Clinical significance of phospholipid-dependent anti-beta 2-glycoprotein I (beta 2-GPI) antibodies in systemic lupus erythematosus.

abstract：:Neuropsychiatric lupus is a well-recognized complication of systemic lupus erythematosus (SLE) and encompasses a wide variety of neurological manifestations. Although isolated cranial nerve involvement is rare, it can cause significant morbidity and disability. This report describes a case with isolated vagus nerve in...

journal_title：Lupus

authors： Yu KH,Yang CH,Chu CC

更新日期：2007-01-01 00:00:00

abstract：:Cardio-pulmonary manifestations of systemic lupus erythematosus (SLE) are well recognized in adults. We report the occurrence of clinically significant cardio-pulmonary disease in a cohort of predominantly Caucasian children with SLE. All children with SLE attending the Royal Liverpool Children's NHS Trust between 199...

journal_title：Lupus

authors： Beresford MW,Cleary AG,Sills JA,Couriel J,Davidson JE

更新日期：2005-01-01 00:00:00

abstract：:Congenital heart block (CHB) is a syndrome of uncertain pathogenesis leading to cardiac conduction disturbances in the foetus and newborns. It has been proposed that maternal antibodies transmit immunological injury in the developing foetal heart, thus causing irreversible damage of the atrioventricular node, leading ...

journal_title：Lupus

authors： Sirén MK,Julkunen H,Kaaja R,Ekblad H,Koskimies S

更新日期：1999-01-01 00:00:00

abstract：:We report an infant with anticardiolipin (aCL) antibodies who presented with erythematous nodular skin lesions and elevated liver enzyme levels. The cutaneous manifestation was histologically lymphocytic lobular panniculitis with vasculitic and hemorrhagic changes. The infant also had low levels of anti-double strande...

journal_title：Lupus

authors： Miyagawa S,Uchida Y,Taira K,Higuchi M,Hashimoto K,Yoshioka A,Shirai T

更新日期：2000-01-01 00:00:00

abstract：:The objective of this study was to identify risk factors associated with flare during pregnancy in women with systemic lupus erythematosus (SLE). We performed a retrospective analysis of pregnant women with SLE in a referral hospital. Flare was considered according to predetermined definitions. We analyzed 15 clinical...

journal_title：Lupus

authors： Saavedra MA,Sánchez A,Morales S,Navarro-Zarza JE,Ángeles U,Jara LJ

更新日期：2015-02-01 00:00:00

abstract：:Proteinuria is the hallmark of clinical manifestation of disease activity in lupus nephritis (LN) patients, which arises from direct or indirect podocyte injury. This study is to explore the relationship between intrarenal T cell infiltration and podocyte injury in lupus nephritis (LN), and to understand the potential...

journal_title：Lupus

authors： Ma R,Jiang W,Li Z,Sun Y,Wei Z

更新日期：2016-12-01 00:00:00

abstract：:Cells traffic in both directions between the fetus and the mother during pregnancy. Recent studies indicate that a low level of fetal cells commonly persists in the maternal circulation for years after pregnancy completion. The harboring of DNA or cells from another individual at low levels is called microchimerism. C...

journal_title：Lupus

authors： Nelson JL

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVE:Studies have been conducted to determine the causal factors and clinical consequences of non-adherence to treatment in systemic lupus erythematosus (SLE). However, no interventions have been performed to increase drug adherence. Our objective was to assess the effectiveness of pharmaceutical care (PC) for dru...

journal_title：Lupus

authors： Oliveira-Santos M,Verani JFS,Camacho LAB,de Andrade CAF,Klumb EM

更新日期：2019-10-01 00:00:00

abstract：:The objective of this study was to determine the HLA class II associations of the anticardiolipin (aCL) and anti-beta2GPI (abeta2GPI) antibodies in a large series of European patients with systemic lupus erythematosus (SLE). A cohort of 577 European SLE patients was enrolled. aCL and abeta2GPI were measured by ELISA m...

journal_title：Lupus

authors： Galeazzi M,Sebastiani GD,Tincani A,Piette JC,Allegri F,Morozzi G,Bellisai F,Scorza R,Ferrara GB,Carcassi C,Font J,Passiu G,Smolen J,Papasteriades C,Houssiau F,Nebro AF,Ramon Garrido ED,Jedryka-Goral A,Marcolongo R

更新日期：2000-01-01 00:00:00

abstract：:Detection of antineutrophil cytoplasmic antibodies (ANCA) for ANCA-associated vasculitides (AAV) is based on indirect immunofluorescence (IIF) on ethanol-fixed neutrophils and reactivity toward myeloperoxidase (MPO) and proteinase 3 (PR3). According to the international consensus for ANCA testing, presence of ANCA sho...

