematosus (JSLE) patients. METHODS:Some 72 JSLE patients were analyzed for levels of immunoglobulin classes and IgG subclasses and early components of the classical complement pathway. Determination of C4 gene copy n...

journal_title：Lupus

authors： Jesus AA,Liphaus BL,Silva CA,Bando SY,Andrade LE,Coutinho A,Carneiro-Sampaio M

更新日期：2011-10-01 00:00:00

abstract：:Patients with systemic lupus erythematosus (SLE) frequently have gastrointestinal (GI) symptoms. These are usually self-limiting and related to treatment side-effects or concurrent illness. However, abdominal pain may be due to bowel ischaemia which can lead to infarction and perforation. The likelihood of these serio...

journal_title：Lupus

authors： Lian TY,Edwards CJ,Chan SP,Chng HH

更新日期：2003-01-01 00:00:00

abstract：:In 2012, the Systemic Lupus International Collaborating Clinics (SLICC) group published a new set of classification criteria for systemic lupus erythematosus (SLE). Studies applying these criteria to real-life scenarios have found either equal or greater sensitivity and equal or lower specificity to the 1997 ACR class...

journal_title：Lupus

authors： Ungprasert P,Sagar V,Crowson CS,Amin S,Makol A,Ernste FC,Osborn TG,Moder KG,Niewold TB,Maradit-Kremers H,Ramsey-Goldman R,Chowdhary VR

更新日期：2017-03-01 00:00:00

abstract：:Spondyloenchondrodysplasia (SPENCD) is a rare autosomal recessive skeletal dysplasia caused by recessive mutations in the ACP5 gene, and it is characterized by the persistence of chondroid tissue islands within the bone. The clinical spectrum of SPENCD includes neurological involvement and immune dysfunction, such as ...

journal_title：Lupus

authors： Bilginer Y,Düzova A,Topaloğlu R,Batu ED,Boduroğlu K,Güçer Ş,Bodur I,Alanay Y

更新日期：2016-06-01 00:00:00

abstract：:The pathogenesis and therapy of shrinking lungs syndrome in patients with systemic lupus erythematosus remains controversial. It has been previously reported that corticosteroid treatment can be effective. We report a patient with shrinking lungs syndrome who presented a good response to inhaled beta-agonist therapy. ...

journal_title：Lupus

authors： Muñoz-Rodríguez FJ,Font J,Badia JR,Miret C,Barberà JA,Cervera R,Ingelmo M

更新日期：1997-01-01 00:00:00

abstract：:The objective of this study was to determine the HLA class II associations of the anticardiolipin (aCL) and anti-beta2GPI (abeta2GPI) antibodies in a large series of European patients with systemic lupus erythematosus (SLE). A cohort of 577 European SLE patients was enrolled. aCL and abeta2GPI were measured by ELISA m...

journal_title：Lupus

authors： Galeazzi M,Sebastiani GD,Tincani A,Piette JC,Allegri F,Morozzi G,Bellisai F,Scorza R,Ferrara GB,Carcassi C,Font J,Passiu G,Smolen J,Papasteriades C,Houssiau F,Nebro AF,Ramon Garrido ED,Jedryka-Goral A,Marcolongo R

更新日期：2000-01-01 00:00:00