Abstract:
:This study assessed the expression of complement receptor 1 (CR1), decay accelerating factor (DAF) and membrane inhibitor of reactive lysis (CD59) on the erythrocytes and glomerulus of diffuse proliferative glomerulonephritis (DPGN) of systemic lupus erythematosus (SLE) patients using flow cytometry and immunofluorescence techniques to elucidate their role in the pathogenesis of DPGN. Expression of CR1 on the erythrocytes and glomerulus of DPGN patients was reduced compared with expression in normal subjects. However, expression of DAF and CD59 was increased on both erythrocytes and glomerulus of DPGN patients, suggesting the generation of a protective response against complement-mediated injury.
journal_name
Lupusjournal_title
Lupusauthors
Arora M,Arora R,Tiwari SC,Das N,Srivastava LMdoi
10.1191/096120300678828154subject
Has Abstractpub_date
2000-01-01 00:00:00pages
127-31issue
2eissn
0961-2033issn
1477-0962journal_volume
9pub_type
杂志文章相关文献
LUPUS文献大全abstract::Analyses of the medical and economic burden of chronic disorders such as systemic lupus erythematosus (SLE) are valuable for clinical and health policy decisions. We performed a chart-based review of 215 adult SLE patients with active autoantibody-positive disease at the predefined ratio of 30% severe (involvement of ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203316642310
更新日期:2016-10-01 00:00:00
abstract:OBJECTIVES:We aimed to determine 1) ultrasound (US) abnormalities in patients with systemic lupus erythematosus (SLE) with and without hand arthralgia at the day of examination compared with clinical evaluation and healthy controls, and 2) inter-observer reliability of the US abnormalities. METHODS:Thirty-three female...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314561666
更新日期:2015-06-01 00:00:00
abstract::Neonatal antiphospholipid syndrome (neonatal APS) seems to be exceedingly rare, as the antiphospholipid antibodies (aPL) related thrombosis in the neonatal period. The pathogenesis of perinatal aPL related thrombosis may be explained both by the transplacental passage of the maternal antibodies and by the production o...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203314560207
更新日期:2015-03-01 00:00:00
abstract::Lupus anticoagulant-hypoprothrombinemia syndrome (LA-HPS) is a rare acquired disorder caused by prothrombin antibodies. The disease is most common in the pediatric age group (<16 years), and more prevalent in women. There are well-established clinical diseases associated with LA-HPS, most notably systemic lupus erythe...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203314558859
更新日期:2015-06-01 00:00:00
abstract::Neuropsychiatric lupus is a well-recognized complication of systemic lupus erythematosus (SLE) and encompasses a wide variety of neurological manifestations. Although isolated cranial nerve involvement is rare, it can cause significant morbidity and disability. This report describes a case with isolated vagus nerve in...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203307080632
更新日期:2007-01-01 00:00:00
abstract::The objective was to investigate the relation between serum levels of interferon-alpha (IFN-alpha), the activity of an endogenous IFN-alpha inducing factor (SLE-IIF), clinical and immunological disease activity as well as serum levels of antiretroviral antibodies in SLE. Serum levels of IFN-alpha were measured in seri...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/096120300674499064
更新日期:2000-01-01 00:00:00
abstract::Diagnostic strategy studies commonly focus on the accuracy of tests in diagnosing, and grading this body of evidence is a challenge in itself because (1) standard tools for grading evidence were designed for questions about treatment rather than diagnostic testing; and (2) the clinical usefulness of a diagnostic strat...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314543922
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:The main vitamin D source is exposure to ultraviolet radiation, which aggravates cutaneous lupus erythematosus (CLE). OBJECTIVES:The aims of this study were to identify variables associated with lower serum 25-hydroxyvitamin D [25(OH)D] levels in CLE patients and assess the effect of vitamin D restoration o...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314522338
更新日期:2014-06-01 00:00:00
abstract:OBJECTIVES:The objectives of this paper are to prospectively determine the incidence of paediatric systemic lupus erythematosus (pSLE) in Australia as well as describe the demographics, clinical presentation and one-year outcome. STUDY DESIGN:Newly diagnosed cases of pSLE were ascertained prospectively from October 20...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314552118
更新日期:2015-01-01 00:00:00
abstract::Autoantibodies to DNA were discovered over 40 years ago following the discovery a few years earlier of the 'LE' cell phenomenon by Hargraves and colleagues in 1948. These investigators noted that, when leucocytes were incubated with serum from lupus patients, changes in the nucleus could be seen together with phagocyt...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1191/0961203302lu317oa
更新日期:2002-01-01 00:00:00
abstract:Background:Strongyloidiasis can be fatal in systemic lupus erythematosus (SLE) patients, but few epidemiological studies have investigated the burden of this tropical disease among the SLE population. This study aimed to assess the prevalence and associated factors of strongyloidiasis among SLE patients in Southern Tha...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203320911091
更新日期:2020-05-01 00:00:00
abstract::Prothrombin is a common antigenic target of antiphospholipid antibodies, since anti-prothrombin antibodies are detected in about 50-90% of the patients. To allow proper immune recognition, prothrombin must be adsorbed on suitable anionic surfaces. The epitope(s) have not yet been identified: the majority of anti-proth...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/096120339800700209
更新日期:1998-01-01 00:00:00
abstract::Leukopenia and anaemia are observed in about a fifth of all patients with systemic lupus erythematosus (SLE) and may be due either to the destruction of blood cells or their decreased production. The former may be humoral or cell-mediated or result from apoptosis of peripheral blood cells. Several observations suggest...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203303lu423oa
更新日期:2003-01-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is an autoimmune disorder that can affect virtually any organ. Chylous ascites as a presenting manifestation of SLE has been described in a handful of cases in adults. However, to the best of our knowledge this presentation has never been reported in the pediatric age group. Podocyto...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203318817831