journal_title：Lupus

authors： Avery TY,Bons J,van Paassen P,Damoiseaux J

更新日期：2016-07-01 00:00:00

abstract：:Thymus-derived CD4(+)CD25(high)Foxp3(+) T-regulatory cells (Tregs) have an important role in the mechanisms of peripheral immune tolerance and in the prevention of pathogenic autoimmunity through the suppression of proliferation and production of pro-inflammatory cytokines in effector immune cells. Some studies have s...

journal_title：Lupus

authors： La Cava A

更新日期：2008-05-01 00:00:00

abstract：:Numerous drugs have been linked to the induction or exacerbation of systemic cutaneous lupus erythematosus (SCLE). This report presents the third case of the biologic abatacept as an exacerbating medication for SCLE. A 73-year old woman with a remote history of subacute cutaneous lupus and rheumatoid arthritis, well c...

journal_title：Lupus

authors： Figueredo Zamora E,Callen JP,Schadt CR

更新日期：2020-12-22 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a multi-organ inflammatory disorder mainly affecting women and is associated with high cardiovascular morbidity and mortality. We tested the utility of a comprehensive cardiovascular magnetic resonance approach to assess myocardial involvement and to determine its relation to dise...

journal_title：Lupus

authors： Abdel-Aty H,Siegle N,Natusch A,Gromnica-Ihle E,Wassmuth R,Dietz R,Schulz-Menger J

更新日期：2008-06-01 00:00:00

abstract：:Antiphospholipid antibodies (aPL) are associated with an increased incidence of fetal loss, but the pathophysiology remains unclear. One mechanism may involve the binding of aPL directly to the placenta where they may initiate placental thrombosis and infarction. We have developed an immunofluorescent technique to det...

journal_title：Lupus

authors： Donohoe S,Kingdom JC,Mackie IJ

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:Polyarthritis is common to both mixed connective tissue disease (MCTD) and systemic lupus erythematosus (SLE). Apart from being erosive and deforming in the former, we speculated that it was more common and the extent of joints involved would be higher in MCTD. METHODS:This was a cross-sectional study that ...

journal_title：Lupus

authors： Gunashekar S,Prakash M,Minz RW,Sharma A,Sharma S,Dhir V

更新日期：2018-11-01 00:00:00

abstract：:Objective Several studies have evaluated the prevalence of rheumatoid factor (RF) and anti-citrullinated proteins antibodies (ACPA) in systemic lupus erythematosus (SLE) patients but no data are available on the anti-carbamylated proteins (anti-CarP), a new biomarker for rheumatoid arthritis (RA). We evaluated the ant...

journal_title：Lupus

authors： Massaro L,Ceccarelli F,Colasanti T,Pendolino M,Perricone C,Cipriano E,Natalucci F,Capalbo G,Lucchetti R,Pecani A,Vomero M,Mancini R,Spinelli FR,Alessandri C,Valesini G,Conti F

更新日期：2018-01-01 00:00:00

abstract：:We describe a human monoclonal antibody designated WRI 176 beta and a common idiotype that it carries. This antibody was derived from the spleen of a patient with SLE. WRI 176 is an IgM kappa monoclonal reacting with ssDNA, dsDNA, poly(dT) and it is likely that mAb WRI 176 beta is a representative of the so-called nat...

journal_title：Lupus

authors： Blanco F,Longhurst C,Watts R,Kalsi J,Wiloch HW,Youinou P,Latchman DS,Isenberg DA

更新日期：1994-02-01 00:00:00

abstract：:We retrospectively evaluated the clinical outcome of 45 female and 11 male patients with biopsy-proven lupus nephritis, followed at our hospital between February 1974 and February 1990. In the majority signs of nephritis were present at the time systemic lupus erythematosus was diagnosed (range: -42-156 months) and th...

journal_title：Lupus

authors： Derksen RH,Hené RJ,Kater L

更新日期：1992-02-01 00:00:00

abstract：:Heart valve disease (HVD) is the most common cardiac manifestation in the antiphospholipid syndrome (APS). Valve lesions should be described according to the established definition. HVD is progressive despite anticoagulant/antiplatelet treatments. Around 4-6% of patients with HVD in APS will require valve replacement ...

journal_title：Lupus

authors： Amigo MC

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVES:The objective of this paper is to perform the cross-cultural validation of the French version of the LupusPRO, a disease-targeted patient-reported outcome measure, among systemic lupus erythematosus (SLE) patients in Canada. METHODS:The French version of the LupusPRO and the MOS SF-36 were administered; dem...

