Cross-reactivity and pathogenicity of anti-DNA autoantibodies in systemic lupus erythematosus.

abstract：:A girl with neuropsychiatric lupus demonstrated Parkinsonian features soon after commencing risperidone. The single photon emission computed tomography scan showed hyperperfusion of the basal ganglia. Symptoms abated with the addition of dopaminergic agents to immunosuppressive therapy. The literature on juvenile Park...

journal_title：Lupus

authors： Khubchandani RP,Viswanathan V,Desai J

更新日期：2007-01-01 00:00:00

abstract：:Belimumab is a monoclonal antibody against soluble B-lymphocyte stimulator, an essential growth factor for B-cell maturation and activation, which was approved by the US FDA in 2011 for patients with active autoantibody-positive systemic lupus erythematosus (SLE) who have failed standard treatment. Here we present the...

journal_title：Lupus

authors： Fredericks CA,Kvam KA,Bear J,Crabtree GS,Josephson SA

更新日期：2014-06-01 00:00:00

abstract：:Utilizing this unique animal model of thrombosis we demonstrated that human (IgG, IgM or IgA) polyclonal and monoclonal antiphospholipid antibodies derived from APS patients have a significant enhancing effect on thrombus formation. This effect is reversed by treatment of the mice with hydroxychloroquine (plaquenil). ...

journal_title：Lupus

authors： Pierangeli SS,Harris EN

更新日期：1996-10-01 00:00:00

abstract：:The purpose of this study was to evaluate the clinical characteristics of women with systemic lupus erythematosus (SLE) sent for a dual energy X-ray absorptiometry (DEXA) study, and to analyse the factors associated with a lower bone mineral density in these patients. Women with SLE who had a DEXA done between 1 Janua...

journal_title：Lupus

authors： Pineau CA,Urowitz MB,Fortin PJ,Ibanez D,Gladman DD

更新日期：2004-01-01 00:00:00

abstract：:We report the occurrence of visceral leishmaniasis in three patients coming from the northern part of Italy treated with immunosuppressive drugs for different rheumatic conditions. This paper highlights the importance of adequate work-up in those patients presenting with serious clinical manifestations that can compli...

journal_title：Lupus

authors： Castellino G,Govoni M,Lo Monaco A,Montecucco C,Colombo F,Trotta F

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVES:The objective of this paper is to perform the cross-cultural validation of the French version of the LupusPRO, a disease-targeted patient-reported outcome measure, among systemic lupus erythematosus (SLE) patients in Canada. METHODS:The French version of the LupusPRO and the MOS SF-36 were administered; dem...

journal_title：Lupus

authors： Bourré-Tessier J,Clarke AE,Kosinski M,Mikolaitis-Preuss RA,Bernatsky S,Block JA,Jolly M

更新日期：2014-12-01 00:00:00

abstract：:Objective Adherence to medication has a major impact on treatment control and success especially in chronic diseases but often remains unrecognized. Besides clinical, socioeconomic, disease-related and treatment-related parameters, general and personal health beliefs, as well as perception of health, can affect adhere...

journal_title：Lupus

authors： Chehab G,Sauer GM,Richter JG,Brinks R,Willers R,Fischer-Betz R,Winkler-Rohlfing B,Schneider M

更新日期：2018-09-01 00:00:00

abstract：:We retrospectively evaluated the clinical outcome of 45 female and 11 male patients with biopsy-proven lupus nephritis, followed at our hospital between February 1974 and February 1990. In the majority signs of nephritis were present at the time systemic lupus erythematosus was diagnosed (range: -42-156 months) and th...

journal_title：Lupus

authors： Derksen RH,Hené RJ,Kater L

更新日期：1992-02-01 00:00:00

abstract：:Organizing pneumonia is an inflammatory lung entity that presents with a huge variety of clinical, radiological and pathological patterns. Organizing pneumonia can be idiopathic or secondary to other diseases. Corticosteroid therapy is usually the first-line treatment showing clinical improvement in most cases. This r...

journal_title：Lupus

authors： Giménez AR,Pastrana DB,Huaranga MAR,Izquierdo JR,Cabrera B,García AN,Rodríguez CCR

更新日期：2019-04-01 00:00:00

abstract：:Vaccination has been perhaps the most important achievement in medicine of the last century. A hoard of infectious diseases that used to claim the lives of many, especially children, have been prevented and some even eradicated. However, it is possible that within this gift there is hidden a 'Trojan Horse'. During the...

