The association of malignancy with SLE: an analysis of 150 patients under long-term review.

abstract：:Systemic lupus erythematosus may present with renal manifestations that frequently are difficult to categorize and lupus nephritis is an important predictor of poor outcome. The type and spectrum of renal injury may remain undiagnosed until full-blown nephritic and/or nephrotic syndrome appear with increased risk of e...

journal_title：Lupus

authors： Ortega LM,Schultz DR,Lenz O,Pardo V,Contreras GN

更新日期：2010-04-01 00:00:00

abstract：:In 2012, the Systemic Lupus International Collaborating Clinics (SLICC) group published a new set of classification criteria for systemic lupus erythematosus (SLE). Studies applying these criteria to real-life scenarios have found either equal or greater sensitivity and equal or lower specificity to the 1997 ACR class...

journal_title：Lupus

authors： Ungprasert P,Sagar V,Crowson CS,Amin S,Makol A,Ernste FC,Osborn TG,Moder KG,Niewold TB,Maradit-Kremers H,Ramsey-Goldman R,Chowdhary VR

更新日期：2017-03-01 00:00:00

abstract：:The aim of this study was to use transthoracic Doppler echocardiographic (TTE) imaging methods to identify cardiac dysfunction, an indicator of subclinical atherosclerosis in asymptomatic systemic lupus erythematosus (SLE) patients in terms of cardiac effects. This study involved 80 patients: a study group (n = 50) an...

journal_title：Lupus

authors： Barutcu A,Aksu F,Ozcelik F,Barutcu CA,Umit GE,Pamuk ON,Altun A

更新日期：2015-09-01 00:00:00

abstract：INTRODUCTION:Several studies have shown that Hispanic patients generally experience a worse renal prognosis than non-Hispanic white patients with lupus. To date, there is no report on American College of Rheumatology (ACR) renal response criteria (ACR-RRC) in patients from Latin America. OBJECTIVE:To evaluate treatmen...

journal_title：Lupus

authors： Vinicki JP,Paniego FM,De Rosa G,Dubinsky D,Laborde HA,Marini A,Nasswetter G

更新日期：2016-02-01 00:00:00

abstract：:To determine whether killer cell immunologlobulin-like receptor (KIR) genotypes are associated with vasculitis, vascular arterial events or anticardiolipin (aCL) antibodies in patients with lupus. A total of 304 patients followed prospectively at the University of Toronto Lupus Clinic were assessed for the occurrence ...

journal_title：Lupus

authors： Toloza S,Pellett F,Chandran V,Ibanez D,Urowitz M,Gladman D

更新日期：2008-09-01 00:00:00

abstract：:Antiphospholipid syndrome (APS) is an autoimmune disease characterized by recurrent thrombotic events, miscarriages and thrombocytopenia with persistently positive antiphospholipid antibodies.( 1,2 ) APS may be isolated (primary APS) or associated to a connective tissue disease, most often systemic lupus erythematosus...

journal_title：Lupus

authors： Taipa R,Santos E

更新日期：2011-11-01 00:00:00

abstract：:Background While thrombopoeitin (TPO) agonists that act to simulate platelet production have been approved for use in steroid-refractory chronic immune thrombocytopenia purpura (ITP), there are few data on the safety and efficacy of these medications in patients with concurrent systemic lupus erythematosus (SLE) or an...

journal_title：Lupus

authors： Lusa A,Carlson A

更新日期：2018-09-01 00:00:00

abstract：:Cytotoxic therapy is a cornerstone for patients with severe systemic lupus erythematosus (SLE). High-dose cyclophosphamide, 200 mg/kg, can induce a complete remission without the need for stem cell rescue in patients with autoimmune illnesses. Here we report on our first four patients treated for severe SLE with this ...

journal_title：Lupus

authors： Gladstone DE,Prestrud AA,Pradhan A,Styler MJ,Topolsky DL,Crilley PA,Hoch S,Huppert A,Brodsky I

更新日期：2002-01-01 00:00:00

abstract：INTRODUCTION:Anti-RNP autoantibodies occur either in mixed connective tissue disease (MCTD) (with a frequently favorable prognosis), or in systemic lupus erythematosus (SLE) cases with aggressive major organ disease. It is uncertain how to assess for the risk of severe disease in anti-RNP + patients. METHODS:Following...

journal_title：Lupus

authors： Carpintero MF,Martinez L,Fernandez I,Romero AC,Mejia C,Zang YJ,Hoffman RW,Greidinger EL

更新日期：2015-09-01 00:00:00

abstract：:Corrigendum to A North American perspective of content and quality of websites in the English language on childhood-onset lupus erythematosus by C Cutler et al. Published in Lupus (2018) 27, 762-770. DOI: 10.1177/0961203317746246 . The authors wish to highlight the following correction. The subheading in Table 5 shoul...

