Abstract:
:Cyclophosphamide (CYC) is used in severe neuropsychiatric systemic lupus erythematosus (NPSLE), but long-term data regarding its efficacy and safety are lacking. We identified NPSLE cases who received CYC from two centres during the period 1999-2013 and had regular follow-up. General and neuropsychiatric outcome at last follow-up visit were determined, and major complications were documented. CYC was administered in 50 neuropsychiatric events. Median age was 45.0 years and 46% of patients were positive for antiphospholipid antibodies. Most frequent indications were psychosis (11 cases), polyneuropathy (six cases), and cerebrovascular disease, seizure disorder and cranial neuropathy (five cases). CYC was mainly administered as monthly pulses (median number: 8.0 (range 3-26), median cumulative dose: 7.2 g (range 2.4-33.8)). Cases were followed for a median of 46.5 months (range 5-408). At last follow-up, partial or complete response of NPSLE was observed in 84% of events; 10% had stable disease, whereas the remaining 6% failed to improve or worsened and were rescued with rituximab. In events that responded to CYC, maintenance therapy consisted of azathioprine in 31 events (65.9%), bimonthly or quarterly pulses of intravenous CYC in nine (19.1%), and mycophenolate mofetil in five (10.6%). Relapses were observed in six events (12%) at median eight months after initial response. No malignancies were observed, yet there were three cases of severe infections. Amenorrhea was recorded in three patients, who had not received gonadal protection. In conclusion, cyclophosphamide was efficacious and led to sustained response of severe NPSLE in a cohort with long follow-up.
journal_name
Lupusjournal_title
Lupusauthors
Fanouriakis A,Pamfil C,Sidiropoulos P,Damian L,Flestea A,Gusetu G,Rednic S,Bertsias G,Boumpas DTdoi
10.1177/0961203315622821subject
Has Abstractpub_date
2016-05-01 00:00:00pages
627-36issue
6eissn
0961-2033issn
1477-0962pii
0961203315622821journal_volume
25pub_type
杂志文章,多中心研究相关文献
LUPUS文献大全abstract::One hundred and twenty-nine patients with systemic lupus erythematosus were screened for thyroid function tests. Of these, 8.9% had hyperthyroidism and 3.9% Hashimoto's thyroiditis. Euthyroid sick syndrome was present in 47.8% of patients. There was a high prevalence of antimicrosomal and antithyroglobulin antibodies ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339300200109
更新日期:1993-02-01 00:00:00
abstract:BACKGROUND:GlycA is a novel marker of systemic inflammation detected by nuclear magnetic resonance (NMR) spectroscopy. In the general population, GlycA is correlated with inflammatory markers such as C-reactive protein (CRP) and associated with coronary heart disease and diabetes. The utility of GlycA in patients with ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203315617842
更新日期:2016-03-01 00:00:00
abstract::We report a case of a patient with clinical features of progressive supranuclear palsy and raised titres of anticardiolipin antibodies in blood, thrombocytopenia and livedo reticularis on skin. Magnetic resonance imaging of brain and isotope scan of brain were distinctive of vascular disorder. ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203303lu242CR
更新日期:2003-01-01 00:00:00
abstract::Structural and metabolic abnormalities in the hippocampus have been associated with the pathophysiological mechanism of central nervous system involvement in primary Sjögren syndrome (pSS). Nevertheless, how hippocampal function is altered in pSS remains unknown. The purpose of our study is to investigate the alterati...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203320908936
更新日期:2020-04-01 00:00:00
abstract::Nodular or pseudomembranous tracheobronchitis due to infection by Aspergillus species is an uncommon presentation of invasive aspergillosis. Most cases have been described in severely immunocompromised hosts. We describe the case of a 23-year-old woman, with recently diagnosed systemic lupus erythematosus, who develop...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203302lu206cr
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:There is no report about the association between GATA3 rs3824662 polymorphism and systemic lupus erythematosus (SLE). OBJECTIVE:To investigate the possible role of GATA3 rs3824662 polymorphism as a susceptibility risk factor for either adult SLE (aSLE) or pediatric SLE (pSLE) and to evaluate its role in the...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203318804894
更新日期:2018-11-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is a clinically diverse, complex autoimmune disease which may present with coincident onset of many criteria or slow, gradual symptom accrual. Early intervention has been postulated to delay or prevent the development of more serious sequelae. One option for treatment in this setting...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203307078579