journal_title：Lupus

authors： Aron-Maor A,Shoenfeld Y

更新日期：2001-01-01 00:00:00

abstract：:Heart valve disease (HVD) is the most common cardiac manifestation in the antiphospholipid syndrome (APS). Valve lesions should be described according to the established definition. HVD is progressive despite anticoagulant/antiplatelet treatments. Around 4-6% of patients with HVD in APS will require valve replacement ...

journal_title：Lupus

authors： Amigo MC

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVE:This study aimed to explore the risk factors for 'severe' neuropsychiatric (NP) flare in patients with systemic lupus erythematosus (SLE). METHODS:This retrospective study comprised newly diagnosed 184 adult SLE patients who visited Hokkaido University Hospital between 2006 and 2017. In this study, severe NP...

journal_title：Lupus

authors： Aso K,Kono M,Kono M,Watanabe T,Shimizu Y,Ogata Y,Fujieda Y,Kato M,Oku K,Amengual O,Yasuda S,Atsumi T

更新日期：2020-09-01 00:00:00

abstract：:Endothelial and/or platelet activation likely initiates thrombus formation. Whether antiphospholipid antibody (aPL) is an activator, a toxic response, or a protective response is not clear, nor is it certain whether aPL is germ-line encoded or antigen-driven. The pregnancy model is particularly informative. Alternativ...

journal_title：Lupus

authors： Lockshin MD

更新日期：1996-10-01 00:00:00

abstract：:A special interaction is established during pregnancy between the maternal immune system and fetal cells to allow the survival and the normal growth of the fetus. Fetal cells expressing paternal alloantigens are not recognized as foreign by the mother because of an efficient anatomic barrier and a local immunosuppress...

journal_title：Lupus

authors： Bulla R,Fischetti F,Bossi F,Tedesco F

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:To investigate the clinical characteristics, imaging changes and early diagnostic methods of neuropsychiatric systemic lupus erythematosus (NPSLE). METHODS:Thirty-five SLE patients, of which 16 had overt neuropsychiatric symptoms, underwent examination for multiple autoantibodies, including anti-double-stran...

journal_title：Lupus

authors： Jia J,Xie J,Li H,Wei H,Li X,Hu J,Meng D,Zhang Y,Zhang X

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Cardiomyopathy in systemic lupus erythematosus (SLE) may be secondary to myocardial inflammation (i.e. myocarditis) or to systemic complications such as hypertension. Symptomatic left ventricular dysfunction is the most common clinical presentation of cardiomyopathy and is potentially life threatening. Ident...

journal_title：Lupus

authors： Appenzeller S,Pineau CA,Clarke AE

更新日期：2011-08-01 00:00:00

abstract：:The objective of this study was to identify risk factors associated with flare during pregnancy in women with systemic lupus erythematosus (SLE). We performed a retrospective analysis of pregnant women with SLE in a referral hospital. Flare was considered according to predetermined definitions. We analyzed 15 clinical...

journal_title：Lupus

authors： Saavedra MA,Sánchez A,Morales S,Navarro-Zarza JE,Ángeles U,Jara LJ

更新日期：2015-02-01 00:00:00

abstract：:Criteria of organ-specific autoimmunity are fulfilled in a subset of patients with myocarditis/dilated cardiomyopathy (DCM). In particular, circulating heart-reactive autoantibodies are found in patients and symptom-free relatives. These autoantibodies are directed against multiple antigens, some of which are expresse...

journal_title：Lupus

authors： Caforio AL,Daliento L,Angelini A,Bottaro S,Vinci A,Dequal G,Tona F,Iliceto S,Thiene G,McKenna WJ

更新日期：2005-01-01 00:00:00

abstract：:Several studies have investigated the potential of various autoantibody tests in the diagnosis of systemic lupus erythematosus (SLE). Many lupus patients initially present with glomerulonephritis. In that clinical situation the main differential diagnosis are other forms of glomerulonephritis. In this study the diagno...

journal_title：Lupus

authors： Heidenreich U,Mayer G,Herold M,Klotz W,Stempfl Al-Jazrawi K,Lhotta K

更新日期：2009-12-01 00:00:00

abstract：:Designing successful randomized controlled trials (RCTs) in systemic lupus erythematosus (SLE) poses many challenges. It remains difficult to correlate alterations in biologic markers with clinical outcome, especially when signs and symptoms are intermittent and broadly variable between patients. Disease activity indi...

journal_title：Lupus

authors： Strand V

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the frequency of primary immunodeficiencies (PID) in juvenile systemic lupus erythematosus (JSLE) patients. METHODS:Some 72 JSLE patients were analyzed for levels of immunoglobulin classes and IgG subclasses and early components of the classical complement pathway. Determination of C4 gene copy n...

