Abstract:
:We report an infant with anticardiolipin (aCL) antibodies who presented with erythematous nodular skin lesions and elevated liver enzyme levels. The cutaneous manifestation was histologically lymphocytic lobular panniculitis with vasculitic and hemorrhagic changes. The infant also had low levels of anti-double stranded DNA (dsDNA) and anti-single stranded DNA (ssDNA) antibodies. There were no detectable antibodies to small nuclear ribonucleoproteins including Ro/SSA and La/SSB. His mother was consistently seronegative for any of these antibodies. Without corticosteroid therapy, cutaneous lesions resolved and anticardiolipin antibodies, but not anti-dsDNA and ssDNA antibodies, normalized within 16 months after the onset of the disease. Our patient demonstrated an uncommon presentation of aCL related cutaneous manifestation, the presentation with panniculitis being only the third such patient reported in the literature. Of great interest was the appearance of aCL antibodies and skin lesions during very early infancy.
journal_name
Lupusjournal_title
Lupusauthors
Miyagawa S,Uchida Y,Taira K,Higuchi M,Hashimoto K,Yoshioka A,Shirai Tdoi
10.1191/096120300678828721subject
Has Abstractpub_date
2000-01-01 00:00:00pages
637-40issue
8eissn
0961-2033issn
1477-0962journal_volume
9pub_type
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