更新日期:2007-01-01 00:00:00
abstract::Diagnosing vulvar intraepithelial neoplasia in a young woman presenting mainly with skin manifestations of lupus and with no other risk factors is a major challenge. The case of a 27-year-old woman with systemic lupus erythematosus and vulvar intraepithelial neoplasia is described. Although progression of vulvar intra...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203309345742
更新日期:2010-01-01 00:00:00
abstract::We investigated the clinical significance of IgG phospholipid-dependent anti-beta 2-glycoprotein I (beta 2-GPI) antibodies in patients with SLE. The study population consisted of 140 patients with SLE. Sera were examined for IgG phospholipid-dependent anti-beta 2-GPI antibodies by ELISA. IgG phospholipid-dependent ant...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339500400609
更新日期:1995-12-01 00:00:00
abstract::The immunopathogenesis of systemic lupus erythematosus has been thoroughly investigated recently, and genome-wide association studies have identified genes statistically associated with lupus. However, the progression to overt disease is dependent on the activation of environmental factors ('triggers'), among which oe...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203311433138
更新日期:2012-05-01 00:00:00
abstract::We report three cases of severe haemorrhagic rupture of luteal ovarian cyst requiring surgical haemostasis in young women treated with long-term oral anticoagulation for antiphospholipid syndrome (APS) who used no contraception. At the time of bleeding, the international normalized ratios were 3.78, 4.24, and 7.11. An...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339900800614
更新日期:1999-01-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is a severe chronic inflammatory autoimmune connective tissue disease. Despite major efforts, SLE remains a poorly understood disease with unpredictable course, unknown etiology and complex pathogenesis. Apoptosis combined with deficiency in clearing apoptotic cells is an important e...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316669240
更新日期:2017-04-01 00:00:00
abstract::Analyses of the medical and economic burden of chronic disorders such as systemic lupus erythematosus (SLE) are valuable for clinical and health policy decisions. We performed a chart-based review of 215 adult SLE patients with active autoantibody-positive disease at the predefined ratio of 30% severe (involvement of ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316642310
更新日期:2016-10-01 00:00:00
abstract::Our aims were to assess the frequency of false-positive IgM antibodies for cytomegalovirus in pregnant women with autoimmune diseases and in healthy women (controls) and to determine their relationship with pregnancy outcome. Data from 133 pregnancies in 118 patients with autoimmune diseases and from 222 pregnancies i...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203310361350
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVES:The objectives of this paper are to prospectively determine the incidence of paediatric systemic lupus erythematosus (pSLE) in Australia as well as describe the demographics, clinical presentation and one-year outcome. STUDY DESIGN:Newly diagnosed cases of pSLE were ascertained prospectively from October 20...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314552118
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVES:Sexual dysfunction in systemic lupus erythematous (SLE) patients is an important issue to be tackled. We aimed to study the prevalence of sexual dysfunction in SLE women and detect its association with depression, functional disability and quality of life. METHODS:This study included 94 SLE females. Ninety-...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203320935518
更新日期:2020-08-01 00:00:00
abstract::The aim of this study was to use transthoracic Doppler echocardiographic (TTE) imaging methods to identify cardiac dysfunction, an indicator of subclinical atherosclerosis in asymptomatic systemic lupus erythematosus (SLE) patients in terms of cardiac effects. This study involved 80 patients: a study group (n = 50) an...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203315570164
更新日期:2015-09-01 00:00:00
abstract::Herein, we investigated the risk of juvenile-onset systemic lupus erythematosus (JSLE) in children with atopic dermatitis (AD). From 2000 to 2007, 192,357 children with newly diagnosed AD and 769,428 matched non-AD controls were identified. By the end of 2008, incidences and hazard ratios (HRs) of JSLE were measured. ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314543920
更新日期:2014-12-01 00:00:00
