Abstract:
:Leukopenia and anaemia are observed in about a fifth of all patients with systemic lupus erythematosus (SLE) and may be due either to the destruction of blood cells or their decreased production. The former may be humoral or cell-mediated or result from apoptosis of peripheral blood cells. Several observations suggest the occurrence of the latter reduced in vitro proliferation of pluripotent bone marrow progenitors from the bone marrow aspirates of SLE patients,reduced counts of CD34+ cells in bone marrow aspirates in SLE patients, apoptosis of lymphopoietic progenitors and apoptosis of bone marrow cells. The aim of our study was to investigate whether humoral factors may induce suppression of haematopoiesis by increased apoptosis of CD34+ cells. For this purpose, we incubated allogeneic CD34+-enriched cells with sera of 18 leukopenic SLE patients. Apoptosis was induced by four of 18 sera. This effect was independent of complement-inhibition and FAS-blockade. Although reduced proliferation of autologous pluripotent bone marrow progenitors has been attributed to an IgG serum inhibitor, removal of IgG from these four proapoptotic sera had no effect on apoptosis of allogeneic CD34+ cells. The proapoptotic effect was associated with high titres of anti-dsDNA antibodies and low haemoglobin concentrations, but not with high titres of antinuclear antibodies, TNF-alpha and IFN-alpha of the sera tested.
journal_name
Lupusjournal_title
Lupusauthors
Tiefenthaler M,Bacher N,Linert H,Mühlmann O,Hofer S,Sepp N,Amberger A,Geisen F,Obermoser G,Konwalinka Gdoi
10.1191/0961203303lu423oasubject
Has Abstractpub_date
2003-01-01 00:00:00pages
471-8issue
6eissn
0961-2033issn
1477-0962journal_volume
12pub_type
杂志文章相关文献
LUPUS文献大全abstract::Protein S deficiency is rare in systemic lupus erythematosus (SLE) and is generally associated with the presence of antiphospholipid (APL) antibodies. Lack of protein S can cause skin necrosis, but when it does it is generally in response to warfarin exposure. In this article, we describe the case of a patient who had...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203319843345
更新日期:2019-06-01 00:00:00
abstract::A 7-year-old boy presented with adrenal insufficiency. He subsequently developed venous thrombosis in the limbs and was diagnosed with primary antiphospholipid syndrome (PAPS) based on clinical and laboratory parameters. Both adrenals were normal on imaging. He required thrombolysis and anticoagulation. The progressiv...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203310397965
更新日期:2011-10-01 00:00:00
abstract::We investigated the clinical significance of IgG phospholipid-dependent anti-beta 2-glycoprotein I (beta 2-GPI) antibodies in patients with SLE. The study population consisted of 140 patients with SLE. Sera were examined for IgG phospholipid-dependent anti-beta 2-GPI antibodies by ELISA. IgG phospholipid-dependent ant...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339500400609
更新日期:1995-12-01 00:00:00
abstract::The levels of 'putative' anti-idiotypic antibodies reactive with F(ab')2 fragments of affinity purified DNA binding antibodies from five SLE patients were measured in the serum of active and inactive systemic lupus erythematosus (SLE) patients, their relatives, spouses and healthy non-related individuals. Serum anti-i...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/096120398678919958
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:The main vitamin D source is exposure to ultraviolet radiation, which aggravates cutaneous lupus erythematosus (CLE). OBJECTIVES:The aims of this study were to identify variables associated with lower serum 25-hydroxyvitamin D [25(OH)D] levels in CLE patients and assess the effect of vitamin D restoration o...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314522338
更新日期:2014-06-01 00:00:00
abstract::Although a few reports in recent years have suggested that patients with antiphospholipid antibodies (aPL) are prone to developing primary anetoderma (PA), it is still unclear how often aPL are detected in unselected PA patients. We studied nine consecutive PA patients for the presence of autoimmune antibodies and dis...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203303lu403oa
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVES:To determine the frequency and the time to complete recovery identified by Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) and the time to partial recovery identified by the SLEDAI-2K Responder Index 50 (SRI-50) in three laboratory systems over 10 years. METHODS:This is a retrospective ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203312454344
更新日期:2012-10-01 00:00:00