journal_title：Lupus

authors：

更新日期：2018-12-01 00:00:00

abstract：:Recent accumulated evidence suggests that prolactin (PRL) is an important immunomodulator and might have a role in the pathogenesis of systemic lupus erythematosus (SLE). Our aim was to assess the frequency of hyperprolactinemia in women with SLE and to evaluate its correlation with disease activity. PRL plasma levels...

journal_title：Lupus

authors： Jimena P,Aguirre MA,López-Curbelo A,de Andrés M,Garcia-Courtay C,Cuadrado MJ

更新日期：1998-01-01 00:00:00

abstract：OBJECTIVE:Systemic lupus erythematosus (SLE) is a chronic, relapsing-remitting autoimmune disorder that involves multiple organ systems including the central nervous system. Among the items included in the nomenclature for neuropsychiatric SLE, mood disorders have been identified. The aim of this paper is to review the...

journal_title：Lupus

authors： Palagini L,Mosca M,Tani C,Gemignani A,Mauri M,Bombardieri S

更新日期：2013-04-01 00:00:00

abstract：:Our aims were to assess the frequency of false-positive IgM antibodies for cytomegalovirus in pregnant women with autoimmune diseases and in healthy women (controls) and to determine their relationship with pregnancy outcome. Data from 133 pregnancies in 118 patients with autoimmune diseases and from 222 pregnancies i...

journal_title：Lupus

authors： De Carolis S,Santucci S,Botta A,Garofalo S,Martino C,Perrelli A,Salvi S,Degennaro V,de Belvis A,Ferrazzani S,Scambia G

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVES:The objective of this paper is to perform the cross-cultural validation of the French version of the LupusPRO, a disease-targeted patient-reported outcome measure, among systemic lupus erythematosus (SLE) patients in Canada. METHODS:The French version of the LupusPRO and the MOS SF-36 were administered; dem...

journal_title：Lupus

authors： Bourré-Tessier J,Clarke AE,Kosinski M,Mikolaitis-Preuss RA,Bernatsky S,Block JA,Jolly M

更新日期：2014-12-01 00:00:00

abstract：:Cyclophosphamide (CYC) is used in severe neuropsychiatric systemic lupus erythematosus (NPSLE), but long-term data regarding its efficacy and safety are lacking. We identified NPSLE cases who received CYC from two centres during the period 1999-2013 and had regular follow-up. General and neuropsychiatric outcome at la...

journal_title：Lupus

authors： Fanouriakis A,Pamfil C,Sidiropoulos P,Damian L,Flestea A,Gusetu G,Rednic S,Bertsias G,Boumpas DT

更新日期：2016-05-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a clinically diverse, complex autoimmune disease which may present with coincident onset of many criteria or slow, gradual symptom accrual. Early intervention has been postulated to delay or prevent the development of more serious sequelae. One option for treatment in this setting...

journal_title：Lupus

authors： James JA,Kim-Howard XR,Bruner BF,Jonsson MK,McClain MT,Arbuckle MR,Walker C,Dennis GJ,Merrill JT,Harley JB

更新日期：2007-01-01 00:00:00

abstract：:This study was designed to investigate whether Foxp3( +) regulatory T (Treg) cells play a role in the histopathologic changes of primary Sjögren's Syndrome (pSS) and to evaluate other factors possibly associated with Foxp3(+) Treg cells in pSS patients. The number of FoxP3-expressing T cells in peripheral blood (PB) o...

journal_title：Lupus

authors： Sarigul M,Yazisiz V,Bassorgun CI,Ulker M,Avci AB,Erbasan F,Gelen T,Gorczynski RM,Terzioglu E

更新日期：2010-02-01 00:00:00

abstract：:A case of recurrent cerebral infarctions in a 42-year-old woman affected by polyarteritis nodosa and antiphospholipid syndrome is reported. Two-dimensional echocardiography revealed grossly thickened mitral valve leaflets, possibly related to the presence of antiphospholipid antibodies. Thus, an embolic source at mitr...

journal_title：Lupus

authors： Morelli S,Perrone C,Paroli M

更新日期：1998-01-01 00:00:00

abstract：:Herein, we investigated the risk of juvenile-onset systemic lupus erythematosus (JSLE) in children with atopic dermatitis (AD). From 2000 to 2007, 192,357 children with newly diagnosed AD and 769,428 matched non-AD controls were identified. By the end of 2008, incidences and hazard ratios (HRs) of JSLE were measured. ...

journal_title：Lupus

authors： Wei CC,Lin CL,Tsai JD,Shen TC,Sung FC

更新日期：2014-12-01 00:00:00

abstract：:Atherosclerosis is an inflammatory disease, leading to the formation of pro-inflammatory and pro-oxidative lipids that generate an immune response. Several antigens have been shown to activate the immune response and affect the development of atherogenesis. Systemic lupus erythematosus is an autoimmune and inflammator...