abstract::Objective Several studies have evaluated the prevalence of rheumatoid factor (RF) and anti-citrullinated proteins antibodies (ACPA) in systemic lupus erythematosus (SLE) patients but no data are available on the anti-carbamylated proteins (anti-CarP), a new biomarker for rheumatoid arthritis (RA). We evaluated the ant...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203317713141
更新日期:2018-01-01 00:00:00
abstract::Spondyloenchondrodysplasia (SPENCD) is a rare autosomal recessive skeletal dysplasia caused by recessive mutations in the ACP5 gene, and it is characterized by the persistence of chondroid tissue islands within the bone. The clinical spectrum of SPENCD includes neurological involvement and immune dysfunction, such as ...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203316629000
更新日期:2016-06-01 00:00:00
abstract::Neurological involvement in antiphospholipid antibody syndrome (APS) is common, and its occurrence increases morbidity and mortality. Patients may present variable neurological involvement, such as cerebrovascular disease, cognitive dysfunction, headache, seizures, movement disorders, multiple sclerosis-like syndrome,...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203318776110
更新日期:2018-08-01 00:00:00
abstract::Current management of primary or secondary antiphospholipid antibody (aPL) syndromes with known embolic phenomena requiring anticoagulation is empiric in the setting of elective orthopedic procedures. Short-term withdrawal of warfarin with continuance of aspirin and glucocorticoid therapy was undertaken for sequential...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339200100311
更新日期:1992-05-01 00:00:00
abstract::Although many types of neurological disorders and events have been described in association with antiphospholipid antibodies (aPL) and the antiphospholipid syndrome (APS), only ischaemic stroke is reasonably well established and accepted as a diagnostic criterion for the syndrome. We propose to evaluate, classify and ...
journal_title:Lupus
pub_type: 共识发展会议,杂志文章,评审
doi:10.1191/0961203303lu392oa
更新日期:2003-01-01 00:00:00
abstract::Panniculitis rarely occurs in the course of systemic lupus erythematosus (SLE). When it occurs, it is thought to be mainly lupus erythematosus panniculitis (LEP). Here we describe a 32-year old Japanese woman with chronic SLE, who simultaneously presented facial lymphocytic lobular panniculitis and pancytopenia due to...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203307077560
更新日期:2007-01-01 00:00:00
abstract::Thalidomide has been shown to be an effective treatment for cutaneous forms of lupus erythematous refractory to other therapies. Thalidomide has very serious side effects, including teratogenicity and neuropathy, which limit its clinical use in lupus to such severe refractory cases. Efficacy has been confirmed in seve...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1191/096120301677213822
更新日期:2001-01-01 00:00:00
abstract::To determine whether killer cell immunologlobulin-like receptor (KIR) genotypes are associated with vasculitis, vascular arterial events or anticardiolipin (aCL) antibodies in patients with lupus. A total of 304 patients followed prospectively at the University of Toronto Lupus Clinic were assessed for the occurrence ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203308089443
更新日期:2008-09-01 00:00:00
abstract::Recent studies have revealed new populations of T/B cells, including central/effector memory, follicular T cells and CXCR3+ or CXCR4+ B cells. In the present study, changes in these populations of CD4+ T cells were examined on the basis of the expression of CD62L, CCR7 and CXCR5 in patients with systemic lupus erythem...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203307085246
更新日期:2008-01-01 00:00:00
abstract::This review briefly defines the heat shock proteins (hsps), their classification and their functions. The hypothesis that links hsps to the development of autoimmunity is explored, together with the rationale for investigation of the relationship between hsps and systemic lupus erythematosus (SLE). Thus, published wor...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/096120339100100102
更新日期:1991-11-01 00:00:00
abstract::Severe acute respiratory syndrome coronavirus (SARS-CoV-2), the virus causing Coronavirus disease 2019 (COVID-19), has had a huge impact on health services with a high mortality associated with complications including pneumonia and acute respiratory distress syndrome. Historical evidence suggests that Lupus patients h...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203320961848
更新日期:2020-11-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is an autoreactive T cell mediated autoimmune disease. Immunization with inactivated autoreactive T cells may induce idiotype anti-idiotypic reaction to deplete specific subsets of autoreactive T cells involved in SLE. Six SLE patients unsuitable or refused to use immunosuppressants ...
journal_title:Lupus
pub_type: 临床试验,杂志文章
doi:10.1191/0961203305lu2239oa
更新日期:2005-01-01 00:00:00