abstract::The objective of this study was to determine the vitamin D status and its relationship with disease and therapy features and with bone mineral density in women with systemic lupus erythematosus. Non-pregnant systemic lupus erythematosus women with dual-energy X-ray absorptiometry and vitamin D measurements performed b...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203309345775
更新日期:2010-01-01 00:00:00
abstract::Systemic lupus erythematosus is a chronic, relapsing autoimmune disease that can affect multiple organ systems. An increased prevalence of drug allergy has been reported in lupus patients compared with the general population. Using a cohort of 417 lupus patients, we found a history of sulpha allergy in 27.3% of patien...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203307086640
更新日期:2008-03-01 00:00:00
abstract::Nephropathy of antiphospholipid antibody syndrome (NAPS) is an increasingly well-recognized aspect of antiphospholipid syndrome. The most characteristic histopathology is that of thrombotic microangiopathy, and thrombosis occurring in the renal vasculature is thought to be the initiating event. Other less common patho...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203308098629
更新日期:2009-05-01 00:00:00
abstract::Detection of antineutrophil cytoplasmic antibodies (ANCA) for ANCA-associated vasculitides (AAV) is based on indirect immunofluorescence (IIF) on ethanol-fixed neutrophils and reactivity toward myeloperoxidase (MPO) and proteinase 3 (PR3). According to the international consensus for ANCA testing, presence of ANCA sho...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316640921
更新日期:2016-07-01 00:00:00
abstract::Antiphospholipid antibodies (aPL) are associated with an increased incidence of fetal loss, but the pathophysiology remains unclear. One mechanism may involve the binding of aPL directly to the placenta where they may initiate placental thrombosis and infarction. We have developed an immunofluorescent technique to det...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/096120399678840756
更新日期:1999-01-01 00:00:00
abstract::The aim of this study was to investigate two patients with antiphospholipid syndrome (APS) who suffered from multiple repeated pregnancy losses of probably genetically impaired embryos. Sera from these patients contained high levels of IgG antibodies against cardiolipin, IgG and IgM phosphatidyl inositol, IgG phosphat...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203312442581
更新日期:2012-06-01 00:00:00
abstract::Renal involvement is one of the main complications of systemic lupus erythematosus, causing a significant impact on patients' morbidity and mortality. Renal biopsy is still the gold standard of diagnosis, but it has many limitations. In this sense, several recent studies aim to identify biomarkers that not only predic...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203319826695
更新日期:2019-03-01 00:00:00
abstract::The registry is a prospective, European, multicentric, longitudinal study, which follows a cohort of children born to mothers with antiphospholipid syndrome (APS). It was started in 2003. In this report, we update the results obtained from the study of 110 mothers and 112 children (two twin births). Eighty per cent of...
journal_title:Lupus
pub_type: 杂志文章,多中心研究
doi:10.1177/0961203309106951
更新日期:2009-09-01 00:00:00
abstract::Glycans (sugars or carbohydrates) are predominant surface components of cells such as erythrocytes, immune cells and microorganisms. As such, they give rise to high levels of anti-glycan antibodies of all classes. Antibodies to certain defined mono, di and oligosaccharides that are common in bacterial, fungal and para...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1191/0961203306lu2331oa
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:The feed-forward loop of type I interferons (IFNs) production and subsequent immunopathology of systemic lupus erythematosus (SLE) has been hypothesised to be disrupted with inhibition of IFNα or type I IFN receptor subunit 1 (IFNAR). This systematic review and meta-analysis present the treatment efficacy and...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203320959702
更新日期:2020-12-01 00:00:00
abstract::To assess bladder function in systemic lupus erythematosus (SLE) patients with recurrent urinary tract infections (UTIs). A convenience sample of consecutive patients with SLE (American College of Rheumatology criteria), with recurrent UTIs (>/=3 events in the preceding 12 months), without history of central nervous s...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203308093458
更新日期:2008-12-01 00:00:00
abstract::The relationship between disease activity, cumulative damage and self-reported quality of life was examined in 96 patients with Systematic Lupus Erythematosus (SLE). Disease activity was measured by the SLE Disease Activity Index (SLEDAI) and cumulative damage by the Systematic Lupus International Cooperating Clinics/...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339700600305