journal_title：Lupus

authors： Jesus AA,Liphaus BL,Silva CA,Bando SY,Andrade LE,Coutinho A,Carneiro-Sampaio M

更新日期：2011-10-01 00:00:00

abstract：:Rheumatoid Arthritis (RA) is a chronic disease with significant morbidity and functional disability. The traditional treatment for RA relied on the use of NSAIDs early in the disease course, followed by disease-modifying agents later. More recently, the disease-modifying anti-rheumatic drugs (DMARDs) have become the m...

journal_title：Lupus

authors： Khraishi MM,Singh G

更新日期：1996-06-01 00:00:00

abstract：OBJECTIVE:The objective of this report is to assess the presence and viral load of JC polyomavirus (JCV) DNA in cerebrospinal fluid (CSF) and plasma from neuropsychiatric systemic lupus erythematosus (NPSLE) patients in comparison to controls and to investigate if different types of immunosuppressive treatments were co...

journal_title：Lupus

authors： Iacobaeus E,Hopia L,Khademi M,Lundén M,Hammarin AL,Svenungsson E,Andersson M

更新日期：2013-03-01 00:00:00

abstract：:Neonatal antiphospholipid syndrome (neonatal APS) seems to be exceedingly rare, as the antiphospholipid antibodies (aPL) related thrombosis in the neonatal period. The pathogenesis of perinatal aPL related thrombosis may be explained both by the transplacental passage of the maternal antibodies and by the production o...

journal_title：Lupus

authors： De Carolis MP,Salvi S,Botta A,Cocca C,Garufi C,Lanzone A,De Carolis S

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Pregnancies in women with systemic lupus erythematosus (SLE) and lupus nephritis are considered high-risk due to high rates of maternal and fetal complications. However, there has not been a formal analysis addressing the issue of maternal deaths in these women. The aim of this study was to pe...

journal_title：Lupus

authors： Ritchie J,Smyth A,Tower C,Helbert M,Venning M,Garovic V

更新日期：2012-04-01 00:00:00

abstract：:The objective of this study was to determine whether anticardiolipin antibodies (ACL) in SLE patients are associated with a specific pattern of lupus nephritis and/or with renal microvascular changes. Patients with SLE, followed prospectively between June 1991-May 1994 at The Wellesley Hospital Lupus Clinic, who under...

journal_title：Lupus

authors： Abu-Shakra M,Urowitz MB,Gladman DD,Ritchie S

更新日期：1996-02-01 00:00:00

abstract：:Neuropsychiatric manifestations of systemic lupus erythematosus are common and disabling yet their pathogenesis is poorly understood. We investigated the role of cerebrovascular endothelial dysfunction in systemic lupus erythematosus and its neuropsychiatric manifestations. Subjects with systemic lupus erythematosus w...

journal_title：Lupus

authors： Davey R,Bamford J,Emery P

更新日期：2010-06-01 00:00:00

abstract：INTRODUCTION:Patients with systemic lupus erythematosus (SLE) with B-lymphocyte stimulator (BLyS) levels ≥ 2 ng/mL are at increased risk of flare. A regression analysis was undertaken to identify routine clinical measures that correlate with BLyS ≥ 2 ng/mL. Efficacy and safety of belimumab 10 mg/kg were examined in pat...

journal_title：Lupus

authors： Roth DA,Thompson A,Tang Y,Hammer AE,Molta CT,Gordon D

更新日期：2016-04-01 00:00:00

abstract：:The registry is a prospective, European, multicentric, longitudinal study, which follows a cohort of children born to mothers with antiphospholipid syndrome (APS). It was started in 2003. In this report, we update the results obtained from the study of 110 mothers and 112 children (two twin births). Eighty per cent of...

journal_title：Lupus

authors： Boffa MC,Lachassinne E,Boinot C,De Carolis S,Rovere-Querini P,Avcin T,Biasini-Rebaioli C,Le Toumelin P,Aurousseau MH,Tincani A

更新日期：2009-09-01 00:00:00

abstract：:Thiazolidinediones (TZDs) are selective ligands of peroxisome-proliferator-activated receptor gamma increasingly used in the treatment of type 2 diabetes. Both in vitro and in vivo studies provide evidence that TZDs have anti-inflammatory properties. TZDs inhibit macrophage activation and decrease inflammatory cytokin...

journal_title：Lupus

authors： Consoli A,Devangelio E

更新日期：2005-01-01 00:00:00