journal_title：Lupus

authors： Carvalho JF,Pereira RM,Shoenfeld Y

更新日期：2009-11-01 00:00:00

abstract：:Estrogens and their receptors may play a role in the pathogenesis of systemic lupus erythematosus. Genetic alterations in the exon 8-coding region of the estrogen receptor alpha alter the intracellular signalling of estrogens, leading in enhanced or diminished activity. We investigated whether genetic alterations in e...

journal_title：Lupus

authors： Kassi E,Vlachoyiannopoulos PG,Kominakis A,Kiaris H,Moutsopoulos HM,Moutsatsou P

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVES:To determine the frequency and the time to complete recovery identified by Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) and the time to partial recovery identified by the SLEDAI-2K Responder Index 50 (SRI-50) in three laboratory systems over 10 years. METHODS:This is a retrospective ...

journal_title：Lupus

authors： Touma Z,Gladman DD,Ibañez D,Urowitz MB

更新日期：2012-10-01 00:00:00

abstract：:We conducted an open-labeled, prospective study to determine the efficacy and safety of tacrolimus as an alternative therapeutic option for those patients with refractory lupus nephritis. The study population comprised one male and eight female patients with diffuse proliferative lupus nephritis. All patients had fail...

journal_title：Lupus

authors： Lee T,Oh KH,Joo KW,Kim YS,Ahn C,Han JS,Kim S,Chin HJ

更新日期：2010-07-01 00:00:00

abstract：:Patients with antiphospholipid syndrome (APS) produce antiphospholipid antibodies (aPL) and develop vascular thrombosis that may occur in large or small vessels in the arterial or venous beds. On the other hand, many individuals produce aPL and yet never develop thrombotic events. Toll-like receptor 4 (TLR4) appears t...

journal_title：Lupus

authors： Laplante P,Fuentes R,Salem D,Subang R,Gillis MA,Hachem A,Farhat N,Qureshi ST,Fletcher CA,Roubey RA,Merhi Y,Thorin É,Levine JS,Mackman N,Rauch J

更新日期：2016-02-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease with a complex pathogenesis. Published data have revealed that serum levels of proinflammatory cytokines are increased in SLE patients. The aim of our study was to evaluate whether monotherapy with chloroquine phosphate affects IL-1beta, IL-6, IL-18 and TNF-a...

journal_title：Lupus

authors： Wozniacka A,Lesiak A,Narbutt J,McCauliffe DP,Sysa-Jedrzejowska A

更新日期：2006-01-01 00:00:00

abstract：:The management of lupus nephritis is typified by popular misconceptions: that there is a 'standard of care', that treatment has well-defined aims and that the optimum length of treatment is established. In reality, however, uncertainties still exist and the evidence base remains weak. Until recently, initial therapy f...

journal_title：Lupus

authors： Jayne D

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:This study aimed to explore the risk factors for 'severe' neuropsychiatric (NP) flare in patients with systemic lupus erythematosus (SLE). METHODS:This retrospective study comprised newly diagnosed 184 adult SLE patients who visited Hokkaido University Hospital between 2006 and 2017. In this study, severe NP...

journal_title：Lupus

authors： Aso K,Kono M,Kono M,Watanabe T,Shimizu Y,Ogata Y,Fujieda Y,Kato M,Oku K,Amengual O,Yasuda S,Atsumi T

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVES:Impaired function of polymorphonuclear cells (PMNs) in systemic lupus erythematosus (SLE) leads to severe gram-positive and gram-negative bacterial infection, and to major morbidity and mortality. Few studies have focused on the association of impaired function of PMNs and SLE patients' susceptibility to inf...

journal_title：Lupus

authors： Wu SA,Yeh KW,Lee WI,Yao TC,Kuo ML,Huang B,Huang JL

更新日期：2013-03-01 00:00:00

abstract：:Neurological involvement in antiphospholipid antibody syndrome (APS) is common, and its occurrence increases morbidity and mortality. Patients may present variable neurological involvement, such as cerebrovascular disease, cognitive dysfunction, headache, seizures, movement disorders, multiple sclerosis-like syndrome,...

journal_title：Lupus

authors： Ricarte IF,Dutra LA,Abrantes FF,Toso FF,Barsottini OGP,Silva GS,de Souza AWS,Andrade D

更新日期：2018-08-01 00:00:00

abstract：:Controversy exists concerning the prevalence of headache in systemic lupus erythematosus (SLE) and its importance as a neuropsychiatric manifestation, especially when it occurs independently of disease activity and with the typical characteristics of primary chronic headache. Most reports to date have either studied b...

journal_title：Lupus

authors： Fernández-Nebro A,Palacios-Muñoz R,Gordillo J,Abarca-Costalago M,De Haro-Liger M,Rodríguez-Andreu J,González-Santos P

更新日期：1999-01-01 00:00:00