journal_title：Lupus

authors： Bourré-Tessier J,Clarke AE,Kosinski M,Mikolaitis-Preuss RA,Bernatsky S,Block JA,Jolly M

更新日期：2014-12-01 00:00:00

abstract：:Monoclonal antiphospholipid antibodies (aPL) have been utilized to dissect the relationship between their sequence, structure, binding and biological properties relevant to the pathogenesis of the antiphospholipid syndrome. In particular, sequence analysis of aPL has highlighted the clustering of certain amino acid re...

journal_title：Lupus

authors： Lambrianides A,Giles IP

更新日期：2010-04-01 00:00:00

abstract：:Objective People affected by chronic rheumatic conditions, such as systemic lupus erythematosus (SLE), frequently rely on the Internet and search engines to look for terms related to their disease and its possible causes, symptoms and treatments. 'Infodemiology' and 'infoveillance' are two recent terms created to desc...

journal_title：Lupus

authors： Radin M,Sciascia S

更新日期：2017-07-01 00:00:00

abstract：:Previous studies in our laboratory showed a dose-dependent and hormone-specific increase in CD154 expression in T cells from females with systemic lupus erythematosus (SLE). This present study investigates if the estrogen-dependent increase in CD154 expression is due to stabilization of the messenger RNA. T cells from...

journal_title：Lupus

authors： Li X,Rider V,Kimler BF,Abdou NI

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:In a previous study performed 9 ± 3.6 years ago, 74 asymptomatic patients with systemic lupus erythematosus (SLE) and/or antiphospholipid syndrome (APS) underwent lung function testing. A significantly low diffusion capacity (DLCO) ranging from 45% to 70% was recorded in 28 of the 74 (37.8%) patients who wer...

journal_title：Lupus

authors： Elalouf O,Fireman E,Levartovsky D,Kaufman I,Rogovski O,Elkayam O,Caspi D,Paran D

更新日期：2015-08-01 00:00:00

abstract：:A case of recurrent cerebral infarctions in a 42-year-old woman affected by polyarteritis nodosa and antiphospholipid syndrome is reported. Two-dimensional echocardiography revealed grossly thickened mitral valve leaflets, possibly related to the presence of antiphospholipid antibodies. Thus, an embolic source at mitr...

journal_title：Lupus

authors： Morelli S,Perrone C,Paroli M

更新日期：1998-01-01 00:00:00

abstract：:Skin involvement in systemic lupus erythematosus (SLE) occurs in varied forms. Lupus erythematosus tumidus (LET) is not known to occur with SLE. In our patient presented below, LET occurred in a patient with SLE. Some of the lesions progressed to scarring discoid lesions, while others responded very well to hydoxychlo...

journal_title：Lupus

authors： Jolly M,Laumann AE,Shea CR,Utset TO

更新日期：2004-01-01 00:00:00

abstract：:Anti-idiotypic antibody and its F(ab')2 fragments prepared from pooled normal human IgG had a partial inhibitory effect on the spontaneous in vitro secretion of anti-DNA antibodies from blood mononuclear cells of lupus patients. The inhibitory effect was specific for anti-DNA secretion as the anti-idiotype failed to i...

journal_title：Lupus

authors： Evans M,Abdou NI

更新日期：1993-12-01 00:00:00

abstract：:This study was conducted to determine kidney transplantation (KTx) outcomes for Greek patients with renal failure caused by lupus nephritis (LN) compared with matched controls, kidney recipients with other causes of end-stage renal disease (ESRD). Twenty-six patients with systemic lupus erythematosus (SLE) subjected t...

journal_title：Lupus

authors： Lionaki S,Kapitsinou PP,Iniotaki A,Kostakis A,Moutsopoulos HM,Boletis JN

更新日期：2008-07-01 00:00:00

abstract：:Structural and metabolic abnormalities in the hippocampus have been associated with the pathophysiological mechanism of central nervous system involvement in primary Sjögren syndrome (pSS). Nevertheless, how hippocampal function is altered in pSS remains unknown. The purpose of our study is to investigate the alterati...

journal_title：Lupus

authors： Zhang XD,Zhao LR,Zhou JM,Su YY,Ke J,Cheng Y,Li JL,Shen W

更新日期：2020-04-01 00:00:00

abstract：:The objective of the study was to analyse the prevalence and clinical significance of hypocomplementemia in a large series of patients diagnosed either with systemic lupus erythematosus (SLE) or with primary antiphospholipid syndrome (APS) and its association with the main clinical, hematological and immunological fea...

journal_title：Lupus

authors： Ramos-Casals M,Campoamor MT,Chamorro A,Salvador G,Segura S,Botero JC,Yagüe J,Cervera R,Ingelmo M,Font J

更新日期：2004-01-01 00:00:00