更新日期:1997-01-01 00:00:00
abstract::Perinatal thrombosis in infants born to mothers with antiphospholipid antibodies (aPL) is a rare event, but with risk of death or severe sequelae. We analysed 16 infants with such perinatal thrombosis reported in the literature in the last 20 years. Thromboses were arterial (13/16), mostly strokes (8/16). Hydrops feta...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203307079039
更新日期:2007-01-01 00:00:00
abstract::Several studies have investigated the potential of various autoantibody tests in the diagnosis of systemic lupus erythematosus (SLE). Many lupus patients initially present with glomerulonephritis. In that clinical situation the main differential diagnosis are other forms of glomerulonephritis. In this study the diagno...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203309345753
更新日期:2009-12-01 00:00:00
abstract::Deficiency of mannan-binding lectin (MBL) has been reported to impact susceptibility to severe infections and atherosclerosis in systemic lupus erythematosus (SLE). In this study, MBL gene polymorphisms were analysed in 143 SLE patients and the frequency of severe infections and organ damage according to SLICC/ACR Dam...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/09612033070160040201
更新日期:2007-01-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is characterized by multiple autoantibodies and complement activation. Recent studies have suggested that anti-nuclear antibody (ANA) positivity may disappear over time in some SLE patients. Anti-double-stranded DNA (dsDNA) antibody titers and complement levels may vary with time and...
journal_title:Lupus
pub_type: 历史文章,杂志文章
doi:10.1177/0961203310385738
更新日期:2011-03-01 00:00:00
abstract::Results for lupus anticoagulant (LA) are expressed as ratio of patient-to-normal clotting times (LA-ratio) according to the equation LA-ratio = (Patient(Clotting time)/Normal(Clotting time)). However, numerical results vary according to the method used for testing, thus making difficult the between-method and between-...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203312438114
更新日期:2012-06-01 00:00:00
abstract::Our aims were to assess the frequency of false-positive IgM antibodies for cytomegalovirus in pregnant women with autoimmune diseases and in healthy women (controls) and to determine their relationship with pregnancy outcome. Data from 133 pregnancies in 118 patients with autoimmune diseases and from 222 pregnancies i...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203310361350
更新日期:2010-06-01 00:00:00
abstract::Objective The objectives of this paper are to objectively measure habitual physical activity levels in patients with primary Sjögren's syndrome (pSS) with mild disease activity and to determine to which extent it may be associated with physical capacity and function and clinical features. Methods In this cross-section...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316674819
更新日期:2017-06-01 00:00:00
abstract::One hundred and twenty-nine patients with systemic lupus erythematosus were screened for thyroid function tests. Of these, 8.9% had hyperthyroidism and 3.9% Hashimoto's thyroiditis. Euthyroid sick syndrome was present in 47.8% of patients. There was a high prevalence of antimicrosomal and antithyroglobulin antibodies ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339300200109
更新日期:1993-02-01 00:00:00
abstract::Objective We aimed to evaluate the relationship between telomere length and systemic lupus erythematosus (SLE). Methods PUBMED and EMBASE databases were searched; meta-analyses were performed comparing telomere length in SLE patients and healthy controls, and on SLE patients in subgroups based on ethnicity, sample typ...
journal_title:Lupus
pub_type: 杂志文章,meta分析
doi:10.1177/0961203316662721
更新日期:2017-03-01 00:00:00
abstract::Cells traffic in both directions between the fetus and the mother during pregnancy. Recent studies indicate that a low level of fetal cells commonly persists in the maternal circulation for years after pregnancy completion. The harboring of DNA or cells from another individual at low levels is called microchimerism. C...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1191/0961203302lu271oa
更新日期:2002-01-01 00:00:00
abstract::To study whether monoclonal anticardiolipin antibodies (aCL), derived from patients with antiphospholipid syndrome (APS), have similar pathogenic potential, we have employed an experimental model of antiphospholipid syndrome. Monoclonal aCL were produced by the combined method of EBV transformation and somatic cell hy...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339500400307
更新日期:1995-06-01 00:00:00