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:Acute exercise increases IL-6, IL-10 and TNF-α levels in healthy subjects. There is no study evaluating the effect of exercise on cytokines level in systemic lupus erythematosus (SLE) patients. OBJECTIVE:Our aim was to assess IL-10, IL-6 and TNF-α levels at baseline and after acute physical exercise in pati...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203313508832
更新日期:2013-12-01 00:00:00
abstract::A 7-year-old boy presented with adrenal insufficiency. He subsequently developed venous thrombosis in the limbs and was diagnosed with primary antiphospholipid syndrome (PAPS) based on clinical and laboratory parameters. Both adrenals were normal on imaging. He required thrombolysis and anticoagulation. The progressiv...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203310397965
更新日期:2011-10-01 00:00:00
abstract::Systemic lupus erythematosus is the prototypic multi-system autoimmune disease characterized by the production of multiple autoantibodies. The development of disease depends on a genetic predisposition and exposure to environmental factors including UV light, drugs, and infections. The association of parasitic infecti...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203309345735
更新日期:2009-11-01 00:00:00
abstract::Systemic lupus erythematosus is a chronic, relapsing autoimmune disease that can affect multiple organ systems. An increased prevalence of drug allergy has been reported in lupus patients compared with the general population. Using a cohort of 417 lupus patients, we found a history of sulpha allergy in 27.3% of patien...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203307086640
更新日期:2008-03-01 00:00:00
abstract::Cytomegalovirus (CMV) is particularly dangerous in systemic lupus erythematosus (SLE), being a problem both for the differential diagnosis with disease flare and for the management of SLE flare with immunosuppressive drugs. We report on four cases of SLE with concomitant CMV infection, having some common clinical and ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203319825570
更新日期:2019-03-01 00:00:00
abstract::We describe a case of active systemic lupus erythematosus (SLE) complicated with a large amount of pericardial effusion with diastolic collapse of right ventricle suggestive of tamponade. Isolates from surgical drainage of pericardial fluid showed Acinetobacter baumannii exhibiting multiple antibiotics resistance. Des...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/096120339700600513
更新日期:1997-01-01 00:00:00
abstract::C4d deposition in peritubular capillaries (PTC) has been used as a marker of antibody-mediated rejection (AMR). However, PTC C4d deposition is not described in patients with lupus nephritis (LN). C4d deposition in PTC was detected in 455 patients with biopsy proven LN in the present study. Renal tissues from 21 cases ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203307083279
更新日期:2007-01-01 00:00:00
abstract::The disease activity of patients suffering from lupus nephritis usually becomes quiescent after the onset of end stage renal failure. Reactivation of lupus activity, especially after a long period of dialysis, is uncommon. Factors that might trigger off lupus reactivation after dialysis have not been well defined. We ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203302lu096cr
更新日期:2002-01-01 00:00:00
abstract::We have previously shown that elevation of anticardiolipin antibodies (aCL) at the first prenatal visit is associated with increased fetal loss in normal pregnancy. The variation in aCL levels during normal pregnancy has not been established. To examine this question we measured IgG, IgM and IgA aCL levels five times ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339500400506
更新日期:1995-10-01 00:00:00
abstract::The purpose of this study was to determine the prevalence and correlates of fibromyalgia (FM) in a prospective, multiethnic systemic lupus (SLE) cohort. A total of 266 SLE patients with disease duration of < or = 5 years at study entry were evaluated longitudinally for the presence of FM (per ACR criteria). Sociodemog...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1191/0961203303lu330oa
更新日期:2003-01-01 00:00:00
abstract::Current management of primary or secondary antiphospholipid antibody (aPL) syndromes with known embolic phenomena requiring anticoagulation is empiric in the setting of elective orthopedic procedures. Short-term withdrawal of warfarin with continuance of aspirin and glucocorticoid therapy was undertaken for sequential...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339200100311
更新日期:1992-05-01 00:00:00
abstract::Belimumab is a monoclonal antibody against soluble B-lymphocyte stimulator, an essential growth factor for B-cell maturation and activation, which was approved by the US FDA in 2011 for patients with active autoantibody-positive systemic lupus erythematosus (SLE) who have failed standard treatment. Here we present the...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314524292
更新日期:2014-06-01 00:00:00
abstract::Objective The objective of this study was to describe the clinical and immunological pattern and disease outcome in Egyptian systemic lupus erythematosus patients. Patients and methods The medical records of 770 systemic lupus erythematosus patients who were followed from 2002-2015 at Kasr Alainy Hospital, Cairo Unive...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203318776085
更新日期:2018-08-01 00:00:00
abstract::Objective Several studies have evaluated the prevalence of rheumatoid factor (RF) and anti-citrullinated proteins antibodies (ACPA) in systemic lupus erythematosus (SLE) patients but no data are available on the anti-carbamylated proteins (anti-CarP), a new biomarker for rheumatoid arthritis (RA). We evaluated the ant...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203317713141
更新日期:2018-01-01 00:00:00
abstract::We studied the effect of beta 2-GPI on binding of antibodies in sera from patients with leprosy and patients with the antiphospholipid syndrome (APS) to CL in enzyme-linked immunosorbent assays (ELISAs). Increased levels of IgG aCL were detected in 59 of 61 leprosy patients' sera by the standard aCL-ELISA in the prese...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/096120339400300615
更新日期:1994-12-01 00:00:00
abstract::Children born to women with systemic lupus erythematosus seem to have a potentially increased risk of neurodevelopmental disorders compared to children born to healthy women. Recent experimental data suggest in utero exposure to maternal antibodies and cytokines as important risk factors for neurodevelopmental disorde...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203314541691
更新日期:2014-10-01 00:00:00